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• Structure and properties
• bonding and molecular structure
• chemical reactivity and organic reactions
• alkanes
• cycloalkanes
• stereochemistry
• alkenes
• alkyl halides
• alkynes, dienes and orbital symmetry
• aromaticity and benzene
• aromatic substitution, arenes
• spectroscopy and structure proof
• alcohols and thiols
• ethers, epoxides, glycols and thioethers
• aldehydes and ketones
• carboxylic acids
• acid derivatives
• carbanion-enolates and enols
• amines
• phenols and their derivatives
• aromatic heterocyclic compounds
• amino acids, peptides and proteins
• carbohydrates.
• (source: Nielsen Book Data)

Master organic chemistry with "Schaum's" - the high-performance solved-problem guide. It will help you cut study time, hone problem-solving skills, and achieve your personal best on exams! Students love "Schaum's Solved Problem Guides" because they produce results. Each year, thousands of students improve their test scores and final grades with these indispensable guides. Get the edge on your classmates. Use "Schaum's"! If you don't have a lot of time but want to excel in class, use this book to: brush up before tests; study quickly and more effectively; and, learn the best strategies for solving tough problems in step-by-step detail. Review what you've learned in class by solving thousands of relevant problems that test your skill.Compatible with any classroom text, "Schaum's Solved Problem Guides" let you practice at your own pace and remind you of all the important problem-solving techniques you need to remember fast! And "Schaum's" are so complete, they're perfect for preparing for graduate or professional exams. Inside you will find: 3000 solved problems with complete solutions, the largest selection of solved problems yet published on this subject; an index to help you quickly locate the types of problems you want to solve; problems like those you'll find on your exams; techniques for choosing the correct approach to problems; and, guidance toward the quickest, most efficient solutions.If you want top grades and thorough understanding of organic chemistry, this powerful study tool is the best tutor you can have! Chapters include: Structure and Properties; Bonding and Molecular Structure; Chemical Reactivity and Organic Reactions; Alkanes; Cycloalkanes; Stereochemistry; Alkenes; Alkyl Halides; Alkynes, Dienes, and Orbital Symmetry; Aromaticity and Benzene; Aromatic Substitution, Arenes; Spectroscopy and Structure Proof; Alcohols and Thiols; Ethers, Epoxides, Glycols, and Thioethers; Aldehydes and Ketones; Carboxylic Acids; Acid Derivatives; Carbanion-Enolates and Enols; Amines; Phenols and Their Derivatives; Aromatic Heterocyclic Compounds; Amino Acids, Peptides, and Proteins; and, Carbohydrates.
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• Alkylation of Enolates and Other Carbon Nucleophiles.- Reactions of Carbon Nucleophiles with Carbonyl Groups.- Functional Group Interconversion, Protection and Deprotection.- Electrophilic Additions to Carbon-Carbon Multiple Bonds.- Reduction of Carbon-Carbon Multiple, Carbonyl Groups, and Other Functional Groups.- Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations.- Organometallic Compounds of the Group I, II, and III Metals.- Reactions Involving the Transition Metals.- Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silicon, and Tin.- Reactions Involving Carbocations, Carbenes, and Radicals as Intermediates.- Aromatic Substitution Reactions.- Oxidations.- Planning and Execution of Multistep Syntheses.
• (source: Nielsen Book Data)

• Chemical Bonding and Structure.- Stereochemistry, Conformation and Stereoselectivity.- Structural Effects on Stability and Reactivity.- Nucleophilic Substitution.- Polar Addition and Elimination Reactions.- Carbanions and Other Carbon Nucleophiles.- Addition, Condensation and Substitution Reactions of Carbonyl Compounds.- Aromaticity.- Aromatic Substitution.- Concerted Pericyclic Reactions.- Free Radical Reactions.- Photochemistry.
• (source: Nielsen Book Data)

Since its original appearance in 1977, Advanced Organic Chemistry has maintained its place as the premier textbook in the field, offering broad coverage of the structure, reactivity and synthesis of organic compounds. As in the earlier editions, the text contains extensive references to both the primary and review literature and provides examples of data and reactions that illustrate and document the generalizations. While the text assumes completion of an introductory course in organic chemistry, it reviews the fundamental concepts for each topic that is discussed. The two-part fifth edition has been substantially revised and reorganized for greater clarity. Among the changes: Updated material reflecting advances in the field since 2001??'s Fourth Edition, especially in computational chemistry; A companion Web site provides digital models for study of structure, reaction and selectivity; Solutions to the exercises provided to instructors online. The control of reactivity to achieve specific syntheses is one of the overarching goals of organic chemistry. Part B describes the most general and useful synthetic reactions, organized on the basis of reaction type. Together with Part A: Structure and Mechanisms, the two volumes are intended to provide the advanced undergraduate or beginning graduate student in chemistry with a sufficient foundation to comprehend and use the research literature in organic chemistry.
(source: Nielsen Book Data)
The two-part, fifth edition of Advanced Organic Chemistry has been substantially revised and reorganized for greater clarity. The material has been updated to reflect advances in the field since the previous edition, especially in computational chemistry. Part A covers fundamental structural topics and basic mechanistic types. It can stand-alone; together, with Part B: Reaction and Synthesis, the two volumes provide a comprehensive foundation for the study in organic chemistry. Companion websites provide digital models for study of structure, reaction and selectivity for students and exercise solutions for instructors.
(source: Nielsen Book Data)

• Alkylation of Nuclephilic Carbon
• Reactions of Carbon Nucleophiles with Carbonyl Groups
• Functional Group Interconversion by Nucleophilic Substitution
• Electrophilic Additions to Carbon-Carbon Multiple Bonds
• Reduction of Carbonyl and Other Functional Groups
• Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations
• Organometallic Compounds of the Group I and II Metals
• Reactions Involving the Transition Metals
• Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silicon and Tin
• Reactions Involving Carbocations, Carbenes and Radicals as Reactive Intermediates
• Aromatic Substitution Reactions
• Oxidations
• Planning and Execution of Multi-Step Syntheses.
• (source: Nielsen Book Data)

• Chemical bonding and structure
• stereochemical principles
• conformational, steric and stereoelectronic effects
• study and description of organic reaction mechanisms
• nucleophilic substitution
• polar addition and elimination reactions
• cabanions and other nucleophilic carbon species
• reactions of carbonyl compounds
• aromaticity
• aromatic substitution
• concerted pericyclic reactions
• free-radical reactions
• photochemistry.
• (source: Nielsen Book Data)

• Preface to the Fourth Edition. Part A: Structure and Mechanisms.
• 1. Chemical Bonding and Structure.
• 2. Stereochemical Principles.
• 3. Conformational, Steric, and Stereoelectronic Effects.
• 4. Study and Description of Organic Reaction Mechanisms.
• 5. Nucleophilic Substitution.
• 6. Polar Addition and Elimination Reactions.
• 7. Cabanions and Other Nucleophilic Carbon Species.
• 8. Reactions of Carbonyl Compounds.
• 9. Aromaticity.
• 10. Aromatic Substitution.
• 11. Concerted Pericyclic Reactions.
• 12. Free-Radical Reactions.
• 13. Photochemistry. References. Index.
• (source: Nielsen Book Data)

Since its original appearance in 1977, "Advanced Organic Chemistry" has found wide use as a text providing broad coverage of the structure, reactivity and synthesis of organic compounds. The Fourth Edition provides updated material but continues the essential elements of the previous edition. The material in Part A is organized on the basis of fundamental structural topics such as structure, stereochemistry, conformation and aromaticity and basic mechanistic types, including nucleophilic substitution, addition reactions, carbonyl chemistry, aromatic substitution and free radical reactions. The material in Part B is organized on the basis of reaction type with emphasis on reactions of importance in laboratory synthesis. As in the earlier editions, the text contains extensive references to both the primary and review literature and provides examples of data and reactions that illustrate and document the generalizations. While the text assumes completion of an introductory course in organic chemistry, it reviews the fundamental concepts for each topic that is discussed. The Fourth Edition updates certain topics that have advanced rapidly in the decade since the Third Edition was published, including computational chemistry, structural manifestations of aromaticity, enantioselective reactions and lanthanide catalysis. The two parts stand alone, although there is considerable cross-referencing. Part A emphasizes quantitative and qualitative description of structural effects on reactivity and mechanism. Part B emphasizes the most general and useful synthetic reactions. The focus is on the core of organic chemistry, but the information provided forms the foundation for future study and research in medicinal and pharmaceutical chemistry, biological chemistry and physical properties of organic compounds. The New Revised 5th Edition will be available shortly.
(source: Nielsen Book Data)
The control of reactivity to achieve specific syntheses is one of the overarching goals of organic chemistry. In the decade since the publication of the third edition, major advances have been made in the development of efficient new methods, particularly catalytic processes, and in means for control of reaction stereochemistry. This volume assumes a level of familiarity with structural and mechanistic concepts comparable to that in the companion volume, Part A, "Structures and Mechanisms". Together, the two volumes are intended to provide the advanced undergraduate or beginning graduate student in chemistry with a sufficient foundation to comprehend and use the research literature in organic chemistry. The New Revised 5th Edition will be available shortly.
(source: Nielsen Book Data)

• General introduction Safety Safety is your primary responsibility Safe working practice Safety risk assessments Common hazards Accident and emergency procedures Bibliography Keeping records of laboratory work Introduction The laboratory notebook Keeping records of data Some tips on report and thesis preparation References Equipping the laboratory and the bench Introduction Setting up the laboratory General laboratory equipment The individual bench Equipment for parallel experiments Equipment for controlled experimentation Purification and drying of solvents Introduction Purification of solvents Drying agents Drying of solvents References Reagents: Preparation, purification, and handling Introduction Classification of reagents for handling Techniques for obtaining pure and dry reagents Techniques for handling and measuring reagents Preparation and titration of simple organometallic reagents and lithium amide bases Preparation of diazomethane References Gases Introduction Use of gas cylinders Handling gases Measurement of gases Inert gases Reagent gases References Vacuum pumps Introduction House vacuum systems (low vacuum) Medium vacuum pumps High vacuum pumps Pressure measurement and regulation Carrying out the reaction Introduction Reactions with air-sensitive reagents Reaction monitoring Reactions at other than room temperature Driving equilibria Agitation Use of controlled reactor systems References Working up the reaction Introduction Quenching the reaction Isolation of the crude product Data that need to be collected on the crude product prior to purification Purification Introduction Crystallization Distillation Sublimation Flash chromatography Dry-column flash chromatography Preparative TLC Medium pressure and prepacked chromatography systems Preparative HPLC References Small-scale reactions Introduction Reactions at or below room temperature Reactions above room temperature Reactions in NMR tubes Purification of materials Large-scale reactions Introduction Carrying out the reaction Workup and product isolation Purification of the products Special procedures Introduction Catalytic hydrogenation Photolysis Ozonolysis Flash vacuum pyrolysis (FVP) Liquid ammonia reactions Microwave reactions References Characterization Introduction NMR spectra IR spectra UV spectroscopy Mass spectrometry Melting point (m.p.) and boiling point (b.p.) Optical rotation Microanalysis Keeping the data Troubleshooting: What to do when things don't work The chemical literature The structure of the chemical literature Some important paper-based sources of chemical information Some important electronic-based sources of chemical information How to find chemical information Current awareness References Appendices Properties of common solvents Properties of common gases Approximate pKa values for some common reagents versus common bases Common Bronsted acids Common Lewis acids Common reducing reagents Common oxidizing reagents Index.
• (source: Nielsen Book Data)

Any research that uses new organic chemicals, or ones that are not commercially available, will at some time require the synthesis of such compounds. Therefore, organic synthesis is important in many areas of both applied and academic research, from chemistry to biology, biochemistry, and materials science. The third edition of a bestseller, Advanced Practical Organic Chemistry is a guide that explains the basic techniques of organic chemistry, presenting the necessary information for readers to carry out widely used modern organic synthesis reactions. This book is written for advanced undergraduate and graduate students as well as industrial organic chemists, particularly those involved in pharmaceutical, agrochemical, and other areas of fine chemical research. It provides the novice or nonspecialist with the often difficult-to-find information on reagent properties needed to perform general techniques. With over 80 years combined experience training and developing organic research chemists in industry and academia, the authors offer sufficient guidance for researchers to perform reactions under conditions that give the highest chance of success, including the appropriate precautions to take and proper experimental protocols. The text also covers the following topics: * Record keeping and equipment * Solvent purification and reagent preparation * Using gases and working with vacuum pumps * Purification, including crystallization and distillation * Small-scale and large-scale reactions * Characterization, including NMR spectra, melting point and boiling point, and microanalysis * Efficient ways to find information in the chemical literature With fully updated text and all newly drawn figures, the third edition provides a powerful tool for building the knowledge on the most up-to-date techniques commonly used in organic synthesis.
(source: Nielsen Book Data)

• Safety
• keeping records of laboratory work
• equipping the laboratory and the bench
• purification and drying of solvents
• reagents - purification and handling
• gases
• vacuum pumps
• carrying out the reaction
• working up the reaction
• purification
• small-scale reactions
• large-scale reactions
• characterization
• the chemical literature
• special procedures
• trouble shooting.
• (source: Nielsen Book Data)

Any research which uses new organic chemicals or those which are not available commercially will at some time require the synthesis of such compounds. This practical book covers the most up-to-date techniques commonly used in organic synthesis, and updates the first edition. This book should be of interest to: postgraduate industrial and advanced undergraduate organic chemists; biologists, biochemists and genetic engineers; material scientists; polymer researchers; and pharmaceutical, agrochemical and others involved with fine chemicals research and electronics.
(source: Nielsen Book Data)

• Chapter 1. Introduction
• * Nomenclature, Structure, and Stability * Generation of Carbocations * The Non-Classical Ion Controversy * Electrophilic Addition to Alkenes * Electrophilic Aromatic Substitution * Elimination reactions * Rearrangement Reactions of Carbocations * References
• Chapter 2. Nucleophilic Aliphatic Substitution - SN1
• * Introduction *-Activated Alcohols-Bronsted Acids *-Activated Alcohols-Lewis Acids * Alkylation of Aldehydes and Ketones * Glycosylation * Friedel-Crafts Alkylation and Acylation * Electrophilic Fluorination Using Fluoronium Ion * Miscellaneous SN1-related Reactions * References
• Chapter 3. Nucleophilic Aliphatic Substitution - SN2
• * Construction of Quaternary Stereogenic Centers * Sulfur Chemistry * Organometallic Chemistry * Macrocyclization * Glycosylation * Nucleoside Analogues *N-Alkylation * Cyclotetraphosphazenes * Conformationally Locked Tetrahydropyran Ring * The Ionic Liquid Effect * Silver Chemistry * References Chapter 4. Electrophilic Addition to Alkenes
• * Introduction * Cyclopropanation * Hydroboration/Oxidation * The Pauson-Khand Reaction * Prins Reaction * Schmidt Reaction * Halogenation * Oxymercuration/Reduction * Epoxidation * Gold-Catalyzed Alkyne Hydration * Conclusion * References
• Chapter 5. Electrophilic Aromatic Substitution
• * Introduction * Nitration * Halogenation * Friedel-Crafts Alkylation * Friedel-Crafts Acylation * Applications of Friedel-Crafts Reaction on Total Synthesis * Miscellaneous Electrophilic Aromatic Substitution Reactions * References
• Chapter 6. Fragmentation and Rearrangement Reactions
• * Claisen Rearrangements * Cope Rearrangements * Cope Rearrangements * Aldehyde (or Ketone) Formation Rearrangements * Carboxylic Acid Formation Rearrangements * Alcohol Formation Rearrangements * Amine Formation Rearrangement * Amides * Hydrocarbon Rearrangements * Oxacyclic, Carbocyclic, Oxazoles, Tetrahydrapuran and Tetrahydropuran Formation Rearrangements * Rearrangements resulting in less common functional groups * Fragmentations * References.
• (source: Nielsen Book Data)

Carbocation chemistry is not only fundamental to the advancement of organic chemistry, it also has found widespread applications in organic synthesis. It is not an exaggeration to say that carbocation chemistry is part of the foundation of organic chemistry. Carbocation Chemistry: Applications in Organic Synthesis provides a panoramic view of carbocation chemistry with an emphasis on synthetic applications. This book is an invaluable tool for organic, medicinal and analytical chemists, including those working in biochemistry as well as the petroleum, plastics and pharmaceutical industries. It is also suitable for upper level undergraduates and graduates in organic chemistry, biochemistry and medicinal chemistry.
(source: Nielsen Book Data)

• Introduction Synthesis of Pyrroles and N-Vinylpyrroles by the Reaction of Ketones (Ketoximes) with Acetylenes Heterocyclization of ketoximes with acetylene Regioselectivity of the reaction Substituted acetylenes in reactions with ketoximes Vinyl halogenides and dihalogenethanes as synthetic equivalents of acetylene Intermediate stages and side reactions delta-Carbolines from 3-acylindoles and acetylene Reaction of ketoximes with acetylene in the presence of ketones. One-pot assembly of 4-methylen-3-oxa-1-azabicyclo[3.1.0]hexanes Transformations of aldoximes in the systems MOH/DMSO and MOH/DMSO/acetylene Mechanism of pyrrole synthesis from ketoximes and acetylene Novel Aspects of NH- and N-Vinylpyrroles Reactivity Reaction with the participation of the pyrrole ring Reactions with participation of the vinyl group Conclusions References Index.
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During the last 30 years, knowledge of the essential role that pyrrole structures play in the chemistry of living organisms, drug design, and the development of advanced materials has increased. Correspondingly, research on the diverse issues of synthetic, theoretical, and applied chemistry has snowballed. Devoted to the latest achievements of this field, Chemistry of Pyrroles covers the discovery and development of a novel, facile, and highly effective method for the construction of the pyrrole ring from ketones (ketoximes) and acetylene in superbase catalytic systems (Trofimov reaction). It provides cutting-edge details on the preparation of valuable but previously inaccessible pyrrole compounds. It includes approximately 1,000 structures of novel pyrrole compounds, their yields, and physical-chemical characteristics. The authors analyze conditions of typical syntheses, limitations of their applicability, and possibility of vinyl chloride or dichloroethane application instead of acetylene. They examine chemical engineering aspects of the first synthesis of tetrahydroindole and indole from commercially available oxime of cyclohexanone and acetylene. In addition, the book discusses new facets of pyrroles and N-vinyl pyrroles reactivity in the reactions with the participation of both the pyrrole ring and N-vinyl groups. The book provides condensed, clear-cut information on novel syntheses of substituted pyrroles as key structural units of living matter (chlorophyll and hemoglobin), pharmaceuticals, and monomers for optoelectronic materials. It includes tables that provide references to original works, forming a guide to a variety of the reactions and synthesized compounds discussed. With coverage of the broad range of pyrrole chemistry and methods for their synthesis, it provides both a theoretical and an experimental basis for drug design.
(source: Nielsen Book Data)

• Separation and purification of mixtures
• Modification of sp3 carbon
• Substitution at non-aryl sp2 carbon
• Addition at non-aryl sp2 carbon
• Electrophilic Aromatic Substitution
• Nucleophilic Aromatic Substitution
• Transition Metal Catalysed Substitution
• Addition to sp carbon
• Preparation of alkenes
• Peryciclic reactions
• Radical reactions
• Oxidations
• Reductions
• Rearrangements
• Biotransformations
• Polymerization reactions
• Other transformations
• Chiral Resolutions--.
• (source: Nielsen Book Data)

This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected contributions from around the world and standardized them for publication. Each experiment will explore a modern chemistry scenario, such as: sustainable chemistry; application in the pharmaceutical industry; catalysis and material sciences, to name a few. All the experiments will be complemented with a set of questions to challenge the students and a section for the instructors, concerning the results obtained and advice on getting the best outcome from the experiment. A section covering practical aspects with tips and advice for the instructors, together with the results obtained in the laboratory by students, has been compiled for each experiment. Targeted at professors and lecturers in chemistry, this useful text will provide up to date experiments putting the science into context for the students.
(source: Nielsen Book Data)

• PREFACE TO THE SECOND EDITION
• .1. INTRODUCTION.1.1 The Structure and Forms of Water.1.2 Properties of Water.1.3 Solvation.1.4 Hydrophobic Effect.1.5 Salt Effect.1.6 Water Under Extreme Conditions.References.
• 2. ALKANES.2.1 Oxygenation of Alkanes.2.2 Halogenation of Alkanes.2.3 Formation of Carbon-Carbon Bonds.2.4 D/H Exchange of Alkanes in Water.References.
• 3. ALKENES.3.1 Reduction.3.2 Electrophilic Additions.3.3 Radical Reactions of Alkenes.3.4 Carbene Reactions.3.5 Alkene Isomerization.3.6 Transition-Metal Catalyzed C-C Formation Reactions.3.7 Olefin Metathesis.3.8 Reaction of Allylic C-H Bond
• .4. ALKYNES.4.1 Reaction of Terminal Alkynes.4.2 Additions of C C bonds.4.3 Transition-Metal Catalyzed Cycloadditions.4.4 Other Reactions.References.
• 5. ALCOHOLS, PHENOLS, ETHERS, THIOLS, AND THIOETHERS.5.1 Oxidation of Alcohols.5.2 Substitutions/Elimination.5.3 Addition of Alcohols, Phenols, and Thiols to Alkene and Alkyne Bonds.5.4 Addition of Alcohols to C=O Bonds: Esterification and Acetal Formations.5.5 Reaction of Ethers and Cyclic Ethers.5.6 Reaction of Sulfur Compounds
• .6. ORGANIC HALIDES.6.1 General.6.2 Reduction.6.3 Elimination Reactions.6.4 Nucleophilic Substitutions.6.5 Reductive Coupling.6.6 Carbonylation of Organic Halides.6.7 Transition-Metal Catalyzed Coupling Reactions.References.
• 7. AROMATIC COMPOUNDS.7.1 General.7.2 Substitution Reactions.7.3 Oxidation Reactions.7.4 Reductions.References.
• 8. ALDEHDYE AND KETONES.8.1 Reduction.8.2 Oxidation.8.3 Nucleophilic Addition: C-C Bond Formation.8.4 Pinacol Coupling.8.5 Other Reactions (Halogenation and Oxidation of alpha-H).References.
• 9. CARBOXYLIC ACIDS AND DERIVATIVES.9.1 General.9.2 Carboxylic Acids.9.3 Carboxylic Acid Derivatives.References.
• 10. CONJUGATED CARBONYL COMPOUNDS.10.1 Reduction.10.2 Epoxidation, Dihydroxylation, Hydroxyamination.10.3 Conjugate Addition: Heteroatom.10.4 C-C Bond Formation.10.5 Other Reactions.References.
• 11. NITROGEN COMPOUNDS.11.1 Amines.11.2 Imines.11.3 Diazo Compounds.11.4 Azides.11.5 Nitro Compounds.References.
• 12. PERICYCLIC REACTIONS.12.1 Introduction.12.2 Diels-Alder Reactions.12.3 Sigmatropic Rearrangements.12.4 Photochemical Cycloaddition Reactions.References. INDEX.
• (source: Nielsen Book Data)

This is an extensive update of the classic reference on organic reactions in water. Published almost a decade ago, the first edition has served as the guide for research in this burgeoning field. Due to the cost, safety, efficiency, and environmental friendliness of water as a solvent, there are many new applications in industry and academic laboratories. More than forty percent of this extensively updated second edition covers new reactions. For ease of reference, it is organized by functional groups.A core reference, "Comprehensive Organic Reactions in Aqueous Media, Second Edition": provides the most comprehensive coverage of aqueous organicreactions available; covers the basic principles and theory and progresses to applications; includes alkanes, alkenes, aromatics, electrophilic substitutions, carbonyls, alpha, beta-unsaturated carbonyls, carbon-nitrogen bonds, organic halides, pericyclic reactions, photochemical reactions, click chemistry, and multi-step syntheses; and, provides examples of applications in industry. This is the premier reference for chemists and chemical engineers in industry or research, as well as for students in advanced-level courses.
(source: Nielsen Book Data)

• Acknowledgements.Preface.
• Chapter 1. Quantum Mechanics for Organic Chemistry .
• Chapter 2. Fundamentals of Organic Chemistry.
• Chapter 3. Pericyclic Reactions.
• Chapter 4. Diradicals and Carbenes.Chapter 5.Organic Reactions of Anions.
• Chapter 6. Solution-Phase Organic Chemistry.
• Chapter 7. Organic Reaction Dynamics.
• (source: Nielsen Book Data)

'[This book] collects together, largely for the first time, a series of chapters dedicated to all the ways in which molecular modeling/computational chemistry can impact organic chemistry' - Christopher J. Cramer, author of "Essentials of Computational Chemistry: Theories and Models". "Computational Organic Chemistry" provides a practical overview of the ways in which computational modeling methods and applications can be used in organic chemistry to predict the structure and reactivity of organic molecules. After a concise survey of computational methods, the book presents in-depth case studies that show how various computational methods have provided critical insight into the nature of organic mechanisms. With a focus on methodologies, this unique resource: discusses simple molecular properties, pericyclic reactions, carbenes and radicals, anion chemistry, solvent effects, and more; features sidebars that offer a personal look at some of the leading practitioners in the field; conveys the strengths and limitations of each method, so that readers develop a feel for the correct 'tool' to use in the context of a specific problem; and, further informs readers with a supporting Web site that provides links to materials cited and features a blog that discusses and provides links to new relevant articles. This is a great reference for practicing physical organic and computational chemists, as well as a thought-provoking textbook for graduate-level courses in computational chemistry and organic chemistry.
(source: Nielsen Book Data)

• Foreword vii Preface ix Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles 1 Kevin H. Shaughnessy, Engelbert Ciganek, and Rebecca B. DeVasher
• Index 675.
• (source: Nielsen Book Data)

The metal-catalyzed amination of aryl and alkenyl electrophiles has developed into a widely used methodology for the synthesis of natural products, active pharmaceutical ingredients, agricultural chemicals, and materials for molecular electronics. Copper catalysts promote the coupling of a wide range of nitrogen nucleophiles, including amines, amides, and heteroaromatic nitrogen compounds with aryl and alkenyl halides. The reactivity profile of copper catalysts is complementary to that of palladium catalysts in many cases. Copper catalysts are highly effective with less nucleophilic nitrogen nucleophiles, such as amides and azoles, whereas palladium catalysts are more effective with more nucleophilic amine nucleophiles. Copper is an attractive alternative to palladium due to its significantly lower cost. In addition, high activity palladium catalysts require expensive and often air-sensitive ligands, whereas the modern copper systems use relatively stable and inexpensive diamine or amino acid ligands. Copper-catalyzed C N coupling reactions are tolerant of a wide range of functional groups and have been applied to the synthesis of a variety of complex natural products. Significant work has also been done to understand the mechanism of these reactions. Current mechanistic understanding of these methodologies is covered in this monograph. The contents of the book are taken from the comprehensive review of the topic in the Organic Reactions series. Optimal experimental conditions for the amination of aryl and alkenyl halides with all classes of nitrogen nucleophiles are presented. Specific experimental procedures from the literature are provided for the major classes of copper-catalyzed C N coupling reactions. A tabular survey of all examples of Cu-catalyzed arylation and alkenylation of nitrogen nucleophiles is presented in 35 tables organized by nitrogen nucleophile and electrophilic coupling partner. The literature is covered through December 2015 and provides 300 recent citations to supplement the 680 citations of the original hardbound chapter. These latest literature references have been collected in separate sections according to the sequence of the tables in the tabular survey section. In each of the sections, the individual citations have been arranged in alphabetic order of the author names. Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles is intended to provide organic chemists with an accessible, but detailed, introduction to this important class of transformations.
(source: Nielsen Book Data)

"The CrossFire system is a complete chemical information system comprising the Beilstein Database, the CrossFire search and retrieval server software and the Beilstein Commander client" --p. 8
The Beilstein database contains data from the Beilstein Handbook (1779-1959), primary literature from 1960 to 1979, and primary literature data from 1979. Cf. p. 11.