Overview of paclitaxel research - progress on many fronts, Matthew Suffness-- paclitaxel - from discovery to clinic, Monroe E. Wall and Mansukh C. Wani-- current status of clinical trials with paclitaxel and docetaxel, F.A. Holmes et al-- the Pacific yew environmental impact statement, S.J. Campbell and S.A. Whitney-- paclitaxel biosynthesis - the early steps, Rodney Croteau et al-- bioactive metabolites of the endophytic fungi of Pacific yew, taxus brevifolia - paclitaxel, taxanes and other bioactive compounds, Andrea Stierle et al-- metabolism of taxoid drugs, M. Vuihorgne et al-- pharmacology and antitumour effect of novel paclitaxel formulations, R.M. Straubinger et al-- phosphatase-activated prodrugs of paclitaxel, D.M. Vyas et al-- microtubule polymerization dynamics, mitotic block and cell death by paclitaxel at low concentrations, Mary Ann Jordon and Leslie Wilson-- photoincorporation of a paclitaxel photoaffinity analogue into the n-terminal
31 amino acids of b-tubulin, Susan Band Horwitz et al-- paclitaxel, a mimetic of bacterial lipopolysaccharide (LPS) in murine macrophages, S.N. Vogel et al-- the roles of the cytoskeleton in steroidogenesis - the actions of paclitaxel and other cytoskeletal agents, Pamela J. Massey et al-- chemistry and structure-activity relationships of taxoids with modified skeletons, F. Gueritte-Voegelein et al. (Part contents).
(source: Nielsen Book Data)
Developed from a symposium sponsored by the Divisions of the Chemical Health and Safety, Medicinal Chemistry and Organic Chemistry at the 207th National Meeting of the American Chemical Society held in San Diego, California, March 13-17, 1994, this work presents a general overview of the development of taxol as an anticancer drug, including the discovery, initial development, current status, supply issues and recent clinical developments. It discusses in detail the cellular mechanism of action and the toxicity of taxol. The book presents drug delivery and taxotere metabolism, and explains semisynthetic and medicinal chemistry studies. It also covers approaches to the total synthesis of taxol. (source: Nielsen Book Data)