Annotating new genes : from in silico screening to experimental validation
QH324.2 .U24 2012
- Unknown QH324.2 .U24 2012
- Includes bibliographical references and index.
- Databases and software to make your research life easier-- How to program like a bioinformatician? Case study: C-It, knowledge database for screening evolutionarily conserved, tissue-enriched, uncharacterized genes-- Experimental validation: concepts and practice-- Further application: adult stem cells and tissue regenerations-- Conclusion.
- (source: Nielsen Book Data)
- Publisher's Summary
- In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cover programming guidelines, including a specific case study on the use of C-It for in silico screening. The second half of the book offers a step-by-step guide to experimental validation concepts and procedures, as well as an overview of additional potential applications of this approach in the field of stem cells and tissue regeneration, before a concluding chapter summarises the concepts and theories presented. * Focuses not only on screening but also on biological validations* Provides details of databases and software (web interface) products for biologists with minimal computation skills* Offers a step-by-step outline of the procedure involved.
(source: Nielsen Book Data)
- Publication date
- Shizuka Uchida.
- Woodhead publishing series in biomedicine ; 15