Evolution by Tumor Neofunctionalization [electronic resource] : the Role of Tumors in the Origin of New Cell Types, Tissues and Organs
- Kozlov, Andrei P.
- Burlington : Elsevier Science, 2014.
- Physical description
- 1 online resource (248 pages)
- Front Cover; Evolution by Tumor Neofunctionalization; Copyright Page; Contents; Acknowledgements; Introduction; 1. The Modern Synthesis of Evolutionary Biology and the Health Sciences; 2. Evolution and Pathology; 2.1 Pathogens and Pathologies May Have Adaptive and/or Evolutionary Importance; 2.2 Evolution vs. Pathology Paradox of Mutations; 3. The Widespread Occurrence of Tumors in Multicellular Organisms; 3.1 Comparative Oncological Data on the Prevalence of Tumors in Different Groups of Multicellular Organisms.
- 3.2 Ancient Origin and Conservatism of Cellular Oncogenes and Tumor Suppressor Genes3.3 The Widespread Occurrence of Tumors Suggests that They May Be Evolutionarily Meaningful; 4. Features of Tumors that Could Be Used in Evolution; 4.1 Unusual Genes and Gene Sets are Activated in Tumors and may Participate in the Origin of New Cell Types; 4.2 Tumor Cells Can Differentiate with the Loss of Malignancy that may Lead to the Origin of New Cell Types; 4.3 Tumors Provide Excessive Cell Masses Functionally Unnecessary to the Organism that Could be used for the Origin of New ...
- 4.4 Tumors as Atypical Organs/Tissues that may Eventually Evolve into Normal Structures4.4.1 Morphogenetic Potential of Tumors May Be Used in the Origin of Morphological Novelties and Diversity; 5. Tumors Might Participate in the Evolution of Ontogenesis; 5.1 Tumors and Normal Embryogenesis; 5.2 Tumors as Disease of Differentiation; 5.3 The Epithelial to Mesenchymal Transition (EMT) Occurs in Normal and Neoplastic Development; 5.4 Tumors, Evo-Devo and Addition of Final Stages in the Evolution of Ontogenesis.
- 5.5 The Human Brain, as the Most Recently Evolved Organ, Recapitulates Many Features Resembling those of Tumors5.5.1 The Expansion of Brain Size During Mammalian and Primate Evolution Involved Many Protooncogenes and Tumor Suppressor ... ; 5.5.2 Human Cerebral Cortex as a Result of Selection for Tumor Growth; 5.5.3 Brain Enlargement, Microcephaly Genes and Tumors; 18.104.22.168 MCPH1 is a Tumor Suppressor Gene Interrelated with the other Tumor Suppressor, BRCA1; 22.214.171.124 ASPM is a Major Determinant of Human Cerebral Cortical Size, and is Overexpressed in Tumors and Testis.
- 5.5.4 Long-Term Neural Stem Cell Expansion Leads to Brain Tumors5.6 The Eutherian Placenta is Evolutionary Innovation and Recapitulates Many Tumor Features; 6. Tumors that Might Play a Role in Evolution; 6.1 Hereditary Tumors; 6.2 Fetal, Neonatal and Infantile Tumors; 6.3 Benign Tumors, Carcinomas in situ and Pseudodiseases; 6.4 Tumors at the Early and Intermediate Stages of Progression; 6.5 Tumors that Spontaneously Regress; 6.6 Sustainable Tumor Masses; 7. Tumors that have Played a Role in Evolution; 7.1 The Nitrogen-Fixing Root Nodules of Legumes.
- Publisher's Summary
- Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution. This book will stimulate thinking on this topic by specialists in the fields of evolutionary biology, oncology, molecular biology, molecular evolution, embryology, evo-devo, tumor immunology, pathology and clinical oncology. * Covers the role that tumors might play in evolution.* Provides multidisciplinary approach that will appeal to a wide circle of professionals in the fields of evolutionary biology, oncology, molecular biology, and more.
(source: Nielsen Book Data)
- Publication date
- 7.2 Melanomatous Cells and Macromelanophores of Xiphophorus Fishes.
- Available in another form
- Print version: Kozlov, Andrei P. Evolution by Tumor Neofunctionalization : The Role of Tumors in the Origin of New Cell Types, Tissues and Organs. Burlington : Elsevier Science, ©2014 9780128001653