xv, 463 pages : illustrations (some colored) ; 26 cm.
Includes bibliographical references and index.
Bacterial mutation assays / Errol Zeiger
In vitro mouse lymphoma (L5178Y Tk+/- -3.7.2C) forward mutation assay / Melissa R. Schisler, Martha M. Moore, and B. Bhaskar Gollapudi
Erythrocyte-based pig-a gene mutation assay / Jeffrey C. Bemis, Nikki E. Hall, and Stephen D. Dertinger
Detection of in vivo mutation in the Hprt and pig-a genes of rat lymphocytes / Vasily N. Dobrovolsky ... [et al.]
In vivo cII, gpt, and spi- gene mutation assays in transgenic mice and rats / Mugimane G. Manjanatha ... [et al.]
In vitro cytogenetic assays : chromosomal aberrations and micronucleus tests / Julian Laubenthal ... [et al.]
Comet assay : assessment of in vitro and in vivo DNA damage / Mahima Bajpayee, Ashutosh Kumar, and Alok Dhawan
Comet assay in human biomonitoring / Diana Anderson, Alok Dhawan, and Julian Laubenthal
Comet assay in marine animals / Giada Frenzilli and Brett P. Lyons
Unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo / Fabrice Nesslany
32P-postlabeling analysis of DNA adducts / Heinz H. Schmeiser, Marie Stiborova, and Volker M. Arlt
Micronucleus assay with tetrad cells of tradescantia / Miroslav Mišík ... [et al.]
Wing-spot and the comet tests as useful assays detecting genotoxicity in Drosophila / Ricard Marcos and Erico R. Carmona
Genotoxicity guidelines recommended by International Conference of Harmonization (ICH) / Gireesh H. Kamath and K.S. Rao.
Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals.In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetictoxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successfulMethods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips ontroubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.