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Book
1 volume (various pagings) : color illustrations ; 29 cm
  • 1 Biochemistry and the Language of Chemistry 2 The Chemical Foundation of Life: Weak Interactions in an Aqueous Environment 3 The Energetics of Life 4 Nucleic Acids 5 Introduction to Proteins: The Primary Level of Protein Structure 6 The Three-Dimensional Structure of Proteins 7 Protein Function and Evolution 8 Enzymes: Biological Catalysts 9 Carbohydrates: Sugars, Saccharides, Glycans 10 Lipids, Membranes, and Cellular Transport 11 Chemical Logic of Metabolism 12 Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway 13 The Citric Acid Cycle 14 Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism 15 Photosynthesis 16 Lipid Metabolism 17 Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates 18 Amino Acid and Nitrogen Metabolism 19 Nucleotide Metabolism 20 Mechanisms of Signal Transduction 21 Genes, Genomes, and Chromosomes 22 DNA Replication 23 DNA Repair, Recombination, and Rearrangement 24 Transcription and Post-transcriptional Processing 25 Information Decoding: Translation and Post-translational Protein Processing 26 Regulation of Gene Expression.
  • (source: Nielsen Book Data)
NOTE: Before purchasing, check with your instructor to ensure you select the correct ISBN. Several versions of Pearson's MyLab & Mastering products exist for each title, and registrations are not transferable. To register for and use Pearson's MyLab & Mastering products, you may also need a Course ID, which your instructor will provide. Used books, rentals, and purchases made outside of Pearson If purchasing or renting from companies other than Pearson, the access codes for Pearson's MyLab & Mastering products may not be included, may be incorrect, or may be previously redeemed. Check with the seller before completing your purchase. For one or two semester biochemistry courses (science majors). This package includes MasteringChemistry(R). A highly visual, precise and fresh approach to guide today's mixed-science majors to a deeper understanding of biochemistry Biochemistry: Concepts and Connections engages students in the rapidly evolving field of biochemistry, better preparing them for the challenges of 21st century science through quantitative reasoning skills and a rich, chemical perspective on biological processes. This concise first edition teaches mixed-science-majors the chemical logic underlying the mechanisms, pathways, and processes in living cells through groundbreaking biochemical art and a clear narrative that illustrates biochemistry's relation to all other life sciences. Integration of biochemistry's experimental underpinnings alongside the presentation of modern techniques encourages students to appreciate and consider how their understanding of biochemistry can and will contribute to solving problems in medicine, agricultural sciences, environmental sciences, and forensics. The text is fully integrated with MasteringChemistry to provide support for students before, during, and after class. Highlights include interactive animations and tutorials based on the textbook's biochemical art program and Foundation Figures to help students visualize complex processes, apply, and test conceptual understanding as well as quantitative reasoning. Superior support beyond the classroom with MasteringChemistry MasteringChemistry from Pearson is the leading online homework, tutorial, and assessment system, designed to improve results by engaging students before, during, and after class with powerful content. Instructors ensure students arrive prepared by assigning interaction with relevant biochemical concepts before class, and encourage critical thinking, visualization, and retention with in-class resources such as Learning CatalyticsTM. Students can further master concepts after class by interacting with biochemistry animations, problem sets, and tutorial assignments that provide hints and answer-specific feedback. The Mastering gradebook records scores for all automatically graded assignments in one place, while diagnostic tools give instructors access to rich data to assess student understanding and misconceptions. Mastering brings learning full circle by continuously adapting to each student and making learning more personal than ever-before, during, and after class. 0321839765 / 9780321839763 Biochemistry: Concepts and Connections Plus MasteringChemistry with eText -- Access Card Package Package consists of: 0133871975 / 9780133871975 MasteringChemistry with Pearson eText -- ValuePack Access -- for Biochemistry: Concepts and Connections 0321839927 / 9780321839923 Biochemistry: Concepts and Connections.
(source: Nielsen Book Data)
  • 1 Biochemistry and the Language of Chemistry 2 The Chemical Foundation of Life: Weak Interactions in an Aqueous Environment 3 The Energetics of Life 4 Nucleic Acids 5 Introduction to Proteins: The Primary Level of Protein Structure 6 The Three-Dimensional Structure of Proteins 7 Protein Function and Evolution 8 Enzymes: Biological Catalysts 9 Carbohydrates: Sugars, Saccharides, Glycans 10 Lipids, Membranes, and Cellular Transport 11 Chemical Logic of Metabolism 12 Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway 13 The Citric Acid Cycle 14 Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism 15 Photosynthesis 16 Lipid Metabolism 17 Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates 18 Amino Acid and Nitrogen Metabolism 19 Nucleotide Metabolism 20 Mechanisms of Signal Transduction 21 Genes, Genomes, and Chromosomes 22 DNA Replication 23 DNA Repair, Recombination, and Rearrangement 24 Transcription and Post-transcriptional Processing 25 Information Decoding: Translation and Post-translational Protein Processing 26 Regulation of Gene Expression.
  • (source: Nielsen Book Data)
NOTE: Before purchasing, check with your instructor to ensure you select the correct ISBN. Several versions of Pearson's MyLab & Mastering products exist for each title, and registrations are not transferable. To register for and use Pearson's MyLab & Mastering products, you may also need a Course ID, which your instructor will provide. Used books, rentals, and purchases made outside of Pearson If purchasing or renting from companies other than Pearson, the access codes for Pearson's MyLab & Mastering products may not be included, may be incorrect, or may be previously redeemed. Check with the seller before completing your purchase. For one or two semester biochemistry courses (science majors). This package includes MasteringChemistry(R). A highly visual, precise and fresh approach to guide today's mixed-science majors to a deeper understanding of biochemistry Biochemistry: Concepts and Connections engages students in the rapidly evolving field of biochemistry, better preparing them for the challenges of 21st century science through quantitative reasoning skills and a rich, chemical perspective on biological processes. This concise first edition teaches mixed-science-majors the chemical logic underlying the mechanisms, pathways, and processes in living cells through groundbreaking biochemical art and a clear narrative that illustrates biochemistry's relation to all other life sciences. Integration of biochemistry's experimental underpinnings alongside the presentation of modern techniques encourages students to appreciate and consider how their understanding of biochemistry can and will contribute to solving problems in medicine, agricultural sciences, environmental sciences, and forensics. The text is fully integrated with MasteringChemistry to provide support for students before, during, and after class. Highlights include interactive animations and tutorials based on the textbook's biochemical art program and Foundation Figures to help students visualize complex processes, apply, and test conceptual understanding as well as quantitative reasoning. Superior support beyond the classroom with MasteringChemistry MasteringChemistry from Pearson is the leading online homework, tutorial, and assessment system, designed to improve results by engaging students before, during, and after class with powerful content. Instructors ensure students arrive prepared by assigning interaction with relevant biochemical concepts before class, and encourage critical thinking, visualization, and retention with in-class resources such as Learning CatalyticsTM. Students can further master concepts after class by interacting with biochemistry animations, problem sets, and tutorial assignments that provide hints and answer-specific feedback. The Mastering gradebook records scores for all automatically graded assignments in one place, while diagnostic tools give instructors access to rich data to assess student understanding and misconceptions. Mastering brings learning full circle by continuously adapting to each student and making learning more personal than ever-before, during, and after class. 0321839765 / 9780321839763 Biochemistry: Concepts and Connections Plus MasteringChemistry with eText -- Access Card Package Package consists of: 0133871975 / 9780133871975 MasteringChemistry with Pearson eText -- ValuePack Access -- for Biochemistry: Concepts and Connections 0321839927 / 9780321839923 Biochemistry: Concepts and Connections.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Permanent reserve
RB112.5 .A664 2016 Unknown

2. Biochemistry [2015]

Book
xxxii, 1056, 48, 43, 43 pages : illustrations (some color) ; 29 cm
  • PART I: THE MOLECULAR DESIGN OF LIFE 1. Biochemistry: An Evolving Science 2. Protein Composition and Structure 3. Exploring Proteins and Proteomes 4. DNA, RNA, and the Flow of Genetic Information 5. Exploring Genes and Genomes 6. Exploring Evolution and Bioinformatics 7. Hemoglobin: Portrait of a Protein in Action 8. Enzymes: Basic Concepts and Kinetics 9. Catalytic Strategies 10. Regulatory Strategies 11. Carbohydrates 12. Lipids and Cell Membranes 13. Membrane Channels and Pumps 14. Signal-Transduction Pathways PART II: TRANSDUCING AND STORING ENERGY 15. Metabolism: Basic Concepts and Design 16. Glycolysis and Gluconeogenesis 17. The Citric Acid Cycle 18. Oxidative Phosphorylation 19. The Light Reactions of Photosynthesis 20. The Calvin Cycle and the Pentose Phosphate Pathway 21. Glycogen Metabolism 22. Fatty Acid Metabolism 23. Protein Turnover and Amino Acid Catabolism PART III: SYNTHESIZING THE MOLECULES OF LIFE 24. The Biosynthesis of Amino Acids 25. Nucleotide Biosynthesis 26. The Biosynthesis of Membrane Lipids and Steroids 27. The Integration of Metabolism 28. DNA Replication, Repair, and Recombination 29. RNA Synthesis and Processing 30. Protein Synthesis 31. The Control of Gene Expression in Prokaryotes 32. The Control of Gene Expression in Eukaryotes PART IV: RESPONDING TO ENVIRONMENTAL CHANGES 33. Sensory Systems 34. The Immune System 35. Molecular Motors 36. Drug Development.
  • (source: Nielsen Book Data)
For four decades, this extraordinary textbook played an pivotal role in the way biochemistry is taught, offering exceptionally clear writing, innovative graphics, coverage of the latest research techniques and advances, and a signature emphasis on physiological and medical relevance. Those defining features are at the heart of this edition.
(source: Nielsen Book Data)
  • PART I: THE MOLECULAR DESIGN OF LIFE 1. Biochemistry: An Evolving Science 2. Protein Composition and Structure 3. Exploring Proteins and Proteomes 4. DNA, RNA, and the Flow of Genetic Information 5. Exploring Genes and Genomes 6. Exploring Evolution and Bioinformatics 7. Hemoglobin: Portrait of a Protein in Action 8. Enzymes: Basic Concepts and Kinetics 9. Catalytic Strategies 10. Regulatory Strategies 11. Carbohydrates 12. Lipids and Cell Membranes 13. Membrane Channels and Pumps 14. Signal-Transduction Pathways PART II: TRANSDUCING AND STORING ENERGY 15. Metabolism: Basic Concepts and Design 16. Glycolysis and Gluconeogenesis 17. The Citric Acid Cycle 18. Oxidative Phosphorylation 19. The Light Reactions of Photosynthesis 20. The Calvin Cycle and the Pentose Phosphate Pathway 21. Glycogen Metabolism 22. Fatty Acid Metabolism 23. Protein Turnover and Amino Acid Catabolism PART III: SYNTHESIZING THE MOLECULES OF LIFE 24. The Biosynthesis of Amino Acids 25. Nucleotide Biosynthesis 26. The Biosynthesis of Membrane Lipids and Steroids 27. The Integration of Metabolism 28. DNA Replication, Repair, and Recombination 29. RNA Synthesis and Processing 30. Protein Synthesis 31. The Control of Gene Expression in Prokaryotes 32. The Control of Gene Expression in Eukaryotes PART IV: RESPONDING TO ENVIRONMENTAL CHANGES 33. Sensory Systems 34. The Immune System 35. Molecular Motors 36. Drug Development.
  • (source: Nielsen Book Data)
For four decades, this extraordinary textbook played an pivotal role in the way biochemistry is taught, offering exceptionally clear writing, innovative graphics, coverage of the latest research techniques and advances, and a signature emphasis on physiological and medical relevance. Those defining features are at the heart of this edition.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Request at circulation desk
QP514.2 .S66 2015 Unknown On Reserve 2-hour loan
QP514.2 .S66 2015 Unknown On Reserve 2-hour loan
QP514.2 .S66 2015 Unknown On Reserve 2-hour loan
QP514.2 .S66 2015 Unknown On Reserve 2-hour loan
QP514.2 .S66 2015 Unknown On Reserve 2-hour loan
CHEM-181-01, CHEM-181-01, CHEMENG-181-01, CHEMENG-181-01, CHEMENG-281-01, CHEMENG-281-01
Course
CHEM-181-01 -- Biochemistry I
Instructor(s)
Du Bois, Justin
Course
CHEM-181-01 -- Biochemistry I
Instructor(s)
Khosla, Chaitan
Course
CHEMENG-181-01 -- Biochemistry I
Instructor(s)
Du Bois, Justin
Course
CHEMENG-181-01 -- Biochemistry I
Instructor(s)
Khosla, Chaitan
Course
CHEMENG-281-01 -- Biochemistry I
Instructor(s)
Du Bois, Justin
Course
CHEMENG-281-01 -- Biochemistry I
Instructor(s)
Khosla, Chaitan
Book
xxvi, 285 pages : illustrations ; 24 cm.
  • Preface Research of Local Characteristics of Process of Separation of a Dust in a Rotoklon-- Regina R. Usmanova, Roman Jozwik, and Gennady E. Zaikov Lecture Note on Topological Modelling of Materials Based on Different Binders Incorporated with Powder Fillers-- R. Z. Rakhimov, N. R. Rakhimova, O. V. Stoyanov, G. E. Zaikov, J. Richert, and E. Klodzinska Research Note on Structure and Properties of Metal-Filled Polyarylates Obtained Explosive Pressing-- N. A. Adamenko and S. M. Ryzhova Technical Note on the Effect of Ozonation on Crude Oil Foamability and Properties Contributing to It-- A. V. Stavitskayaa, M. L. Konstantinovab, S. D. Razumovskiyb, and R. Z. Safieva Research Note on Synthesis, Structure and Properties of Composite Material Based on Polydiphenylamine and Cobalt Nanoparticles-- S. Zh. Ozkan and G. P. Karpacheva Research Note on Synthesis in the Interfacial Conditions of Hybrid Dispersed Magnetic Nanomaterial Based on Poly-N-Phenylanthranilic Acid-- S. Zh. Ozkan, I. S. Eremeev, and G. P. Karpacheva Technical Note on Biodegradable Blends of Poly (3-Hydroxybutyrate) with an Ethylene-Propylene Rubber-- A. A. Ol'khov, A. L. Iordanskii, Yu. N. Pankova, W. Tyszkiewicz, and G. E. Zaikov Melaphen Prevents Mitochondrial Swelling Caused by Stress-- E. M. Mil, V. I. Binyukov, I. V. Zigacheva, A. A. Albantova , S. G. Fattahov, and A. I. Konovalov Antioxidant Activity of Some Isobornylphenol Derivatives at Destruction of Polyvinyl Chloride-- V. R. Khairullina, A. Ya. Gerchikov, R. M. Akhmetkhanov, I. T. Gabitov, I. Yu. Chukicheva, A. V. Kuchin, and G. E. Zaikov Pd Complex of 5, 10, 15, 20 - Tetra (4-Carbomethoxyphenyl) Porphyrin Luminescence Study in Interaction with b-Cyclodextrin and Human Serum Albumin in Solutions-- I. A. Nagovitsyn, G. K. Chudinova, G. V. Sin'ko, G. A.Ptitsyn, V. A. Danilov, A. I. Zubov, V. V. Kurilkin, and G. G. Komissarov Technical Note on Bioantioxidant Action of the Essential Oils from Oregano, Clove Bud, Lemon and Ginger Extract in the Liver of Mice in vivo-- E. B. Burlakova, T. A. Misharina, L. D. Fatkullina, E. S. Alinkina, A. I. Kozachenko, L. G. Nagler, and I. B. Medvedeva Research Note on Mechanochemical Halide Modification of Elastomers with Fluorine-Containing Modificator and Properties Materials Based on It-- Yu. O. Andriasyan, I. A. Mikhaylov, G. E. Zaikov, and A. A. Popov Research Note on Complex Forming Properties of the New Composite Materials Based on Dialdehide Cellulose and Acrylate Derivatives of Guanidine With D-Elements-- S. Yu. Khashirova, A. A. Zhansitov, and S. A. Elcheparova Technical Note on the Effect of Zinc Precursor Solutions on Nucleation and Growth of Znonanorod Films Deposited by Spray Pyrolysis Technique-- Lan Anh Luu Thi, Ngoc Minh Le, Hong Viet Nguyen, Phi Hung Pham, Mateus Manuel Neto, Ngoc Trung Nguyen, and Thach Son Vo Acid-Base Properties of Ionizable Biopolymeric Compositions by pK Spectroscopy: Research Note-- S. V. Frolova, L. A. Kuvshinova, and M. A. Ryazanov The Effectiveness of Inoculation of the Seeds of Galega orientalis with Microbial Agents Vogal and Rhizophos: Research Note-- Vera Iv. Bushuyeva Variety Differences of Galega orientalis Lam. in Radionuclide Accumulation: Research Note-- Vera Iv. Bushuyeva Methodic Fundamentals of the Fruit Crops Production Orchards Distribution in Ukraine: Research Note-- Mykola O. Bublyk, Lyudmyla A. Fryziuk, and Lyudmyla M. Levchuk Technical Note on Biodegradable Film Materials Based on Polyethylene, Modified Chitosan-- M. V. Bazunova, D. R. Valiev, R. M. Akhmetkhanov, and G. E. Zaikov Comparison of Free-Radical Scavenging Properties of Glutathione Under Neutral and Acidic Conditions-- Katarina Valachova, Tamer M. Tamer, and Ladislav Soltes Supramolecular Decomposition of the Aralkyl Hydroperoxides in the Presence of EtNBr-- N. A. Turovskij, E. V. Raksha, Yu. V. Berestneva, E. N. Pasternak, M. Yu. Zubritskij, I. A. Opeida, and G. E. Zaikov The Study of Elastic Polyurethane Thermal Stability by Differential Scanning Calorimetry-- I. A. Novakov, M. A. Vaniev, D. V. Medvedev, N. V. Sidorenko, G. V. Medvedev, and D. O. Gusev Index.
  • (source: Nielsen Book Data)
This important volume highlights the latest developments and trends in chemistry, biochemistry, and biology. It presents the developments of advanced materials and respective tools to characterize and predict the material properties and behavior. The book provides original, theoretical, and important experimental results that use non-routine methodologies often unfamiliar to the usual readers. The papers on novel applications of more familiar experimental techniques and analyses of chemical, biochemistry, and biological programs indicate the need for new experimental approaches.
(source: Nielsen Book Data)
  • Preface Research of Local Characteristics of Process of Separation of a Dust in a Rotoklon-- Regina R. Usmanova, Roman Jozwik, and Gennady E. Zaikov Lecture Note on Topological Modelling of Materials Based on Different Binders Incorporated with Powder Fillers-- R. Z. Rakhimov, N. R. Rakhimova, O. V. Stoyanov, G. E. Zaikov, J. Richert, and E. Klodzinska Research Note on Structure and Properties of Metal-Filled Polyarylates Obtained Explosive Pressing-- N. A. Adamenko and S. M. Ryzhova Technical Note on the Effect of Ozonation on Crude Oil Foamability and Properties Contributing to It-- A. V. Stavitskayaa, M. L. Konstantinovab, S. D. Razumovskiyb, and R. Z. Safieva Research Note on Synthesis, Structure and Properties of Composite Material Based on Polydiphenylamine and Cobalt Nanoparticles-- S. Zh. Ozkan and G. P. Karpacheva Research Note on Synthesis in the Interfacial Conditions of Hybrid Dispersed Magnetic Nanomaterial Based on Poly-N-Phenylanthranilic Acid-- S. Zh. Ozkan, I. S. Eremeev, and G. P. Karpacheva Technical Note on Biodegradable Blends of Poly (3-Hydroxybutyrate) with an Ethylene-Propylene Rubber-- A. A. Ol'khov, A. L. Iordanskii, Yu. N. Pankova, W. Tyszkiewicz, and G. E. Zaikov Melaphen Prevents Mitochondrial Swelling Caused by Stress-- E. M. Mil, V. I. Binyukov, I. V. Zigacheva, A. A. Albantova , S. G. Fattahov, and A. I. Konovalov Antioxidant Activity of Some Isobornylphenol Derivatives at Destruction of Polyvinyl Chloride-- V. R. Khairullina, A. Ya. Gerchikov, R. M. Akhmetkhanov, I. T. Gabitov, I. Yu. Chukicheva, A. V. Kuchin, and G. E. Zaikov Pd Complex of 5, 10, 15, 20 - Tetra (4-Carbomethoxyphenyl) Porphyrin Luminescence Study in Interaction with b-Cyclodextrin and Human Serum Albumin in Solutions-- I. A. Nagovitsyn, G. K. Chudinova, G. V. Sin'ko, G. A.Ptitsyn, V. A. Danilov, A. I. Zubov, V. V. Kurilkin, and G. G. Komissarov Technical Note on Bioantioxidant Action of the Essential Oils from Oregano, Clove Bud, Lemon and Ginger Extract in the Liver of Mice in vivo-- E. B. Burlakova, T. A. Misharina, L. D. Fatkullina, E. S. Alinkina, A. I. Kozachenko, L. G. Nagler, and I. B. Medvedeva Research Note on Mechanochemical Halide Modification of Elastomers with Fluorine-Containing Modificator and Properties Materials Based on It-- Yu. O. Andriasyan, I. A. Mikhaylov, G. E. Zaikov, and A. A. Popov Research Note on Complex Forming Properties of the New Composite Materials Based on Dialdehide Cellulose and Acrylate Derivatives of Guanidine With D-Elements-- S. Yu. Khashirova, A. A. Zhansitov, and S. A. Elcheparova Technical Note on the Effect of Zinc Precursor Solutions on Nucleation and Growth of Znonanorod Films Deposited by Spray Pyrolysis Technique-- Lan Anh Luu Thi, Ngoc Minh Le, Hong Viet Nguyen, Phi Hung Pham, Mateus Manuel Neto, Ngoc Trung Nguyen, and Thach Son Vo Acid-Base Properties of Ionizable Biopolymeric Compositions by pK Spectroscopy: Research Note-- S. V. Frolova, L. A. Kuvshinova, and M. A. Ryazanov The Effectiveness of Inoculation of the Seeds of Galega orientalis with Microbial Agents Vogal and Rhizophos: Research Note-- Vera Iv. Bushuyeva Variety Differences of Galega orientalis Lam. in Radionuclide Accumulation: Research Note-- Vera Iv. Bushuyeva Methodic Fundamentals of the Fruit Crops Production Orchards Distribution in Ukraine: Research Note-- Mykola O. Bublyk, Lyudmyla A. Fryziuk, and Lyudmyla M. Levchuk Technical Note on Biodegradable Film Materials Based on Polyethylene, Modified Chitosan-- M. V. Bazunova, D. R. Valiev, R. M. Akhmetkhanov, and G. E. Zaikov Comparison of Free-Radical Scavenging Properties of Glutathione Under Neutral and Acidic Conditions-- Katarina Valachova, Tamer M. Tamer, and Ladislav Soltes Supramolecular Decomposition of the Aralkyl Hydroperoxides in the Presence of EtNBr-- N. A. Turovskij, E. V. Raksha, Yu. V. Berestneva, E. N. Pasternak, M. Yu. Zubritskij, I. A. Opeida, and G. E. Zaikov The Study of Elastic Polyurethane Thermal Stability by Differential Scanning Calorimetry-- I. A. Novakov, M. A. Vaniev, D. V. Medvedev, N. V. Sidorenko, G. V. Medvedev, and D. O. Gusev Index.
  • (source: Nielsen Book Data)
This important volume highlights the latest developments and trends in chemistry, biochemistry, and biology. It presents the developments of advanced materials and respective tools to characterize and predict the material properties and behavior. The book provides original, theoretical, and important experimental results that use non-routine methodologies often unfamiliar to the usual readers. The papers on novel applications of more familiar experimental techniques and analyses of chemical, biochemistry, and biological programs indicate the need for new experimental approaches.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
QD415 .C446 2015 Unknown
Book
xvi, 523 pages, 53 variously numbered pages ; 28 cm
  • 0 Chemistry for a Sustainable Future 1 The Air We Breathe 2 Protecting the Ozone Layer 3 The Chemistry of Global Climate Change 4 Energy from Combustion 5 Water for Life 6 Neutralizing the Threat of Acid Rain 7 The Fires of Nuclear Fission 8 Energy from Electron Transfer 9 The World of Polymers and Plastics 10 Manipulating Molecules and Designing Drugs 11 Nutrition: Food for Thought 12 Genetic Engineering and the Molecules of Life Appendixes Appendix 1: Measure for Measure - Conversion Factors and Constants Appendix 2: The Power of Exponents Appendix 3: Clearing the Logjam Appendix 4: Answers to Your Turn Questions Not Answered in the Text Appendix 5: Answers to Selected End-of-Chapter Questions.
  • (source: Nielsen Book Data)
Following in the tradition of the first seven editions, the goal of this successful, issues-based textbook, Chemistry in Context, is to establish chemical principles on a need-to-know basis for non-science majors, enabling them to learn chemistry in the context of their own lives and significant issues facing science and the world. The non-traditional approach of Chemistry in Context reflects today's technological issues and the chemistry principles within them. Global warming, alternate fuels, nutrition, and genetic engineering are examples of issues that are covered in Chemistry in Context.
(source: Nielsen Book Data)
  • 0 Chemistry for a Sustainable Future 1 The Air We Breathe 2 Protecting the Ozone Layer 3 The Chemistry of Global Climate Change 4 Energy from Combustion 5 Water for Life 6 Neutralizing the Threat of Acid Rain 7 The Fires of Nuclear Fission 8 Energy from Electron Transfer 9 The World of Polymers and Plastics 10 Manipulating Molecules and Designing Drugs 11 Nutrition: Food for Thought 12 Genetic Engineering and the Molecules of Life Appendixes Appendix 1: Measure for Measure - Conversion Factors and Constants Appendix 2: The Power of Exponents Appendix 3: Clearing the Logjam Appendix 4: Answers to Your Turn Questions Not Answered in the Text Appendix 5: Answers to Selected End-of-Chapter Questions.
  • (source: Nielsen Book Data)
Following in the tradition of the first seven editions, the goal of this successful, issues-based textbook, Chemistry in Context, is to establish chemical principles on a need-to-know basis for non-science majors, enabling them to learn chemistry in the context of their own lives and significant issues facing science and the world. The non-traditional approach of Chemistry in Context reflects today's technological issues and the chemistry principles within them. Global warming, alternate fuels, nutrition, and genetic engineering are examples of issues that are covered in Chemistry in Context.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
QD415 .C482 2015 Unavailable At bindery Request
QD415 .C482 2015 Unavailable At bindery Request
Book
xiii, 146 p. : ill. ; 24 cm
  • Carbohydrates Lipids Proteins Enzymes Inorganics Vitamins Steroids Plant Acids Flavonoids Alkaloids Tannins Resins Glycosides Gums Balsams Volatile Oils Analgesics Anesthetics Sulfa Drugs (Sulfonamides) Psychotropic Drugs Antibiotics Nucleic Acids General Bibliography.
  • (source: Nielsen Book Data)
Written by an author with more than 40 years of teaching experience in the field, Experiments in Pharmaceutical Chemistry, Second Edition responds to a critical classroom need for material on directed laboratory investigations in biological and pharmaceutical chemistry. This new edition supplies 75 experiments, expanding the range of topics to 22 major areas of pharmaceutical chemistry. These include biochemical groups, botanical classes important to pharmacy, and major drug classifications: Carbohydrates Lipids Proteins Enzymes Inorganics Vitamins Steroids Plant Acids Flavonoids Alkaloids Tannins Resins Glycosides Gums Balsams Volatile Oils Analgesics Anesthetics Sulfa Drugs (Sulfonamides) Psychotropic Drugs Antibiotics Nucleic Acids Sections contain introductions to basic concepts underlying the fields addressed and a specific bibliography relating to each field. Each experiment provides detailed instructions in a user-friendly format, and can be carried out, in most cases, without the need for expensive instrumentation. This comprehensive laboratory manual offers much-needed instructional material for teaching laboratory classes in pharmaceutical chemistry. The breadth of subject matter covered provides a variety of choices for structuring a laboratory course.
(source: Nielsen Book Data)
  • Carbohydrates Lipids Proteins Enzymes Inorganics Vitamins Steroids Plant Acids Flavonoids Alkaloids Tannins Resins Glycosides Gums Balsams Volatile Oils Analgesics Anesthetics Sulfa Drugs (Sulfonamides) Psychotropic Drugs Antibiotics Nucleic Acids General Bibliography.
  • (source: Nielsen Book Data)
Written by an author with more than 40 years of teaching experience in the field, Experiments in Pharmaceutical Chemistry, Second Edition responds to a critical classroom need for material on directed laboratory investigations in biological and pharmaceutical chemistry. This new edition supplies 75 experiments, expanding the range of topics to 22 major areas of pharmaceutical chemistry. These include biochemical groups, botanical classes important to pharmacy, and major drug classifications: Carbohydrates Lipids Proteins Enzymes Inorganics Vitamins Steroids Plant Acids Flavonoids Alkaloids Tannins Resins Glycosides Gums Balsams Volatile Oils Analgesics Anesthetics Sulfa Drugs (Sulfonamides) Psychotropic Drugs Antibiotics Nucleic Acids Sections contain introductions to basic concepts underlying the fields addressed and a specific bibliography relating to each field. Each experiment provides detailed instructions in a user-friendly format, and can be carried out, in most cases, without the need for expensive instrumentation. This comprehensive laboratory manual offers much-needed instructional material for teaching laboratory classes in pharmaceutical chemistry. The breadth of subject matter covered provides a variety of choices for structuring a laboratory course.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
RS407 .D53 2014 Unknown
Book
xv, 458 pages : illustrations (some color) ; 25 cm
  • From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design CONCEPTS, TOOLS, LIGANDS AND SCAFFOLDS FOR STRUCTURE-BASED DESIGN OF INHIBITORS Design of Inhibitors of Aspartic Acid Proteases Design of Serine Protease Inhibitors Design of Proteosome Inhibitors Design of Cysteine Protease Inhibitors Design of Metalloprotease Inhibitors Structure-Based Design of Protein Kinase Inhibitors Protein X-Ray Crystallography in Structure-Based Drug Design Structure-Based Design Strategies for Targeting G-Protein Coupled Receptors (GPCRs) STRUCTURE-BASED DESIGN OF FDA-APPROVED INHIBITOR DRUG AND DRUGS UNDERGOING CLINICAL DEVELOPMENT Angiotensin-Converting Enzyme Inhibitors for the Treatment of Hypertension: Design and Discovery of Captopril HIV-1 Protease Inhibitors for the Treatment of HIV Infection and AIDS: Design of Saquinavir, and Darunavir Protein Kinase Inhibitor Drugs for Targeted Cancer Therapy: Design and Discovery of Imatinib, Nilotinib and Dasatinib NS3/4A Serine Protease Inhibitors for the Treatment of HCV: Design and Discovery of Boceprevir and Telaprevir Proteasome Inhibitors for the Treatment of Relapsed Multiple Myeloma: Design and Discovery of Bortezomib and Carfilzomib Direct Thrombin Inhibitors as Anticoagulant Drugs Development of Direct Thrombin Inhibitor, Dabigatran Etexilate, as an Anticoagulant Drug Non-Nucleoside HIV Reverse Transcriptase Inhibitors for the Treatment of HIV/AIDS: Design and Development of Etravirine and Rilpivirine Renin Inhibitor for the Treatment of Hypertension: Design and Discovery of Aliskiren Neuraminidase Inhibitors for the Treatment of Influenza: Design and Discovery of Zanamivir and Oseltamivir Carbonic Anhydrase Inhibitors for the Treatment of Glaucoma: Design and Discovery of Dorzolamide Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease: Preclinical and Clinical Inhibitors Index.
  • (source: Nielsen Book Data)
In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design. As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in structure-based drug design with the novice in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design.
(source: Nielsen Book Data)
  • From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design CONCEPTS, TOOLS, LIGANDS AND SCAFFOLDS FOR STRUCTURE-BASED DESIGN OF INHIBITORS Design of Inhibitors of Aspartic Acid Proteases Design of Serine Protease Inhibitors Design of Proteosome Inhibitors Design of Cysteine Protease Inhibitors Design of Metalloprotease Inhibitors Structure-Based Design of Protein Kinase Inhibitors Protein X-Ray Crystallography in Structure-Based Drug Design Structure-Based Design Strategies for Targeting G-Protein Coupled Receptors (GPCRs) STRUCTURE-BASED DESIGN OF FDA-APPROVED INHIBITOR DRUG AND DRUGS UNDERGOING CLINICAL DEVELOPMENT Angiotensin-Converting Enzyme Inhibitors for the Treatment of Hypertension: Design and Discovery of Captopril HIV-1 Protease Inhibitors for the Treatment of HIV Infection and AIDS: Design of Saquinavir, and Darunavir Protein Kinase Inhibitor Drugs for Targeted Cancer Therapy: Design and Discovery of Imatinib, Nilotinib and Dasatinib NS3/4A Serine Protease Inhibitors for the Treatment of HCV: Design and Discovery of Boceprevir and Telaprevir Proteasome Inhibitors for the Treatment of Relapsed Multiple Myeloma: Design and Discovery of Bortezomib and Carfilzomib Direct Thrombin Inhibitors as Anticoagulant Drugs Development of Direct Thrombin Inhibitor, Dabigatran Etexilate, as an Anticoagulant Drug Non-Nucleoside HIV Reverse Transcriptase Inhibitors for the Treatment of HIV/AIDS: Design and Development of Etravirine and Rilpivirine Renin Inhibitor for the Treatment of Hypertension: Design and Discovery of Aliskiren Neuraminidase Inhibitors for the Treatment of Influenza: Design and Discovery of Zanamivir and Oseltamivir Carbonic Anhydrase Inhibitors for the Treatment of Glaucoma: Design and Discovery of Dorzolamide Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease: Preclinical and Clinical Inhibitors Index.
  • (source: Nielsen Book Data)
In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design. As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in structure-based drug design with the novice in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
RS403 .G55 2014 Unknown
Book
1 v. (various pagings) : ill. (chiefly col.) ; 29 cm.
Voet and Pratt's 4th edition of "Principles of Biochemistry, " challenges readers to better understand the chemistry behind the biological structure and reactions occurring in living systems. The latest edition continues this tradition, and additionally incorporates coverage of recent research and an expanded focus on preparing and supporting students throughout the course. With the addition of new conceptual assessment content to "WileyPLUS, " providing the opportunity to assess conceptual understanding of key introductory biochemistry concepts and retrain themselves on their misconceptionsWileyPLUS sold separately from text.
(source: Nielsen Book Data)
Voet and Pratt's 4th edition of "Principles of Biochemistry, " challenges readers to better understand the chemistry behind the biological structure and reactions occurring in living systems. The latest edition continues this tradition, and additionally incorporates coverage of recent research and an expanded focus on preparing and supporting students throughout the course. With the addition of new conceptual assessment content to "WileyPLUS, " providing the opportunity to assess conceptual understanding of key introductory biochemistry concepts and retrain themselves on their misconceptionsWileyPLUS sold separately from text.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
QD415 .V63 2013 Unknown
Book
xvii, 486 p. : ill., (some col.) ; 28 cm.
  • 1. Fundamentals of Chemical Biology 2. The Chemical Origins of Biology 3. DNA 4. RNA 5. Peptide and Protein Structure 6. Protein Function 7. Glycobiology 8. Polyketides & Terpenes 9. Chemical Control of Signal Transduction A sample chapter and detailed table of contents are available at www.garlandscience.com/bioorganic-chembio.
  • (source: Nielsen Book Data)
Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.
(source: Nielsen Book Data)
  • 1. Fundamentals of Chemical Biology 2. The Chemical Origins of Biology 3. DNA 4. RNA 5. Peptide and Protein Structure 6. Protein Function 7. Glycobiology 8. Polyketides & Terpenes 9. Chemical Control of Signal Transduction A sample chapter and detailed table of contents are available at www.garlandscience.com/bioorganic-chembio.
  • (source: Nielsen Book Data)
Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
QD415 .V36 2013 Unknown
Book
1 v. (various pagings) : ill. (some col.) ; 29 cm.
  • The Foundations of Biochemistry
  • I. STRUCTURE AND CATALYSIS. Water
  • Amino Acids, Peptides, and Proteins
  • The Three-Dimensional Structure of Proteins
  • Protein Function
  • Enzymes
  • Carbohydrates and Glycobiology
  • Nucleotides and Nucleic Acids
  • DNA-Based Information Technologies
  • Lipids
  • Biological Membranes and Transport
  • Biosignaling
  • II. BIOENERGETICS AND METABOLISM. Bioenergetics and Biochemical Reaction Types
  • Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
  • Principles of Metabolic Regulation
  • The Citric Acid Cycle-- Fatty Acid Catabolism
  • Amino Acid Oxidation and the Production of Urea
  • Oxidative Phosphorylation and Photophosphorylation Oxidative Phosphorylation
  • Carbohydrate Biosynthesis in Plants and Bacteria
  • Lipid biosynthesis
  • Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
  • Hormonal Regulation and Integration of Mammalian Metabolism
  • III. INFORMATION PATHWAYS. Genes and Chromosomes
  • DNA Metabolism
  • RNA Metabolism
  • Protein Metabolism
  • Regulation of Gene Expression.
  • The Foundations of Biochemistry
  • I. STRUCTURE AND CATALYSIS. Water
  • Amino Acids, Peptides, and Proteins
  • The Three-Dimensional Structure of Proteins
  • Protein Function
  • Enzymes
  • Carbohydrates and Glycobiology
  • Nucleotides and Nucleic Acids
  • DNA-Based Information Technologies
  • Lipids
  • Biological Membranes and Transport
  • Biosignaling
  • II. BIOENERGETICS AND METABOLISM. Bioenergetics and Biochemical Reaction Types
  • Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
  • Principles of Metabolic Regulation
  • The Citric Acid Cycle-- Fatty Acid Catabolism
  • Amino Acid Oxidation and the Production of Urea
  • Oxidative Phosphorylation and Photophosphorylation Oxidative Phosphorylation
  • Carbohydrate Biosynthesis in Plants and Bacteria
  • Lipid biosynthesis
  • Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
  • Hormonal Regulation and Integration of Mammalian Metabolism
  • III. INFORMATION PATHWAYS. Genes and Chromosomes
  • DNA Metabolism
  • RNA Metabolism
  • Protein Metabolism
  • Regulation of Gene Expression.
Biology Library (Falconer), Chemistry & ChemEng Library (Swain), Marine Biology Library (Miller)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QD415 .L44 2013 Unknown
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Permanent reserve
QD415 .L44 2013 Unknown
Status of items at Marine Biology Library (Miller)
Marine Biology Library (Miller) Status
Stacks
QD415 .L44 2013 Unknown

10. Biochemistry [2012]

Book
xxxii, 1054, [132] p. : ill. ; 28 cm.
  • Biochemistry: an evolving science
  • Protein composition and structure
  • Exploring proteins and proteomes
  • DNA, RNA, and the flow of genetic information
  • Exploring genes and genomes
  • Exploring evolution and bioinformatics
  • Hemoglobin: portrait of a protein in action
  • Enzymes: basic concepts and kinetics
  • Catalytic strategies
  • Regulatory strategies
  • Carbohydrates
  • Lipids and cell membranes
  • Membrane channels and pumps
  • Signal-transduction pathways
  • Metabolism: basic concepts and design
  • Glycolysis and gluconeogenesis
  • The citric acid cycle
  • Oxidative phosphorylation
  • The light reactions of photosynthesis
  • The calvin cycle and the pentose phosphate pathway
  • Glycogen metabolism
  • Fatty acid metabolism
  • Protein turnover and amino acid catabolism
  • The biosynthesis of amino acids
  • Nucleotide biosynthesis
  • The biosynthesis of membrane lipids and steroids
  • The integration of metabolism
  • DNA replication, repair, and recombination
  • RNA synthesis and processing
  • Protein synthesis
  • The control of gene expression in prokaryotes
  • The control of gene expression in eukaryotes
  • Sensory systems
  • The immune system
  • Molecular motors
  • Drug development.
  • Biochemistry: an evolving science
  • Protein composition and structure
  • Exploring proteins and proteomes
  • DNA, RNA, and the flow of genetic information
  • Exploring genes and genomes
  • Exploring evolution and bioinformatics
  • Hemoglobin: portrait of a protein in action
  • Enzymes: basic concepts and kinetics
  • Catalytic strategies
  • Regulatory strategies
  • Carbohydrates
  • Lipids and cell membranes
  • Membrane channels and pumps
  • Signal-transduction pathways
  • Metabolism: basic concepts and design
  • Glycolysis and gluconeogenesis
  • The citric acid cycle
  • Oxidative phosphorylation
  • The light reactions of photosynthesis
  • The calvin cycle and the pentose phosphate pathway
  • Glycogen metabolism
  • Fatty acid metabolism
  • Protein turnover and amino acid catabolism
  • The biosynthesis of amino acids
  • Nucleotide biosynthesis
  • The biosynthesis of membrane lipids and steroids
  • The integration of metabolism
  • DNA replication, repair, and recombination
  • RNA synthesis and processing
  • Protein synthesis
  • The control of gene expression in prokaryotes
  • The control of gene expression in eukaryotes
  • Sensory systems
  • The immune system
  • Molecular motors
  • Drug development.
Biology Library (Falconer), Chemistry & ChemEng Library (Swain)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QP514.2 .S66 2012 Unknown
QP514.2 .S66 2012 Unknown
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Permanent reserve
QP514.2 .S66 2012 Unknown
QP514.2 .S66 2012 Unknown
QP514.2 .S66 2012 Unknown
QP514.2 .S66 2012 Unknown
Book
1 v. (various pagings) : ill. (chiefly col.), col. maps ; 28 cm.
  • Chemistry for a sustainable future
  • The air we breathe
  • Protecting the ozone layer
  • The chemistry of global warming
  • Energy, chemistry, and society
  • The water for life
  • Neutralizing the threat of acid rain
  • The fires of nuclear fission
  • Energy from electron transfer
  • The world of Polymers and plastics
  • Manipulating molecules and designing drugs
  • Nutrition: food for thought
  • Genetic engineering and the molecules of life.
Following in the tradition of the first six editions, the goal of this successful, issues-based textbook, "Chemistry in Context, " seventh edition, is to establish chemical principles on a need-to-know basis for non-science majors, enabling them to learn chemistry in the context of their own lives and significant issues facing science and the world. The non traditional approach of "Chemistry in Context" reflects today's technological issues and the chemistry principles imbedded within them. The seventh edition applies sustainability principles wherever possible. Global warming, alternate fuels, nutrition, and genetic engineering are examples of issues that are covered in "Chemistry in Context.".
(source: Nielsen Book Data)
  • Chemistry for a sustainable future
  • The air we breathe
  • Protecting the ozone layer
  • The chemistry of global warming
  • Energy, chemistry, and society
  • The water for life
  • Neutralizing the threat of acid rain
  • The fires of nuclear fission
  • Energy from electron transfer
  • The world of Polymers and plastics
  • Manipulating molecules and designing drugs
  • Nutrition: food for thought
  • Genetic engineering and the molecules of life.
Following in the tradition of the first six editions, the goal of this successful, issues-based textbook, "Chemistry in Context, " seventh edition, is to establish chemical principles on a need-to-know basis for non-science majors, enabling them to learn chemistry in the context of their own lives and significant issues facing science and the world. The non traditional approach of "Chemistry in Context" reflects today's technological issues and the chemistry principles imbedded within them. The seventh edition applies sustainability principles wherever possible. Global warming, alternate fuels, nutrition, and genetic engineering are examples of issues that are covered in "Chemistry in Context.".
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
QD415 .C482 2012 Unknown

12. Biochemistry [2011]

Book
xxv, 1428, 53 p. : ill. (some col.) ; 29 cm.
  • Guide to Media Resources xvi PART I INTRODUCTION AND BACKGROUND 1 1 Life 3 2 Aqueous Solutions 40 3 Thermodynamic Principles: A Review 52 PART II BIOMOLECULES 65 4 Amino Acids 67 5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 82 6 Techniques of Protein and Nucleic Acid Purifications 129 7 Covalent Structures of Proteins and Nucleic Acids 163 8 Three-Dimensional Structures of Proteins 221 9 Protein Folding, Dynamics, and Structural Evolution 278 10 Hemoglobin: Protein Function in Microcosm 323 11 Sugars and Polysaccharides 359 12 Lipids and Membranes 386 PART III MECHANISMS OF ENZYME ACTION 467 13 Introduction to Enzymes 469 14 Rates of Enzymatic Reactions 482 15 Enzymatic Catalysis 506 PART IV METABOLISM 557 16 Introduction to Metabolism 559 17 Glycolysis 593 18 Glycogen Metabolism 638 19 Signal Transduction 671 20 Transport through Membranes 744 21 Citric Acid Cycle 789 22 Electron Transport and Oxidative Phosphorylation 823 23 Other Pathways of Carbohydrate Metabolism 871 24 Photosynthesis 901 25 Lipid Metabolism 940 26 Amino Acid Metabolism 1019 27 Energy Metabolism: Integration and Organ Specialization 1088 28 Nucleotide Metabolism 1107 PART V EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION 1143 29 Nucleic Acid Structures 1145 30 DNA Replication, Repair, and Recombination 1173 31 Transcription 1260 32 Translation 1338 33 Viruses: Paradigms for Cellular Function W-1 34 Eukaryotic Gene Expression W-53 35 Molecular Physiology W-165 (Chapters 33--35 are available on our website, www.wiley.com/college/voet ) xii.
  • (source: Nielsen Book Data)
The "Gold Standard" in Biochemistry text books, Biochemistry 4e , is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.
(source: Nielsen Book Data)
  • Guide to Media Resources xvi PART I INTRODUCTION AND BACKGROUND 1 1 Life 3 2 Aqueous Solutions 40 3 Thermodynamic Principles: A Review 52 PART II BIOMOLECULES 65 4 Amino Acids 67 5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 82 6 Techniques of Protein and Nucleic Acid Purifications 129 7 Covalent Structures of Proteins and Nucleic Acids 163 8 Three-Dimensional Structures of Proteins 221 9 Protein Folding, Dynamics, and Structural Evolution 278 10 Hemoglobin: Protein Function in Microcosm 323 11 Sugars and Polysaccharides 359 12 Lipids and Membranes 386 PART III MECHANISMS OF ENZYME ACTION 467 13 Introduction to Enzymes 469 14 Rates of Enzymatic Reactions 482 15 Enzymatic Catalysis 506 PART IV METABOLISM 557 16 Introduction to Metabolism 559 17 Glycolysis 593 18 Glycogen Metabolism 638 19 Signal Transduction 671 20 Transport through Membranes 744 21 Citric Acid Cycle 789 22 Electron Transport and Oxidative Phosphorylation 823 23 Other Pathways of Carbohydrate Metabolism 871 24 Photosynthesis 901 25 Lipid Metabolism 940 26 Amino Acid Metabolism 1019 27 Energy Metabolism: Integration and Organ Specialization 1088 28 Nucleotide Metabolism 1107 PART V EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION 1143 29 Nucleic Acid Structures 1145 30 DNA Replication, Repair, and Recombination 1173 31 Transcription 1260 32 Translation 1338 33 Viruses: Paradigms for Cellular Function W-1 34 Eukaryotic Gene Expression W-53 35 Molecular Physiology W-165 (Chapters 33--35 are available on our website, www.wiley.com/college/voet ) xii.
  • (source: Nielsen Book Data)
The "Gold Standard" in Biochemistry text books, Biochemistry 4e , is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Request at circulation desk
QP514.2 .V64 2011 Unknown On Reserve 2-hour loan
QP514.2 .V64 2011 Unknown On Reserve 2-hour loan
CHEM-181-01, CHEM-181-01, CHEMENG-181-01, CHEMENG-181-01, CHEMENG-281-01, CHEMENG-281-01
Course
CHEM-181-01 -- Biochemistry I
Instructor(s)
Du Bois, Justin
Course
CHEM-181-01 -- Biochemistry I
Instructor(s)
Khosla, Chaitan
Course
CHEMENG-181-01 -- Biochemistry I
Instructor(s)
Du Bois, Justin
Course
CHEMENG-181-01 -- Biochemistry I
Instructor(s)
Khosla, Chaitan
Course
CHEMENG-281-01 -- Biochemistry I
Instructor(s)
Du Bois, Justin
Course
CHEMENG-281-01 -- Biochemistry I
Instructor(s)
Khosla, Chaitan
Book
ix, 233 p. : ill. ; 25 cm.
  • Biological Molecules-- Spectroscopy-- Mass Spectrometry-- Hydrodynamics-- Thermodynamics and Interactions-- Kinetics-- Chromatography and Electrophoresis-- Single Molecules-- Subject Index.
  • (source: Nielsen Book Data)
Biophysical Chemistry covers the physical chemistry of biological macromolecules and the experimental techniques used to study them. Topics covered include: an introduction to biological molecules; spectroscopy, mass spectrometry and hydrodynamics of macromolecules; a "bluffer's guide" to molecular thermodynamics; biomolecular kinetics; chromatography and electrophoresis; and single-molecule methods. The easily digestible, pragmatic approach captures the reader with the fascinating challenges the subject poses for theoretical and experimental scientists. This book will be ideal for early undergraduates studying chemical or physical sciences and will act as a basis for more advanced study. Students in other areas of biological sciences will appreciate the less intimidating approach to physical chemistry as demonstrated here. Ideal for the needs of undergraduate chemistry students, Tutorial Chemistry Texts is a major series consisting of short, single topic or modular texts concentrating on the fundamental areas of chemistry taught in undergraduate science courses. Each book provides a concise account of the basic principles underlying a given subject, embodying an independent-learning philosophy and including worked examples.
(source: Nielsen Book Data)
  • Biological Molecules-- Spectroscopy-- Mass Spectrometry-- Hydrodynamics-- Thermodynamics and Interactions-- Kinetics-- Chromatography and Electrophoresis-- Single Molecules-- Subject Index.
  • (source: Nielsen Book Data)
Biophysical Chemistry covers the physical chemistry of biological macromolecules and the experimental techniques used to study them. Topics covered include: an introduction to biological molecules; spectroscopy, mass spectrometry and hydrodynamics of macromolecules; a "bluffer's guide" to molecular thermodynamics; biomolecular kinetics; chromatography and electrophoresis; and single-molecule methods. The easily digestible, pragmatic approach captures the reader with the fascinating challenges the subject poses for theoretical and experimental scientists. This book will be ideal for early undergraduates studying chemical or physical sciences and will act as a basis for more advanced study. Students in other areas of biological sciences will appreciate the less intimidating approach to physical chemistry as demonstrated here. Ideal for the needs of undergraduate chemistry students, Tutorial Chemistry Texts is a major series consisting of short, single topic or modular texts concentrating on the fundamental areas of chemistry taught in undergraduate science courses. Each book provides a concise account of the basic principles underlying a given subject, embodying an independent-learning philosophy and including worked examples.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
QD476.2 .C66 2011 Unknown
Book
xxii, 289 p., 4 p. of plates : ill. (some col.) ; 24 cm
  • From Nanoparticles to Nanocomposites: An Overview, A. S. Pereira, A. L. Daniel-da-Silva, T. Trindade Polymers for Biomedical Applications: Chemical Modification and Biofunctionalization, M. H. Gil, J. F. J. Coelho, P. Ferreira, P. Alves Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules, P. Hervella, G. Lollo, F. Oyarzun-Ampuero, G. Rivera, D. Torres, M. J. Alonso Inorganic Nanoparticles Biofunctionalization, P. Howes, M. Green Silica-Based Materials: Bioprocesses and Nanocomposites, T. Coradin Synthetic Strategies for Polymer Based Nanocomposite Particles, A. C. C. Esteves, A. Barros-Timmons Synthesis of Nanocomposite Particles Using Supercritical Fluids: A Bridge with Bio-Applications, C. Aymonier, A. C. Le Meur, V. Heroguez Biocomposites Containing Magnetic Nanoparticles, A. L. Daniel-da-Silva, N. J. O. Silva, T. Trindade, A. M. Gil Multifunctional Nanocomposite Particles for Biomedical Applications, Y. K. Gun'ko, A. Y. Gunko Bio-Applications of Functionalized Magnetic Nanoparticles and Their Nanocomposites, P. Tartaj Anti-Microbial Properties of Polymer Nanocomposites, S. V. Manorama, P. Basak, S. Singh Microcatheters: A Bio-Application of Carbon Nanotube Filled Composites, M. Endo, S. Koyama, Y. A. Kim Biosensing Applications Using Nanoparticles, R. Baltazar, C. R. Vistas, G. N. M. Ferreira.
  • (source: Nielsen Book Data)
This book provides a concise state of the art of the synthesis and properties of nanocomposite particles with interest for diverse bio-applications. Contributions are mainly related to the chemical design of nanocomposite particles, their properties as well as their constituent materials, and the tailoring of bio-interfaces that may be relevant to the fields of clinical diagnosis and drug delivery procedures, among other bio-applications.
(source: Nielsen Book Data)
  • From Nanoparticles to Nanocomposites: An Overview, A. S. Pereira, A. L. Daniel-da-Silva, T. Trindade Polymers for Biomedical Applications: Chemical Modification and Biofunctionalization, M. H. Gil, J. F. J. Coelho, P. Ferreira, P. Alves Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules, P. Hervella, G. Lollo, F. Oyarzun-Ampuero, G. Rivera, D. Torres, M. J. Alonso Inorganic Nanoparticles Biofunctionalization, P. Howes, M. Green Silica-Based Materials: Bioprocesses and Nanocomposites, T. Coradin Synthetic Strategies for Polymer Based Nanocomposite Particles, A. C. C. Esteves, A. Barros-Timmons Synthesis of Nanocomposite Particles Using Supercritical Fluids: A Bridge with Bio-Applications, C. Aymonier, A. C. Le Meur, V. Heroguez Biocomposites Containing Magnetic Nanoparticles, A. L. Daniel-da-Silva, N. J. O. Silva, T. Trindade, A. M. Gil Multifunctional Nanocomposite Particles for Biomedical Applications, Y. K. Gun'ko, A. Y. Gunko Bio-Applications of Functionalized Magnetic Nanoparticles and Their Nanocomposites, P. Tartaj Anti-Microbial Properties of Polymer Nanocomposites, S. V. Manorama, P. Basak, S. Singh Microcatheters: A Bio-Application of Carbon Nanotube Filled Composites, M. Endo, S. Koyama, Y. A. Kim Biosensing Applications Using Nanoparticles, R. Baltazar, C. R. Vistas, G. N. M. Ferreira.
  • (source: Nielsen Book Data)
This book provides a concise state of the art of the synthesis and properties of nanocomposite particles with interest for diverse bio-applications. Contributions are mainly related to the chemical design of nanocomposite particles, their properties as well as their constituent materials, and the tailoring of bio-interfaces that may be relevant to the fields of clinical diagnosis and drug delivery procedures, among other bio-applications.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
RS201 .N35 N35 2011 Unknown
Book
xxiii, 1044, 53, 30 p. : ill. (some col.) ; 27 cm.
Renowned for its student-friendly writing style and fresh perspective, John McMurry's ORGANIC CHEMISTRY WITH BIOLOGICAL APPLICATIONS offers full coverage of the foundations of organic chemistry--enhanced by biological examples throughout. Based on user feedback, McMurry continues to discuss the organic chemistry of biological pathways and now adds two dozen additional organic chemistry topics, as well as new problems, new illustrations, and new essays. Media integration with Organic OWL, a customizable online learning system and assessment tool, reduces faculty workload, facilitates instruction, and helps students master concepts through tutorials, simulations, and algorithmically generated homework questions.
(source: Nielsen Book Data)
Renowned for its student-friendly writing style and fresh perspective, John McMurry's ORGANIC CHEMISTRY WITH BIOLOGICAL APPLICATIONS offers full coverage of the foundations of organic chemistry--enhanced by biological examples throughout. Based on user feedback, McMurry continues to discuss the organic chemistry of biological pathways and now adds two dozen additional organic chemistry topics, as well as new problems, new illustrations, and new essays. Media integration with Organic OWL, a customizable online learning system and assessment tool, reduces faculty workload, facilitates instruction, and helps students master concepts through tutorials, simulations, and algorithmically generated homework questions.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Permanent reserve
QD251.3 .M365 2011 Unknown
Book
xxvi, 590 p. : col. ill. ; 27 cm.
  • PART 1 - BIOCHEMICAL THERMODYNAMICS -- 1. The First Law -- 2. The Second Law -- 3. Phase Equilibria -- 4. Chemical Equilibrium -- 5. Thermodynamics of Ion and Electron Transport -- PART 2- THE KINETICS OF LIFE PROCESSES -- 6. The Rates of Reactions -- 7. Accounting for the Rate Laws -- 8. Complex Biochemical Processes -- PART 3 - BIOMOLECULAR STRUCTURE -- 9. Microscopic Systems and Quantization -- 10. The Chemical Bond -- 11. Macromolecules and Self-Assembly -- PART 4 - BIOMOLECULAR SPECTROSCOPY -- 12. Optical Techniques and Photobiology -- 14. Magnetic Resonance.
  • (source: Nielsen Book Data)
Physical chemistry lies at the heart of the behaviour of those macromolecules and molecular assemblies that have vital roles in all living organisms. Physical principles determine the stability of proteins and nucleic acids, the rate at which biochemical reactions proceed, the transport of molecules across biological molecules; they allow us to describe structure and reactivity in complex biological systems, and make sense of how these systems operate. Physical Chemistry for the Life Sciences provides a balanced presentation of the concepts of physical chemistry, and their extensive applications to biology and biochemistry. It is written to straddle the worlds of physical chemistry and the life sciences and to show students how the tools of physical chemistry can elucidate and illuminate biological questions. Opening with a suite of chapters on Biochemical Thermodynamics, with a focus on energy conversion in biological cells and the factors that stabilize proteins, nucleic acids, and cell membranes, the book goes on to explore the Kinetics of Life Processes, examining the rates of chemical reactions, how rates can help characterise the mechanism of a reaction, and how enzymes affect reaction rates. A third section, Biomolecular Structure, looks at how concepts of physical chemistry can be used to establish those 'rules' that govern the assembly of complex biological structures, while the final section, Biomolecular Spectroscopy, describes the major techniques in biochemistry that are being applied to help us to explore biochemical processes and systems ever further. Physical Chemistry for the Life Sciences places emphasis on clear explanations of difficult concepts, with an eye toward building insight into biochemical phenomena. An extensive range of learning features, including worked examples, illustrations, self-tests, and case studies, support student learning throughout, while special attention is given to providing extensive help to students with those mathematical concepts and techniques that are so central to a sound understanding of physical chemistry. Balancing clarity and rigor of exposition of basic concepts with extensive discussion of biological techniques and processes, Physical Chemistry for the Life Sciences is the perfect resource for every life science student who seeks to master those essentials of physical chemistry that underpin life itself. Online Resource Centre For students: - Web links for each chapter, pointing students to interesting sources of related information and data, to facilitate self-directed learning - A list of key equations for each chapter, to help students revise and master the key mathematical concepts that underpin the subject - Living graphs, which present graphs from the text in interactive format, and enable students to strengthen their learning by manipulating key variables and exploring the consequeneces - Three-dimensional, interactive models of the biomolecules appearing in the end-of-book atlas of structures For registered adopters of the book: Figures in electronic format.
(source: Nielsen Book Data)
  • PART 1 - BIOCHEMICAL THERMODYNAMICS -- 1. The First Law -- 2. The Second Law -- 3. Phase Equilibria -- 4. Chemical Equilibrium -- 5. Thermodynamics of Ion and Electron Transport -- PART 2- THE KINETICS OF LIFE PROCESSES -- 6. The Rates of Reactions -- 7. Accounting for the Rate Laws -- 8. Complex Biochemical Processes -- PART 3 - BIOMOLECULAR STRUCTURE -- 9. Microscopic Systems and Quantization -- 10. The Chemical Bond -- 11. Macromolecules and Self-Assembly -- PART 4 - BIOMOLECULAR SPECTROSCOPY -- 12. Optical Techniques and Photobiology -- 14. Magnetic Resonance.
  • (source: Nielsen Book Data)
Physical chemistry lies at the heart of the behaviour of those macromolecules and molecular assemblies that have vital roles in all living organisms. Physical principles determine the stability of proteins and nucleic acids, the rate at which biochemical reactions proceed, the transport of molecules across biological molecules; they allow us to describe structure and reactivity in complex biological systems, and make sense of how these systems operate. Physical Chemistry for the Life Sciences provides a balanced presentation of the concepts of physical chemistry, and their extensive applications to biology and biochemistry. It is written to straddle the worlds of physical chemistry and the life sciences and to show students how the tools of physical chemistry can elucidate and illuminate biological questions. Opening with a suite of chapters on Biochemical Thermodynamics, with a focus on energy conversion in biological cells and the factors that stabilize proteins, nucleic acids, and cell membranes, the book goes on to explore the Kinetics of Life Processes, examining the rates of chemical reactions, how rates can help characterise the mechanism of a reaction, and how enzymes affect reaction rates. A third section, Biomolecular Structure, looks at how concepts of physical chemistry can be used to establish those 'rules' that govern the assembly of complex biological structures, while the final section, Biomolecular Spectroscopy, describes the major techniques in biochemistry that are being applied to help us to explore biochemical processes and systems ever further. Physical Chemistry for the Life Sciences places emphasis on clear explanations of difficult concepts, with an eye toward building insight into biochemical phenomena. An extensive range of learning features, including worked examples, illustrations, self-tests, and case studies, support student learning throughout, while special attention is given to providing extensive help to students with those mathematical concepts and techniques that are so central to a sound understanding of physical chemistry. Balancing clarity and rigor of exposition of basic concepts with extensive discussion of biological techniques and processes, Physical Chemistry for the Life Sciences is the perfect resource for every life science student who seeks to master those essentials of physical chemistry that underpin life itself. Online Resource Centre For students: - Web links for each chapter, pointing students to interesting sources of related information and data, to facilitate self-directed learning - A list of key equations for each chapter, to help students revise and master the key mathematical concepts that underpin the subject - Living graphs, which present graphs from the text in interactive format, and enable students to strengthen their learning by manipulating key variables and exploring the consequeneces - Three-dimensional, interactive models of the biomolecules appearing in the end-of-book atlas of structures For registered adopters of the book: Figures in electronic format.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Request at circulation desk
QP517 .P49 A86 2011 Unknown On Reserve 2-hour loan
CHEM-181-01, CHEM-181-01, CHEMENG-181-01, CHEMENG-181-01, CHEMENG-281-01, CHEMENG-281-01
Course
CHEM-181-01 -- Biochemistry I
Instructor(s)
Du Bois, Justin
Course
CHEM-181-01 -- Biochemistry I
Instructor(s)
Khosla, Chaitan
Course
CHEMENG-181-01 -- Biochemistry I
Instructor(s)
Du Bois, Justin
Course
CHEMENG-181-01 -- Biochemistry I
Instructor(s)
Khosla, Chaitan
Course
CHEMENG-281-01 -- Biochemistry I
Instructor(s)
Du Bois, Justin
Course
CHEMENG-281-01 -- Biochemistry I
Instructor(s)
Khosla, Chaitan
Book
ix, 238 p. : ill. (some col.) ; 25 cm.
  • 1 - Introductory notes-- Inspiring hierarchical-- Encoding instructive-- Starting lowest-- Picturing biological-- 2 - Re-cycling hereditary-- Coding dual-- Deoxyribonucleic-- Building up in two-- Keeping in shape-- Priming topological-- Re-sequencing basic-- Choosing the fittest-- Evolving diverse-- Primary motifs-- Gluing universal-- Alienating axial-- Fixing spatial-- Hinting geometric: secondary motifs-- Crossing double-- Reporting visible-- Translating symmetrical-- Extending cohisive-- Sharing mutual-- Multiplying traversal-- Tiling square-- Scaffolding algorithmic-- Pursuing autonomous-- Lengthening to shorten-- Gathering to limit-- Assigning arbitrary-- Synchronizing local-- Prescribing general-- Adding up to third-- Wrapping to shut-- Framing to classify-- Outlook-- References-- 3- Re-caging within-- Enclosing to deliver-- Transporting foreign-- Fitting flat and straight-- Spiralling along-- Packing out and in-- Spooling around-- Tunnelling through-- Escaping walled-- Capturing on and off-- Storing exchangeable-- Reacting nano-- Clustering spherical-- Contriving consistent-- Scaling hosting-- Following linear-- Channelling inner-- Converting outer-- Repairing from inside-- Uninviting levy-- Necessitating exterior-- Antagonising dressing-- Buffering masking-- Renting occasional-- Phasing wet-- Facing concentric-- Encircling between-- Singling out unique-- Sharing the balance-- Driving symmetrical-- Sealing annular-- Outlook-- References-- 4 - Re-assembling multiple-- Keeping all in touch-- Unravelling the essential-- Winding three in one-- Aligning stagger-- Tapering polar-- Branching and stretching-- Replicating apparent-- Scrapping refusal-- Tempting compatible-- Likening synthetic-- Recovering intelligent-- Restoring available-- Prompting longitudinal-- Invoking granted-- Reposing modular-- Displacing coil-- Settling lateral-- Bundling exclusive-- Permitting distinctive-- Inviting captive-- Clearing limiting-- Equilibrating transitional-- Extracting minimal-- Gambling beyond-- Guiding proliferative-- Feeding proximate-- Rooting renewal-- Accepting inescapable-- Patterning positional-- Relating interfacial-- Grafting integral-- Outlook-- References-- 5 - Concluding remarks-- Learning fluent-- Parsing semantic-- Drawing pragmatic-- 6 - Revealing contributory.
  • (source: Nielsen Book Data)
The progress of today's science and technology encounters an increasing demand for finer and more efficiently performing materials with properties superior over those of current and hence ageing devices. Whether this is concerned with electronics or drug delivery, cancer diagnostics or alternative energy sources, the search for means of miniaturizing the existing materials or devising fundamentally new components with higher capacities appears to be relentless. A saving solution to this is widely proposed as the design and fabrication of nanostructures, molecular architectures with dimensions featured below 100 nm. Replicating Nature's designs faithfully reproduced over millions of years provides perhaps the most straightforward route to success. Nature offers examples of nanodefined self-assemblies in virtually all levels of biological organization. However explicit guidance to the fabrication of functional or specialist nanostructures is of paramount importance. Nanotechnology is often referred to as building nanoscale structures from bottom up. However, while it is visually clear what is at "up" little is given and understood what is at the "bottom". This new book gives the notion of and provides rules for building nanostructures from basics - the very bottom. The main objective of this publication is to bring together contemporary approaches for designing nanostructures that employ naturally derived self-assembling motifs as synthetic platforms. The book has been written to satisfy the demands that motivate the search for and principles that prove to help the design of novel nanostructures. The overall goal is to compile the existing understanding of rules that govern biomolecular self-assembly into a practical guide to molecular nanotechnology. It is written in the shape of a review referenced as fully as permissible within the context of biomolecular design, which forms a general trend throughout. The volume is composed of three core chapters focusing on three prominent topics of applied nanotechnology where the role of nanodesign is predominant. The three key areas from which popular highlights can be drawn are: -employing the genetic repository, DNA, for creating various geometric nanoscale objects and patterns -the empirical pursuit of an artificial virus, a magic bullet in gene therapy -designing artificial extracellular matrices for regenerative medicine Specific applications that arise from designed nanoscale assemblies as well as fabrication and characterization techniques are of secondary importance and whenever they appear serve as progress and innovation highlights. The book takes an unconventional approach in delivering material of this kind. It does not lead straight to applications or methods as most nanotechnology works tend to do, but instead it focuses on the initial and primary aspect of "nano" rather than on "technology". Nanodesign is unique in its own field - illustrations are essential and the cohort of brilliant bioinspired designs reported to date form a major part of the publication. In addition, key bibliographic references are covered as fully as possible. A special appendix giving a short list of leading world laboratories engaged in bioinspired nanodesign is also included.
(source: Nielsen Book Data)
  • 1 - Introductory notes-- Inspiring hierarchical-- Encoding instructive-- Starting lowest-- Picturing biological-- 2 - Re-cycling hereditary-- Coding dual-- Deoxyribonucleic-- Building up in two-- Keeping in shape-- Priming topological-- Re-sequencing basic-- Choosing the fittest-- Evolving diverse-- Primary motifs-- Gluing universal-- Alienating axial-- Fixing spatial-- Hinting geometric: secondary motifs-- Crossing double-- Reporting visible-- Translating symmetrical-- Extending cohisive-- Sharing mutual-- Multiplying traversal-- Tiling square-- Scaffolding algorithmic-- Pursuing autonomous-- Lengthening to shorten-- Gathering to limit-- Assigning arbitrary-- Synchronizing local-- Prescribing general-- Adding up to third-- Wrapping to shut-- Framing to classify-- Outlook-- References-- 3- Re-caging within-- Enclosing to deliver-- Transporting foreign-- Fitting flat and straight-- Spiralling along-- Packing out and in-- Spooling around-- Tunnelling through-- Escaping walled-- Capturing on and off-- Storing exchangeable-- Reacting nano-- Clustering spherical-- Contriving consistent-- Scaling hosting-- Following linear-- Channelling inner-- Converting outer-- Repairing from inside-- Uninviting levy-- Necessitating exterior-- Antagonising dressing-- Buffering masking-- Renting occasional-- Phasing wet-- Facing concentric-- Encircling between-- Singling out unique-- Sharing the balance-- Driving symmetrical-- Sealing annular-- Outlook-- References-- 4 - Re-assembling multiple-- Keeping all in touch-- Unravelling the essential-- Winding three in one-- Aligning stagger-- Tapering polar-- Branching and stretching-- Replicating apparent-- Scrapping refusal-- Tempting compatible-- Likening synthetic-- Recovering intelligent-- Restoring available-- Prompting longitudinal-- Invoking granted-- Reposing modular-- Displacing coil-- Settling lateral-- Bundling exclusive-- Permitting distinctive-- Inviting captive-- Clearing limiting-- Equilibrating transitional-- Extracting minimal-- Gambling beyond-- Guiding proliferative-- Feeding proximate-- Rooting renewal-- Accepting inescapable-- Patterning positional-- Relating interfacial-- Grafting integral-- Outlook-- References-- 5 - Concluding remarks-- Learning fluent-- Parsing semantic-- Drawing pragmatic-- 6 - Revealing contributory.
  • (source: Nielsen Book Data)
The progress of today's science and technology encounters an increasing demand for finer and more efficiently performing materials with properties superior over those of current and hence ageing devices. Whether this is concerned with electronics or drug delivery, cancer diagnostics or alternative energy sources, the search for means of miniaturizing the existing materials or devising fundamentally new components with higher capacities appears to be relentless. A saving solution to this is widely proposed as the design and fabrication of nanostructures, molecular architectures with dimensions featured below 100 nm. Replicating Nature's designs faithfully reproduced over millions of years provides perhaps the most straightforward route to success. Nature offers examples of nanodefined self-assemblies in virtually all levels of biological organization. However explicit guidance to the fabrication of functional or specialist nanostructures is of paramount importance. Nanotechnology is often referred to as building nanoscale structures from bottom up. However, while it is visually clear what is at "up" little is given and understood what is at the "bottom". This new book gives the notion of and provides rules for building nanostructures from basics - the very bottom. The main objective of this publication is to bring together contemporary approaches for designing nanostructures that employ naturally derived self-assembling motifs as synthetic platforms. The book has been written to satisfy the demands that motivate the search for and principles that prove to help the design of novel nanostructures. The overall goal is to compile the existing understanding of rules that govern biomolecular self-assembly into a practical guide to molecular nanotechnology. It is written in the shape of a review referenced as fully as permissible within the context of biomolecular design, which forms a general trend throughout. The volume is composed of three core chapters focusing on three prominent topics of applied nanotechnology where the role of nanodesign is predominant. The three key areas from which popular highlights can be drawn are: -employing the genetic repository, DNA, for creating various geometric nanoscale objects and patterns -the empirical pursuit of an artificial virus, a magic bullet in gene therapy -designing artificial extracellular matrices for regenerative medicine Specific applications that arise from designed nanoscale assemblies as well as fabrication and characterization techniques are of secondary importance and whenever they appear serve as progress and innovation highlights. The book takes an unconventional approach in delivering material of this kind. It does not lead straight to applications or methods as most nanotechnology works tend to do, but instead it focuses on the initial and primary aspect of "nano" rather than on "technology". Nanodesign is unique in its own field - illustrations are essential and the cohort of brilliant bioinspired designs reported to date form a major part of the publication. In addition, key bibliographic references are covered as fully as possible. A special appendix giving a short list of leading world laboratories engaged in bioinspired nanodesign is also included.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
TP248.25 .N35 R93 2009 Unknown
Book
xv, 594 p. : ill. (some col.) ; 29 cm.
  • List of Contributors. Series Preface. Volume Preface. Part 1: Methods. Calculation of Bonding Properties (Gernot Frenking and Moritz von Hopffgarden). Determining Transition States in Bioinorganic Reactions (Marcus Lundberg and Keiji Morokuma). Quantum Mechanical/Molecular Mechanical (QM/MM) Methods and Applications in Bioinorganic Chemistry (Ulf Ryde). Ab initio and Semiempirical Methods (Serge I. Gorelsky). Spectroscopic Properties of Proten-Bound Cofactors: Calculation by Combined Quantum Mechanical/Molecular Mechanical (QM/MM) Approaches (Mahesh Sundararajan, Christoph Riplinger, Maylis Orio, Frank Wennmohs and Frank Neese). Spectroscopic Properties Obtained from Time-Dependent Density Functional Theory (TD-DFT) (Jochen Autschbach). Nuclear Magnetic Resonance (NMR) Parameters of Transition Metal Complexes: Methods and Applications (Martin Kaupp and Michael Buhl). Calculation of Reduction Potential and pKa. Quantum-Chemistry-Centered Normal Coordinate Analysis (QCC-NCA): Application of NCA for the Simulation of the Vibrational Spectra of Large Molecules (Nicolai Lehnert). Molecular Mechanics in Bioinorganic Chemistry (Robert J. Deeth). Multiconfigurational Quantum Mechanics (QM) for Heavy Element Compounds (Bjorn O. Roos). Approximate Density Functionals: Which Should I Choose? (Dmitrij Rappoport, Nathan R. M. Crawford, Filipp Furche and Kieron Burke). Spin Contamination in Inorganic Chemistry Calculations (Jason L. Sonnerberg, H. Bernhard Schlegel and Hrant P. Hratchian). Gaussian Basis Sets for Quantum Mechanical (QM) Calculations (Kirk A. Peterson). Part 2: Case Studies - Bioinorganic. Modeling Metalloenzymes with Density Functional and Mixed Quantum Mechanical/Molecular Mechanical (QM/MM) Calculations: Progress and Challenges (Richard A. Friesner). Broken Symmetry States of Iron-Sulfur Clusters (Louis Noodleman and David A. Case). Water Oxidation by the Manganese Cluster in Photosynthesis (Per E. M. Siegbahn). Nature of the Catecholate-Fe(III) Bond: High Affinity Binding and Substrate Activation in Bioinorganic Chemistry (Edward I. Solomon, Monita Y. M. Pau and Rosalie K. Hocking). Computational Studies: B12 Cofactors and Their Interaction with Enzyme Active Sites (Thomas C. Brunold). Reaction Coordinate of Pyranopterin Molybdenum Enzymes (Martin L. Kirk, Sushilla Knottenbelt and Abebe Habtegabre). Electronic Structure Calculations: Dinitrogen Reduction in Nitrogenase and Synthetic Model Systems (Felix Tuczek). Hydrogenases: Theoretical Investigations Towards Bioinspired H2 Production and Activation (Maurizio Bruschi, Giuseppe Zampella, Claudio Grego, Luca Bertini, Piercarlo Fantucci and Luca De Gioia). Computational Studies: Cisplatin (Yogita Mantri and Mu-Hyun Baik). Computational Methods: Modeling of Reactivity in Zn-Containing Enzymes (Jon I. Mujika, Adrian J. Mulholland and Jeremy N. Harvey). Combined Density Functional Theory (DFT) and Electrostatics Study of the Proton Pumping Mechanism in Cytochrome c Oxidase (Jason Quenneville, Dragan M. Popovi& and Alexei A. Stuchebrukhov). Computational Studies: Proton/Water Coupling to Metal in Biological Reaction Mechanisms (Y. Bu and R. I. Cukier). Computational Studies: Chemical Evolution of Metal Sites (Kasper P. Jensen). Part 3: Case Studies - Inorganic. Electronic Structure Calculations: Transition Metal-NO Complexes (Abhik Ghosh, Jeanet Conradie and Kathrin H. Hopmann). Structural Origins of Noninnocent Coordination Chemistry (Robert K. Szilagyi). Electronic Structure of Metal-Metal Bonds (John E. McGrady). Computational Methods: Transition Metal Clusters (Regis Gautier, Jean-Francois Halet and Jean-Yves Saillard). Computational Methods: Heteropolyoxoanions (Josep M. Poblet and Xavier Lopez). Electronic Structure Calculations: Metal Carbonyls (Chantal Daniel). Potential Energy Surfaces for Metal-Assisted Chemical Reactions (Tiziana Marino, Maria del Carmen Michelini, Nino Russo, Emilia Sicilia and Marirosa Toscano). Computational Methods: Lanthanides and Actinides (M. Dolg and X. Cao). Spin-Orbit Coupling: Effects in Heavy Element Chemistry (Nikolas Kaltsoyannis). Noble Gas Compounds: Reliable Computational Methods (David A. Dixon). Computational Studies: Boranes (Oottikkal Shameema and Eluvathingal D. Jemmis). Multiple Aromaticity, Multiple Antiaromaticity, and Conflicting Aromaticity in Inorganic Systems (Dmitry Yu. Zubarev and Aledander I. Boldyrev). Theoretical Aspects of Main Group Multiple Bonded Systems (Ioan Silaghi-Dumitrescu, Petronela Petrar, Gabriela Nemes and R. Bruce King). Index.
  • (source: Nielsen Book Data)
A much-needed integration of inorganic chemistry with computational strategies and methods, this resource focuses on applications for inorganic and bioinorganic systems. The coverage helps to understand the spectroscopy and function of enzymes and related compounds, and provides a snapshot of the state-of-the-art in application of computational techniques to (bio)inorganic systems. Expert authors in the area provide practical descriptions of the methods employed and describe case studies in a number of areas of current research in which these methods have made an essential contribution.
(source: Nielsen Book Data)
  • List of Contributors. Series Preface. Volume Preface. Part 1: Methods. Calculation of Bonding Properties (Gernot Frenking and Moritz von Hopffgarden). Determining Transition States in Bioinorganic Reactions (Marcus Lundberg and Keiji Morokuma). Quantum Mechanical/Molecular Mechanical (QM/MM) Methods and Applications in Bioinorganic Chemistry (Ulf Ryde). Ab initio and Semiempirical Methods (Serge I. Gorelsky). Spectroscopic Properties of Proten-Bound Cofactors: Calculation by Combined Quantum Mechanical/Molecular Mechanical (QM/MM) Approaches (Mahesh Sundararajan, Christoph Riplinger, Maylis Orio, Frank Wennmohs and Frank Neese). Spectroscopic Properties Obtained from Time-Dependent Density Functional Theory (TD-DFT) (Jochen Autschbach). Nuclear Magnetic Resonance (NMR) Parameters of Transition Metal Complexes: Methods and Applications (Martin Kaupp and Michael Buhl). Calculation of Reduction Potential and pKa. Quantum-Chemistry-Centered Normal Coordinate Analysis (QCC-NCA): Application of NCA for the Simulation of the Vibrational Spectra of Large Molecules (Nicolai Lehnert). Molecular Mechanics in Bioinorganic Chemistry (Robert J. Deeth). Multiconfigurational Quantum Mechanics (QM) for Heavy Element Compounds (Bjorn O. Roos). Approximate Density Functionals: Which Should I Choose? (Dmitrij Rappoport, Nathan R. M. Crawford, Filipp Furche and Kieron Burke). Spin Contamination in Inorganic Chemistry Calculations (Jason L. Sonnerberg, H. Bernhard Schlegel and Hrant P. Hratchian). Gaussian Basis Sets for Quantum Mechanical (QM) Calculations (Kirk A. Peterson). Part 2: Case Studies - Bioinorganic. Modeling Metalloenzymes with Density Functional and Mixed Quantum Mechanical/Molecular Mechanical (QM/MM) Calculations: Progress and Challenges (Richard A. Friesner). Broken Symmetry States of Iron-Sulfur Clusters (Louis Noodleman and David A. Case). Water Oxidation by the Manganese Cluster in Photosynthesis (Per E. M. Siegbahn). Nature of the Catecholate-Fe(III) Bond: High Affinity Binding and Substrate Activation in Bioinorganic Chemistry (Edward I. Solomon, Monita Y. M. Pau and Rosalie K. Hocking). Computational Studies: B12 Cofactors and Their Interaction with Enzyme Active Sites (Thomas C. Brunold). Reaction Coordinate of Pyranopterin Molybdenum Enzymes (Martin L. Kirk, Sushilla Knottenbelt and Abebe Habtegabre). Electronic Structure Calculations: Dinitrogen Reduction in Nitrogenase and Synthetic Model Systems (Felix Tuczek). Hydrogenases: Theoretical Investigations Towards Bioinspired H2 Production and Activation (Maurizio Bruschi, Giuseppe Zampella, Claudio Grego, Luca Bertini, Piercarlo Fantucci and Luca De Gioia). Computational Studies: Cisplatin (Yogita Mantri and Mu-Hyun Baik). Computational Methods: Modeling of Reactivity in Zn-Containing Enzymes (Jon I. Mujika, Adrian J. Mulholland and Jeremy N. Harvey). Combined Density Functional Theory (DFT) and Electrostatics Study of the Proton Pumping Mechanism in Cytochrome c Oxidase (Jason Quenneville, Dragan M. Popovi& and Alexei A. Stuchebrukhov). Computational Studies: Proton/Water Coupling to Metal in Biological Reaction Mechanisms (Y. Bu and R. I. Cukier). Computational Studies: Chemical Evolution of Metal Sites (Kasper P. Jensen). Part 3: Case Studies - Inorganic. Electronic Structure Calculations: Transition Metal-NO Complexes (Abhik Ghosh, Jeanet Conradie and Kathrin H. Hopmann). Structural Origins of Noninnocent Coordination Chemistry (Robert K. Szilagyi). Electronic Structure of Metal-Metal Bonds (John E. McGrady). Computational Methods: Transition Metal Clusters (Regis Gautier, Jean-Francois Halet and Jean-Yves Saillard). Computational Methods: Heteropolyoxoanions (Josep M. Poblet and Xavier Lopez). Electronic Structure Calculations: Metal Carbonyls (Chantal Daniel). Potential Energy Surfaces for Metal-Assisted Chemical Reactions (Tiziana Marino, Maria del Carmen Michelini, Nino Russo, Emilia Sicilia and Marirosa Toscano). Computational Methods: Lanthanides and Actinides (M. Dolg and X. Cao). Spin-Orbit Coupling: Effects in Heavy Element Chemistry (Nikolas Kaltsoyannis). Noble Gas Compounds: Reliable Computational Methods (David A. Dixon). Computational Studies: Boranes (Oottikkal Shameema and Eluvathingal D. Jemmis). Multiple Aromaticity, Multiple Antiaromaticity, and Conflicting Aromaticity in Inorganic Systems (Dmitry Yu. Zubarev and Aledander I. Boldyrev). Theoretical Aspects of Main Group Multiple Bonded Systems (Ioan Silaghi-Dumitrescu, Petronela Petrar, Gabriela Nemes and R. Bruce King). Index.
  • (source: Nielsen Book Data)
A much-needed integration of inorganic chemistry with computational strategies and methods, this resource focuses on applications for inorganic and bioinorganic systems. The coverage helps to understand the spectroscopy and function of enzymes and related compounds, and provides a snapshot of the state-of-the-art in application of computational techniques to (bio)inorganic systems. Expert authors in the area provide practical descriptions of the methods employed and describe case studies in a number of areas of current research in which these methods have made an essential contribution.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
QP517 .Q34 C66 2009 Unknown
Book
ix, 301 p. : ill. (chiefly col.) ; 24 cm.
  • Introduction: What is Biophysical Chemistry? PART 1: BASIC METHODS IN BIOPHYSICAL CHEMISTRY Basic Optical Principles Optical Properties of Biomolecules Basic Fluorescence Techniques Chiroptical and Scattering Methods Magnetic resonance techniques Mass spectrometry PART 2: ADVANCED METHODS IN BIOPHYSICAL CHEMISTRY Fluorescene Microscopy Single-Biomolecule Techniques Ultrafast and Nonlinear Spectroscopy Special Techniques Assay Development, Readers and High-Throughput Screening.
  • (source: Nielsen Book Data)
The only introductory text to address contemporary methods, the really interesting stuff to spice up a standard biophysics course is to be found here. Accessible and didactically written, it is based on a graduate course taught by the author for several years. By presenting a mix of basic theory and real life application examples, he successfully bridges the gap between theory and experiment. Divided into two major parts, this advanced textbook explains all relevant methods used in current industrial research. The first part, basic biophysical chemistry, surveys basic spectroscopic techniques and properties that are the prerequisite for the more sophisticated technologies discussed in the remainder of the book. The second part covers modern, cutting-edge bioanalytical techniques based on physical methods, such as confocal fluorescence, ultrafast spectroscopy, optical tweezers, single molecule electrical measurements, quantum dots, and single molecule force microscopy. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented.
(source: Nielsen Book Data)
  • Introduction: What is Biophysical Chemistry? PART 1: BASIC METHODS IN BIOPHYSICAL CHEMISTRY Basic Optical Principles Optical Properties of Biomolecules Basic Fluorescence Techniques Chiroptical and Scattering Methods Magnetic resonance techniques Mass spectrometry PART 2: ADVANCED METHODS IN BIOPHYSICAL CHEMISTRY Fluorescene Microscopy Single-Biomolecule Techniques Ultrafast and Nonlinear Spectroscopy Special Techniques Assay Development, Readers and High-Throughput Screening.
  • (source: Nielsen Book Data)
The only introductory text to address contemporary methods, the really interesting stuff to spice up a standard biophysics course is to be found here. Accessible and didactically written, it is based on a graduate course taught by the author for several years. By presenting a mix of basic theory and real life application examples, he successfully bridges the gap between theory and experiment. Divided into two major parts, this advanced textbook explains all relevant methods used in current industrial research. The first part, basic biophysical chemistry, surveys basic spectroscopic techniques and properties that are the prerequisite for the more sophisticated technologies discussed in the remainder of the book. The second part covers modern, cutting-edge bioanalytical techniques based on physical methods, such as confocal fluorescence, ultrafast spectroscopy, optical tweezers, single molecule electrical measurements, quantum dots, and single molecule force microscopy. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
QD476.2 .W34 2009 Unknown
Book
xxv, 385 p. : ill. (some col.) ; 24 cm.
  • Introduction. Preface: Beyond the Historical Perspective on Hydrogen and Electron Transfers. Chapter 1: The Transition State Theory Description of Enzyme Catalysis for Classically Activated Reactions: Introduction-- Quantifying the Catalytic Activity of Enzymes-- Free Energy Analysis of Enzyme Catalysis-- Transition State Stabilisation or Ground State Destabilisation?-- Selective Stabilisation of Transition Structures by Enzymes-- Enzyme Flexibility and Dynamics. Chapter 2: Introduction to Quantum Behavior - A Primer: Introduction-- Classical Mechanics-- Quantum Mechanics-- Heisenberg Uncertainty Principle-- The Schrodinger Equation-- Electronic Structure Calculations-- Born-Oppenheimer Approximation-- Hartree-Fock Theory-- Basis sets-- Zero-point Energy-- Density Functional Theory-- DFT Calculations of Free Energies of Activation of Enzyme Models-- DFT Calculations of Kinetic Isotope Effects-- Quantum Mechanics/Molecular Mechanics Methods-- Summary and Outlook. Chapter 3: Quantum Catalysis in Enzymes: Introduction-- Theory-- Variational Transition State Theory-- The Transmission Coefficient-- One-Dimensional Tunneling-- Multidimensional Tunneling-- Ensemble Averaging-- Examples-- Liver Alcohol Dehydrogenase-- Dihydrofolate Reductase-- Soybean-Lipoxygenase-1 and Methylmalonyl-CoA Mutase-- Other Systems and Perspectives-- Concluding Remarks. Chapter 4: Selected Theoretical Models and Computational Methods for Enzymatic Tunneling: Introduction-- Vibronically Nonadiabatic Reactions: Proton-coupled Electron Transfer-- Theory-- Application to Lipoxygenase-- Predominantly Adiabatic Reactions: Proton and Hydride Transfer-- Theory-- Application to Dihydrofolate Reductase-- Emerging Concepts About Enzyme Catalysis. Chapter 5: Kinetic Isotope Effects from Hybrid Classical and Quantum Path Integral Computations: Introduction-- Theoretical Background-- Path Integral Quantum Transition State Theory-- Centroid Path Integral Simulations-- Kinetic Isotope Effects-- Sequential Centroid Path Integral and Umbrella Sampling (PI/UM)-- The PI-FEP/UM Method-- Kleinert's Variational Perturbation (KP) Theory-- Potential Energy Surface-- Combined QM/MM Potentials-- The MOVB Potential-- Computational Details-- Illustrative Examples-- Proton Transfer between Viscosity-- Multiple Reactive Configurations and a Place for Single-Molecule Measurements. Chapter 10. Computational Simulations of Tunnelling Reactions in Enzymes-- Introduction-- Molecular Mechanical Methods-- Quantum Mechanical Methods-- Combined Quantum Mechanical/Molecular Mechanical Methods-- Improving Semiempirical QM Calculations-- Calculation of Potential Energy Surfaces and Free Energy Surfaces-- Simulation of the H-tunnelling Event-- Calculation of H-tunnelling Rates and Kinetic Isotope Effects-- Analysing Molecular Dynamics Trajectories-- A Case Study: Aromatic Amine Dehydrogenase (AADH)-- Preparation of the System-- Analysis of the H-tunnelling Step in AADH-- Analysis of the Role of Promoting Motions in Driving Tunnelling-- Comparison of Short-range Motions in AADH with Long Range Motions in Dihydrofolate Reductase-- Summary. Chapter 11. Tunneling Does Not Contribute Significantly to Enzyme Catalysis, But Studying Temperature Dependence of Isotope Effects is Useful-- Introduction-- Methods-- Simulating Temperature Dependence of KIEs in Enzymes-- Concluding Remarks. Chapter 12: The Use of X-Ray Crystallography to Study Enzymic H-Tunnelling-- Introduction-- X-Ray Crystallography: A Brief Overview-- Accuracy of X-Ray Diffraction Structures-- Dynamic Information from X-Ray Crystallography-- Examples of H-tunnelling Systems Studied by Crystallography-- Crystallographic Studies of AADH Catalytic Mechanism-- Crystallographic Studies of MR-- Conclusions. Chapter 13: The Strengths and Weaknesses of Model Reactions for the Assessment of Tunneling in Enzymic Reactions-- Model Reactions for Biochemical Processes-- Model Reactions Relevant to Enzymic Tunneling-- Isotope Effect Temperature Dependences and the Configurational-Search Framework (CSF) for their Interpretation-- The Traditionally Dependent Category-- The Underdependent Tunneling Category-- The Overdependent Tunneling Category-- Example 1. Hydride Transfer in a Thermophilic Alcohol Dehydrogenase-- The Kirby-Walwyn Intramolecular Model Reaction-- The Powell-Bruice Tunneling Model Reaction-- Enzymic Tunneling in Alcohol Dehydrogenases-- Model Reactions and the Catalytic Power of Alcohol Dehydrogenase-- Example 2. Hydrogen-atom Transfer in Methylmalonyl Coenzyme A Mutase (MCM)-- Non-enzymic Tunneling in the Finke Model Reactions for MCM-- Enzymic Tunneling in MCM-- Model Reactions and MCM Catalytic Power-- The Roles of Theory in the Comparison of Model and Enzymic Reactions-- Model Reactions, Enzymic Accelerations, and Quantum Tunneling. Chapter 14: Long-Distance Electron Tunneling in Proteins: Introduction-- Electronic Coupling and Tunneling Pathways-- Direct Method-- Avoided Crossing-- Application of Koopmans' Theorem-- Generalized Mulliken-Hush Method-- The Propagator Method-- Protein Pruning-- Tunneling Pathways-- The Method of Tunneling Currents-- General Relations-- Many-Electron Picture-- Calculation of Current Density. Hartree-Fock Approximation-- Interatomic Tunneling Currents-- Many-Electron Aspects-- One Tunneling Orbital (OTO) Approximation and Polarization Effects-- The Limitation of the SCF Description of Many-Electron Tunneling-- Correlation Effects. Polarization Cloud Dynamics. Beyond Hartree-Fock Methods-- Quantum Interference Effects. Quantized Vertices-- Electron Transfer or Hole Transfer? Exchange Effects-- Dynamical Aspects.Chapter 15. Proton-coupled Electron Transfer: The Engine that Drives Radical Transport and Catalysis in Biology-- Introduction-- PCET Model Systems-- Unidirectional PCET Networks-- Bidirectional PCET Networks-- PCET Biocatalysis-- PCET in Enzymes: A Study of Ribonucleotide Reductase-- The PCET Pathway in RNR-- PCET in the ?2 Subunit of RNR-- PCET in ?2 Subunit of RNR: PhotoRNRs-- A Model for PCET in RNR-- Concluding Remarks.
  • (source: Nielsen Book Data)
In recent years, there has been an explosion in knowledge and research associated with the field of enzyme catalysis and H-tunneling. Rich in its breath and depth, this introduction to modern theories and methods of study is suitable for experienced researchers those new to the subject. Edited by two leading experts, and bringing together the foremost practitioners in the field, this up-to-date account of a rapidly developing field sits at the interface between biology, chemistry and physics. It covers computational, kinetic and structural analysis of tunnelling and the synergy in combining these methods (with a major focus on H-tunneling reactions in enzyme systems). The book starts with a brief overview of proton and electron transfer history by Nobel Laureate, Rudolph A. Marcus. The reader is then guided through chapters covering almost every aspect of reactions in enzyme catalysis ranging from descriptions of the relevant quantum theory and quantum/classical theoretical methodology to the description of experimental results. The theoretical interpretation of these large systems includes both quantum mechanical and statistical mechanical computations, as well as simple more approximate models. Most of the chapters focus on enzymatic catalysis of hydride, proton and H" transfer, an example of the latter being proton coupled electron transfer. There is also a chapter on electron transfer in proteins. This is timely since the theoretical framework developed fifty years ago for treating electron transfers has now been adapted to H-transfers and electron transfers in proteins. Accessible in style, this book is suitable for a wide audience but will be particularly useful to advanced level undergraduates, postgraduates and early postdoctoral workers.
(source: Nielsen Book Data)
  • Introduction. Preface: Beyond the Historical Perspective on Hydrogen and Electron Transfers. Chapter 1: The Transition State Theory Description of Enzyme Catalysis for Classically Activated Reactions: Introduction-- Quantifying the Catalytic Activity of Enzymes-- Free Energy Analysis of Enzyme Catalysis-- Transition State Stabilisation or Ground State Destabilisation?-- Selective Stabilisation of Transition Structures by Enzymes-- Enzyme Flexibility and Dynamics. Chapter 2: Introduction to Quantum Behavior - A Primer: Introduction-- Classical Mechanics-- Quantum Mechanics-- Heisenberg Uncertainty Principle-- The Schrodinger Equation-- Electronic Structure Calculations-- Born-Oppenheimer Approximation-- Hartree-Fock Theory-- Basis sets-- Zero-point Energy-- Density Functional Theory-- DFT Calculations of Free Energies of Activation of Enzyme Models-- DFT Calculations of Kinetic Isotope Effects-- Quantum Mechanics/Molecular Mechanics Methods-- Summary and Outlook. Chapter 3: Quantum Catalysis in Enzymes: Introduction-- Theory-- Variational Transition State Theory-- The Transmission Coefficient-- One-Dimensional Tunneling-- Multidimensional Tunneling-- Ensemble Averaging-- Examples-- Liver Alcohol Dehydrogenase-- Dihydrofolate Reductase-- Soybean-Lipoxygenase-1 and Methylmalonyl-CoA Mutase-- Other Systems and Perspectives-- Concluding Remarks. Chapter 4: Selected Theoretical Models and Computational Methods for Enzymatic Tunneling: Introduction-- Vibronically Nonadiabatic Reactions: Proton-coupled Electron Transfer-- Theory-- Application to Lipoxygenase-- Predominantly Adiabatic Reactions: Proton and Hydride Transfer-- Theory-- Application to Dihydrofolate Reductase-- Emerging Concepts About Enzyme Catalysis. Chapter 5: Kinetic Isotope Effects from Hybrid Classical and Quantum Path Integral Computations: Introduction-- Theoretical Background-- Path Integral Quantum Transition State Theory-- Centroid Path Integral Simulations-- Kinetic Isotope Effects-- Sequential Centroid Path Integral and Umbrella Sampling (PI/UM)-- The PI-FEP/UM Method-- Kleinert's Variational Perturbation (KP) Theory-- Potential Energy Surface-- Combined QM/MM Potentials-- The MOVB Potential-- Computational Details-- Illustrative Examples-- Proton Transfer between Viscosity-- Multiple Reactive Configurations and a Place for Single-Molecule Measurements. Chapter 10. Computational Simulations of Tunnelling Reactions in Enzymes-- Introduction-- Molecular Mechanical Methods-- Quantum Mechanical Methods-- Combined Quantum Mechanical/Molecular Mechanical Methods-- Improving Semiempirical QM Calculations-- Calculation of Potential Energy Surfaces and Free Energy Surfaces-- Simulation of the H-tunnelling Event-- Calculation of H-tunnelling Rates and Kinetic Isotope Effects-- Analysing Molecular Dynamics Trajectories-- A Case Study: Aromatic Amine Dehydrogenase (AADH)-- Preparation of the System-- Analysis of the H-tunnelling Step in AADH-- Analysis of the Role of Promoting Motions in Driving Tunnelling-- Comparison of Short-range Motions in AADH with Long Range Motions in Dihydrofolate Reductase-- Summary. Chapter 11. Tunneling Does Not Contribute Significantly to Enzyme Catalysis, But Studying Temperature Dependence of Isotope Effects is Useful-- Introduction-- Methods-- Simulating Temperature Dependence of KIEs in Enzymes-- Concluding Remarks. Chapter 12: The Use of X-Ray Crystallography to Study Enzymic H-Tunnelling-- Introduction-- X-Ray Crystallography: A Brief Overview-- Accuracy of X-Ray Diffraction Structures-- Dynamic Information from X-Ray Crystallography-- Examples of H-tunnelling Systems Studied by Crystallography-- Crystallographic Studies of AADH Catalytic Mechanism-- Crystallographic Studies of MR-- Conclusions. Chapter 13: The Strengths and Weaknesses of Model Reactions for the Assessment of Tunneling in Enzymic Reactions-- Model Reactions for Biochemical Processes-- Model Reactions Relevant to Enzymic Tunneling-- Isotope Effect Temperature Dependences and the Configurational-Search Framework (CSF) for their Interpretation-- The Traditionally Dependent Category-- The Underdependent Tunneling Category-- The Overdependent Tunneling Category-- Example 1. Hydride Transfer in a Thermophilic Alcohol Dehydrogenase-- The Kirby-Walwyn Intramolecular Model Reaction-- The Powell-Bruice Tunneling Model Reaction-- Enzymic Tunneling in Alcohol Dehydrogenases-- Model Reactions and the Catalytic Power of Alcohol Dehydrogenase-- Example 2. Hydrogen-atom Transfer in Methylmalonyl Coenzyme A Mutase (MCM)-- Non-enzymic Tunneling in the Finke Model Reactions for MCM-- Enzymic Tunneling in MCM-- Model Reactions and MCM Catalytic Power-- The Roles of Theory in the Comparison of Model and Enzymic Reactions-- Model Reactions, Enzymic Accelerations, and Quantum Tunneling. Chapter 14: Long-Distance Electron Tunneling in Proteins: Introduction-- Electronic Coupling and Tunneling Pathways-- Direct Method-- Avoided Crossing-- Application of Koopmans' Theorem-- Generalized Mulliken-Hush Method-- The Propagator Method-- Protein Pruning-- Tunneling Pathways-- The Method of Tunneling Currents-- General Relations-- Many-Electron Picture-- Calculation of Current Density. Hartree-Fock Approximation-- Interatomic Tunneling Currents-- Many-Electron Aspects-- One Tunneling Orbital (OTO) Approximation and Polarization Effects-- The Limitation of the SCF Description of Many-Electron Tunneling-- Correlation Effects. Polarization Cloud Dynamics. Beyond Hartree-Fock Methods-- Quantum Interference Effects. Quantized Vertices-- Electron Transfer or Hole Transfer? Exchange Effects-- Dynamical Aspects.Chapter 15. Proton-coupled Electron Transfer: The Engine that Drives Radical Transport and Catalysis in Biology-- Introduction-- PCET Model Systems-- Unidirectional PCET Networks-- Bidirectional PCET Networks-- PCET Biocatalysis-- PCET in Enzymes: A Study of Ribonucleotide Reductase-- The PCET Pathway in RNR-- PCET in the ?2 Subunit of RNR-- PCET in ?2 Subunit of RNR: PhotoRNRs-- A Model for PCET in RNR-- Concluding Remarks.
  • (source: Nielsen Book Data)
In recent years, there has been an explosion in knowledge and research associated with the field of enzyme catalysis and H-tunneling. Rich in its breath and depth, this introduction to modern theories and methods of study is suitable for experienced researchers those new to the subject. Edited by two leading experts, and bringing together the foremost practitioners in the field, this up-to-date account of a rapidly developing field sits at the interface between biology, chemistry and physics. It covers computational, kinetic and structural analysis of tunnelling and the synergy in combining these methods (with a major focus on H-tunneling reactions in enzyme systems). The book starts with a brief overview of proton and electron transfer history by Nobel Laureate, Rudolph A. Marcus. The reader is then guided through chapters covering almost every aspect of reactions in enzyme catalysis ranging from descriptions of the relevant quantum theory and quantum/classical theoretical methodology to the description of experimental results. The theoretical interpretation of these large systems includes both quantum mechanical and statistical mechanical computations, as well as simple more approximate models. Most of the chapters focus on enzymatic catalysis of hydride, proton and H" transfer, an example of the latter being proton coupled electron transfer. There is also a chapter on electron transfer in proteins. This is timely since the theoretical framework developed fifty years ago for treating electron transfers has now been adapted to H-transfers and electron transfers in proteins. Accessible in style, this book is suitable for a wide audience but will be particularly useful to advanced level undergraduates, postgraduates and early postdoctoral workers.
(source: Nielsen Book Data)
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
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QC176.8 .T8 Q37 2009 Unknown

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