Search results

487 results

View results as:
Number of results to display per page
Book
1 online resource.
  • Molecular simulations: methodology
  • Molecular simulations: applications
  • Use of structural database or experimental information in modeling protein structure and dynamics
  • Applications of molecular quantum mechanics.
Since the second half of the 20th century machine computations have played a critical role in science and engineering. Computer-based techniques have become especially important in molecular biology, since they often represent the only viable way to gain insights into the behavior of a biological system as a whole. The complexity of biological systems, which usually needs to be analyzed on different time- and size-scales and with different levels of accuracy, requires the application of different approaches, ranging from comparative analysis of sequences and structural databases, to the analysis of networks of interdependence between cell components and processes, through coarse-grained modeling to atomically detailed simulations, and finally to molecular quantum mechanics. This book provides a comprehensive overview of modern computer-based techniques for computing the structure, properties and dynamics of biomolecules and biomolecular processes. The twenty-two chapters, written by scientists from all over the world, address the theory and practice of computer simulation techniques in the study of biological phenomena. The chapters are grouped into four thematic sections dealing with the following topics: the methodology of molecular simulations; applications of molecular simulations; bioinformatics methods and use of experimental information in molecular simulations; and selected applications of molecular quantum mechanics. The book includes an introductory chapter written by Harold A. Scheraga, one of the true pioneers in simulation studies of biomacromolecules.
  • Molecular simulations: methodology
  • Molecular simulations: applications
  • Use of structural database or experimental information in modeling protein structure and dynamics
  • Applications of molecular quantum mechanics.
Since the second half of the 20th century machine computations have played a critical role in science and engineering. Computer-based techniques have become especially important in molecular biology, since they often represent the only viable way to gain insights into the behavior of a biological system as a whole. The complexity of biological systems, which usually needs to be analyzed on different time- and size-scales and with different levels of accuracy, requires the application of different approaches, ranging from comparative analysis of sequences and structural databases, to the analysis of networks of interdependence between cell components and processes, through coarse-grained modeling to atomically detailed simulations, and finally to molecular quantum mechanics. This book provides a comprehensive overview of modern computer-based techniques for computing the structure, properties and dynamics of biomolecules and biomolecular processes. The twenty-two chapters, written by scientists from all over the world, address the theory and practice of computer simulation techniques in the study of biological phenomena. The chapters are grouped into four thematic sections dealing with the following topics: the methodology of molecular simulations; applications of molecular simulations; bioinformatics methods and use of experimental information in molecular simulations; and selected applications of molecular quantum mechanics. The book includes an introductory chapter written by Harold A. Scheraga, one of the true pioneers in simulation studies of biomacromolecules.
Book
1 online resource (248 pages)
  • Front Cover; Evolution by Tumor Neofunctionalization; Copyright Page; Contents; Acknowledgements; Introduction; 1. The Modern Synthesis of Evolutionary Biology and the Health Sciences; 2. Evolution and Pathology; 2.1 Pathogens and Pathologies May Have Adaptive and/or Evolutionary Importance; 2.2 Evolution vs. Pathology Paradox of Mutations; 3. The Widespread Occurrence of Tumors in Multicellular Organisms; 3.1 Comparative Oncological Data on the Prevalence of Tumors in Different Groups of Multicellular Organisms.
  • 3.2 Ancient Origin and Conservatism of Cellular Oncogenes and Tumor Suppressor Genes3.3 The Widespread Occurrence of Tumors Suggests that They May Be Evolutionarily Meaningful; 4. Features of Tumors that Could Be Used in Evolution; 4.1 Unusual Genes and Gene Sets are Activated in Tumors and may Participate in the Origin of New Cell Types; 4.2 Tumor Cells Can Differentiate with the Loss of Malignancy that may Lead to the Origin of New Cell Types; 4.3 Tumors Provide Excessive Cell Masses Functionally Unnecessary to the Organism that Could be used for the Origin of New ...
  • 4.4 Tumors as Atypical Organs/Tissues that may Eventually Evolve into Normal Structures4.4.1 Morphogenetic Potential of Tumors May Be Used in the Origin of Morphological Novelties and Diversity; 5. Tumors Might Participate in the Evolution of Ontogenesis; 5.1 Tumors and Normal Embryogenesis; 5.2 Tumors as Disease of Differentiation; 5.3 The Epithelial to Mesenchymal Transition (EMT) Occurs in Normal and Neoplastic Development; 5.4 Tumors, Evo-Devo and Addition of Final Stages in the Evolution of Ontogenesis.
  • 5.5 The Human Brain, as the Most Recently Evolved Organ, Recapitulates Many Features Resembling those of Tumors5.5.1 The Expansion of Brain Size During Mammalian and Primate Evolution Involved Many Protooncogenes and Tumor Suppressor ... ; 5.5.2 Human Cerebral Cortex as a Result of Selection for Tumor Growth; 5.5.3 Brain Enlargement, Microcephaly Genes and Tumors; 5.5.3.1 MCPH1 is a Tumor Suppressor Gene Interrelated with the other Tumor Suppressor, BRCA1; 5.5.3.2 ASPM is a Major Determinant of Human Cerebral Cortical Size, and is Overexpressed in Tumors and Testis.
  • 5.5.4 Long-Term Neural Stem Cell Expansion Leads to Brain Tumors5.6 The Eutherian Placenta is Evolutionary Innovation and Recapitulates Many Tumor Features; 6. Tumors that Might Play a Role in Evolution; 6.1 Hereditary Tumors; 6.2 Fetal, Neonatal and Infantile Tumors; 6.3 Benign Tumors, Carcinomas in situ and Pseudodiseases; 6.4 Tumors at the Early and Intermediate Stages of Progression; 6.5 Tumors that Spontaneously Regress; 6.6 Sustainable Tumor Masses; 7. Tumors that have Played a Role in Evolution; 7.1 The Nitrogen-Fixing Root Nodules of Legumes.
Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular o.
  • Front Cover; Evolution by Tumor Neofunctionalization; Copyright Page; Contents; Acknowledgements; Introduction; 1. The Modern Synthesis of Evolutionary Biology and the Health Sciences; 2. Evolution and Pathology; 2.1 Pathogens and Pathologies May Have Adaptive and/or Evolutionary Importance; 2.2 Evolution vs. Pathology Paradox of Mutations; 3. The Widespread Occurrence of Tumors in Multicellular Organisms; 3.1 Comparative Oncological Data on the Prevalence of Tumors in Different Groups of Multicellular Organisms.
  • 3.2 Ancient Origin and Conservatism of Cellular Oncogenes and Tumor Suppressor Genes3.3 The Widespread Occurrence of Tumors Suggests that They May Be Evolutionarily Meaningful; 4. Features of Tumors that Could Be Used in Evolution; 4.1 Unusual Genes and Gene Sets are Activated in Tumors and may Participate in the Origin of New Cell Types; 4.2 Tumor Cells Can Differentiate with the Loss of Malignancy that may Lead to the Origin of New Cell Types; 4.3 Tumors Provide Excessive Cell Masses Functionally Unnecessary to the Organism that Could be used for the Origin of New ...
  • 4.4 Tumors as Atypical Organs/Tissues that may Eventually Evolve into Normal Structures4.4.1 Morphogenetic Potential of Tumors May Be Used in the Origin of Morphological Novelties and Diversity; 5. Tumors Might Participate in the Evolution of Ontogenesis; 5.1 Tumors and Normal Embryogenesis; 5.2 Tumors as Disease of Differentiation; 5.3 The Epithelial to Mesenchymal Transition (EMT) Occurs in Normal and Neoplastic Development; 5.4 Tumors, Evo-Devo and Addition of Final Stages in the Evolution of Ontogenesis.
  • 5.5 The Human Brain, as the Most Recently Evolved Organ, Recapitulates Many Features Resembling those of Tumors5.5.1 The Expansion of Brain Size During Mammalian and Primate Evolution Involved Many Protooncogenes and Tumor Suppressor ... ; 5.5.2 Human Cerebral Cortex as a Result of Selection for Tumor Growth; 5.5.3 Brain Enlargement, Microcephaly Genes and Tumors; 5.5.3.1 MCPH1 is a Tumor Suppressor Gene Interrelated with the other Tumor Suppressor, BRCA1; 5.5.3.2 ASPM is a Major Determinant of Human Cerebral Cortical Size, and is Overexpressed in Tumors and Testis.
  • 5.5.4 Long-Term Neural Stem Cell Expansion Leads to Brain Tumors5.6 The Eutherian Placenta is Evolutionary Innovation and Recapitulates Many Tumor Features; 6. Tumors that Might Play a Role in Evolution; 6.1 Hereditary Tumors; 6.2 Fetal, Neonatal and Infantile Tumors; 6.3 Benign Tumors, Carcinomas in situ and Pseudodiseases; 6.4 Tumors at the Early and Intermediate Stages of Progression; 6.5 Tumors that Spontaneously Regress; 6.6 Sustainable Tumor Masses; 7. Tumors that have Played a Role in Evolution; 7.1 The Nitrogen-Fixing Root Nodules of Legumes.
Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular o.
Book
1 online resource (xii, 139 pages) : illustrations (some color).
  • An overview and practical guide to building Markov state models
  • Markov model theory
  • Estimation and Validation of Markov models
  • Uncertainty estimation
  • Analysis of Markov models
  • Transition Path Theory
  • Understanding Protein Folding using Markov state models
  • Understanding Molecular Recognition by Kinetic Network Models Constructed from Molecular Dynamics Simulations
  • Markov State and Diffusive Stochastic Models in Electron Spin Resonance
  • Software for building Markov state models.
The aim of this book volume is to explain the importance of Markov state models to molecular simulation, how they work, and how they can be applied to a range of problems. The Markov state model (MSM) approach aims to address two key challenges of molecular simulation: 1) How to reach long timescales using short simulations of detailed molecular models 2) How to systematically gain insight from the resulting sea of data MSMs do this by providing a compact representation of the vast conformational space available to biomolecules by decomposing it into states sets of rapidly interconverting conformations and the rates of transitioning between states.This kinetic definition allows one to easily vary the temporal and spatial resolution of an MSM from high-resolution models capable of quantitative agreement with (or prediction of) experiment to low-resolution models that facilitate understanding. Additionally, MSMs facilitate the calculation of quantities that are difficult to obtain from more direct MD analyses, such as the ensemble of transition pathways. This book introduces the mathematical foundations of Markov models, how they can be used to analyze simulations and drive efficient simulations, and some of the insights these models have yielded in a variety of applications of molecular simulation.
  • An overview and practical guide to building Markov state models
  • Markov model theory
  • Estimation and Validation of Markov models
  • Uncertainty estimation
  • Analysis of Markov models
  • Transition Path Theory
  • Understanding Protein Folding using Markov state models
  • Understanding Molecular Recognition by Kinetic Network Models Constructed from Molecular Dynamics Simulations
  • Markov State and Diffusive Stochastic Models in Electron Spin Resonance
  • Software for building Markov state models.
The aim of this book volume is to explain the importance of Markov state models to molecular simulation, how they work, and how they can be applied to a range of problems. The Markov state model (MSM) approach aims to address two key challenges of molecular simulation: 1) How to reach long timescales using short simulations of detailed molecular models 2) How to systematically gain insight from the resulting sea of data MSMs do this by providing a compact representation of the vast conformational space available to biomolecules by decomposing it into states sets of rapidly interconverting conformations and the rates of transitioning between states.This kinetic definition allows one to easily vary the temporal and spatial resolution of an MSM from high-resolution models capable of quantitative agreement with (or prediction of) experiment to low-resolution models that facilitate understanding. Additionally, MSMs facilitate the calculation of quantities that are difficult to obtain from more direct MD analyses, such as the ensemble of transition pathways. This book introduces the mathematical foundations of Markov models, how they can be used to analyze simulations and drive efficient simulations, and some of the insights these models have yielded in a variety of applications of molecular simulation.
Book
xii, 139 pages : illustrations (some color) ; 26 cm
  • An overview and practical guide to building Markov state models
  • Markov model theory
  • Estimation and Validation of Markov models
  • Uncertainty estimation
  • Analysis of Markov models
  • Transition Path Theory
  • Understanding Protein Folding using Markov state models
  • Understanding Molecular Recognition by Kinetic Network Models Constructed from Molecular Dynamics Simulations
  • Markov State and Diffusive Stochastic Models in Electron Spin Resonance
  • Software for building Markov state models.
The aim of this book volume is to explain the importance of Markov state models to molecular simulation, how they work, and how they can be applied to a range of problems. The Markov state model (MSM) approach aims to address two key challenges of molecular simulation: 1) How to reach long timescales using short simulations of detailed molecular models 2) How to systematically gain insight from the resulting sea of data MSMs do this by providing a compact representation of the vast conformational space available to biomolecules by decomposing it into states sets of rapidly interconverting conformations and the rates of transitioning between states.This kinetic definition allows one to easily vary the temporal and spatial resolution of an MSM from high-resolution models capable of quantitative agreement with (or prediction of) experiment to low-resolution models that facilitate understanding. Additionally, MSMs facilitate the calculation of quantities that are difficult to obtain from more direct MD analyses, such as the ensemble of transition pathways. This book introduces the mathematical foundations of Markov models, how they can be used to analyze simulations and drive efficient simulations, and some of the insights these models have yielded in a variety of applications of molecular simulation.
  • An overview and practical guide to building Markov state models
  • Markov model theory
  • Estimation and Validation of Markov models
  • Uncertainty estimation
  • Analysis of Markov models
  • Transition Path Theory
  • Understanding Protein Folding using Markov state models
  • Understanding Molecular Recognition by Kinetic Network Models Constructed from Molecular Dynamics Simulations
  • Markov State and Diffusive Stochastic Models in Electron Spin Resonance
  • Software for building Markov state models.
The aim of this book volume is to explain the importance of Markov state models to molecular simulation, how they work, and how they can be applied to a range of problems. The Markov state model (MSM) approach aims to address two key challenges of molecular simulation: 1) How to reach long timescales using short simulations of detailed molecular models 2) How to systematically gain insight from the resulting sea of data MSMs do this by providing a compact representation of the vast conformational space available to biomolecules by decomposing it into states sets of rapidly interconverting conformations and the rates of transitioning between states.This kinetic definition allows one to easily vary the temporal and spatial resolution of an MSM from high-resolution models capable of quantitative agreement with (or prediction of) experiment to low-resolution models that facilitate understanding. Additionally, MSMs facilitate the calculation of quantities that are difficult to obtain from more direct MD analyses, such as the ensemble of transition pathways. This book introduces the mathematical foundations of Markov models, how they can be used to analyze simulations and drive efficient simulations, and some of the insights these models have yielded in a variety of applications of molecular simulation.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER Unknown
Book
vii, 426 p. : ill. (some col.).
  • Cancer panomics: Computational methods and infrastructure for integrative analysis of cancer high-throughput "OMICS" data. Session introduction / Soren Brunak ... [et al.]
  • Tumor haplotype assembly algorithms for cancer genomics / Derek Aguiar, Wendy S.W. Wong, Sorin Istrail
  • Extracting significant sample-specific cancer mutations using their protein interactions / Liviu Badea
  • The stream algorithm: Computationally efficient ridge-regression via Bayesian model averaging, and applications to pharmacogenomic prediction of cancer cell line sensitivity / Elias Chaibub Neto ... [et al.]
  • Sharing information to reconstruct patient-specific pathways in heterogeneous diseases / Anthony Gitter ... [et al.]
  • Detecting statistical interaction between somatic mutational events and germline variation from next-generation sequence data / Hao Hu, Chad D. Huff
  • Systematic assessment of analytical methods for drug sensitivity prediction from cancer cell line data / In Sock Jang ... [et al.]
  • Integrative analysis of two cell lines derived from a non-small-lung cancer patient - A panomics approach / Oleg Mayba ... [et al.]
  • An integrated approach to blood-based cancer diagnosis and biomarker discovery / Martin Renqiang Min ... [et al.]
  • Multiplex meta-analysis of medulloblastoma expression studies with external controls / Alexander A. Morgan ... [et al.]
  • Computational approaches to drug repurposing and pharmacology. Session introduction / S. Joshua Swamidass ... [et al.]
  • Challenges in secondary analysis of high throughput screening data / Aurora S. Blucher, Shannon K. McWeeney
  • Drug intervention response predictions with paradigm (DIRPP) identifies drug resistant cancer cell lines and pathway mechanisms of resistance / Douglas Brubaker ... [et al.]
  • Anti-infectious drug repurposing using an integrated chemical genomics and structural systems biology approach / Clara Ng ... [et al.]
  • Drug-target interaction prediction by integrating chemical, genomic, functional and pharmacological data / Fan Yang, Jinbo Xu, Jianyang Zeng
  • Prediction of off-target drug effects through data fusion / Emmanuel R. Yera, Ann E. Cleves, Ajay N. Jain
  • Exploring the pharmacogenomics knowledge base (PharmGKB) for repositioning breast cancer drugs by leveraging web ontology language (OWL) and cheminformatics approaches / Qian Zhu ... [et al.]
  • Detecting and characterizing pleiotropy: New methods for uncovering the connection between the complexity of genomic architecture and multiple phenotypes. Session introduction / Anna L. Tyler, Dana C. Crawford, Sarah A. Pendergrass
  • Using the bipartite human phenotype network to reveal pleiotropy and epistasis beyond the gene / Christian Darabos, Samantha H. Harmon, Jason H. Moore
  • Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield personalized medicine research project biobank / Molly A. Hall ... [et al.]
  • Dissection of complex gene expression using the combined analysis of pleiotropy and epistasis / Vivek M. Philip, Anna L. Tyler, Gregory W. Carter
  • Personalized medicine: From genotypes and molecular phenotypes towards therapy. Session introduction / Jennifer Listgarten ... [et al.]
  • PATH-SCAN: A reporting tool for identifying clinically actionable variants / Roxana Daneshjou ... [et al.]
  • Imputation-based assessment of next generation rare exome variant arrays / Alicia R. Martin ... [et al.]
  • Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients/ Matthew Oetjens ... [et al.]
  • Robust reverse engineering of dynamic gene networks under sample size heterogeneity / Ankur P. Parikh, Wei Wu, Eric P. Xing
  • Variant priorization and analysis incorporating problematic regions of the genome / Anil Patwardhan ... [et al.]
  • Bags of words models of epitope sets: HIV viral load regression with counting grids / Alessandro Perina, Pietro Lovato, Nebojsa Jojic
  • Joint association discovery and diagnosis of Alzheimer's disease by supervised heterogeneous multiview learning / Shandian Zhe ... [et al.]
  • Text and data mining for biomedical discover. Session introduction / Graciela H. Gonzalez ... [et al.]
  • Vector quantization kernels for the classification of protein sequences and structures / Wyatt T. Clark, Predrag Radivojac
  • Combining Heterogenous data for prediction of disease related and pharmacogenes / Christopher S. Funk, Lawrence E. Hunter, K. Bretonnel Cohen
  • A novel profile biomarker diagnosis for mass spectral proteomics / Henry Han
  • Towards pathway curation through literature mining - A case study using PharmGKB / Ravikumar K.E., Kavishwar B. Wagholikar, Hongfang Liu
  • Sparse generalized functional linear model for predicting remission status of depression patients / Yashu Liu ... [et al.]
  • Development of a data-mining algorithm to identify ages at reproductive milestones in electronic medical records / Jennifer Malinowski, Eric Farber-Eger, Dana C. Crawford
  • An efficient algorithm to integrate network and attribute data for gene function prediction / Shankar Vembu, Quaid Morris
  • Matrix factorization-based data fusion for gene function prediction in Baker's yeast and slime mold / Marinka Zitnik, Blaz Zupan
  • Workshops. Applications of bioinformatics to non-coding RNAs in the era of next-generation sequencing / Chao Cheng, Jason Moore, Casey Greene
  • Building the next generation of quantitative biologists / Kristine A. Pattin ... [et al.]
  • Uncovering the etiology of autism spectrum disorders: Genomics, bioinformatics, environment, data collection and exploration, and future possibilities / Sarah A. Pendergrass, Santhosh Girirajan, Scott Selleck.
The Pacific Symposium on Biocomputing (PSB) 2014 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2014 will be held from January 3 – 7, 2014 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference. PSB 2014 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
  • Cancer panomics: Computational methods and infrastructure for integrative analysis of cancer high-throughput "OMICS" data. Session introduction / Soren Brunak ... [et al.]
  • Tumor haplotype assembly algorithms for cancer genomics / Derek Aguiar, Wendy S.W. Wong, Sorin Istrail
  • Extracting significant sample-specific cancer mutations using their protein interactions / Liviu Badea
  • The stream algorithm: Computationally efficient ridge-regression via Bayesian model averaging, and applications to pharmacogenomic prediction of cancer cell line sensitivity / Elias Chaibub Neto ... [et al.]
  • Sharing information to reconstruct patient-specific pathways in heterogeneous diseases / Anthony Gitter ... [et al.]
  • Detecting statistical interaction between somatic mutational events and germline variation from next-generation sequence data / Hao Hu, Chad D. Huff
  • Systematic assessment of analytical methods for drug sensitivity prediction from cancer cell line data / In Sock Jang ... [et al.]
  • Integrative analysis of two cell lines derived from a non-small-lung cancer patient - A panomics approach / Oleg Mayba ... [et al.]
  • An integrated approach to blood-based cancer diagnosis and biomarker discovery / Martin Renqiang Min ... [et al.]
  • Multiplex meta-analysis of medulloblastoma expression studies with external controls / Alexander A. Morgan ... [et al.]
  • Computational approaches to drug repurposing and pharmacology. Session introduction / S. Joshua Swamidass ... [et al.]
  • Challenges in secondary analysis of high throughput screening data / Aurora S. Blucher, Shannon K. McWeeney
  • Drug intervention response predictions with paradigm (DIRPP) identifies drug resistant cancer cell lines and pathway mechanisms of resistance / Douglas Brubaker ... [et al.]
  • Anti-infectious drug repurposing using an integrated chemical genomics and structural systems biology approach / Clara Ng ... [et al.]
  • Drug-target interaction prediction by integrating chemical, genomic, functional and pharmacological data / Fan Yang, Jinbo Xu, Jianyang Zeng
  • Prediction of off-target drug effects through data fusion / Emmanuel R. Yera, Ann E. Cleves, Ajay N. Jain
  • Exploring the pharmacogenomics knowledge base (PharmGKB) for repositioning breast cancer drugs by leveraging web ontology language (OWL) and cheminformatics approaches / Qian Zhu ... [et al.]
  • Detecting and characterizing pleiotropy: New methods for uncovering the connection between the complexity of genomic architecture and multiple phenotypes. Session introduction / Anna L. Tyler, Dana C. Crawford, Sarah A. Pendergrass
  • Using the bipartite human phenotype network to reveal pleiotropy and epistasis beyond the gene / Christian Darabos, Samantha H. Harmon, Jason H. Moore
  • Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield personalized medicine research project biobank / Molly A. Hall ... [et al.]
  • Dissection of complex gene expression using the combined analysis of pleiotropy and epistasis / Vivek M. Philip, Anna L. Tyler, Gregory W. Carter
  • Personalized medicine: From genotypes and molecular phenotypes towards therapy. Session introduction / Jennifer Listgarten ... [et al.]
  • PATH-SCAN: A reporting tool for identifying clinically actionable variants / Roxana Daneshjou ... [et al.]
  • Imputation-based assessment of next generation rare exome variant arrays / Alicia R. Martin ... [et al.]
  • Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients/ Matthew Oetjens ... [et al.]
  • Robust reverse engineering of dynamic gene networks under sample size heterogeneity / Ankur P. Parikh, Wei Wu, Eric P. Xing
  • Variant priorization and analysis incorporating problematic regions of the genome / Anil Patwardhan ... [et al.]
  • Bags of words models of epitope sets: HIV viral load regression with counting grids / Alessandro Perina, Pietro Lovato, Nebojsa Jojic
  • Joint association discovery and diagnosis of Alzheimer's disease by supervised heterogeneous multiview learning / Shandian Zhe ... [et al.]
  • Text and data mining for biomedical discover. Session introduction / Graciela H. Gonzalez ... [et al.]
  • Vector quantization kernels for the classification of protein sequences and structures / Wyatt T. Clark, Predrag Radivojac
  • Combining Heterogenous data for prediction of disease related and pharmacogenes / Christopher S. Funk, Lawrence E. Hunter, K. Bretonnel Cohen
  • A novel profile biomarker diagnosis for mass spectral proteomics / Henry Han
  • Towards pathway curation through literature mining - A case study using PharmGKB / Ravikumar K.E., Kavishwar B. Wagholikar, Hongfang Liu
  • Sparse generalized functional linear model for predicting remission status of depression patients / Yashu Liu ... [et al.]
  • Development of a data-mining algorithm to identify ages at reproductive milestones in electronic medical records / Jennifer Malinowski, Eric Farber-Eger, Dana C. Crawford
  • An efficient algorithm to integrate network and attribute data for gene function prediction / Shankar Vembu, Quaid Morris
  • Matrix factorization-based data fusion for gene function prediction in Baker's yeast and slime mold / Marinka Zitnik, Blaz Zupan
  • Workshops. Applications of bioinformatics to non-coding RNAs in the era of next-generation sequencing / Chao Cheng, Jason Moore, Casey Greene
  • Building the next generation of quantitative biologists / Kristine A. Pattin ... [et al.]
  • Uncovering the etiology of autism spectrum disorders: Genomics, bioinformatics, environment, data collection and exploration, and future possibilities / Sarah A. Pendergrass, Santhosh Girirajan, Scott Selleck.
The Pacific Symposium on Biocomputing (PSB) 2014 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2014 will be held from January 3 – 7, 2014 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference. PSB 2014 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
Book
1 online resource (355 p.)
  • 1. Plant signaling: response to reactive oxygen species
  • 2. SNARE proteins as signalling elements
  • 3. Plant Rab GTPases in membrane trafficking and signaling
  • 4."PtdIns4P and PtdIns(4,5)P2 as signalling phosphoinositides involved in tip growth "
  • 5. Sugar signaling in plant growth and development
  • 6. Nitrogen regulation and signalling in plants
  • 7. "Phosphorus deficiency in plants: responses, adaptive mechanisms and signaling"
  • 8. Reactive oxygen species-associated mechanism of acclamatory stress tolerance, signaling and redox-regulated gene expression in plants
  • 9. Cyclic nucleotide gated channels-Essential signalling components in plants for fertilization and immunity responses
  • 10. Signaling in response to cold stress
  • 11. Cell Signaling during Drought and Salt Stress
  • 12. Heat signaling and stress responses in photosynthesis
  • 13. Senescence: Regulation and Signaling
  • 14. Molecular builders of cell walls of Lignocellulosic feedstock: a source for biofuels
  • 15. Recent Trends in Jasmonate Signaling Pathway
  • 16. Salicylic acid signaling
  • 17. Ethylene signaling in plants- introspection
  • 18. Plant, Mycorrhizal fungi and bacterial network
  • 19. Self-Incompatibility patterns and signal transduction
  • 20. Plant Disease Resistance genes: From perception to signal transduction.
Plant signalling has emerged as an integrated field which has become indispensable in recent times to study any biological process. Over the last decade, an enormous amount of information has been generated in this field and the advances in information technology gave birth to bioinformatics which has helped greatly in managing the galaxy of information. It is now possible to view the different information TMs in a systems biology approach which has unravelled the association/ new processes and thus helped us enormously in understanding of the biological processes.
  • 1. Plant signaling: response to reactive oxygen species
  • 2. SNARE proteins as signalling elements
  • 3. Plant Rab GTPases in membrane trafficking and signaling
  • 4."PtdIns4P and PtdIns(4,5)P2 as signalling phosphoinositides involved in tip growth "
  • 5. Sugar signaling in plant growth and development
  • 6. Nitrogen regulation and signalling in plants
  • 7. "Phosphorus deficiency in plants: responses, adaptive mechanisms and signaling"
  • 8. Reactive oxygen species-associated mechanism of acclamatory stress tolerance, signaling and redox-regulated gene expression in plants
  • 9. Cyclic nucleotide gated channels-Essential signalling components in plants for fertilization and immunity responses
  • 10. Signaling in response to cold stress
  • 11. Cell Signaling during Drought and Salt Stress
  • 12. Heat signaling and stress responses in photosynthesis
  • 13. Senescence: Regulation and Signaling
  • 14. Molecular builders of cell walls of Lignocellulosic feedstock: a source for biofuels
  • 15. Recent Trends in Jasmonate Signaling Pathway
  • 16. Salicylic acid signaling
  • 17. Ethylene signaling in plants- introspection
  • 18. Plant, Mycorrhizal fungi and bacterial network
  • 19. Self-Incompatibility patterns and signal transduction
  • 20. Plant Disease Resistance genes: From perception to signal transduction.
Plant signalling has emerged as an integrated field which has become indispensable in recent times to study any biological process. Over the last decade, an enormous amount of information has been generated in this field and the advances in information technology gave birth to bioinformatics which has helped greatly in managing the galaxy of information. It is now possible to view the different information TMs in a systems biology approach which has unravelled the association/ new processes and thus helped us enormously in understanding of the biological processes.
Book
1 online resource.
Book
1 online resource (vi, 220 pages) : ill. (some color). Digital: text file; PDF.
  • Bioinformatics for complex diseases: the basics
  • Network based diagnosis of complex diseases
  • Applications in Detection and Treatment of Complex Diseases.
The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc.
  • Bioinformatics for complex diseases: the basics
  • Network based diagnosis of complex diseases
  • Applications in Detection and Treatment of Complex Diseases.
The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc.
Book
1 online resource.
  • Clinical Bioinformatics in Human Proteomics Research / Duojiao Wu, Haihao Li
  • Proteomics Defines Protein Interaction Network of Signaling Pathways / Shitao Li
  • Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation / Jessica Duarte, Jean-Michel Serufuri, Nicola Mulder
  • Proteomics and Cancer Research / Elena Lopez Villar
  • Toward Development of Novel Peptide-Based Cancer Therapeutics: Computational Design and Experimental Evaluation / Elena Pirogova, Taghrid Istivan
  • Advances in Proteomic Methods / Xianyin Lai
  • Clinical and Biomedical Mass Spectrometry: New Frontiers in Drug Developments and Diagnosis / Ákos Végvári, Melinda Rezeli
  • Disease Biomarkers: Modelling MR Spectroscopy and Clinical Applications / Luis Martí-Bonmati
  • Processing of Mass Spectrometry Data in Clinical Applications / Dario Di Silvestre, Pietro Brunetti, Pier Luigi Mauri
  • Bioinformatics Approach for Finding Target Protein in Infectious Disease / Hemant Ritturaj Kushwaha, Indira Ghosh
  • Identification of Network Biomarkers for Cancer Diagnosis / Jiajia Chen, Luonan Chen
  • Software Development for Quantitative Proteomics Using Stable Isotope Labeling / Xin Huang, Shi-Jian Ding
  • Clinical Translation of Protein Biomarkers Integrated with Bioinformatics / Xu Yang, Juanjuan Zhou, Chaoqin Du
  • Proteomic Approaches for Urine Biomarker Discovery in Bladder Cancer / Ming-Hui Yang, Yu-Chang Tyan
  • Antibody Microarrays and Multiplexing / Jerry Zhou, Larissa Belov, Nicola Armstrong
  • Proteomics in Anaesthesia and Intensive Care Medicine / Ornella Piazza, Giuseppe De Benedictis.
  • Clinical Bioinformatics in Human Proteomics Research / Duojiao Wu, Haihao Li
  • Proteomics Defines Protein Interaction Network of Signaling Pathways / Shitao Li
  • Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation / Jessica Duarte, Jean-Michel Serufuri, Nicola Mulder
  • Proteomics and Cancer Research / Elena Lopez Villar
  • Toward Development of Novel Peptide-Based Cancer Therapeutics: Computational Design and Experimental Evaluation / Elena Pirogova, Taghrid Istivan
  • Advances in Proteomic Methods / Xianyin Lai
  • Clinical and Biomedical Mass Spectrometry: New Frontiers in Drug Developments and Diagnosis / Ákos Végvári, Melinda Rezeli
  • Disease Biomarkers: Modelling MR Spectroscopy and Clinical Applications / Luis Martí-Bonmati
  • Processing of Mass Spectrometry Data in Clinical Applications / Dario Di Silvestre, Pietro Brunetti, Pier Luigi Mauri
  • Bioinformatics Approach for Finding Target Protein in Infectious Disease / Hemant Ritturaj Kushwaha, Indira Ghosh
  • Identification of Network Biomarkers for Cancer Diagnosis / Jiajia Chen, Luonan Chen
  • Software Development for Quantitative Proteomics Using Stable Isotope Labeling / Xin Huang, Shi-Jian Ding
  • Clinical Translation of Protein Biomarkers Integrated with Bioinformatics / Xu Yang, Juanjuan Zhou, Chaoqin Du
  • Proteomic Approaches for Urine Biomarker Discovery in Bladder Cancer / Ming-Hui Yang, Yu-Chang Tyan
  • Antibody Microarrays and Multiplexing / Jerry Zhou, Larissa Belov, Nicola Armstrong
  • Proteomics in Anaesthesia and Intensive Care Medicine / Ornella Piazza, Giuseppe De Benedictis.
Book
1 online resource : ill.
  • Scaffold Design for Bone Tissue Engineering: From Micrometric to Nanometric Level / Vincenzo Guarino, Maria Grazia Raucci, Marco A. Alvarez-Perez, Valentina Cirillo and Alfredo Ronca, et al.
  • Molecular Scissors: From Biomaterials Implant to Tissue Remodeling / Tudor Petreus, Iulian Antoniac, Paul Sirbu and Carmen Elena Cotrutz
  • Synthetic Morphogens and Pro-morphogens for Aided Tissue Regeneration / Matteo Santin
  • The Role of Oxidative Stress in the Response of Endothelial Cells to Metals / Roman Tsaryk, Kirsten Peters, Ronald E. Unger, Dieter Scharnweber and C. James Kirkpatrick
  • Comparative Properties of Ethyl, n-Butyl, and n-Octyl Cyanoacrylate Bioadhesives Intended for Wound Closure / Ana María Villarreal-Gómez, Rafael Torregrosa-Coque and José Miguel Martín-Martínez
  • Development of Bioabsorbable Interference Screws: How Biomaterials Composition and Clinical and Retrieval Studies Influence the Innovative Screw Design and Manufacturing Processes / Iulian Antoniac, Dan Laptoiu, Diana Popescu, Cosmin Cotrut and Radu Parpala
  • Modeling and Numerical Analysis of a Cervical Spine Unit / Mirela Toth-Tascau and Dan Ioan Stoia
  • Carbon Nanotubes in Acrylic Bone Cement / Nicholas Dunne, Ross Ormsby and Christina A. Mitchell
  • Exploring the Future of Hydrogels in Rapid Prototyping: A Review on Current Trends and Limitations / Thomas Billiet, Mieke Vandenhaute, Jorg Schelfhout, Sandra Van Vlierberghe and Peter Dubruel.
  • Scaffold Design for Bone Tissue Engineering: From Micrometric to Nanometric Level / Vincenzo Guarino, Maria Grazia Raucci, Marco A. Alvarez-Perez, Valentina Cirillo and Alfredo Ronca, et al.
  • Molecular Scissors: From Biomaterials Implant to Tissue Remodeling / Tudor Petreus, Iulian Antoniac, Paul Sirbu and Carmen Elena Cotrutz
  • Synthetic Morphogens and Pro-morphogens for Aided Tissue Regeneration / Matteo Santin
  • The Role of Oxidative Stress in the Response of Endothelial Cells to Metals / Roman Tsaryk, Kirsten Peters, Ronald E. Unger, Dieter Scharnweber and C. James Kirkpatrick
  • Comparative Properties of Ethyl, n-Butyl, and n-Octyl Cyanoacrylate Bioadhesives Intended for Wound Closure / Ana María Villarreal-Gómez, Rafael Torregrosa-Coque and José Miguel Martín-Martínez
  • Development of Bioabsorbable Interference Screws: How Biomaterials Composition and Clinical and Retrieval Studies Influence the Innovative Screw Design and Manufacturing Processes / Iulian Antoniac, Dan Laptoiu, Diana Popescu, Cosmin Cotrut and Radu Parpala
  • Modeling and Numerical Analysis of a Cervical Spine Unit / Mirela Toth-Tascau and Dan Ioan Stoia
  • Carbon Nanotubes in Acrylic Bone Cement / Nicholas Dunne, Ross Ormsby and Christina A. Mitchell
  • Exploring the Future of Hydrogels in Rapid Prototyping: A Review on Current Trends and Limitations / Thomas Billiet, Mieke Vandenhaute, Jorg Schelfhout, Sandra Van Vlierberghe and Peter Dubruel.
Book
1 online resource.
  • X-Ray Analysis of Prokaryotic and Eukaryotic Ribosomes / Lasse B. Jenner, Adam Ben-Shem, Natalia Demeshkina, Marat Yusupov and Gulnara Yusupova
  • A Passage Through the Ribosome by Cryo-EM / Partha P. Datta and Ananya Chatterjee
  • Molecular Dynamics Simulations of the Ribosome / Karissa Y. Sanbonmatsu, Scott C. Blanchard and Paul C. Whitford
  • Structural Analyses of the Ribosome by Chemical Modification Methods / Jonathan A. Leshin, Arturas Meskauskas and Jonathan D. Dinman
  • Methods for Studying the Interactions of Translation Factors with the Ribosome / Assen Marintchev
  • Riboproteomic Approaches to Understanding IRES Elements / Encarnacion Martinez-Salas, David Piñeiro and Noemi Fernandez
  • Rapid Kinetic Analysis of Protein Synthesis / Marina V. Rodnina and Wolfgang Wintermeyer
  • Investigating RNAs Involved in Translational Control by NMR and SAXS / Kathryn D. Mouzakis, Jordan E. Burke and Samuel E. Butcher
  • Analyses of RNA-Ligand Interactions by Fluorescence Anisotropy / Aparna Kishor, Gary Brewer and Gerald M. Wilson
  • Approaches for the Identification and Characterization of RNA-Protein Interactions / Saiprasad Palusa and Jeffrey Wilusz
  • A Multidisciplinary Approach to RNA Localisation / Russell S. Hamilton, Graeme Ball and Ilan Davis
  • Virtual Screening for RNA-Interacting Small Molecules / Hyun-Ju Park and So-Jung Park
  • The "Fifth" RNA Nucleotide: A Role for Ribosomal RNA Pseudouridylation in Control of Gene Expression at the Translational Level / Mary McMahon, Cristian Bellodi and Davide Ruggero
  • Translational Control of Synaptic Plasticity and Memory / Arkady Khoutorsky, Christos Gkogkas and Nahum Sonenberg.
  • X-Ray Analysis of Prokaryotic and Eukaryotic Ribosomes / Lasse B. Jenner, Adam Ben-Shem, Natalia Demeshkina, Marat Yusupov and Gulnara Yusupova
  • A Passage Through the Ribosome by Cryo-EM / Partha P. Datta and Ananya Chatterjee
  • Molecular Dynamics Simulations of the Ribosome / Karissa Y. Sanbonmatsu, Scott C. Blanchard and Paul C. Whitford
  • Structural Analyses of the Ribosome by Chemical Modification Methods / Jonathan A. Leshin, Arturas Meskauskas and Jonathan D. Dinman
  • Methods for Studying the Interactions of Translation Factors with the Ribosome / Assen Marintchev
  • Riboproteomic Approaches to Understanding IRES Elements / Encarnacion Martinez-Salas, David Piñeiro and Noemi Fernandez
  • Rapid Kinetic Analysis of Protein Synthesis / Marina V. Rodnina and Wolfgang Wintermeyer
  • Investigating RNAs Involved in Translational Control by NMR and SAXS / Kathryn D. Mouzakis, Jordan E. Burke and Samuel E. Butcher
  • Analyses of RNA-Ligand Interactions by Fluorescence Anisotropy / Aparna Kishor, Gary Brewer and Gerald M. Wilson
  • Approaches for the Identification and Characterization of RNA-Protein Interactions / Saiprasad Palusa and Jeffrey Wilusz
  • A Multidisciplinary Approach to RNA Localisation / Russell S. Hamilton, Graeme Ball and Ilan Davis
  • Virtual Screening for RNA-Interacting Small Molecules / Hyun-Ju Park and So-Jung Park
  • The "Fifth" RNA Nucleotide: A Role for Ribosomal RNA Pseudouridylation in Control of Gene Expression at the Translational Level / Mary McMahon, Cristian Bellodi and Davide Ruggero
  • Translational Control of Synaptic Plasticity and Memory / Arkady Khoutorsky, Christos Gkogkas and Nahum Sonenberg.
Book
1 online resource.
  • Introduction and Overview / Rick Russell
  • Comparative Analysis of the Higher-Order Structure of RNA / Robin R. Gutell
  • Graph Applications to RNA Structure and Function / Namhee Kim, Katherine Niccole Fuhr, Tamar Schlick
  • Prediction and Coarse-Grained Modeling of RNA Structures / Zhen Xia, Pengyu Ren
  • Studying RNA Folding Using Site-Directed Spin Labeling / Xiaojun Zhang, Peter Z. Qin
  • The RNA Recognition Motif and Messenger RNA / Kathleen B. Hall
  • Memory Effects in RNA Folding Dynamics Revealed by Single-Molecule Fluorescence / Rui Zhao, David Rueda
  • An Integrated Picture of HDV Ribozyme Catalysis / Barbara L. Golden, Sharon Hammes-Schiffer, Paul R. Carey
  • Combining Biochemical and Structural Information to Model RNA-Protein Complex Assembly / Maithili Saoji, Chun Geng, Paul J. Paukstelis
  • Following RNA Folding From Local and Global Perspectives / Michael Brenowitz, Lois Pollack
  • The Roles of Chaperones in RNA Folding / Pilar Tijerina, Rick Russell.
  • Introduction and Overview / Rick Russell
  • Comparative Analysis of the Higher-Order Structure of RNA / Robin R. Gutell
  • Graph Applications to RNA Structure and Function / Namhee Kim, Katherine Niccole Fuhr, Tamar Schlick
  • Prediction and Coarse-Grained Modeling of RNA Structures / Zhen Xia, Pengyu Ren
  • Studying RNA Folding Using Site-Directed Spin Labeling / Xiaojun Zhang, Peter Z. Qin
  • The RNA Recognition Motif and Messenger RNA / Kathleen B. Hall
  • Memory Effects in RNA Folding Dynamics Revealed by Single-Molecule Fluorescence / Rui Zhao, David Rueda
  • An Integrated Picture of HDV Ribozyme Catalysis / Barbara L. Golden, Sharon Hammes-Schiffer, Paul R. Carey
  • Combining Biochemical and Structural Information to Model RNA-Protein Complex Assembly / Maithili Saoji, Chun Geng, Paul J. Paukstelis
  • Following RNA Folding From Local and Global Perspectives / Michael Brenowitz, Lois Pollack
  • The Roles of Chaperones in RNA Folding / Pilar Tijerina, Rick Russell.
Book
1 online resource.
  • Defective Apoptosis Signaling in Cancer / Daniel E. Johnson
  • The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells / David M Hockenbery, Mark Tom, Cori Abikoff and Daciana Margineantu
  • Emerging Opportunities for Targeting the Tumor-Stroma Interactions for Increasing the Efficacy of Chemotherapy / Rajesh R. Nair, Anthony W. Gebhard and Lori A. Hazlehurst
  • The Role of Autophagy in Drug Resistance and Potential for Therapeutic Targeting / Reshma Rangwala and Ravi Amaravadi
  • MicroRNAs in Cell Death and Cancer / Jong Kook Park and Thomas D. Schmittgen
  • Targeting DNA Repair Pathways for Cancer Therapy / Conchita Vens and Robert W. Sobol
  • Molecular Chaperones and How Addiction Matters in Cancer Therapy / Monica L. Guzman, Maeve A. Lowery, Tony Taldone, John Koren III and Erica DaGama Gomes, et al.
  • Sphingolipid Metabolism and Signaling as a Target for Cancer Treatment / Vinodh Rajagopalan and Yusuf A. Hannun
  • Leading Small Molecule Inhibitors of Anti-Apoptotic Bcl-2 Family Members / Victor Y. Yazbeck and Daniel E. Johnson
  • SMAC IAP Addiction in Cancer / Matthew F. Brown, Kan He and Jian Yu
  • Harnessing Death Receptor Signaling for Cancer Treatment / Simone Fulda
  • Proteasome Inhibition as a Novel Strategy for Cancer Treatment / Min Shen and Q. Ping Dou
  • New Agents and Approaches for Targeting the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR Cell Survival Pathways / James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams and Richard A. Franklin, et al.
  • Activation of Immune-Mediated Tumor Cell Death by Chemotherapy / Melanie J. McCoy, Anna K. Nowak and Richard A. Lake.
  • Defective Apoptosis Signaling in Cancer / Daniel E. Johnson
  • The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells / David M Hockenbery, Mark Tom, Cori Abikoff and Daciana Margineantu
  • Emerging Opportunities for Targeting the Tumor-Stroma Interactions for Increasing the Efficacy of Chemotherapy / Rajesh R. Nair, Anthony W. Gebhard and Lori A. Hazlehurst
  • The Role of Autophagy in Drug Resistance and Potential for Therapeutic Targeting / Reshma Rangwala and Ravi Amaravadi
  • MicroRNAs in Cell Death and Cancer / Jong Kook Park and Thomas D. Schmittgen
  • Targeting DNA Repair Pathways for Cancer Therapy / Conchita Vens and Robert W. Sobol
  • Molecular Chaperones and How Addiction Matters in Cancer Therapy / Monica L. Guzman, Maeve A. Lowery, Tony Taldone, John Koren III and Erica DaGama Gomes, et al.
  • Sphingolipid Metabolism and Signaling as a Target for Cancer Treatment / Vinodh Rajagopalan and Yusuf A. Hannun
  • Leading Small Molecule Inhibitors of Anti-Apoptotic Bcl-2 Family Members / Victor Y. Yazbeck and Daniel E. Johnson
  • SMAC IAP Addiction in Cancer / Matthew F. Brown, Kan He and Jian Yu
  • Harnessing Death Receptor Signaling for Cancer Treatment / Simone Fulda
  • Proteasome Inhibition as a Novel Strategy for Cancer Treatment / Min Shen and Q. Ping Dou
  • New Agents and Approaches for Targeting the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR Cell Survival Pathways / James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams and Richard A. Franklin, et al.
  • Activation of Immune-Mediated Tumor Cell Death by Chemotherapy / Melanie J. McCoy, Anna K. Nowak and Richard A. Lake.
Book
1 online resource.
Book
1 online resource : col. ill.
  • Part 1. Chembiomolecular Chemistry
  • Chemistry of Mycolactones, the Causative Toxins of Buruli Ulcer / Yoshito Kishi
  • Practical Synthesis of Tamiflu and Beyond / Motomu Kanai
  • An Approach Toward Identification of Target Proteins of Maitotoxin Based on Organic Synthesis / Tohru Oishi, Keiichi Konoki, Rie Tamate, Kohei Torikai and Futoshi Hasegawa, et al.
  • Inhibitors of Fatty Acid Amide Hydrolase / Dale L. Boger
  • Small Molecule Tools for Cell Biology and Cell Therapy / Motonari Uesugi
  • Toward the Discovery of Small Molecules Affecting RNA Function / Shiori Umemoto, Changfeng Hong, Jinhua Zhang, Takeo Fukuzumi and Asako Murata, et al.
  • New Insights from a Focused Library Approach Aiming at Development of Inhibitors of Dual-Specificity Protein Phosphatases / Go Hirai, Ayako Tsuchiya and Mikiko Sodeoka
  • The Deep Oceans as a Source for New Treatments for Cancer / William Fenical, James J. La Clair, Chambers C. Hughes, Paul R. Jensen and Susana P. Gaudêncio, et al.
  • Search for New Medicinal Seeds from Marine Organisms / Motomasa Kobayashi, Naoyuki Kotoku and Masayoshi Arai
  • Identification of Protein-Small Molecule Interactions by Chemical Array / Hiroyuki Osada and Siro Simizu.
  • Part 2. Chembiomolecular Biology
  • Small Molecule-Induced Proximity / Fu-Sen Liang and Gerald R. Crabtree
  • High-Throughput Screening for Small Molecule Modulators of FGFR2-IIIb Pre-mRNA Splicing / Erik S. Anderson, Peter Stoilov, Robert Damoiseaux and Douglas L. Black
  • Identification of Signaling Pathways That Mediate Dietary Restriction-Induced Longevity in Caenorhabditis elegans / Masaharu Uno, Sakiko Honjoh and Eisuke Nishida
  • Roles for the Stress-Responsive Kinases ASK1 and ASK2 in Tumorigenesis / Miki Kamiyama, Takehiro Sato, Kohsuke Takeda and Hidenori Ichijo
  • Tailored Synthetic Surfaces to Control Human Pluripotent Stem Cell Self-Renewal / Laura L. Kiessling
  • Cell-Surface Glycoconjugates Controlling Human T-Lymphocyte Homing: Implications for Bronchial Asthma and Atopic Dermatitis / Reiji Kannagi, Keiichiro Sakuma and Katsuyuki Ohmori
  • Establishment of a Novel System for Studying the Syk Function in B Cells / Tomohiro Kurosaki and Clifford A. Lowell
  • Visual Screening for the Natural Compounds That Affect the Formation of Nuclear Structures / Kaya Shigaki, Kazuaki Tokunaga, Yuki Mihara, Yota Matsuo and Yamato Kojimoto, et al.
  • Versatile Orphan Nuclear Receptor NR4A2 as a Promising Molecular Target for Multiple Sclerosis and Other Autoimmune Diseases / Shinji Oki, Benjamin J. E. Raveney, Yoshimitsu Doi and Takashi Yamamura
  • Antiviral MicroRNA / Ryota Ouda and Takashi Fujita
  • Synaptic Function Monitored Using Chemobiomolecular Indicators / Masamitsu Iino.
  • Part 3. Chembiomolecular Medicinal Chemistry
  • Practical Catalytic Asymmetric Synthesis of a Promising Drug Candidate / Masakatsu Shibasaki
  • Hunting the Targets of Natural Product-Inspired Compounds / Slava Ziegler and Herbert Waldmann
  • Chemical Approaches for Understanding and Controlling Infectious Diseases / Hirokazu Arimoto
  • Nongenomic Mechanism-Mediated Renal Fibrosis-Decreasing Activity of a Series of PPAR-[gamma] Agonists / Hiroyuki Miyachi
  • Novel Carbohydrate-Based Inhibitors That Target Influenza A Virus Sialidase / Mark von Itzstein
  • Multidrug Efflux Pumps and Development of Therapeutic Strategies to Control Infectious Diseases / Kunihiko Nishino
  • Enzymes as Chemotherapeutic Agents / Ronald T. Raines
  • Mechanism of Action of New Antiinfectious Agents from Microorganisms / Nobuhiro Koyama and Hiroshi Tomoda
  • Correction of RNA Splicing with Antisense Oligonucleotides as a Therapeutic Strategy for a Neurodegenerative Disease / Yimin Hua, Kentaro Sahashi, Frank Rigo, Gene Hung and C. Frank Bennett, et al.
  • Modulation of Pre-mRNA Splicing Patterns with Synthetic Chemicals and Their Clinical Applications / Masatoshi Hagiwara.
At the forefront of life sciences today is the emerging discipline of chembiomolecular science. This new term describes the integration of the frontier fields of chemical biology, chemistry, and pharmacology. Chembiomolecular science aims to elucidate new biological mechanisms as potential drug targets and enhance the creation of new drug therapies. This book comprises the proceedings of the Uehara Memorial Foundation Symposium 2011, which focused on the most recent advances in chembiomolecular science made by leading experts in the field. The book is divided into three main topics. The first is the chemical approach to understanding complex biological systems on a molecular level using chemical compounds as a probe. The second describes the biological approach used to develop new lead drug compounds. The third focuses on the biological system that serves as the potential drug target, the beginning step in the process of developing new drugs. Replete with the latest research, the book will draw the attention of all scientists interested in the synergies between chemistry and biology to elucidate life on a molecular level and to promote drug discovery. Ultimately, the book helps promote the understanding of biological functions at the molecular level and create new pharmaceuticals that can contribute to improving human health.
  • Part 1. Chembiomolecular Chemistry
  • Chemistry of Mycolactones, the Causative Toxins of Buruli Ulcer / Yoshito Kishi
  • Practical Synthesis of Tamiflu and Beyond / Motomu Kanai
  • An Approach Toward Identification of Target Proteins of Maitotoxin Based on Organic Synthesis / Tohru Oishi, Keiichi Konoki, Rie Tamate, Kohei Torikai and Futoshi Hasegawa, et al.
  • Inhibitors of Fatty Acid Amide Hydrolase / Dale L. Boger
  • Small Molecule Tools for Cell Biology and Cell Therapy / Motonari Uesugi
  • Toward the Discovery of Small Molecules Affecting RNA Function / Shiori Umemoto, Changfeng Hong, Jinhua Zhang, Takeo Fukuzumi and Asako Murata, et al.
  • New Insights from a Focused Library Approach Aiming at Development of Inhibitors of Dual-Specificity Protein Phosphatases / Go Hirai, Ayako Tsuchiya and Mikiko Sodeoka
  • The Deep Oceans as a Source for New Treatments for Cancer / William Fenical, James J. La Clair, Chambers C. Hughes, Paul R. Jensen and Susana P. Gaudêncio, et al.
  • Search for New Medicinal Seeds from Marine Organisms / Motomasa Kobayashi, Naoyuki Kotoku and Masayoshi Arai
  • Identification of Protein-Small Molecule Interactions by Chemical Array / Hiroyuki Osada and Siro Simizu.
  • Part 2. Chembiomolecular Biology
  • Small Molecule-Induced Proximity / Fu-Sen Liang and Gerald R. Crabtree
  • High-Throughput Screening for Small Molecule Modulators of FGFR2-IIIb Pre-mRNA Splicing / Erik S. Anderson, Peter Stoilov, Robert Damoiseaux and Douglas L. Black
  • Identification of Signaling Pathways That Mediate Dietary Restriction-Induced Longevity in Caenorhabditis elegans / Masaharu Uno, Sakiko Honjoh and Eisuke Nishida
  • Roles for the Stress-Responsive Kinases ASK1 and ASK2 in Tumorigenesis / Miki Kamiyama, Takehiro Sato, Kohsuke Takeda and Hidenori Ichijo
  • Tailored Synthetic Surfaces to Control Human Pluripotent Stem Cell Self-Renewal / Laura L. Kiessling
  • Cell-Surface Glycoconjugates Controlling Human T-Lymphocyte Homing: Implications for Bronchial Asthma and Atopic Dermatitis / Reiji Kannagi, Keiichiro Sakuma and Katsuyuki Ohmori
  • Establishment of a Novel System for Studying the Syk Function in B Cells / Tomohiro Kurosaki and Clifford A. Lowell
  • Visual Screening for the Natural Compounds That Affect the Formation of Nuclear Structures / Kaya Shigaki, Kazuaki Tokunaga, Yuki Mihara, Yota Matsuo and Yamato Kojimoto, et al.
  • Versatile Orphan Nuclear Receptor NR4A2 as a Promising Molecular Target for Multiple Sclerosis and Other Autoimmune Diseases / Shinji Oki, Benjamin J. E. Raveney, Yoshimitsu Doi and Takashi Yamamura
  • Antiviral MicroRNA / Ryota Ouda and Takashi Fujita
  • Synaptic Function Monitored Using Chemobiomolecular Indicators / Masamitsu Iino.
  • Part 3. Chembiomolecular Medicinal Chemistry
  • Practical Catalytic Asymmetric Synthesis of a Promising Drug Candidate / Masakatsu Shibasaki
  • Hunting the Targets of Natural Product-Inspired Compounds / Slava Ziegler and Herbert Waldmann
  • Chemical Approaches for Understanding and Controlling Infectious Diseases / Hirokazu Arimoto
  • Nongenomic Mechanism-Mediated Renal Fibrosis-Decreasing Activity of a Series of PPAR-[gamma] Agonists / Hiroyuki Miyachi
  • Novel Carbohydrate-Based Inhibitors That Target Influenza A Virus Sialidase / Mark von Itzstein
  • Multidrug Efflux Pumps and Development of Therapeutic Strategies to Control Infectious Diseases / Kunihiko Nishino
  • Enzymes as Chemotherapeutic Agents / Ronald T. Raines
  • Mechanism of Action of New Antiinfectious Agents from Microorganisms / Nobuhiro Koyama and Hiroshi Tomoda
  • Correction of RNA Splicing with Antisense Oligonucleotides as a Therapeutic Strategy for a Neurodegenerative Disease / Yimin Hua, Kentaro Sahashi, Frank Rigo, Gene Hung and C. Frank Bennett, et al.
  • Modulation of Pre-mRNA Splicing Patterns with Synthetic Chemicals and Their Clinical Applications / Masatoshi Hagiwara.
At the forefront of life sciences today is the emerging discipline of chembiomolecular science. This new term describes the integration of the frontier fields of chemical biology, chemistry, and pharmacology. Chembiomolecular science aims to elucidate new biological mechanisms as potential drug targets and enhance the creation of new drug therapies. This book comprises the proceedings of the Uehara Memorial Foundation Symposium 2011, which focused on the most recent advances in chembiomolecular science made by leading experts in the field. The book is divided into three main topics. The first is the chemical approach to understanding complex biological systems on a molecular level using chemical compounds as a probe. The second describes the biological approach used to develop new lead drug compounds. The third focuses on the biological system that serves as the potential drug target, the beginning step in the process of developing new drugs. Replete with the latest research, the book will draw the attention of all scientists interested in the synergies between chemistry and biology to elucidate life on a molecular level and to promote drug discovery. Ultimately, the book helps promote the understanding of biological functions at the molecular level and create new pharmaceuticals that can contribute to improving human health.
Book
1 online resource.
Book
1 online resource (288 p.)
  • Introduction / Dimosthenis Kizis, George Siragakis
  • Immunodiagnostics in food allergen testing / Jennifer Anne Rice, Anthony Joseph Lupo
  • Molecular testing for food allergens / Terence Lok, Ting Lau
  • LC-MS/MS techniques for food allergen testing / Manos Christofakis, Aglaia Xila
  • Detection of animal allergens in foods / Katerina Rizou
  • Detection of plant allergens in foods / Dimosthenis Kizis
  • Gluten testing in foods, pharmaceuticals and cosmetics / Joanna Leszczyńska, Iwona Majak, Adrian Bartos
  • Food allergen testing in alcoholic and other beverages / Rebecca Kokkinofta, George Siragakis
  • Allergens in the food industry: customer and legislation demands / Antonis Lampidonis, George Siragakis
  • Reference materials for food allergen testing / Sándor Tömösközi, Kitti Török, Zsuzsanna Bugyi, Lívia Hajas
  • Proficiency schemes for food allergen testing / Charalampos Alexopoulos, Elias Kakoulides, Evgenia Lampi
  • Index.
An in-depth review of the current scientific knowledge on food allergens testing, covering the major methodologies and techniques used to detect food allergens. Food allergens are a series of agents, mainly proteins, which cause various unpleasant and sometimes clinical symptoms in humans through consumption of foods. Perhaps surprisingly, there are no treatments against food allergies which have been found to be 100% effective. The scope for individual difference in terms of how a person reacts to a given allergen is massive, making it incredibly difficult and complex to try an.
  • Introduction / Dimosthenis Kizis, George Siragakis
  • Immunodiagnostics in food allergen testing / Jennifer Anne Rice, Anthony Joseph Lupo
  • Molecular testing for food allergens / Terence Lok, Ting Lau
  • LC-MS/MS techniques for food allergen testing / Manos Christofakis, Aglaia Xila
  • Detection of animal allergens in foods / Katerina Rizou
  • Detection of plant allergens in foods / Dimosthenis Kizis
  • Gluten testing in foods, pharmaceuticals and cosmetics / Joanna Leszczyńska, Iwona Majak, Adrian Bartos
  • Food allergen testing in alcoholic and other beverages / Rebecca Kokkinofta, George Siragakis
  • Allergens in the food industry: customer and legislation demands / Antonis Lampidonis, George Siragakis
  • Reference materials for food allergen testing / Sándor Tömösközi, Kitti Török, Zsuzsanna Bugyi, Lívia Hajas
  • Proficiency schemes for food allergen testing / Charalampos Alexopoulos, Elias Kakoulides, Evgenia Lampi
  • Index.
An in-depth review of the current scientific knowledge on food allergens testing, covering the major methodologies and techniques used to detect food allergens. Food allergens are a series of agents, mainly proteins, which cause various unpleasant and sometimes clinical symptoms in humans through consumption of foods. Perhaps surprisingly, there are no treatments against food allergies which have been found to be 100% effective. The scope for individual difference in terms of how a person reacts to a given allergen is massive, making it incredibly difficult and complex to try an.
Book
1 online resource (481 p.)
  • Ecophysiology of Fungal Bioremediation. An Introduction to Bioremediation / Babak Pakdaman Sardrood, Ebrahim Mohammadi Goltapeh, Ajit Varma
  • The Bioremediation Potential of Different Ecophysiological Groups of Fungi / Antonella Anastasi, Valeria Tigini, Giovanna Cristina Varese
  • Fungal Wood Decay Processes as a Basis for Bioremediation / Barbara Piškur, Miha Humar, Ajda Ulčnik, Dušan Jurc, Franc Pohleven
  • Application of Mycoremediation Against Organic Pollutants. Mycoremediation of Paper, Pulp and Cardboard Industrial Wastes and Pollutants / Shweta Kulshreshtha, Nupur Mathur, Pradeep Bhatnagar
  • Degradation of Petroleum Pollutant Materials by Fungi / Eri Hara, Hiroo Uchiyama
  • Bioremediation of Organic Pollutants Using Phanerochaete chrysosporium / M. H. Fulekar, Bhawana Pathak, Jyoti Fulekar, Tanvi Godambe
  • Bioremediation of PAH-Contaminated Soil by Fungi / Irma Susana Morelli, Mario Carlos Nazareno Saparrat, María Teresa Del Panno
  • Sequential Soil Vapor Extraction and Bioremediation Processes Applied to BTEX-Contaminated Soils / António Alves Soares, José Tomás Albergaria, Valentina F. Domingues, Paolo De Marco
  • Biological Remediation of Petroleum Hydrocarbons in Soil: Suitability of Different Technologies Applied in Mesocosm and Microcosm Trials / M. Nazaré F. Couto, M. Clara P. Basto, M. Teresa S. D. Vasconcelos
  • Pesticides Removal Using Actinomycetes and Plants / Analía Alvarez, María S. Fuentes, Claudia S. Benimeli, Sergio A. Cuozzo
  • Mycoremediation of Inorganic Pollutants. Mycoremediation of Heavy Metals / Younes Rezaee Danesh, Mehdi Tajbakhsh, Ebrahim Mohammadi Goltapeh, Ajit Varma
  • Mycorrhizae Adsorb and Bioaccumulate Heavy and Radioactive Metals / Hassan Zare-Maivan
  • Mycoremediation: Agricultural and Forest Ecosystem Sustainability. Upscaling the Biogeochemical Role of Arbuscular Mycorrhizal Fungi in Metal Mobility / A. Neagoe, Virgil Iordache, Erika Kothe
  • Fungi and Their Role in Phytoremediation of Heavy Metal-Contaminated Soils / Mozhgan Sepehri, Habib Khodaverdiloo, Mehdi Zarei
  • Sustainable Agriculture in Saline-Arid and Semiarid by Use Potential of AM Fungi on Mitigates NaCl Effects / Mohammad Javad Zarea, Ebrahim Mohammadi Goltapeh, Nasrin Karimi, Ajit Varma
  • White-Rot Fungi in Bioremediation / Safiye Elif Korcan, İbrahim Hakkı Ciğerci, Muhsin Konuk
  • Techniques in Mycoremediation. Effect of Mobilising Agents on Mycoremediation of Soils Contaminated by Hydrophobic Persistent Pollutants / Alessandro D'Annibale, Ermanno Federici, Maurizio Petruccioli
  • New Insights into the Use of Filamentous Fungi and Their Degradative Enzymes as Tools for Assessing the Ecotoxicity of Contaminated Soils During Bioremediation Processes / Christian Mougin, Nathalie Cheviron, Marc Pinheiro, Jérémie D. Lebrun, Hassan Boukcim
  • Bioremediation and Genetically Modified Organisms / Morad Jafari, Younes Rezaee Danesh, Ebrahim Mohammadi Goltapeh, Ajit Varma
  • Molecular Techniques in Fungal Bioremediation / Morad Jafari, Younes Rezaee Danesh, Yubert Ghoosta
  • Bioremediation of Heavy Metals Using Metal Hyperaccumulator Plants
  • Sangita Talukdar, Soniya Bhardwaj.
Biological remediation methods have been successfully used to treat polluted soils. While bacteria have produced good results in bioremediation for quite some time now, the use of fungi to decontaminate soils has only recently been established. This volume of Soil Biology discusses the potentials of filamentous fungi in bioremediation. Fungi suitable for degradation, as well as genetically modified organisms, their biochemistry, enzymology, and practical applications are described. Chapters include topics such as pesticide removal, fungal wood decay processes, remediation of soils contaminated with heavy and radioactive metals, of paper and cardboard industrial wastes, and of petroleum pollutants.
  • Ecophysiology of Fungal Bioremediation. An Introduction to Bioremediation / Babak Pakdaman Sardrood, Ebrahim Mohammadi Goltapeh, Ajit Varma
  • The Bioremediation Potential of Different Ecophysiological Groups of Fungi / Antonella Anastasi, Valeria Tigini, Giovanna Cristina Varese
  • Fungal Wood Decay Processes as a Basis for Bioremediation / Barbara Piškur, Miha Humar, Ajda Ulčnik, Dušan Jurc, Franc Pohleven
  • Application of Mycoremediation Against Organic Pollutants. Mycoremediation of Paper, Pulp and Cardboard Industrial Wastes and Pollutants / Shweta Kulshreshtha, Nupur Mathur, Pradeep Bhatnagar
  • Degradation of Petroleum Pollutant Materials by Fungi / Eri Hara, Hiroo Uchiyama
  • Bioremediation of Organic Pollutants Using Phanerochaete chrysosporium / M. H. Fulekar, Bhawana Pathak, Jyoti Fulekar, Tanvi Godambe
  • Bioremediation of PAH-Contaminated Soil by Fungi / Irma Susana Morelli, Mario Carlos Nazareno Saparrat, María Teresa Del Panno
  • Sequential Soil Vapor Extraction and Bioremediation Processes Applied to BTEX-Contaminated Soils / António Alves Soares, José Tomás Albergaria, Valentina F. Domingues, Paolo De Marco
  • Biological Remediation of Petroleum Hydrocarbons in Soil: Suitability of Different Technologies Applied in Mesocosm and Microcosm Trials / M. Nazaré F. Couto, M. Clara P. Basto, M. Teresa S. D. Vasconcelos
  • Pesticides Removal Using Actinomycetes and Plants / Analía Alvarez, María S. Fuentes, Claudia S. Benimeli, Sergio A. Cuozzo
  • Mycoremediation of Inorganic Pollutants. Mycoremediation of Heavy Metals / Younes Rezaee Danesh, Mehdi Tajbakhsh, Ebrahim Mohammadi Goltapeh, Ajit Varma
  • Mycorrhizae Adsorb and Bioaccumulate Heavy and Radioactive Metals / Hassan Zare-Maivan
  • Mycoremediation: Agricultural and Forest Ecosystem Sustainability. Upscaling the Biogeochemical Role of Arbuscular Mycorrhizal Fungi in Metal Mobility / A. Neagoe, Virgil Iordache, Erika Kothe
  • Fungi and Their Role in Phytoremediation of Heavy Metal-Contaminated Soils / Mozhgan Sepehri, Habib Khodaverdiloo, Mehdi Zarei
  • Sustainable Agriculture in Saline-Arid and Semiarid by Use Potential of AM Fungi on Mitigates NaCl Effects / Mohammad Javad Zarea, Ebrahim Mohammadi Goltapeh, Nasrin Karimi, Ajit Varma
  • White-Rot Fungi in Bioremediation / Safiye Elif Korcan, İbrahim Hakkı Ciğerci, Muhsin Konuk
  • Techniques in Mycoremediation. Effect of Mobilising Agents on Mycoremediation of Soils Contaminated by Hydrophobic Persistent Pollutants / Alessandro D'Annibale, Ermanno Federici, Maurizio Petruccioli
  • New Insights into the Use of Filamentous Fungi and Their Degradative Enzymes as Tools for Assessing the Ecotoxicity of Contaminated Soils During Bioremediation Processes / Christian Mougin, Nathalie Cheviron, Marc Pinheiro, Jérémie D. Lebrun, Hassan Boukcim
  • Bioremediation and Genetically Modified Organisms / Morad Jafari, Younes Rezaee Danesh, Ebrahim Mohammadi Goltapeh, Ajit Varma
  • Molecular Techniques in Fungal Bioremediation / Morad Jafari, Younes Rezaee Danesh, Yubert Ghoosta
  • Bioremediation of Heavy Metals Using Metal Hyperaccumulator Plants
  • Sangita Talukdar, Soniya Bhardwaj.
Biological remediation methods have been successfully used to treat polluted soils. While bacteria have produced good results in bioremediation for quite some time now, the use of fungi to decontaminate soils has only recently been established. This volume of Soil Biology discusses the potentials of filamentous fungi in bioremediation. Fungi suitable for degradation, as well as genetically modified organisms, their biochemistry, enzymology, and practical applications are described. Chapters include topics such as pesticide removal, fungal wood decay processes, remediation of soils contaminated with heavy and radioactive metals, of paper and cardboard industrial wastes, and of petroleum pollutants.
Book
1 online resource.
  • Introduction
  • From Genomes to Protein Functions
  • Co-Evolutionary Signals Within Genome Sequences Reflect Functional Dependence of Proteins
  • Chromosomal Proximity of Genes as an Indicator of Functional Linkage
  • Analyses of Complex Genome-Scale Biological Networks
  • Applications of Protein Interaction Networks.
  • Introduction
  • From Genomes to Protein Functions
  • Co-Evolutionary Signals Within Genome Sequences Reflect Functional Dependence of Proteins
  • Chromosomal Proximity of Genes as an Indicator of Functional Linkage
  • Analyses of Complex Genome-Scale Biological Networks
  • Applications of Protein Interaction Networks.