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Book
1 online resource. Digital: text file; PDF.
  • Biomedical Signal Processing.- Biomedical Imaging and Image Processing.- Biosensors and Bioinstrumentation.- Bio-micro/nano Technologies.- Biomaterials.- Biomechanics, Robotics and Minimally Invasive Surgery.- Cardiovascular, Respiratory and Endocrine Systems Engineering.- Neural and Rehabilitation Engineering.- Molecular, Cellular and Tissue Engineering.- Bioinformatics and Computational Biology.- Clinical Engineering and Health Technology Assessment.- Health Informatics, E-health and Telemedicine.- Biomedical Engineering Education.- Biomimetic Organ-on-Chip Systems.- Nanotechnology and Pulsed Electric Fields.- Advanced techniques for treating deep seated tumor using Electrochemotherapy (ECT) and Irreversible Electroporation (IRE). Bioimpedance.- Workshop: Radiological Equipment Maintenance Issues.- Real-time neuroimaging of the human brain: Methods and applications.- Certification of clinical biomedical engineers: national and international perspectives.- AHP in healthcare decision making and user need elicitation.- Education BME-ENA.- Disaster Preparedness Program for Health Facility's Technology Managers.
  • (source: Nielsen Book Data)
This volume presents the Proceedings of the 6th European Conference of the International Federation for Medical and Biological Engineering (MBEC2014), held in Dubrovnik September 7 - 11, 2014. The general theme of MBEC 2014 is "Towards new horizons in biomedical engineering" The scientific discussions in these conference proceedings include the following themes: - Biomedical Signal Processing - Biomedical Imaging and Image Processing - Biosensors and Bioinstrumentation - Bio-Micro/Nano Technologies - Biomaterials - Biomechanics, Robotics and Minimally Invasive Surgery - Cardiovascular, Respiratory and Endocrine Systems Engineering - Neural and Rehabilitation Engineering - Molecular, Cellular and Tissue Engineering - Bioinformatics and Computational Biology - Clinical Engineering and Health Technology Assessment - Health Informatics, E-Health and Telemedicine - Biomedical Engineering Education.
(source: Nielsen Book Data)
  • Biomedical Signal Processing.- Biomedical Imaging and Image Processing.- Biosensors and Bioinstrumentation.- Bio-micro/nano Technologies.- Biomaterials.- Biomechanics, Robotics and Minimally Invasive Surgery.- Cardiovascular, Respiratory and Endocrine Systems Engineering.- Neural and Rehabilitation Engineering.- Molecular, Cellular and Tissue Engineering.- Bioinformatics and Computational Biology.- Clinical Engineering and Health Technology Assessment.- Health Informatics, E-health and Telemedicine.- Biomedical Engineering Education.- Biomimetic Organ-on-Chip Systems.- Nanotechnology and Pulsed Electric Fields.- Advanced techniques for treating deep seated tumor using Electrochemotherapy (ECT) and Irreversible Electroporation (IRE). Bioimpedance.- Workshop: Radiological Equipment Maintenance Issues.- Real-time neuroimaging of the human brain: Methods and applications.- Certification of clinical biomedical engineers: national and international perspectives.- AHP in healthcare decision making and user need elicitation.- Education BME-ENA.- Disaster Preparedness Program for Health Facility's Technology Managers.
  • (source: Nielsen Book Data)
This volume presents the Proceedings of the 6th European Conference of the International Federation for Medical and Biological Engineering (MBEC2014), held in Dubrovnik September 7 - 11, 2014. The general theme of MBEC 2014 is "Towards new horizons in biomedical engineering" The scientific discussions in these conference proceedings include the following themes: - Biomedical Signal Processing - Biomedical Imaging and Image Processing - Biosensors and Bioinstrumentation - Bio-Micro/Nano Technologies - Biomaterials - Biomechanics, Robotics and Minimally Invasive Surgery - Cardiovascular, Respiratory and Endocrine Systems Engineering - Neural and Rehabilitation Engineering - Molecular, Cellular and Tissue Engineering - Bioinformatics and Computational Biology - Clinical Engineering and Health Technology Assessment - Health Informatics, E-Health and Telemedicine - Biomedical Engineering Education.
(source: Nielsen Book Data)
Book
1 online resource. Digital: text file; PDF.
  • Geriatrics.- Neurodegenerative Diseases.- Geriatric Psychiatry.- Mechanisms of Aging.- Metabolic Aging.- Cognition and Aging.- Immunity and Aging.- End-of-Life Care.- Aging and Environmental Interaction.
  • (source: Nielsen Book Data)
The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international forum for the latest scientific discoveries, medical practices and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2014 takes place in Corfu, Greece, 10-13 April 2014. This volume focuses on the sessions that address geriatrics.
(source: Nielsen Book Data)
  • Geriatrics.- Neurodegenerative Diseases.- Geriatric Psychiatry.- Mechanisms of Aging.- Metabolic Aging.- Cognition and Aging.- Immunity and Aging.- End-of-Life Care.- Aging and Environmental Interaction.
  • (source: Nielsen Book Data)
The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international forum for the latest scientific discoveries, medical practices and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2014 takes place in Corfu, Greece, 10-13 April 2014. This volume focuses on the sessions that address geriatrics.
(source: Nielsen Book Data)
Book
1 online resource. Digital: text file; PDF.
  • Peroxynitrite induces degradation of myosin heavy chain via p38 MAPK and muscle-specific E3 ubiquitin ligases in C2 skeletal myotubes. O. Rom, S. Kaisari, A.Z. Reznick, and D. Aizenbud Alterations in the coagulation system of active smokers from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. G. Delgado, R. Siekmeier, T.B. Grammer, B.O. Boehm, W. Marz, and M.E. Kleber. C-reactive protein and lipoprotein-associated phospholipase A2 in smokers and nonsmokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. M.E. Kleber, R. Siekmeier, G. Delgado, T.B. Grammer, B.R. Winkelmann, H. Scharnagl, B.O. Boehm, and W. Marz Green tea drinking improves erythrocytes and saliva oxidative status in the elderly. B. Narotzki, A.Z. Reznick, T. Mitki, D. Aizenbud, and Y. Levy Cardiovascular effects of N-acetylcysteine in meconium-induced acute lung injury. D. Mokra, I. Tonhajzerova, H. Pistekova, Z. Visnovcova, A. Drgova, J. Mokry, and A. Calkovska Alterations in vagal-immune pathway in long-lasting mental stress. Z. Visnovcova, D. Mokra, P. Mikolka, M. Mestanik, A. Jurko, M. Javorka, A. Calkovska, and I. Tonhajzerova Nocturnal parasympathetic modulation of heart rate in obesity-hypoventilation patients. A. Brzecka, M. Pawelec-Winiarz, A. Teplicki, P. Piesiak, and R. Jankowska N-acetylcysteine Alleviates the Meconium-Induced Acute Lung Injury. D. Mokra, A. Drgova, M. Petras, J. Mokry, M. Antosova, and A. Calkovska.
  • (source: Nielsen Book Data)
Cardiorespiratory function is prominently affected by oxidative stress. Cigarette smoking is the archetype of oxidative and nitrative stress and free radical formation. New adverse effects of smoking keep on propping up in research. The chapters provide the comprehensive view of new developments in this area regarding cardiovascular and lung function and muscle catabolism. Alterations in inflammatory cytokines and proteins as well as degradation of muscle proteins due to smoking, by far unrecognized, caused by oxidative stress also are presented. Much less is known about the effect of cognitive stress on vagally-mediated cardiorespiratory function and surprisingly, on vagal immune pathway. The experimental studies also show that clinically important meconium aspiration syndrome contains an oxidative trait which is amenable to antioxidative treatment. This volume creates a source of information on the damaging role of oxidative stress in cardiorespiratory function that has by far not been available.
(source: Nielsen Book Data)
  • Peroxynitrite induces degradation of myosin heavy chain via p38 MAPK and muscle-specific E3 ubiquitin ligases in C2 skeletal myotubes. O. Rom, S. Kaisari, A.Z. Reznick, and D. Aizenbud Alterations in the coagulation system of active smokers from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. G. Delgado, R. Siekmeier, T.B. Grammer, B.O. Boehm, W. Marz, and M.E. Kleber. C-reactive protein and lipoprotein-associated phospholipase A2 in smokers and nonsmokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. M.E. Kleber, R. Siekmeier, G. Delgado, T.B. Grammer, B.R. Winkelmann, H. Scharnagl, B.O. Boehm, and W. Marz Green tea drinking improves erythrocytes and saliva oxidative status in the elderly. B. Narotzki, A.Z. Reznick, T. Mitki, D. Aizenbud, and Y. Levy Cardiovascular effects of N-acetylcysteine in meconium-induced acute lung injury. D. Mokra, I. Tonhajzerova, H. Pistekova, Z. Visnovcova, A. Drgova, J. Mokry, and A. Calkovska Alterations in vagal-immune pathway in long-lasting mental stress. Z. Visnovcova, D. Mokra, P. Mikolka, M. Mestanik, A. Jurko, M. Javorka, A. Calkovska, and I. Tonhajzerova Nocturnal parasympathetic modulation of heart rate in obesity-hypoventilation patients. A. Brzecka, M. Pawelec-Winiarz, A. Teplicki, P. Piesiak, and R. Jankowska N-acetylcysteine Alleviates the Meconium-Induced Acute Lung Injury. D. Mokra, A. Drgova, M. Petras, J. Mokry, M. Antosova, and A. Calkovska.
  • (source: Nielsen Book Data)
Cardiorespiratory function is prominently affected by oxidative stress. Cigarette smoking is the archetype of oxidative and nitrative stress and free radical formation. New adverse effects of smoking keep on propping up in research. The chapters provide the comprehensive view of new developments in this area regarding cardiovascular and lung function and muscle catabolism. Alterations in inflammatory cytokines and proteins as well as degradation of muscle proteins due to smoking, by far unrecognized, caused by oxidative stress also are presented. Much less is known about the effect of cognitive stress on vagally-mediated cardiorespiratory function and surprisingly, on vagal immune pathway. The experimental studies also show that clinically important meconium aspiration syndrome contains an oxidative trait which is amenable to antioxidative treatment. This volume creates a source of information on the damaging role of oxidative stress in cardiorespiratory function that has by far not been available.
(source: Nielsen Book Data)
Book
1 online resource : ill.
  • Part I. Childhood. Cognitive Abilities in Childhood and Adolescence / Sally J. Wadsworth, Robin P. Corley and John C. DeFries
  • Interactions Between Socioeconomic Status and Components of Variation in Cognitive Ability / Eric Turkheimer and Erin E. Horn
  • Genetic and Environmental Influences on Intellectual Disability in Childhood / Michèle Carlier and Pierre L. Roubertoux
  • Part II. Adulthood. Cognition in Middle Adulthood / William S. Kremen and Caitlin S. Moore, Carol E. Franz, Matthew S. Panizzon and Michael J. Lyons
  • Normative Cognitive Aging / Wendy Johnson, Matt McGue and Ian J. Deary
  • Gene by Environment Interplay in Cognitive Aging / Chandra A. Reynolds, Deborah Finkel and Catalina Zavala
  • Dementia: Genes, Environments, Interactions / Margaret Gatz, Jung Yun Jang, Ida K. Karlsson and Nancy L. Pedersen
  • Part III. Biology and Neurobiology. Brain Imaging and Cognition / Iván Chavarría-Siles, Guillén Fernández and Danielle Posthuma
  • Animal Models of General Cognitive Ability for Genetic Research into Cognitive Functioning / Michael J. Galsworthy, Rosalind Arden and Christopher F. Chabris
  • Part IV. Conclusion. Future Directions / Deborah Finkel and Chandra A. Reynolds.
Behavior Genetics of Cognition across the Lifespan Deborah Finkel and Chandra A. Reynolds, editors Series: Advances in Behavioral Genetics Series Editor: Yong-Kyu Kim One of the primary advances for the 21st century is progress beyond the need to defend the findings of behavioral genetic investigations of intelligence. With the advent of developmental behavioral genetics-and molecular genetics-researchers have taken their discoveries far beyond simple nature/nurture constructs to a finer understanding of how genes and environment intersect to affect cognitive function. Behavior Genetics of Cognition across the Lifespan presents the state of the field in well-documented detail as noted experts examine gene-environment interactions in cognitive function from childhood into old age. Fluidity is at the heart of this coverage: normative and non-normative brain development get equal attention, and statistical, molecular, biological, brain imaging, and neurobiological approaches contribute separately and in combination to the findings. All major life stages are examined as periods of gene-based cognitive change, including midlife, which until recently has been considered a period for marking time until "real" age-related change occurs. And the book is written so that individual chapters can be as useful on their own as the volume is as a whole. Among the topics covered in depth: Cognitive abilities in childhood and adolescence Genetic and environmental influences on intellectual disabilities in childhood Cognition in middle adulthood Gene by environment interplay in cognitive aging Dementia: genes, environments, interactions Brain imaging and cognition By synthesizing where the field is today--and identifying issues that need further attention--Behavior Genetics of Cognition across the Lifespan is a bedrock text for behavioral geneticists, cognitive psychologists and neuroscientists.
  • Part I. Childhood. Cognitive Abilities in Childhood and Adolescence / Sally J. Wadsworth, Robin P. Corley and John C. DeFries
  • Interactions Between Socioeconomic Status and Components of Variation in Cognitive Ability / Eric Turkheimer and Erin E. Horn
  • Genetic and Environmental Influences on Intellectual Disability in Childhood / Michèle Carlier and Pierre L. Roubertoux
  • Part II. Adulthood. Cognition in Middle Adulthood / William S. Kremen and Caitlin S. Moore, Carol E. Franz, Matthew S. Panizzon and Michael J. Lyons
  • Normative Cognitive Aging / Wendy Johnson, Matt McGue and Ian J. Deary
  • Gene by Environment Interplay in Cognitive Aging / Chandra A. Reynolds, Deborah Finkel and Catalina Zavala
  • Dementia: Genes, Environments, Interactions / Margaret Gatz, Jung Yun Jang, Ida K. Karlsson and Nancy L. Pedersen
  • Part III. Biology and Neurobiology. Brain Imaging and Cognition / Iván Chavarría-Siles, Guillén Fernández and Danielle Posthuma
  • Animal Models of General Cognitive Ability for Genetic Research into Cognitive Functioning / Michael J. Galsworthy, Rosalind Arden and Christopher F. Chabris
  • Part IV. Conclusion. Future Directions / Deborah Finkel and Chandra A. Reynolds.
Behavior Genetics of Cognition across the Lifespan Deborah Finkel and Chandra A. Reynolds, editors Series: Advances in Behavioral Genetics Series Editor: Yong-Kyu Kim One of the primary advances for the 21st century is progress beyond the need to defend the findings of behavioral genetic investigations of intelligence. With the advent of developmental behavioral genetics-and molecular genetics-researchers have taken their discoveries far beyond simple nature/nurture constructs to a finer understanding of how genes and environment intersect to affect cognitive function. Behavior Genetics of Cognition across the Lifespan presents the state of the field in well-documented detail as noted experts examine gene-environment interactions in cognitive function from childhood into old age. Fluidity is at the heart of this coverage: normative and non-normative brain development get equal attention, and statistical, molecular, biological, brain imaging, and neurobiological approaches contribute separately and in combination to the findings. All major life stages are examined as periods of gene-based cognitive change, including midlife, which until recently has been considered a period for marking time until "real" age-related change occurs. And the book is written so that individual chapters can be as useful on their own as the volume is as a whole. Among the topics covered in depth: Cognitive abilities in childhood and adolescence Genetic and environmental influences on intellectual disabilities in childhood Cognition in middle adulthood Gene by environment interplay in cognitive aging Dementia: genes, environments, interactions Brain imaging and cognition By synthesizing where the field is today--and identifying issues that need further attention--Behavior Genetics of Cognition across the Lifespan is a bedrock text for behavioral geneticists, cognitive psychologists and neuroscientists.
Book
1 online resource (295 pages)
Calculus of Thought: Neuromorphic Logistic Regression in Cognitive Machines is a must-read for all scientists about a very simple computation method designed to simulate big-data neural processing. This book is inspired by the Calculus Ratiocinator idea of Gottfried Leibniz, which is that machine computation should be developed to simulate human cognitive processes, thus avoiding problematic subjective bias in analytic solutions to practical and scientific problems. The reduced error logistic regression (RELR) method is proposed as such a "Calculus of Thought." This book reviews how RELR's completely automated processing may parallel important aspects of explicit and implicit learning in neural processes. It emphasizes the fact that RELR is really just a simple adjustment to already widely used logistic regression, along with RELR's new applications that go well beyond standard logistic regression in prediction and explanation. Readers will learn how RELR solves some of the most basic problems in today's big and small data related to high dimensionality, multi-colinearity, and cognitive bias in capricious outcomes commonly involving human behavior. Features include: provides a high-level introduction and detailed reviews of the neural, statistical and machine learning knowledge base as a foundation for a new era of smarter machines; argues that smarter machine learning to handle both explanation and prediction without cognitive bias must have a foundation in cognitive neuroscience and must embody similar explicit and implicit learning principles that occur in the brain; and offers a new neuromorphic foundation for machine learning based upon the reduced error logistic regression (RELR) method and provides simple examples of RELR computations in toy problems that can be accessed in spreadsheet workbooks through a companion website.
(source: Nielsen Book Data)
Calculus of Thought: Neuromorphic Logistic Regression in Cognitive Machines is a must-read for all scientists about a very simple computation method designed to simulate big-data neural processing. This book is inspired by the Calculus Ratiocinator idea of Gottfried Leibniz, which is that machine computation should be developed to simulate human cognitive processes, thus avoiding problematic subjective bias in analytic solutions to practical and scientific problems. The reduced error logistic regression (RELR) method is proposed as such a "Calculus of Thought." This book reviews how RELR's completely automated processing may parallel important aspects of explicit and implicit learning in neural processes. It emphasizes the fact that RELR is really just a simple adjustment to already widely used logistic regression, along with RELR's new applications that go well beyond standard logistic regression in prediction and explanation. Readers will learn how RELR solves some of the most basic problems in today's big and small data related to high dimensionality, multi-colinearity, and cognitive bias in capricious outcomes commonly involving human behavior. Features include: provides a high-level introduction and detailed reviews of the neural, statistical and machine learning knowledge base as a foundation for a new era of smarter machines; argues that smarter machine learning to handle both explanation and prediction without cognitive bias must have a foundation in cognitive neuroscience and must embody similar explicit and implicit learning principles that occur in the brain; and offers a new neuromorphic foundation for machine learning based upon the reduced error logistic regression (RELR) method and provides simple examples of RELR computations in toy problems that can be accessed in spreadsheet workbooks through a companion website.
(source: Nielsen Book Data)
Book
online resource (xiii, 585 pages) : illustrations (some color) ; 26 cm
  • Part I. Neurohistological Techniques
  • Brain Tissue Preparation, Sectioning, and Staining / Jingdong Zhang and Huangui Xiong
  • Brain Stereotaxic Injection / Jingdong Zhang and Huangui Xiong
  • Neuronal Tract Tracing with Light and Electron Microscopy / Jingdong Zhang and Huangui Xiong
  • Stereological Analysis / Kristi M. Anderson, Adam M. Szlachetka and R. Lee Mosley
  • Part II. In Vitro Preparations
  • Preparation and Use of Rodent Hippocampal Slices / Huangui Xiong and Jianxun Xia
  • Single-Cell Neuronal Dissociation for Electrophysiological Studies / Yu-Long Li
  • Isolation and Culture of Human Neurons, Microglia, and Astrocytes / Li Wu and Santhi Gorantla
  • Isolation and Culture of Neural Stem/Progenitor Cells / Hui Peng, Qiang Chen and Jialin Zheng
  • Isolation of Mitochondria from Brain Tissue and Cells / Changhai Tian and Jialin Zheng
  • Isolation of Synaptosomes from Archived Brain Tissues / Gurudutt Pendyala, James L. Buescher and Howard S. Fox
  • Xenopus Oocytes Isolation and Microinjection / Huangui Xiong
  • Part III. Leukocyte Isolation and Application in Neuroscience
  • Centrifugal Elutriation for Studies of Neuroimmunity / Santhi Gorantla, Myhanh Che and Howard E. Gendelman
  • Flow Cytometry in Neuroscience Research / Charles Kuszynski
  • Part IV. Standard Laboratory Nucleic Acid and Protein Detections
  • Western Blotting Technique in Biomedical Research / Jianuo Liu, James Haorah and Huangui Xiong
  • Polymerase Chain Reaction (PCR) and Real-Time PCR / Georgette D. Kanmogne
  • Part V. Nanomedicine
  • Nanoformulations / Xin-Ming Liu and Tatiana K. Bronich
  • Neuronanomedicine / JoEllyn M. McMillan, Xin-Ming Liu and Howard E. Gendelman
  • Part VI. Bioimaging
  • Confocal Imaging of Nerve Cells / You Zhou
  • Magnetic Resonance Imaging / Yutong Liu
  • X-Ray, Positron Emission, and Single Photon Emission Tomographic Bioimaging / Katherine A. Estes, Jacob C. Peterson, Adam M. Szlachetka and R. Lee Mosley
  • Noninvasive Neurophysiological Imaging with Magnetoencephalography / Tony W. Wilson
  • Multiphoton Brain Imaging / Anna Dunaevsky
  • Part VII. Neuroelectrophysiology
  • Techniques for Extracellular Recordings / Jingdong Zhang, Jianxun Xia and Huangui Xiong
  • Blind Patch-Clamp Recordings from Rodent Hippocampal Slices / Jianxun Xia and Huangui Xiong
  • Whole-Cell Patch-Clamp Recording / Matthew J. Van Hook and Wallace B. Thoreson
  • Part VIII. Immunohistochemistry and Autoradiography
  • Analysis of Receptor Binding and Quantitative Autoradiography / L. Charles Murrin
  • Techniques in Immunohistochemistry and Immunocytochemistry / Yang Yuan and Jyothi Arikkath
  • Part IX. Analysis of Gene Expression
  • Protein Identification by Mass Spectrometry: Proteomics / Melinda Wojtkiewicz, Kelley Barnett and Pawel Ciborowski
  • DNA Microarrays as a Tool for Neurosciences Research / James D. Eudy, Lynette Smith
  • Metabolomics / Yazen Alnouti
  • Bioinformatic Methods and Resources for Neuroscience Research / Chittibabu Guda
  • Part X. Animal Models: Behavior and Pathology
  • Motor Function in Rodent Models of Neurodegenerative Disorders / Jessica A. Hutter Saunders, Max V. Kuenstling, Robert A. Weir, R. Lee Mosley and Howard E. Gendelman
  • Humanized Mice / Larisa Y. Poluektova and Edward Makarov
  • Animal Models for PD and ALS / Max V. Kuenstling, Adam M. Szlachetka and R. Lee Mosley
  • Animal Models of Alzheimer's Disease / Tomomi Kiyota
  • Animal Models: Behavior and Pathology: Preclinical Assessment of the Putative Cognitive Deficits in HAND / Landhing M. Moran, Rosemarie M. Booze and Charles F. Mactutus.
Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
  • Part I. Neurohistological Techniques
  • Brain Tissue Preparation, Sectioning, and Staining / Jingdong Zhang and Huangui Xiong
  • Brain Stereotaxic Injection / Jingdong Zhang and Huangui Xiong
  • Neuronal Tract Tracing with Light and Electron Microscopy / Jingdong Zhang and Huangui Xiong
  • Stereological Analysis / Kristi M. Anderson, Adam M. Szlachetka and R. Lee Mosley
  • Part II. In Vitro Preparations
  • Preparation and Use of Rodent Hippocampal Slices / Huangui Xiong and Jianxun Xia
  • Single-Cell Neuronal Dissociation for Electrophysiological Studies / Yu-Long Li
  • Isolation and Culture of Human Neurons, Microglia, and Astrocytes / Li Wu and Santhi Gorantla
  • Isolation and Culture of Neural Stem/Progenitor Cells / Hui Peng, Qiang Chen and Jialin Zheng
  • Isolation of Mitochondria from Brain Tissue and Cells / Changhai Tian and Jialin Zheng
  • Isolation of Synaptosomes from Archived Brain Tissues / Gurudutt Pendyala, James L. Buescher and Howard S. Fox
  • Xenopus Oocytes Isolation and Microinjection / Huangui Xiong
  • Part III. Leukocyte Isolation and Application in Neuroscience
  • Centrifugal Elutriation for Studies of Neuroimmunity / Santhi Gorantla, Myhanh Che and Howard E. Gendelman
  • Flow Cytometry in Neuroscience Research / Charles Kuszynski
  • Part IV. Standard Laboratory Nucleic Acid and Protein Detections
  • Western Blotting Technique in Biomedical Research / Jianuo Liu, James Haorah and Huangui Xiong
  • Polymerase Chain Reaction (PCR) and Real-Time PCR / Georgette D. Kanmogne
  • Part V. Nanomedicine
  • Nanoformulations / Xin-Ming Liu and Tatiana K. Bronich
  • Neuronanomedicine / JoEllyn M. McMillan, Xin-Ming Liu and Howard E. Gendelman
  • Part VI. Bioimaging
  • Confocal Imaging of Nerve Cells / You Zhou
  • Magnetic Resonance Imaging / Yutong Liu
  • X-Ray, Positron Emission, and Single Photon Emission Tomographic Bioimaging / Katherine A. Estes, Jacob C. Peterson, Adam M. Szlachetka and R. Lee Mosley
  • Noninvasive Neurophysiological Imaging with Magnetoencephalography / Tony W. Wilson
  • Multiphoton Brain Imaging / Anna Dunaevsky
  • Part VII. Neuroelectrophysiology
  • Techniques for Extracellular Recordings / Jingdong Zhang, Jianxun Xia and Huangui Xiong
  • Blind Patch-Clamp Recordings from Rodent Hippocampal Slices / Jianxun Xia and Huangui Xiong
  • Whole-Cell Patch-Clamp Recording / Matthew J. Van Hook and Wallace B. Thoreson
  • Part VIII. Immunohistochemistry and Autoradiography
  • Analysis of Receptor Binding and Quantitative Autoradiography / L. Charles Murrin
  • Techniques in Immunohistochemistry and Immunocytochemistry / Yang Yuan and Jyothi Arikkath
  • Part IX. Analysis of Gene Expression
  • Protein Identification by Mass Spectrometry: Proteomics / Melinda Wojtkiewicz, Kelley Barnett and Pawel Ciborowski
  • DNA Microarrays as a Tool for Neurosciences Research / James D. Eudy, Lynette Smith
  • Metabolomics / Yazen Alnouti
  • Bioinformatic Methods and Resources for Neuroscience Research / Chittibabu Guda
  • Part X. Animal Models: Behavior and Pathology
  • Motor Function in Rodent Models of Neurodegenerative Disorders / Jessica A. Hutter Saunders, Max V. Kuenstling, Robert A. Weir, R. Lee Mosley and Howard E. Gendelman
  • Humanized Mice / Larisa Y. Poluektova and Edward Makarov
  • Animal Models for PD and ALS / Max V. Kuenstling, Adam M. Szlachetka and R. Lee Mosley
  • Animal Models of Alzheimer's Disease / Tomomi Kiyota
  • Animal Models: Behavior and Pathology: Preclinical Assessment of the Putative Cognitive Deficits in HAND / Landhing M. Moran, Rosemarie M. Booze and Charles F. Mactutus.
Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
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Check Medical Library (Lane) catalog for status
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Book
1 online resource (xiii, 585 pages) : illustrations (some color)
  • Part I. Neurohistological Techniques
  • Brain Tissue Preparation, Sectioning, and Staining / Jingdong Zhang and Huangui Xiong
  • Brain Stereotaxic Injection / Jingdong Zhang and Huangui Xiong
  • Neuronal Tract Tracing with Light and Electron Microscopy / Jingdong Zhang and Huangui Xiong
  • Stereological Analysis / Kristi M. Anderson, Adam M. Szlachetka and R. Lee Mosley
  • Part II. In Vitro Preparations
  • Preparation and Use of Rodent Hippocampal Slices / Huangui Xiong and Jianxun Xia
  • Single-Cell Neuronal Dissociation for Electrophysiological Studies / Yu-Long Li
  • Isolation and Culture of Human Neurons, Microglia, and Astrocytes / Li Wu and Santhi Gorantla
  • Isolation and Culture of Neural Stem/Progenitor Cells / Hui Peng, Qiang Chen and Jialin Zheng
  • Isolation of Mitochondria from Brain Tissue and Cells / Changhai Tian and Jialin Zheng
  • Isolation of Synaptosomes from Archived Brain Tissues / Gurudutt Pendyala, James L. Buescher and Howard S. Fox
  • Xenopus Oocytes Isolation and Microinjection / Huangui Xiong
  • Part III. Leukocyte Isolation and Application in Neuroscience
  • Centrifugal Elutriation for Studies of Neuroimmunity / Santhi Gorantla, Myhanh Che and Howard E. Gendelman
  • Flow Cytometry in Neuroscience Research / Charles Kuszynski
  • Part IV. Standard Laboratory Nucleic Acid and Protein Detections
  • Western Blotting Technique in Biomedical Research / Jianuo Liu, James Haorah and Huangui Xiong
  • Polymerase Chain Reaction (PCR) and Real-Time PCR / Georgette D. Kanmogne
  • Part V. Nanomedicine
  • Nanoformulations / Xin-Ming Liu and Tatiana K. Bronich
  • Neuronanomedicine / JoEllyn M. McMillan, Xin-Ming Liu and Howard E. Gendelman
  • Part VI. Bioimaging
  • Confocal Imaging of Nerve Cells / You Zhou
  • Magnetic Resonance Imaging / Yutong Liu
  • X-Ray, Positron Emission, and Single Photon Emission Tomographic Bioimaging / Katherine A. Estes, Jacob C. Peterson, Adam M. Szlachetka and R. Lee Mosley
  • Noninvasive Neurophysiological Imaging with Magnetoencephalography / Tony W. Wilson
  • Multiphoton Brain Imaging / Anna Dunaevsky
  • Part VII. Neuroelectrophysiology
  • Techniques for Extracellular Recordings / Jingdong Zhang, Jianxun Xia and Huangui Xiong
  • Blind Patch-Clamp Recordings from Rodent Hippocampal Slices / Jianxun Xia and Huangui Xiong
  • Whole-Cell Patch-Clamp Recording / Matthew J. Van Hook and Wallace B. Thoreson
  • Part VIII. Immunohistochemistry and Autoradiography
  • Analysis of Receptor Binding and Quantitative Autoradiography / L. Charles Murrin
  • Techniques in Immunohistochemistry and Immunocytochemistry / Yang Yuan and Jyothi Arikkath
  • Part IX. Analysis of Gene Expression
  • Protein Identification by Mass Spectrometry: Proteomics / Melinda Wojtkiewicz, Kelley Barnett and Pawel Ciborowski
  • DNA Microarrays as a Tool for Neurosciences Research / James D. Eudy, Lynette Smith
  • Metabolomics / Yazen Alnouti
  • Bioinformatic Methods and Resources for Neuroscience Research / Chittibabu Guda
  • Part X. Animal Models: Behavior and Pathology
  • Motor Function in Rodent Models of Neurodegenerative Disorders / Jessica A. Hutter Saunders, Max V. Kuenstling, Robert A. Weir, R. Lee Mosley and Howard E. Gendelman
  • Humanized Mice / Larisa Y. Poluektova and Edward Makarov
  • Animal Models for PD and ALS / Max V. Kuenstling, Adam M. Szlachetka and R. Lee Mosley
  • Animal Models of Alzheimer's Disease / Tomomi Kiyota
  • Animal Models: Behavior and Pathology: Preclinical Assessment of the Putative Cognitive Deficits in HAND / Landhing M. Moran, Rosemarie M. Booze and Charles F. Mactutus.
Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
  • Part I. Neurohistological Techniques
  • Brain Tissue Preparation, Sectioning, and Staining / Jingdong Zhang and Huangui Xiong
  • Brain Stereotaxic Injection / Jingdong Zhang and Huangui Xiong
  • Neuronal Tract Tracing with Light and Electron Microscopy / Jingdong Zhang and Huangui Xiong
  • Stereological Analysis / Kristi M. Anderson, Adam M. Szlachetka and R. Lee Mosley
  • Part II. In Vitro Preparations
  • Preparation and Use of Rodent Hippocampal Slices / Huangui Xiong and Jianxun Xia
  • Single-Cell Neuronal Dissociation for Electrophysiological Studies / Yu-Long Li
  • Isolation and Culture of Human Neurons, Microglia, and Astrocytes / Li Wu and Santhi Gorantla
  • Isolation and Culture of Neural Stem/Progenitor Cells / Hui Peng, Qiang Chen and Jialin Zheng
  • Isolation of Mitochondria from Brain Tissue and Cells / Changhai Tian and Jialin Zheng
  • Isolation of Synaptosomes from Archived Brain Tissues / Gurudutt Pendyala, James L. Buescher and Howard S. Fox
  • Xenopus Oocytes Isolation and Microinjection / Huangui Xiong
  • Part III. Leukocyte Isolation and Application in Neuroscience
  • Centrifugal Elutriation for Studies of Neuroimmunity / Santhi Gorantla, Myhanh Che and Howard E. Gendelman
  • Flow Cytometry in Neuroscience Research / Charles Kuszynski
  • Part IV. Standard Laboratory Nucleic Acid and Protein Detections
  • Western Blotting Technique in Biomedical Research / Jianuo Liu, James Haorah and Huangui Xiong
  • Polymerase Chain Reaction (PCR) and Real-Time PCR / Georgette D. Kanmogne
  • Part V. Nanomedicine
  • Nanoformulations / Xin-Ming Liu and Tatiana K. Bronich
  • Neuronanomedicine / JoEllyn M. McMillan, Xin-Ming Liu and Howard E. Gendelman
  • Part VI. Bioimaging
  • Confocal Imaging of Nerve Cells / You Zhou
  • Magnetic Resonance Imaging / Yutong Liu
  • X-Ray, Positron Emission, and Single Photon Emission Tomographic Bioimaging / Katherine A. Estes, Jacob C. Peterson, Adam M. Szlachetka and R. Lee Mosley
  • Noninvasive Neurophysiological Imaging with Magnetoencephalography / Tony W. Wilson
  • Multiphoton Brain Imaging / Anna Dunaevsky
  • Part VII. Neuroelectrophysiology
  • Techniques for Extracellular Recordings / Jingdong Zhang, Jianxun Xia and Huangui Xiong
  • Blind Patch-Clamp Recordings from Rodent Hippocampal Slices / Jianxun Xia and Huangui Xiong
  • Whole-Cell Patch-Clamp Recording / Matthew J. Van Hook and Wallace B. Thoreson
  • Part VIII. Immunohistochemistry and Autoradiography
  • Analysis of Receptor Binding and Quantitative Autoradiography / L. Charles Murrin
  • Techniques in Immunohistochemistry and Immunocytochemistry / Yang Yuan and Jyothi Arikkath
  • Part IX. Analysis of Gene Expression
  • Protein Identification by Mass Spectrometry: Proteomics / Melinda Wojtkiewicz, Kelley Barnett and Pawel Ciborowski
  • DNA Microarrays as a Tool for Neurosciences Research / James D. Eudy, Lynette Smith
  • Metabolomics / Yazen Alnouti
  • Bioinformatic Methods and Resources for Neuroscience Research / Chittibabu Guda
  • Part X. Animal Models: Behavior and Pathology
  • Motor Function in Rodent Models of Neurodegenerative Disorders / Jessica A. Hutter Saunders, Max V. Kuenstling, Robert A. Weir, R. Lee Mosley and Howard E. Gendelman
  • Humanized Mice / Larisa Y. Poluektova and Edward Makarov
  • Animal Models for PD and ALS / Max V. Kuenstling, Adam M. Szlachetka and R. Lee Mosley
  • Animal Models of Alzheimer's Disease / Tomomi Kiyota
  • Animal Models: Behavior and Pathology: Preclinical Assessment of the Putative Cognitive Deficits in HAND / Landhing M. Moran, Rosemarie M. Booze and Charles F. Mactutus.
Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
Book
1 online resource.
Mathematical Neuroscience is a book for mathematical biologists seeking to discover the complexities of brain dynamics in an integrative way. It is the first research monograph devoted exclusively to the theory and methods of nonlinear analysis of infinite systems based on functional analysis techniques arising in modern mathematics. Neural models that describe the spatio-temporal evolution of coarse-grained variables - such as synaptic or firing rate activity in populations of neurons - and often take the form of integro-differential equations would not normally reflect an integrative approach. This book examines the solvability of infinite systems of reaction diffusion type equations in partially ordered abstract spaces. It considers various methods and techniques of nonlinear analysis, including comparison theorems, monotone iterative techniques, a truncation method, and topological fixed point methods. Infinite systems of such equations play a crucial role in the integrative aspects of neuroscience modeling. The first focused introduction to the use of nonlinear analysis with an infinite dimensional approach to theoretical neuroscience. It combines functional analysis techniques with nonlinear dynamical systems applied to the study of the brain. It introduces powerful mathematical techniques to manage the dynamics and challenges of infinite systems of equations applied to neuroscience modeling.
(source: Nielsen Book Data)
Mathematical Neuroscience is a book for mathematical biologists seeking to discover the complexities of brain dynamics in an integrative way. It is the first research monograph devoted exclusively to the theory and methods of nonlinear analysis of infinite systems based on functional analysis techniques arising in modern mathematics. Neural models that describe the spatio-temporal evolution of coarse-grained variables - such as synaptic or firing rate activity in populations of neurons - and often take the form of integro-differential equations would not normally reflect an integrative approach. This book examines the solvability of infinite systems of reaction diffusion type equations in partially ordered abstract spaces. It considers various methods and techniques of nonlinear analysis, including comparison theorems, monotone iterative techniques, a truncation method, and topological fixed point methods. Infinite systems of such equations play a crucial role in the integrative aspects of neuroscience modeling. The first focused introduction to the use of nonlinear analysis with an infinite dimensional approach to theoretical neuroscience. It combines functional analysis techniques with nonlinear dynamical systems applied to the study of the brain. It introduces powerful mathematical techniques to manage the dynamics and challenges of infinite systems of equations applied to neuroscience modeling.
(source: Nielsen Book Data)
Book
1 online resource (ix, 220 pages) : illustrations (some color)
  • Biological roots of aggression Animal aggression
  • Heritability and genetic bases
  • The aggressive brain
  • The hormonal milieu
  • Aggression across the lifespan
  • development and functions
  • Aggression as a factor of temperament
  • Human aggression Biological background and social functions
  • Deviations from the norm
  • Criminal aggression
  • Aggression-related psychiatric disorders
  • Treatments
  • from psychosurgery to medications.-Neural mechanisms of abnormal aggression Psychiatric disorders and laboratory models
  • theoretical considerations
  • Neural background of abnormal aggression in laboratory models
  • Genetic models
  • Neurodevelopmental models
  • Hormonal models
  • Neural backgrounds
  • common and distinctive features
  • Abnormal aggression in people
  • Gene polymorphisms
  • Brain imaging
  • Hormones
  • Biology and psychopathology
  • an integrative view on aggression.
Mechanisms controlling aggressive behavior started to be identified from late 20's of the 20th century, and subsequent research described such mechanisms in great detail. While the findings are of great relevance for the understanding of aggression per se, they provide limited insights into the mechanisms of abnormal aggression i.e. those mechanisms that underlie aggression-related psychopathologies. While basic phenomena and mechanism of aggression are presented in this book, it is the first that comprehensively describes ultimate and proximate mechanisms that transform normal (laboratory animals) or tolerable (humans) manifestations of aggressiveness into abnormal patterns in laboratory animals and aggression-related psychopathologies in humans. This book is written for behavioral neurobiologists and neuroscientists, interested in social behavior in general and aggressive behavior in particular. The book will also offer important information to neurologists and psychiatrists dealing with aggressive behavior in the clinic and ultimately, may provide means to understand, and on the long run, to discover novel approaches to the treatment of abnormal human aggression.
  • Biological roots of aggression Animal aggression
  • Heritability and genetic bases
  • The aggressive brain
  • The hormonal milieu
  • Aggression across the lifespan
  • development and functions
  • Aggression as a factor of temperament
  • Human aggression Biological background and social functions
  • Deviations from the norm
  • Criminal aggression
  • Aggression-related psychiatric disorders
  • Treatments
  • from psychosurgery to medications.-Neural mechanisms of abnormal aggression Psychiatric disorders and laboratory models
  • theoretical considerations
  • Neural background of abnormal aggression in laboratory models
  • Genetic models
  • Neurodevelopmental models
  • Hormonal models
  • Neural backgrounds
  • common and distinctive features
  • Abnormal aggression in people
  • Gene polymorphisms
  • Brain imaging
  • Hormones
  • Biology and psychopathology
  • an integrative view on aggression.
Mechanisms controlling aggressive behavior started to be identified from late 20's of the 20th century, and subsequent research described such mechanisms in great detail. While the findings are of great relevance for the understanding of aggression per se, they provide limited insights into the mechanisms of abnormal aggression i.e. those mechanisms that underlie aggression-related psychopathologies. While basic phenomena and mechanism of aggression are presented in this book, it is the first that comprehensively describes ultimate and proximate mechanisms that transform normal (laboratory animals) or tolerable (humans) manifestations of aggressiveness into abnormal patterns in laboratory animals and aggression-related psychopathologies in humans. This book is written for behavioral neurobiologists and neuroscientists, interested in social behavior in general and aggressive behavior in particular. The book will also offer important information to neurologists and psychiatrists dealing with aggressive behavior in the clinic and ultimately, may provide means to understand, and on the long run, to discover novel approaches to the treatment of abnormal human aggression.
Book
1 online resource (xii, 132 pages) : illustrations (some color) Digital: text file; PDF.
  • Opioid and Non-Opioid Drug Responding Under States of Chronic Pain: A Timeline Spanning 1980 to Present Day
  • Opioid Self-Administration in the Presence of Chronic Pain: Analgesia or Addiction
  • The Influence of Pain on Reward Processing: Current Literature and Prospects
  • Chronic Pain Stimuli Downregulate Mesolimbic Dopaminergic Transmission: Possible Mechanism of the Suppression of Opioid Reward
  • Drug Addiction and Chronic Pain: A Review of Animal Models
  • Biopharmaceutical Considerations of Opioid Analgesics in Models of Self-Administration: Review and Summary
  • Prenatal Exposure to Opioids
  • Opioids in an Evidence-Based World.
Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.
(source: Nielsen Book Data)
  • Opioid and Non-Opioid Drug Responding Under States of Chronic Pain: A Timeline Spanning 1980 to Present Day
  • Opioid Self-Administration in the Presence of Chronic Pain: Analgesia or Addiction
  • The Influence of Pain on Reward Processing: Current Literature and Prospects
  • Chronic Pain Stimuli Downregulate Mesolimbic Dopaminergic Transmission: Possible Mechanism of the Suppression of Opioid Reward
  • Drug Addiction and Chronic Pain: A Review of Animal Models
  • Biopharmaceutical Considerations of Opioid Analgesics in Models of Self-Administration: Review and Summary
  • Prenatal Exposure to Opioids
  • Opioids in an Evidence-Based World.
Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.
(source: Nielsen Book Data)
Book
1 online resource (1 v.) : ill.
The world of coaching is competitive. Organisations want coaches who deliver results, and can prove it. Many coaching tools and techniques are now fairly well established - but how do they actually work? The coach who can answer this question credibly and convincingly is sought after. This ground-breaking book equips coaches with cutting edge neuroscience information that will help them deliver greater value to their clients. It covers the foundations that coaches need to be aware of and crucially, the ways they can use this new information effectively and practically in their everyday work. Readers will strengthen their kitbag of coaching tools and will be able to explain to their clients the neurological underpinning of the techniques they are using. No forward-thinking coach can afford to be ignorant of recent scientific developments: Neuroscience for Coaches will give them the practical knowledge they need.
(source: Nielsen Book Data)
The world of coaching is competitive. Organisations want coaches who deliver results, and can prove it. Many coaching tools and techniques are now fairly well established - but how do they actually work? The coach who can answer this question credibly and convincingly is sought after. This ground-breaking book equips coaches with cutting edge neuroscience information that will help them deliver greater value to their clients. It covers the foundations that coaches need to be aware of and crucially, the ways they can use this new information effectively and practically in their everyday work. Readers will strengthen their kitbag of coaching tools and will be able to explain to their clients the neurological underpinning of the techniques they are using. No forward-thinking coach can afford to be ignorant of recent scientific developments: Neuroscience for Coaches will give them the practical knowledge they need.
(source: Nielsen Book Data)
Book
1 online resource (x, 174 pages) : illustrations (some color)
  • 1 Introduction (Kazunori Sango and Junji Yamauchi)
  • 2 Recent insights into molecular mechanisms that control growth factor receptor-mediated Schwann cell morphological changes during development (Yuki Miyamoto and Junji Yamauchi)
  • 3 Membrane Skeleton in Schmidt-Lanterman Incisure in Schwann cells of Peripheral Nervous System (Nobuo Terada, Yurika Saitoh, Nobuhiko Ohno, and Shinichi Ohno)
  • 4 Schwann cell-axon interactions: the molecular and metabolic link between Schwann cells and axons (Nobuhiko Ohno, Takashi Sakoh, Yurika Saitoh, Nobuo Terada, and Shinichi Ohno)
  • 5 Schwann cell-dependent regulation of peripheral nerve injury and repair (Keiichiro Susuki)
  • 6 Charcot-Marie-Tooth disease (Toru Ogata)
  • 7 Expression of the transthyretin gene in Schwann cells, and familial amyloidotic polyneuropathy-mediated neurodegeneration (Tatsufumi Murakami and Yoshihide Sunada)
  • 8 Node of Ranvier disruption: a key pathophysiology in immune-mediated neuropathies (Keiichiro Susuki)
  • 9 Pathogenesis of diabetic neuropathy from the viewpoint of Schwann cell abnormalities (Koichi Kato, Eva L. Feldman, and Jiro Nakamura)
  • 10 Spontaneously immortalized adult rodent Schwann cells as valuable tools for the study of peripheral nerve degeneration and regeneration (Kazunori Sango, Masami Tsukamoto, Kazunori Utsunomiya, and Kazuhiko Watabe)
  • BM Index.
This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot?Marie?Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy, and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies, have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop, a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students, and young clinicians.
  • 1 Introduction (Kazunori Sango and Junji Yamauchi)
  • 2 Recent insights into molecular mechanisms that control growth factor receptor-mediated Schwann cell morphological changes during development (Yuki Miyamoto and Junji Yamauchi)
  • 3 Membrane Skeleton in Schmidt-Lanterman Incisure in Schwann cells of Peripheral Nervous System (Nobuo Terada, Yurika Saitoh, Nobuhiko Ohno, and Shinichi Ohno)
  • 4 Schwann cell-axon interactions: the molecular and metabolic link between Schwann cells and axons (Nobuhiko Ohno, Takashi Sakoh, Yurika Saitoh, Nobuo Terada, and Shinichi Ohno)
  • 5 Schwann cell-dependent regulation of peripheral nerve injury and repair (Keiichiro Susuki)
  • 6 Charcot-Marie-Tooth disease (Toru Ogata)
  • 7 Expression of the transthyretin gene in Schwann cells, and familial amyloidotic polyneuropathy-mediated neurodegeneration (Tatsufumi Murakami and Yoshihide Sunada)
  • 8 Node of Ranvier disruption: a key pathophysiology in immune-mediated neuropathies (Keiichiro Susuki)
  • 9 Pathogenesis of diabetic neuropathy from the viewpoint of Schwann cell abnormalities (Koichi Kato, Eva L. Feldman, and Jiro Nakamura)
  • 10 Spontaneously immortalized adult rodent Schwann cells as valuable tools for the study of peripheral nerve degeneration and regeneration (Kazunori Sango, Masami Tsukamoto, Kazunori Utsunomiya, and Kazuhiko Watabe)
  • BM Index.
This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot?Marie?Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy, and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies, have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop, a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students, and young clinicians.
Book
1 online resource (XIV, 274 p. 97 ill., 63 illus. in color.) : ill. Digital: text file; PDF.
  • Chapter 1: Translating Physiological Knowledge to Health Application.- Chapter 2: Translational Research: Journey from Traditional Wisdom to Rational Science.- Chapter 3: Stress Research Varied Paradigms.- Chapter 4: Therapeutic Potential of Intermittent Hypoxia: Lessons from Respiratory Motor Plasticity.- Chapter 5: High Altitude Research and its Practical Clinical Application.- Chapter 6: Nanomaterials in Healthcare.- Chapter 7: Nano toxicity and Cellular Stress Response: Physical and Chemical Properties and Their Link to Translational Research.- Chapter 8 : HIF-1 and EGLN1 Under Hypobaric Hypoxia: Regulation of Master Regulator Paradigm.- Chapter 9: Electrochemical Biosensors for Hypoxia Markers.- Chapter 10 : Determining Nutritional Requirements of Indian Soldiers an Outcome of Translational Research.- Chapter 11 : Improvements in Adjuvants for New Generation Vaccines.- Chapter 12: Rapid Acclimatization Strategies for High Altitude Induction.- Chapter 13 : Noise the Silent Killer.- Chapter 14: Yoga for Preventive, Curative and Promotive Health and Performance.- Chapter 15: Technology Translation from Heat Physiology Research.- Chapter 16: Improving Habitability at High Altitude.- Chapter 17: Inhaled Nitric Oxide Therapy for Treatment of High Altitude Pulmonary Edema.- Chapter 18: High Altitude Medicine: The Path from Genomic Insight to Clinical Application.- Chapter 19 : Hypoxia in Acute Chemical Emergencies: Toxicity, Mechanism and Treatment.- Chapter 20: Hypertension at High Altitude.- Chapter 21: Herbs for Mitigating High Altitude Maladies.- Chapter 22 : Lessons from Twenty Years' Investigations of Intermittent Hypoxia : Principles and Practices.
  • (source: Nielsen Book Data)
Cutting edge technologies can propel a simple finding in basic science to a concept that can be of immense value to the society. While applying novel techniques to unravel the mysteries of biological processes, an offshoot of applied branch emerged. This field, which is now widely referred to as Translational Research utilizes basic science findings and translates these findings into innovative concepts for the benefit of mankind. This branch of science has evolved into a multidisciplinary juggernaut encompassing all known fields of science as varied as biomedicine, environment, law, economics, sociology, etc. With the ever increasing interest in this branch and the dreams and aspirations that this field can bring, basic science researchers are now taking a bold step into this new realm, merging different fields of knowledge to come up with novel inventions. This book "Translational research in environmental and occupational stress" provides and insight into the research that led to discoveries, inventions and development of novel technologies which will have a tremendous impact on the future of mankind.
(source: Nielsen Book Data)
  • Chapter 1: Translating Physiological Knowledge to Health Application.- Chapter 2: Translational Research: Journey from Traditional Wisdom to Rational Science.- Chapter 3: Stress Research Varied Paradigms.- Chapter 4: Therapeutic Potential of Intermittent Hypoxia: Lessons from Respiratory Motor Plasticity.- Chapter 5: High Altitude Research and its Practical Clinical Application.- Chapter 6: Nanomaterials in Healthcare.- Chapter 7: Nano toxicity and Cellular Stress Response: Physical and Chemical Properties and Their Link to Translational Research.- Chapter 8 : HIF-1 and EGLN1 Under Hypobaric Hypoxia: Regulation of Master Regulator Paradigm.- Chapter 9: Electrochemical Biosensors for Hypoxia Markers.- Chapter 10 : Determining Nutritional Requirements of Indian Soldiers an Outcome of Translational Research.- Chapter 11 : Improvements in Adjuvants for New Generation Vaccines.- Chapter 12: Rapid Acclimatization Strategies for High Altitude Induction.- Chapter 13 : Noise the Silent Killer.- Chapter 14: Yoga for Preventive, Curative and Promotive Health and Performance.- Chapter 15: Technology Translation from Heat Physiology Research.- Chapter 16: Improving Habitability at High Altitude.- Chapter 17: Inhaled Nitric Oxide Therapy for Treatment of High Altitude Pulmonary Edema.- Chapter 18: High Altitude Medicine: The Path from Genomic Insight to Clinical Application.- Chapter 19 : Hypoxia in Acute Chemical Emergencies: Toxicity, Mechanism and Treatment.- Chapter 20: Hypertension at High Altitude.- Chapter 21: Herbs for Mitigating High Altitude Maladies.- Chapter 22 : Lessons from Twenty Years' Investigations of Intermittent Hypoxia : Principles and Practices.
  • (source: Nielsen Book Data)
Cutting edge technologies can propel a simple finding in basic science to a concept that can be of immense value to the society. While applying novel techniques to unravel the mysteries of biological processes, an offshoot of applied branch emerged. This field, which is now widely referred to as Translational Research utilizes basic science findings and translates these findings into innovative concepts for the benefit of mankind. This branch of science has evolved into a multidisciplinary juggernaut encompassing all known fields of science as varied as biomedicine, environment, law, economics, sociology, etc. With the ever increasing interest in this branch and the dreams and aspirations that this field can bring, basic science researchers are now taking a bold step into this new realm, merging different fields of knowledge to come up with novel inventions. This book "Translational research in environmental and occupational stress" provides and insight into the research that led to discoveries, inventions and development of novel technologies which will have a tremendous impact on the future of mankind.
(source: Nielsen Book Data)
Book
1 online resource.
  • Introductory concepts
  • Making Sense of Stress: An Evolutionary--Developmental Framework / Marco Del Giudice, Bruce J. Ellis, Elizabeth A. Shirtcliff
  • Prenatal and Maternal Psychosocial Stress in Primates: Adaptive Plasticity or Vulnerability to Pathology? / Dario Maestripieri, Amanda C. E. Klimczuk
  • Adaptive and maladaptive consequences of developmental stress in humans
  • The Everyday Stress Resilience Hypothesis: Unfolding Resilience from a Perspective of Everyday Stress and Coping / Jennifer A. DiCorcia, Akhila V. Sravish, Ed Tronick
  • Ontogeny of Stress Reactivity in the Human Child: Phenotypic Flexibility, Trade-Offs, and Pathology / Mark V. Flinn, Davide Ponzi, Pablo Nepomnaschy, Robert Noone
  • Consequences of Developmental Stress in Humans: Prenatal Stress / Nadine Skoluda, Urs M. Nater
  • Consequences of Developmental Stress in Humans: Adversity Experienced During Childhood and Adolescence / Urs M. Nater, Nadine Skoluda
  • Adaptive and maladaptive consequences of developmental stress in animal models
  • Behavioural and Neuroendocrine Consequences of Prenatal Stress in Rat / Sara Morley-Fletcher, Jérôme Mairesse, Stefania Maccari
  • Developmental Consequences of Prenatal Administration of Glucocorticoids in Rodents and Primates / Jonas Hauser
  • Early Developmental Trajectories of Brain Development: New Directions in the Search for Early Determinants of Health and Longevity / F. Cirulli, A. Berry
  • Adaptive Regulations in Developing Rodents Following Neonatal Challenges / Laurence Coutellier
  • Adaptive and Maladaptive Regulations in Response to Environmental Stress in Adolescent Rodents / Simone Macrì, Giovanni Laviola
  • Oxidative Stress and Hormetic Responses in the Early Life of Birds / David Costantini.
  • Introductory concepts
  • Making Sense of Stress: An Evolutionary--Developmental Framework / Marco Del Giudice, Bruce J. Ellis, Elizabeth A. Shirtcliff
  • Prenatal and Maternal Psychosocial Stress in Primates: Adaptive Plasticity or Vulnerability to Pathology? / Dario Maestripieri, Amanda C. E. Klimczuk
  • Adaptive and maladaptive consequences of developmental stress in humans
  • The Everyday Stress Resilience Hypothesis: Unfolding Resilience from a Perspective of Everyday Stress and Coping / Jennifer A. DiCorcia, Akhila V. Sravish, Ed Tronick
  • Ontogeny of Stress Reactivity in the Human Child: Phenotypic Flexibility, Trade-Offs, and Pathology / Mark V. Flinn, Davide Ponzi, Pablo Nepomnaschy, Robert Noone
  • Consequences of Developmental Stress in Humans: Prenatal Stress / Nadine Skoluda, Urs M. Nater
  • Consequences of Developmental Stress in Humans: Adversity Experienced During Childhood and Adolescence / Urs M. Nater, Nadine Skoluda
  • Adaptive and maladaptive consequences of developmental stress in animal models
  • Behavioural and Neuroendocrine Consequences of Prenatal Stress in Rat / Sara Morley-Fletcher, Jérôme Mairesse, Stefania Maccari
  • Developmental Consequences of Prenatal Administration of Glucocorticoids in Rodents and Primates / Jonas Hauser
  • Early Developmental Trajectories of Brain Development: New Directions in the Search for Early Determinants of Health and Longevity / F. Cirulli, A. Berry
  • Adaptive Regulations in Developing Rodents Following Neonatal Challenges / Laurence Coutellier
  • Adaptive and Maladaptive Regulations in Response to Environmental Stress in Adolescent Rodents / Simone Macrì, Giovanni Laviola
  • Oxidative Stress and Hormetic Responses in the Early Life of Birds / David Costantini.
Book
1 online resource.
  • Part 1. Introduction
  • Adenosine and Metabolism--A Brief Historical Note / Bertil B. Fredholm. Part 2. Molecular biology, pharmacology, and cell biology of adenosine
  • Adenosine Metabolism, Adenosine Kinase, and Evolution / Jaoek Park and Radhey S. Gupta
  • Adenosine and Energy Metabolism--Relationship to Brain Bioenergetics / Xuesong Chen, Liang Hui and Jonathan D. Geiger
  • Adenosine and Autocrine Metabolic Regulation of Neuronal Activity / Masahito Kawamura Jr. and David N. Ruskin
  • Physiologic and Metabolic Regulation of Adenosine: Mechanisms / Chris G. Dulla and Susan A. Masino
  • The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books / Stephanie zur Nedden, Alexander S. Doney and Bruno G. Frenguelli
  • Downstream Pathways of Adenosine / Ana M. Sebastião, Sofia Cristóvão-Ferreira and Joaquim A. Ribeiro
  • Astrocytic ATP Release / Dustin J. Hines and Philip G. Haydon
  • Role of Striatal A2A Receptor Subpopulations in Neurological Disorders / Sergi Ferré, César Quiroz, Marco Orrú, Xavier Guitart and Seema Gulyani, et al..
  • Part 3. Adenosine function and dysfunction in brain health and disease
  • Sleep and Adenosine: Human Studies / Tarja Porkka-Heiskanen
  • Adenosine and Other Purinergic Products in Circadian Timing / Christine Muheim and Steven A. Brown
  • Adenosine in the Immune System / György Haskó, Balázs Koscsó and Balázs Csóka
  • The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation / Kelly L. Drew and Tulasi R. Jinka
  • Adenosine and Stroke / Felicita Pedata, Anna Maria Pugliese, Francesca Corti and Alessia Melani
  • The Many Roles of Adenosine in Traumatic Brain Injury / Patrick M. Kochanek, Jonathan D. Verrier, Amy K. Wagner and Edwin K. Jackson
  • Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitution After Spinal Cord Injury / Kwaku D. Nantwi
  • Adenosine and Pain / Jana Sawynok
  • Symptomatic and Neuroprotective Effects of A2A Receptor Antagonists in Parkinson's Disease / Annalisa Pinna, Nicola Simola, Lucia Frau and Micaela Morelli
  • Adenosine Receptors and Alzheimer's Disease / David Blum, Ursula Sandau, Cyril Laurent, Vânia Batalha and Antoine Leboucher, et al.
  • Adenosine Receptors in Huntington's Disease / David Blum, Alberto Martire, Sylvie Burnouf, Bernard Sablonnière and Pierre Krystkowiak, et al.
  • Adenosine and Multiple Sclerosis / María Victoria Sánchez-Gómez, Estibaliz González-Fernández, Rogelio O. Arellano and Carlos Matute
  • Adenosinergic Perspectives on Schizophrenia: Opportunity for an Integrative Synthesis / Benjamin K. Yee, Philipp Singer and Detlev Boison
  • The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation / John D. Salamone, Merce Correa, Patrick A. Randall, Eric J. Nunes and Marta Pardo, et al.
  • Adenosine and Autism: Physiological Symptoms and Metabolic Opportunities / Julia Svedova, Inge-Marie Eigsti and Susan A. Masino
  • Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes / Traci N. Plumb, Sarah R. Sterlace, Kelly A. Cavanaugh and Thomas R. Minor.
  • Part 4. Adenosine-based therapies
  • Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation / Detlev Boison
  • Ketogenic Diet and Epilepsy: The Role of Adenosine / Jong M. Rho, Beth Zupec-Kania and Susan A. Masino
  • Silk: A Biocompatible and Biodegradable Biopolymer for Therapeutic Adenosine Delivery / Eleanor M. Pritchard, Detlev Boison and David L. Kaplan
  • Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy / Zsolt Kovács and Arpád Dobolyi.
  • Part 1. Introduction
  • Adenosine and Metabolism--A Brief Historical Note / Bertil B. Fredholm. Part 2. Molecular biology, pharmacology, and cell biology of adenosine
  • Adenosine Metabolism, Adenosine Kinase, and Evolution / Jaoek Park and Radhey S. Gupta
  • Adenosine and Energy Metabolism--Relationship to Brain Bioenergetics / Xuesong Chen, Liang Hui and Jonathan D. Geiger
  • Adenosine and Autocrine Metabolic Regulation of Neuronal Activity / Masahito Kawamura Jr. and David N. Ruskin
  • Physiologic and Metabolic Regulation of Adenosine: Mechanisms / Chris G. Dulla and Susan A. Masino
  • The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books / Stephanie zur Nedden, Alexander S. Doney and Bruno G. Frenguelli
  • Downstream Pathways of Adenosine / Ana M. Sebastião, Sofia Cristóvão-Ferreira and Joaquim A. Ribeiro
  • Astrocytic ATP Release / Dustin J. Hines and Philip G. Haydon
  • Role of Striatal A2A Receptor Subpopulations in Neurological Disorders / Sergi Ferré, César Quiroz, Marco Orrú, Xavier Guitart and Seema Gulyani, et al..
  • Part 3. Adenosine function and dysfunction in brain health and disease
  • Sleep and Adenosine: Human Studies / Tarja Porkka-Heiskanen
  • Adenosine and Other Purinergic Products in Circadian Timing / Christine Muheim and Steven A. Brown
  • Adenosine in the Immune System / György Haskó, Balázs Koscsó and Balázs Csóka
  • The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation / Kelly L. Drew and Tulasi R. Jinka
  • Adenosine and Stroke / Felicita Pedata, Anna Maria Pugliese, Francesca Corti and Alessia Melani
  • The Many Roles of Adenosine in Traumatic Brain Injury / Patrick M. Kochanek, Jonathan D. Verrier, Amy K. Wagner and Edwin K. Jackson
  • Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitution After Spinal Cord Injury / Kwaku D. Nantwi
  • Adenosine and Pain / Jana Sawynok
  • Symptomatic and Neuroprotective Effects of A2A Receptor Antagonists in Parkinson's Disease / Annalisa Pinna, Nicola Simola, Lucia Frau and Micaela Morelli
  • Adenosine Receptors and Alzheimer's Disease / David Blum, Ursula Sandau, Cyril Laurent, Vânia Batalha and Antoine Leboucher, et al.
  • Adenosine Receptors in Huntington's Disease / David Blum, Alberto Martire, Sylvie Burnouf, Bernard Sablonnière and Pierre Krystkowiak, et al.
  • Adenosine and Multiple Sclerosis / María Victoria Sánchez-Gómez, Estibaliz González-Fernández, Rogelio O. Arellano and Carlos Matute
  • Adenosinergic Perspectives on Schizophrenia: Opportunity for an Integrative Synthesis / Benjamin K. Yee, Philipp Singer and Detlev Boison
  • The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation / John D. Salamone, Merce Correa, Patrick A. Randall, Eric J. Nunes and Marta Pardo, et al.
  • Adenosine and Autism: Physiological Symptoms and Metabolic Opportunities / Julia Svedova, Inge-Marie Eigsti and Susan A. Masino
  • Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes / Traci N. Plumb, Sarah R. Sterlace, Kelly A. Cavanaugh and Thomas R. Minor.
  • Part 4. Adenosine-based therapies
  • Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation / Detlev Boison
  • Ketogenic Diet and Epilepsy: The Role of Adenosine / Jong M. Rho, Beth Zupec-Kania and Susan A. Masino
  • Silk: A Biocompatible and Biodegradable Biopolymer for Therapeutic Adenosine Delivery / Eleanor M. Pritchard, Detlev Boison and David L. Kaplan
  • Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy / Zsolt Kovács and Arpád Dobolyi.
Book
1 online resource : ill.
  • How Autistic Persons Understand Words (Cerebral Organization of Word Meaning and Autism)
  • How Autistic Persons Perceive the World (Sensory-Motor Function Level in the Brain and Autism)
  • How Autistic Persons Perceive Faces (Cerebral Organization of Face Recognition and Autism)
  • How Autistic Persons Act in the World (Cerebral Organization of Movements and Autism)
  • How Autistic Persons Perceive Space and Spatial Relations (Where System in the Brain and Autism)
  • How Autistic Persons Feel (Cerebral Organization of Limbic Emotion and Autism)
  • Autistic Persons' Sense of Self (Cerebral Organization of Self and Autism)
  • The Left-Hemispheric Self in Autism Revisited
  • Pieces of Autism's Puzzle Fall into Place (Clinical-Brain Pattern of Autism).
  • How Autistic Persons Understand Words (Cerebral Organization of Word Meaning and Autism)
  • How Autistic Persons Perceive the World (Sensory-Motor Function Level in the Brain and Autism)
  • How Autistic Persons Perceive Faces (Cerebral Organization of Face Recognition and Autism)
  • How Autistic Persons Act in the World (Cerebral Organization of Movements and Autism)
  • How Autistic Persons Perceive Space and Spatial Relations (Where System in the Brain and Autism)
  • How Autistic Persons Feel (Cerebral Organization of Limbic Emotion and Autism)
  • Autistic Persons' Sense of Self (Cerebral Organization of Self and Autism)
  • The Left-Hemispheric Self in Autism Revisited
  • Pieces of Autism's Puzzle Fall into Place (Clinical-Brain Pattern of Autism).