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Book
1 online resource : illustrations (chiefly color)
  • * Anatomy of the eye and orbit. * Embryology and early development of the eye and adnexia. * Genetics. * Biochemistry and cell biology. * Physiology of vision and the visual system. * General and ocular pharmacology. * Immunology. * Microbiology and infection. * Pathology.* Index.
  • (source: Nielsen Book Data)
The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. For the first time, this (print) edition also now comes with bonus access to the complete, fully searchable electronic text - including carefully selected additional information and new video content to further explain and expand on key concepts - making The Eye a more flexible, comprehensive and engaging learning package than ever before.
(source: Nielsen Book Data)
  • * Anatomy of the eye and orbit. * Embryology and early development of the eye and adnexia. * Genetics. * Biochemistry and cell biology. * Physiology of vision and the visual system. * General and ocular pharmacology. * Immunology. * Microbiology and infection. * Pathology.* Index.
  • (source: Nielsen Book Data)
The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. For the first time, this (print) edition also now comes with bonus access to the complete, fully searchable electronic text - including carefully selected additional information and new video content to further explain and expand on key concepts - making The Eye a more flexible, comprehensive and engaging learning package than ever before.
(source: Nielsen Book Data)
Book
1 online resource. Digital: text file; PDF.
  • Part I. Human Peripheral Nerve.- 1. Ultrastructure of Myelinated and Unmyelinated Axons.- 2. Macrophages, Mastocytes, and Plasma Cells.- 3. Ultrastructure of the Endoneurium.- 4. Ultrastructure of the Perineurium.- 5. Ultrastructure of the Epineurium .- 6. Origin of the Fascicles and Intraneural Plexus.- 7. Macroscopic View of the Cervical Plexus and Brachial Plexus.- 8. Anna Carrera, Francisco Reina.- 9. Macroscopic View of the Lumbar Plexus and Sacral Plexus.- 10. Cross-sectional Microscopic Anatomy of the Sciatic Nerve and its Dissected Branches.- 11. Cross-sectional Microscopic Anatomy of the Sciatic Nerve and Paraneural Sheaths.- 12. Computerized Tomographic Images of Unintentional Intraneural Injection.- 13. Ultrasound View of Unintentional Intraneural Injection.- 14. Histologic Features of Needle-Nerve and Intraneural Injection Injury as Seen on Light Microscopy.- 15. Structure of Nerve Lesions after "In Vitro" Punctures.- 16. Scanning Electron Microscopy View of In Vitro Intraneural Injections.- 17. Injection of Dye Inside the Paraneural Sheath of the Sciatic Nerve in the Popliteal Fossa.- 18. High-Definition and Three-Dimensional Volumetric Ultrasound Imaging of the Sciatic Nerve.- Part II. Component of the Spinal Canal.- 19. Spinal Dural Sac, Nerve Root Cuffs, Rootlets, and Nerve Roots.- 20. Ultrastructure of Spinal Dura Mater.- 21. Ultrastructure of the Spinal Arachnoid Layer.- 22. Three-Dimensional Reconstruction of Spinal Dural Sac.- 23. Three-dimensional Reconstruction of Spinal Epidural Fat.- 24. Ultrastructure of Human Spinal Trabecular Arachnoid.- 25. Ultrastructure of Spinal Pia Mater.- 26. Ultrastructure of Spinal Subdural Compartment: Origin of Spinal Subdural Space.- 27. Unintentional Subdural and Intradural Placement of Epidural Catheters.- 28. Ultrastructure of Human Spinal Nerve Roots.- 29. Three-dimensional Reconstruction of Cauda Equine Nerve Roots.- 30. Spinal Nerve Root Lesions after "In Vitro" Needle Puncture.- 31. Nerve Root Cuff Lesions after "In Vitro" Needle Puncture and Model of "In Vitro" Nerve Stimuli Caused by Epidural Catheters.- 32. Ligamentum Flavum and Related Spinal Ligaments.- 33. The Ligamentum Flavum.- 34. Subarachnoid (Intrathecal) Ligaments.- 35. Displacement of the Nerve Roots of Cauda Equina in Different Positions.- 36. Nerve Root and Types of Needles Used in Transforaminal Injections.- 37. Three-Dimensional Visualization of Spinal Cerebrospinal Fluid and Cauda Equina Nerve Roots, and Estimation of a Related Vulnerability Ratio.- 38. Ultrastructure of Nerve Root Cuffs: Dura-Epineurium Transition Tissue.- 39. Ultrastructure of Nerve Root Cuffs: Arachnoid Layer-Perineurium Transition Tissue at Preganglionic, Ganglionic, and Postganglionic Levels.- 40. Spinal Cord Stimulation.- 41. Ultrastructure of Dural Lesions Produced in Lumbar Punctures.- 42. Injections of Particulate Steroids for Nerve Root Blockade: Ultrastructural Examination of Complicating Factors.- 43. Nerve Root and Types of Needles Used in Transforaminal Injections.- Part III. Materials.- 44. Needles in Regional Anesthesia.- 45. Catheters in Regional Anesthesia.- 46. Epidural Filters and Particles from Surgical Gloves.- Part IV. Research Techniques.- 47. Three-dimensional Reconstruction of Spinal Cerebrospinal Fluid, Roots, and Surrounding Structures.- 48. Cerebrospinal Fluid and Root Volume Quantification from Magnetic Resonance Images.- 49. Scanning Electron Microscopy.- 50. Transmission Electron Microscopy.
  • (source: Nielsen Book Data)
This is the first atlas to depict in high-resolution images the fine structure of the spinal canal, the nervous plexuses, and the peripheral nerves in relation to clinical practice. The Atlas of Functional Anatomy for Regional Anesthesia and Pain Medicine contains more than 1500 images of unsurpassed quality, most of which have never been published, including scanning electron microscopy images of neuronal ultrastructures, macroscopic sectional anatomy, and three-dimensional images reconstructed from patient imaging studies. Each chapter begins with a short introduction on the covered subject but then allows the images to embody the rest of the work; detailed text accompanies figures to guide readers through anatomy, providing evidence-based, clinically relevant information. Beyond clinically relevant anatomy, the book features regional anesthesia equipment (needles, catheters, surgical gloves) and overview of some cutting edge research instruments (e.g. scanning electron microscopy and transmission electron microscopy). Of interest to regional anesthesiologists, interventional pain physicians, and surgeons, this compendium is meant to complement texts that do not have this type of graphic material in the subjects of regional anesthesia, interventional pain management, and surgical techniques of the spine or peripheral nerves.
(source: Nielsen Book Data)
  • Part I. Human Peripheral Nerve.- 1. Ultrastructure of Myelinated and Unmyelinated Axons.- 2. Macrophages, Mastocytes, and Plasma Cells.- 3. Ultrastructure of the Endoneurium.- 4. Ultrastructure of the Perineurium.- 5. Ultrastructure of the Epineurium .- 6. Origin of the Fascicles and Intraneural Plexus.- 7. Macroscopic View of the Cervical Plexus and Brachial Plexus.- 8. Anna Carrera, Francisco Reina.- 9. Macroscopic View of the Lumbar Plexus and Sacral Plexus.- 10. Cross-sectional Microscopic Anatomy of the Sciatic Nerve and its Dissected Branches.- 11. Cross-sectional Microscopic Anatomy of the Sciatic Nerve and Paraneural Sheaths.- 12. Computerized Tomographic Images of Unintentional Intraneural Injection.- 13. Ultrasound View of Unintentional Intraneural Injection.- 14. Histologic Features of Needle-Nerve and Intraneural Injection Injury as Seen on Light Microscopy.- 15. Structure of Nerve Lesions after "In Vitro" Punctures.- 16. Scanning Electron Microscopy View of In Vitro Intraneural Injections.- 17. Injection of Dye Inside the Paraneural Sheath of the Sciatic Nerve in the Popliteal Fossa.- 18. High-Definition and Three-Dimensional Volumetric Ultrasound Imaging of the Sciatic Nerve.- Part II. Component of the Spinal Canal.- 19. Spinal Dural Sac, Nerve Root Cuffs, Rootlets, and Nerve Roots.- 20. Ultrastructure of Spinal Dura Mater.- 21. Ultrastructure of the Spinal Arachnoid Layer.- 22. Three-Dimensional Reconstruction of Spinal Dural Sac.- 23. Three-dimensional Reconstruction of Spinal Epidural Fat.- 24. Ultrastructure of Human Spinal Trabecular Arachnoid.- 25. Ultrastructure of Spinal Pia Mater.- 26. Ultrastructure of Spinal Subdural Compartment: Origin of Spinal Subdural Space.- 27. Unintentional Subdural and Intradural Placement of Epidural Catheters.- 28. Ultrastructure of Human Spinal Nerve Roots.- 29. Three-dimensional Reconstruction of Cauda Equine Nerve Roots.- 30. Spinal Nerve Root Lesions after "In Vitro" Needle Puncture.- 31. Nerve Root Cuff Lesions after "In Vitro" Needle Puncture and Model of "In Vitro" Nerve Stimuli Caused by Epidural Catheters.- 32. Ligamentum Flavum and Related Spinal Ligaments.- 33. The Ligamentum Flavum.- 34. Subarachnoid (Intrathecal) Ligaments.- 35. Displacement of the Nerve Roots of Cauda Equina in Different Positions.- 36. Nerve Root and Types of Needles Used in Transforaminal Injections.- 37. Three-Dimensional Visualization of Spinal Cerebrospinal Fluid and Cauda Equina Nerve Roots, and Estimation of a Related Vulnerability Ratio.- 38. Ultrastructure of Nerve Root Cuffs: Dura-Epineurium Transition Tissue.- 39. Ultrastructure of Nerve Root Cuffs: Arachnoid Layer-Perineurium Transition Tissue at Preganglionic, Ganglionic, and Postganglionic Levels.- 40. Spinal Cord Stimulation.- 41. Ultrastructure of Dural Lesions Produced in Lumbar Punctures.- 42. Injections of Particulate Steroids for Nerve Root Blockade: Ultrastructural Examination of Complicating Factors.- 43. Nerve Root and Types of Needles Used in Transforaminal Injections.- Part III. Materials.- 44. Needles in Regional Anesthesia.- 45. Catheters in Regional Anesthesia.- 46. Epidural Filters and Particles from Surgical Gloves.- Part IV. Research Techniques.- 47. Three-dimensional Reconstruction of Spinal Cerebrospinal Fluid, Roots, and Surrounding Structures.- 48. Cerebrospinal Fluid and Root Volume Quantification from Magnetic Resonance Images.- 49. Scanning Electron Microscopy.- 50. Transmission Electron Microscopy.
  • (source: Nielsen Book Data)
This is the first atlas to depict in high-resolution images the fine structure of the spinal canal, the nervous plexuses, and the peripheral nerves in relation to clinical practice. The Atlas of Functional Anatomy for Regional Anesthesia and Pain Medicine contains more than 1500 images of unsurpassed quality, most of which have never been published, including scanning electron microscopy images of neuronal ultrastructures, macroscopic sectional anatomy, and three-dimensional images reconstructed from patient imaging studies. Each chapter begins with a short introduction on the covered subject but then allows the images to embody the rest of the work; detailed text accompanies figures to guide readers through anatomy, providing evidence-based, clinically relevant information. Beyond clinically relevant anatomy, the book features regional anesthesia equipment (needles, catheters, surgical gloves) and overview of some cutting edge research instruments (e.g. scanning electron microscopy and transmission electron microscopy). Of interest to regional anesthesiologists, interventional pain physicians, and surgeons, this compendium is meant to complement texts that do not have this type of graphic material in the subjects of regional anesthesia, interventional pain management, and surgical techniques of the spine or peripheral nerves.
(source: Nielsen Book Data)
Video
1 online resource (1 streaming video file (43 min.) : color, sound).
  • Contents: Phenotypic diversity in human populations
  • Selective sweeps
  • Clines of allele frequency
  • Selection on standing variation
  • Polygenic adaptations
  • Adaptive introgression
  • Adaptations to high altitude
  • Genome-wide evidence for local adaptations
  • Interpreting the results of selection scans
  • Convergent adaptations.
  • Contents: Phenotypic diversity in human populations
  • Selective sweeps
  • Clines of allele frequency
  • Selection on standing variation
  • Polygenic adaptations
  • Adaptive introgression
  • Adaptations to high altitude
  • Genome-wide evidence for local adaptations
  • Interpreting the results of selection scans
  • Convergent adaptations.
Book
1 PDF (xv, 116 pages).
  • 1. Introduction and scope
  • 1.1 Definitions
  • 1.2 User engagement vs. user experience
  • 1.3 Characteristics
  • 1.3.1 Focused attention
  • 1.3.2 Positive affect
  • 1.3.3 Aesthetics appeal
  • 1.3.4 Endurability
  • 1.3.5 Novelty
  • 1.3.6 Richness and control
  • 1.3.7 Reputation, trust, and expectation
  • 1.3.8 User context, motivation, incentives, and benefits
  • 1.4 Measurements
  • 1.5 Scope
  • 1.6 Structure
  • 2. Approaches based on self-report methods
  • 2.1 Self-report approaches
  • 2.2 Advantages and limitations of self-report methods
  • 2.2.1 Communication
  • 2.2.2 Methodology bias
  • 2.2.3 Reliability and validity
  • 2.3 Interviews
  • 2.3.1 Types of interviews
  • 2.3.2 Applying interviews to measure user engagement
  • 2.4 Think aloud and think after protocols
  • 2.4.1 Think aloud
  • 2.4.2 Think after
  • 2.4.3 Relationship to user engagement
  • 2.5 Questionnaires
  • 2.6 Questionnaires for measuring user engagement
  • 2.6.1 Survey to evaluate engagement
  • 2.6.2 Engagement and influences on questionnaire
  • 2.6.3 User engagement scale
  • 2.6.4 eHealth engagement scale
  • 2.7 Constructs related to user engagement
  • 2.7.1 Mental workload
  • 2.7.2 Disorientation
  • 2.7.3 Playfulness
  • 2.7.4 Cognitive absorption
  • 2.8 Summary
  • 3. Approaches based on physiological measurements
  • 3.1 Psychophysiological measurements
  • 3.2 Facial expressions
  • 3.3 Eye tracking
  • 3.3.1 Eye tracking and search
  • 3.3.2 Eye tracking and reading
  • 3.3.3 Eye tracking and selection
  • 3.3.4 Summary and limitations
  • 3.4 Cursor tracking
  • 3.4.1 Aligning eye gaze and mouse movement
  • 3.4.2 Mouse movement in search
  • 3.4.3 Mouse movement elsewhere
  • 3.5 Summary
  • 4. Approaches based on web analytics
  • 4.1 Intra-session vs. inter-session engagement
  • 4.2 Some dimensions of online measurements
  • 4.2.1 Dependence on the type of website
  • 4.2.2 Dependence on the type of user
  • 4.2.3 Dependence on the task
  • 4.3 Large-scale measurements
  • 4.4 Intra-session measurements
  • 4.4.1 Dwell time and similar measures
  • 4.4.2 Revisits to a site
  • 4.4.3 Clickthrough rate
  • 4.4.4 Number of pages viewed
  • 4.4.5 Other measurements
  • 4.5 Inter-session measurements
  • 4.5.1 Direct value measurement
  • 4.5.2 Total use measurement
  • 4.5.3 Return-rate measurement
  • 4.6 Summary
  • 5. Beyond desktop, single site, and single task
  • 5.1 Measuring for online multitasking
  • 5.2 Measuring on a network of sites
  • 5.3 Measuring in mobile information seeking
  • 5.4 Summary
  • 6. Enhancing the rigor of user engagement methods and measures
  • 6.1 Scale
  • 6.2 Setting
  • 6.3 Temporality
  • 6.4 Objectivity and subjectivity
  • 6.5 Process- and product-based
  • 6.6 Summary
  • 7. Conclusions and future research directions
  • 7.1 Summary
  • 7.2 Future research directions
  • 7.3 Take-aways
  • Bibliography
  • Authors' biographies
  • Index.
User engagement refers to the quality of the user experience that emphasizes the positive aspects of interacting with an online application and, in particular, the desire to use that application longer and repeatedly. User engagement is a key concept in the design of online applications (whether for desktop, tablet or mobile), motivated by the observation that successful applications are not just used, but are engaged with. Users invest time, attention, and emotion in their use of technology, and seek to satisfy pragmatic and hedonic needs. Measurement is critical for evaluating whether online applications are able to successfully engage users, and may inform the design of and use of applications. User engagement is a multifaceted, complex phenomenon; this gives rise to a number of potential measurement approaches. Common ways to evaluate user engagement include using self-report measures, e.g., questionnaires; observational methods, e.g. facial expression analysis, speech analysis; neuro-physiological signal processing methods, e.g., respiratory and cardiovascular accelerations and decelerations, muscle spasms; and web analytics, e.g., number of site visits, click depth. These methods represent various trade-offs in terms of the setting (laboratory versus "in the wild"), object of measurement (user behaviour, affect or cognition) and scale of data collected. For instance, small-scale user studies are deep and rich, but limited in terms of generalizability, whereas large-scale web analytic studies are powerful but negate users' motivation and context. The focus of this book is how user engagement is currently being measured and various considerations for its measurement. Our goal is to leave readers with an appreciation of the various ways in which to measure user engagement, and their associated strengths and weaknesses. We emphasize the multifaceted nature of user engagement and the unique contextual constraints that come to bear upon attempts to measure engagement in different settings, and across different user groups and web domains. At the same time, this book advocates for the development of "good" measures and good measurement practices that will advance the study of user engagement and improve our understanding of this construct, which has become so vital in our wired world.
  • 1. Introduction and scope
  • 1.1 Definitions
  • 1.2 User engagement vs. user experience
  • 1.3 Characteristics
  • 1.3.1 Focused attention
  • 1.3.2 Positive affect
  • 1.3.3 Aesthetics appeal
  • 1.3.4 Endurability
  • 1.3.5 Novelty
  • 1.3.6 Richness and control
  • 1.3.7 Reputation, trust, and expectation
  • 1.3.8 User context, motivation, incentives, and benefits
  • 1.4 Measurements
  • 1.5 Scope
  • 1.6 Structure
  • 2. Approaches based on self-report methods
  • 2.1 Self-report approaches
  • 2.2 Advantages and limitations of self-report methods
  • 2.2.1 Communication
  • 2.2.2 Methodology bias
  • 2.2.3 Reliability and validity
  • 2.3 Interviews
  • 2.3.1 Types of interviews
  • 2.3.2 Applying interviews to measure user engagement
  • 2.4 Think aloud and think after protocols
  • 2.4.1 Think aloud
  • 2.4.2 Think after
  • 2.4.3 Relationship to user engagement
  • 2.5 Questionnaires
  • 2.6 Questionnaires for measuring user engagement
  • 2.6.1 Survey to evaluate engagement
  • 2.6.2 Engagement and influences on questionnaire
  • 2.6.3 User engagement scale
  • 2.6.4 eHealth engagement scale
  • 2.7 Constructs related to user engagement
  • 2.7.1 Mental workload
  • 2.7.2 Disorientation
  • 2.7.3 Playfulness
  • 2.7.4 Cognitive absorption
  • 2.8 Summary
  • 3. Approaches based on physiological measurements
  • 3.1 Psychophysiological measurements
  • 3.2 Facial expressions
  • 3.3 Eye tracking
  • 3.3.1 Eye tracking and search
  • 3.3.2 Eye tracking and reading
  • 3.3.3 Eye tracking and selection
  • 3.3.4 Summary and limitations
  • 3.4 Cursor tracking
  • 3.4.1 Aligning eye gaze and mouse movement
  • 3.4.2 Mouse movement in search
  • 3.4.3 Mouse movement elsewhere
  • 3.5 Summary
  • 4. Approaches based on web analytics
  • 4.1 Intra-session vs. inter-session engagement
  • 4.2 Some dimensions of online measurements
  • 4.2.1 Dependence on the type of website
  • 4.2.2 Dependence on the type of user
  • 4.2.3 Dependence on the task
  • 4.3 Large-scale measurements
  • 4.4 Intra-session measurements
  • 4.4.1 Dwell time and similar measures
  • 4.4.2 Revisits to a site
  • 4.4.3 Clickthrough rate
  • 4.4.4 Number of pages viewed
  • 4.4.5 Other measurements
  • 4.5 Inter-session measurements
  • 4.5.1 Direct value measurement
  • 4.5.2 Total use measurement
  • 4.5.3 Return-rate measurement
  • 4.6 Summary
  • 5. Beyond desktop, single site, and single task
  • 5.1 Measuring for online multitasking
  • 5.2 Measuring on a network of sites
  • 5.3 Measuring in mobile information seeking
  • 5.4 Summary
  • 6. Enhancing the rigor of user engagement methods and measures
  • 6.1 Scale
  • 6.2 Setting
  • 6.3 Temporality
  • 6.4 Objectivity and subjectivity
  • 6.5 Process- and product-based
  • 6.6 Summary
  • 7. Conclusions and future research directions
  • 7.1 Summary
  • 7.2 Future research directions
  • 7.3 Take-aways
  • Bibliography
  • Authors' biographies
  • Index.
User engagement refers to the quality of the user experience that emphasizes the positive aspects of interacting with an online application and, in particular, the desire to use that application longer and repeatedly. User engagement is a key concept in the design of online applications (whether for desktop, tablet or mobile), motivated by the observation that successful applications are not just used, but are engaged with. Users invest time, attention, and emotion in their use of technology, and seek to satisfy pragmatic and hedonic needs. Measurement is critical for evaluating whether online applications are able to successfully engage users, and may inform the design of and use of applications. User engagement is a multifaceted, complex phenomenon; this gives rise to a number of potential measurement approaches. Common ways to evaluate user engagement include using self-report measures, e.g., questionnaires; observational methods, e.g. facial expression analysis, speech analysis; neuro-physiological signal processing methods, e.g., respiratory and cardiovascular accelerations and decelerations, muscle spasms; and web analytics, e.g., number of site visits, click depth. These methods represent various trade-offs in terms of the setting (laboratory versus "in the wild"), object of measurement (user behaviour, affect or cognition) and scale of data collected. For instance, small-scale user studies are deep and rich, but limited in terms of generalizability, whereas large-scale web analytic studies are powerful but negate users' motivation and context. The focus of this book is how user engagement is currently being measured and various considerations for its measurement. Our goal is to leave readers with an appreciation of the various ways in which to measure user engagement, and their associated strengths and weaknesses. We emphasize the multifaceted nature of user engagement and the unique contextual constraints that come to bear upon attempts to measure engagement in different settings, and across different user groups and web domains. At the same time, this book advocates for the development of "good" measures and good measurement practices that will advance the study of user engagement and improve our understanding of this construct, which has become so vital in our wired world.
Book
1 online resource. Digital: text file; PDF.
  • Peroxynitrite induces degradation of myosin heavy chain via p38 MAPK and muscle-specific E3 ubiquitin ligases in C2 skeletal myotubes. O. Rom, S. Kaisari, A.Z. Reznick, and D. Aizenbud Alterations in the coagulation system of active smokers from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. G. Delgado, R. Siekmeier, T.B. Grammer, B.O. Boehm, W. Marz, and M.E. Kleber. C-reactive protein and lipoprotein-associated phospholipase A2 in smokers and nonsmokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. M.E. Kleber, R. Siekmeier, G. Delgado, T.B. Grammer, B.R. Winkelmann, H. Scharnagl, B.O. Boehm, and W. Marz Green tea drinking improves erythrocytes and saliva oxidative status in the elderly. B. Narotzki, A.Z. Reznick, T. Mitki, D. Aizenbud, and Y. Levy Cardiovascular effects of N-acetylcysteine in meconium-induced acute lung injury. D. Mokra, I. Tonhajzerova, H. Pistekova, Z. Visnovcova, A. Drgova, J. Mokry, and A. Calkovska Alterations in vagal-immune pathway in long-lasting mental stress. Z. Visnovcova, D. Mokra, P. Mikolka, M. Mestanik, A. Jurko, M. Javorka, A. Calkovska, and I. Tonhajzerova Nocturnal parasympathetic modulation of heart rate in obesity-hypoventilation patients. A. Brzecka, M. Pawelec-Winiarz, A. Teplicki, P. Piesiak, and R. Jankowska N-acetylcysteine Alleviates the Meconium-Induced Acute Lung Injury. D. Mokra, A. Drgova, M. Petras, J. Mokry, M. Antosova, and A. Calkovska.
  • (source: Nielsen Book Data)
Cardiorespiratory function is prominently affected by oxidative stress. Cigarette smoking is the archetype of oxidative and nitrative stress and free radical formation. New adverse effects of smoking keep on propping up in research. The chapters provide the comprehensive view of new developments in this area regarding cardiovascular and lung function and muscle catabolism. Alterations in inflammatory cytokines and proteins as well as degradation of muscle proteins due to smoking, by far unrecognized, caused by oxidative stress also are presented. Much less is known about the effect of cognitive stress on vagally-mediated cardiorespiratory function and surprisingly, on vagal immune pathway. The experimental studies also show that clinically important meconium aspiration syndrome contains an oxidative trait which is amenable to antioxidative treatment. This volume creates a source of information on the damaging role of oxidative stress in cardiorespiratory function that has by far not been available.
(source: Nielsen Book Data)
  • Peroxynitrite induces degradation of myosin heavy chain via p38 MAPK and muscle-specific E3 ubiquitin ligases in C2 skeletal myotubes. O. Rom, S. Kaisari, A.Z. Reznick, and D. Aizenbud Alterations in the coagulation system of active smokers from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. G. Delgado, R. Siekmeier, T.B. Grammer, B.O. Boehm, W. Marz, and M.E. Kleber. C-reactive protein and lipoprotein-associated phospholipase A2 in smokers and nonsmokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. M.E. Kleber, R. Siekmeier, G. Delgado, T.B. Grammer, B.R. Winkelmann, H. Scharnagl, B.O. Boehm, and W. Marz Green tea drinking improves erythrocytes and saliva oxidative status in the elderly. B. Narotzki, A.Z. Reznick, T. Mitki, D. Aizenbud, and Y. Levy Cardiovascular effects of N-acetylcysteine in meconium-induced acute lung injury. D. Mokra, I. Tonhajzerova, H. Pistekova, Z. Visnovcova, A. Drgova, J. Mokry, and A. Calkovska Alterations in vagal-immune pathway in long-lasting mental stress. Z. Visnovcova, D. Mokra, P. Mikolka, M. Mestanik, A. Jurko, M. Javorka, A. Calkovska, and I. Tonhajzerova Nocturnal parasympathetic modulation of heart rate in obesity-hypoventilation patients. A. Brzecka, M. Pawelec-Winiarz, A. Teplicki, P. Piesiak, and R. Jankowska N-acetylcysteine Alleviates the Meconium-Induced Acute Lung Injury. D. Mokra, A. Drgova, M. Petras, J. Mokry, M. Antosova, and A. Calkovska.
  • (source: Nielsen Book Data)
Cardiorespiratory function is prominently affected by oxidative stress. Cigarette smoking is the archetype of oxidative and nitrative stress and free radical formation. New adverse effects of smoking keep on propping up in research. The chapters provide the comprehensive view of new developments in this area regarding cardiovascular and lung function and muscle catabolism. Alterations in inflammatory cytokines and proteins as well as degradation of muscle proteins due to smoking, by far unrecognized, caused by oxidative stress also are presented. Much less is known about the effect of cognitive stress on vagally-mediated cardiorespiratory function and surprisingly, on vagal immune pathway. The experimental studies also show that clinically important meconium aspiration syndrome contains an oxidative trait which is amenable to antioxidative treatment. This volume creates a source of information on the damaging role of oxidative stress in cardiorespiratory function that has by far not been available.
(source: Nielsen Book Data)
Video
1 online resource (1 streaming video file (29 min.) : color, sound).
  • Contents: Concepts and pathways in intracellular trafficking
  • Disorders affecting specific trafficking steps
  • Arthrogryposis-Renal dysfunction-Cholestasis (ARC) syndrome
  • ARC syndrome as an example of a trafficking disorder.
  • Contents: Concepts and pathways in intracellular trafficking
  • Disorders affecting specific trafficking steps
  • Arthrogryposis-Renal dysfunction-Cholestasis (ARC) syndrome
  • ARC syndrome as an example of a trafficking disorder.
Book
1 online resource.
This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. It presents an in-depth overview of skeletal biology from the molecular to the organ level. It offers "refresher" level content for clinicians or researchers outside their areas of expertise. It boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology.
(source: Nielsen Book Data)
This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. It presents an in-depth overview of skeletal biology from the molecular to the organ level. It offers "refresher" level content for clinicians or researchers outside their areas of expertise. It boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology.
(source: Nielsen Book Data)
Book
1 online resource (259 pages)
Brain-computer interface (BCI) technology provides a means of communication that allows individuals with severely impaired movement to communicate with assistive devices using the electroencephalogram (EEG) or other brain signals. The practicality of a BCI has been possible due to advances in multi-disciplinary areas of research related to cognitive neuroscience, brain-imaging techniques and human-computer interfaces. However, two major challenges remain in making BCI for assistive robotics practical for day-to-day use: the inherent lower bandwidth of BCI, and how to best handle the unknown embedded noise within the raw EEG. Brain-Computer Interfacing for Assistive Robotics is a result of research focusing on these important aspects of BCI for real-time assistive robotic application. It details the fundamental issues related to non-stationary EEG signal processing (filtering) and the need of an alternative approach for the same. Additionally, the book also discusses techniques for overcoming lower bandwidth of BCIs by designing novel use-centric graphical user interfaces. A detailed investigation into both these approaches is discussed. * An innovative reference on the brain-computer interface (BCI) and its utility in computational neuroscience and assistive robotics* Written for mature and early stage researchers, postgraduate and doctoral students, and computational neuroscientists, this book is a novel guide to the fundamentals of quantum mechanics for BCI* Full-colour text that focuses on brain-computer interfacing for real-time assistive robotic application and details the fundamental issues related with signal processing and the need for alternative approaches* A detailed introduction as well as an in-depth analysis of challenges and issues in developing practical brain-computer interfaces.
(source: Nielsen Book Data)
Brain-computer interface (BCI) technology provides a means of communication that allows individuals with severely impaired movement to communicate with assistive devices using the electroencephalogram (EEG) or other brain signals. The practicality of a BCI has been possible due to advances in multi-disciplinary areas of research related to cognitive neuroscience, brain-imaging techniques and human-computer interfaces. However, two major challenges remain in making BCI for assistive robotics practical for day-to-day use: the inherent lower bandwidth of BCI, and how to best handle the unknown embedded noise within the raw EEG. Brain-Computer Interfacing for Assistive Robotics is a result of research focusing on these important aspects of BCI for real-time assistive robotic application. It details the fundamental issues related to non-stationary EEG signal processing (filtering) and the need of an alternative approach for the same. Additionally, the book also discusses techniques for overcoming lower bandwidth of BCIs by designing novel use-centric graphical user interfaces. A detailed investigation into both these approaches is discussed. * An innovative reference on the brain-computer interface (BCI) and its utility in computational neuroscience and assistive robotics* Written for mature and early stage researchers, postgraduate and doctoral students, and computational neuroscientists, this book is a novel guide to the fundamentals of quantum mechanics for BCI* Full-colour text that focuses on brain-computer interfacing for real-time assistive robotic application and details the fundamental issues related with signal processing and the need for alternative approaches* A detailed introduction as well as an in-depth analysis of challenges and issues in developing practical brain-computer interfaces.
(source: Nielsen Book Data)
Book
1 online resource (295 pages)
Calculus of Thought: Neuromorphic Logistic Regression in Cognitive Machines is a must-read for all scientists about a very simple computation method designed to simulate big-data neural processing. This book is inspired by the Calculus Ratiocinator idea of Gottfried Leibniz, which is that machine computation should be developed to simulate human cognitive processes, thus avoiding problematic subjective bias in analytic solutions to practical and scientific problems. The reduced error logistic regression (RELR) method is proposed as such a "Calculus of Thought." This book reviews how RELR's completely automated processing may parallel important aspects of explicit and implicit learning in neural processes. It emphasizes the fact that RELR is really just a simple adjustment to already widely used logistic regression, along with RELR's new applications that go well beyond standard logistic regression in prediction and explanation. Readers will learn how RELR solves some of the most basic problems in today's big and small data related to high dimensionality, multi-colinearity, and cognitive bias in capricious outcomes commonly involving human behavior. Features include: provides a high-level introduction and detailed reviews of the neural, statistical and machine learning knowledge base as a foundation for a new era of smarter machines; argues that smarter machine learning to handle both explanation and prediction without cognitive bias must have a foundation in cognitive neuroscience and must embody similar explicit and implicit learning principles that occur in the brain; and offers a new neuromorphic foundation for machine learning based upon the reduced error logistic regression (RELR) method and provides simple examples of RELR computations in toy problems that can be accessed in spreadsheet workbooks through a companion website.
(source: Nielsen Book Data)
Calculus of Thought: Neuromorphic Logistic Regression in Cognitive Machines is a must-read for all scientists about a very simple computation method designed to simulate big-data neural processing. This book is inspired by the Calculus Ratiocinator idea of Gottfried Leibniz, which is that machine computation should be developed to simulate human cognitive processes, thus avoiding problematic subjective bias in analytic solutions to practical and scientific problems. The reduced error logistic regression (RELR) method is proposed as such a "Calculus of Thought." This book reviews how RELR's completely automated processing may parallel important aspects of explicit and implicit learning in neural processes. It emphasizes the fact that RELR is really just a simple adjustment to already widely used logistic regression, along with RELR's new applications that go well beyond standard logistic regression in prediction and explanation. Readers will learn how RELR solves some of the most basic problems in today's big and small data related to high dimensionality, multi-colinearity, and cognitive bias in capricious outcomes commonly involving human behavior. Features include: provides a high-level introduction and detailed reviews of the neural, statistical and machine learning knowledge base as a foundation for a new era of smarter machines; argues that smarter machine learning to handle both explanation and prediction without cognitive bias must have a foundation in cognitive neuroscience and must embody similar explicit and implicit learning principles that occur in the brain; and offers a new neuromorphic foundation for machine learning based upon the reduced error logistic regression (RELR) method and provides simple examples of RELR computations in toy problems that can be accessed in spreadsheet workbooks through a companion website.
(source: Nielsen Book Data)
Book
1 online resource (408 pages)
  • History of the study and nomenclature of the claustrum
  • The structure and connections of the claustrum
  • The neurochemical organization of the claustrum
  • Development and evolution of the claustrum
  • Physiology of the claustrum
  • Neurocomputation and coding in the claustrum
  • Structural and functional connectivity of the claustrum in the human brain
  • Delayed development of the claustrum in autism
  • The claustrum in schizophrenia
  • Clinical relations: epilepsy
  • The claustrum and Alzheimer's disease
  • Parkinson's disease and the claustrum
  • Hypotheses relating to the function of the claustrum
  • What is it to be conscious?
  • Selected key areas for future research on the claustrum.
The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being continually discovered. This process is most developed in the major areas of the brain, such as the cortex, thalamus, and striatum. The Claustrum instead focuses on a small, remote, and, until recently, relatively unknown area of the brain. In recent years, researchers have come to believe that the claustrum is concerned with consciousness, a bold hypothesis supported by the claustrum's two-way connections with nearly every other region of the brain and its seeming involvement with multisensory integrations-the hallmark of consciousness. The claustrum, previously in a humble position at the back of the stage, might in fact be the conductor of the brain's orchestra. The Claustrum brings together leading experts on the claustrum from the varied disciplines of neuroscience, providing a state-of-the-art presentation of what is currently known about the claustrum, promising lines of current research (including epigenetics), and projections of new lines of investigation on the horizon. It develops a unifying hypothesis about the claustrum's role in consciousness, as well as the integration of sensory information and other higher brain functions. It discusses the involvement of the claustrum with autism, schizophrenia, epilepsy, Alzheimer's disease, and Parkinson's disease. Coverage of all aspects of the claustrum, from its evolution and development to promising new lines of research, including epigenetics, provides a platform and point of reference for future investigative efforts.
(source: Nielsen Book Data)
  • History of the study and nomenclature of the claustrum
  • The structure and connections of the claustrum
  • The neurochemical organization of the claustrum
  • Development and evolution of the claustrum
  • Physiology of the claustrum
  • Neurocomputation and coding in the claustrum
  • Structural and functional connectivity of the claustrum in the human brain
  • Delayed development of the claustrum in autism
  • The claustrum in schizophrenia
  • Clinical relations: epilepsy
  • The claustrum and Alzheimer's disease
  • Parkinson's disease and the claustrum
  • Hypotheses relating to the function of the claustrum
  • What is it to be conscious?
  • Selected key areas for future research on the claustrum.
The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being continually discovered. This process is most developed in the major areas of the brain, such as the cortex, thalamus, and striatum. The Claustrum instead focuses on a small, remote, and, until recently, relatively unknown area of the brain. In recent years, researchers have come to believe that the claustrum is concerned with consciousness, a bold hypothesis supported by the claustrum's two-way connections with nearly every other region of the brain and its seeming involvement with multisensory integrations-the hallmark of consciousness. The claustrum, previously in a humble position at the back of the stage, might in fact be the conductor of the brain's orchestra. The Claustrum brings together leading experts on the claustrum from the varied disciplines of neuroscience, providing a state-of-the-art presentation of what is currently known about the claustrum, promising lines of current research (including epigenetics), and projections of new lines of investigation on the horizon. It develops a unifying hypothesis about the claustrum's role in consciousness, as well as the integration of sensory information and other higher brain functions. It discusses the involvement of the claustrum with autism, schizophrenia, epilepsy, Alzheimer's disease, and Parkinson's disease. Coverage of all aspects of the claustrum, from its evolution and development to promising new lines of research, including epigenetics, provides a platform and point of reference for future investigative efforts.
(source: Nielsen Book Data)
Book
1 online resource (178 p.)
Clinical Anatomy of the Cranial Nerves combines anatomical knowledge, pathology, clinical examination, and explanation of clinical findings, drawing together material typically scattered throughout anatomical textbooks. All of the pertinent anatomical topics are conveniently organized to instruct on anatomy, but also on how to examine the functioning of this anatomy in the patient. Providing a clear and succinct presentation of the underlying anatomy, with directly related applications of the anatomy to clinical examination, the book also provides unique images of anatomical structures of plastinated cadaveric dissections. These images are the only ones that exist in this form, and have been professionally produced in the Laboratory of Human Anatomy, University of Glasgow under the auspices of the author. These specimens offer a novel way of visualizing the cranial nerves and related important anatomical structures. * Anatomy of cranial nerves described in text format with accompanying high-resolution images of professional, high-quality prosected cadaveric material, demonstrating exactly what the structures (and related ones) look like* Succinct yet comprehensive format with quick and easy access to facts in clearly laid out key regions, common throughout the different cranial nerves* Includes clinical examination and related pathologies, featuring diagnostic summaries of potential clinical presentations and clinically relevant questions on the anatomy of these nerves.
(source: Nielsen Book Data)
Clinical Anatomy of the Cranial Nerves combines anatomical knowledge, pathology, clinical examination, and explanation of clinical findings, drawing together material typically scattered throughout anatomical textbooks. All of the pertinent anatomical topics are conveniently organized to instruct on anatomy, but also on how to examine the functioning of this anatomy in the patient. Providing a clear and succinct presentation of the underlying anatomy, with directly related applications of the anatomy to clinical examination, the book also provides unique images of anatomical structures of plastinated cadaveric dissections. These images are the only ones that exist in this form, and have been professionally produced in the Laboratory of Human Anatomy, University of Glasgow under the auspices of the author. These specimens offer a novel way of visualizing the cranial nerves and related important anatomical structures. * Anatomy of cranial nerves described in text format with accompanying high-resolution images of professional, high-quality prosected cadaveric material, demonstrating exactly what the structures (and related ones) look like* Succinct yet comprehensive format with quick and easy access to facts in clearly laid out key regions, common throughout the different cranial nerves* Includes clinical examination and related pathologies, featuring diagnostic summaries of potential clinical presentations and clinically relevant questions on the anatomy of these nerves.
(source: Nielsen Book Data)
Book
1 online resource.
  • 1. Definition of comparative medicine: History and new identity
  • 2. Smallest unit of life: Cell biology
  • 3. Supporting apparatus of vertebrates: Skeleton and bones
  • 4. Locomotor principles: Anatomy and physiology of skeletal muscles
  • 5. Lifeblood flow: The circulatory systems
  • 6. Steering and communication: Nervous system and sensory organs
  • 7. Surface, barrier, and interface zone: Comparative aspects of the skin
  • 8. Body messaging: The endocrine systems
  • 9. Alimentation and elimination: The principles of gastrointestinal digestion
  • 10. Volume and clearance: Kidneys and excretory systems
  • 11. Breathing: Comparative aspects of the respiratory system
  • 12. Propagation: Mammalian reproduction
  • 13. Common concepts of immune defense
  • 14. Laboratory animal law: An introduction to its history and principles
  • 15. Ethics inlaboratory animal science.
This new volume provides a concise overview of the most basic and exciting chapters of comparative medicine with regards to physiology and function in healthy individuals. The book includes core concepts in anatomy and physiology in human and animal models, which are key to understanding comparative medicine and to making contributions to research in this area. While writing this book, the authors were in constant interdisciplinary dialogue. They aim to contribute to improvements in quality of life for human and animal patients.
  • 1. Definition of comparative medicine: History and new identity
  • 2. Smallest unit of life: Cell biology
  • 3. Supporting apparatus of vertebrates: Skeleton and bones
  • 4. Locomotor principles: Anatomy and physiology of skeletal muscles
  • 5. Lifeblood flow: The circulatory systems
  • 6. Steering and communication: Nervous system and sensory organs
  • 7. Surface, barrier, and interface zone: Comparative aspects of the skin
  • 8. Body messaging: The endocrine systems
  • 9. Alimentation and elimination: The principles of gastrointestinal digestion
  • 10. Volume and clearance: Kidneys and excretory systems
  • 11. Breathing: Comparative aspects of the respiratory system
  • 12. Propagation: Mammalian reproduction
  • 13. Common concepts of immune defense
  • 14. Laboratory animal law: An introduction to its history and principles
  • 15. Ethics inlaboratory animal science.
This new volume provides a concise overview of the most basic and exciting chapters of comparative medicine with regards to physiology and function in healthy individuals. The book includes core concepts in anatomy and physiology in human and animal models, which are key to understanding comparative medicine and to making contributions to research in this area. While writing this book, the authors were in constant interdisciplinary dialogue. They aim to contribute to improvements in quality of life for human and animal patients.
Book
1 online resource (xiii, 585 pages) : illustrations (some color)
  • Part I. Neurohistological Techniques
  • Brain Tissue Preparation, Sectioning, and Staining / Jingdong Zhang and Huangui Xiong
  • Brain Stereotaxic Injection / Jingdong Zhang and Huangui Xiong
  • Neuronal Tract Tracing with Light and Electron Microscopy / Jingdong Zhang and Huangui Xiong
  • Stereological Analysis / Kristi M. Anderson, Adam M. Szlachetka and R. Lee Mosley
  • Part II. In Vitro Preparations
  • Preparation and Use of Rodent Hippocampal Slices / Huangui Xiong and Jianxun Xia
  • Single-Cell Neuronal Dissociation for Electrophysiological Studies / Yu-Long Li
  • Isolation and Culture of Human Neurons, Microglia, and Astrocytes / Li Wu and Santhi Gorantla
  • Isolation and Culture of Neural Stem/Progenitor Cells / Hui Peng, Qiang Chen and Jialin Zheng
  • Isolation of Mitochondria from Brain Tissue and Cells / Changhai Tian and Jialin Zheng
  • Isolation of Synaptosomes from Archived Brain Tissues / Gurudutt Pendyala, James L. Buescher and Howard S. Fox
  • Xenopus Oocytes Isolation and Microinjection / Huangui Xiong
  • Part III. Leukocyte Isolation and Application in Neuroscience
  • Centrifugal Elutriation for Studies of Neuroimmunity / Santhi Gorantla, Myhanh Che and Howard E. Gendelman
  • Flow Cytometry in Neuroscience Research / Charles Kuszynski
  • Part IV. Standard Laboratory Nucleic Acid and Protein Detections
  • Western Blotting Technique in Biomedical Research / Jianuo Liu, James Haorah and Huangui Xiong
  • Polymerase Chain Reaction (PCR) and Real-Time PCR / Georgette D. Kanmogne
  • Part V. Nanomedicine
  • Nanoformulations / Xin-Ming Liu and Tatiana K. Bronich
  • Neuronanomedicine / JoEllyn M. McMillan, Xin-Ming Liu and Howard E. Gendelman
  • Part VI. Bioimaging
  • Confocal Imaging of Nerve Cells / You Zhou
  • Magnetic Resonance Imaging / Yutong Liu
  • X-Ray, Positron Emission, and Single Photon Emission Tomographic Bioimaging / Katherine A. Estes, Jacob C. Peterson, Adam M. Szlachetka and R. Lee Mosley
  • Noninvasive Neurophysiological Imaging with Magnetoencephalography / Tony W. Wilson
  • Multiphoton Brain Imaging / Anna Dunaevsky
  • Part VII. Neuroelectrophysiology
  • Techniques for Extracellular Recordings / Jingdong Zhang, Jianxun Xia and Huangui Xiong
  • Blind Patch-Clamp Recordings from Rodent Hippocampal Slices / Jianxun Xia and Huangui Xiong
  • Whole-Cell Patch-Clamp Recording / Matthew J. Van Hook and Wallace B. Thoreson
  • Part VIII. Immunohistochemistry and Autoradiography
  • Analysis of Receptor Binding and Quantitative Autoradiography / L. Charles Murrin
  • Techniques in Immunohistochemistry and Immunocytochemistry / Yang Yuan and Jyothi Arikkath
  • Part IX. Analysis of Gene Expression
  • Protein Identification by Mass Spectrometry: Proteomics / Melinda Wojtkiewicz, Kelley Barnett and Pawel Ciborowski
  • DNA Microarrays as a Tool for Neurosciences Research / James D. Eudy, Lynette Smith
  • Metabolomics / Yazen Alnouti
  • Bioinformatic Methods and Resources for Neuroscience Research / Chittibabu Guda
  • Part X. Animal Models: Behavior and Pathology
  • Motor Function in Rodent Models of Neurodegenerative Disorders / Jessica A. Hutter Saunders, Max V. Kuenstling, Robert A. Weir, R. Lee Mosley and Howard E. Gendelman
  • Humanized Mice / Larisa Y. Poluektova and Edward Makarov
  • Animal Models for PD and ALS / Max V. Kuenstling, Adam M. Szlachetka and R. Lee Mosley
  • Animal Models of Alzheimer's Disease / Tomomi Kiyota
  • Animal Models: Behavior and Pathology: Preclinical Assessment of the Putative Cognitive Deficits in HAND / Landhing M. Moran, Rosemarie M. Booze and Charles F. Mactutus.
Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
  • Part I. Neurohistological Techniques
  • Brain Tissue Preparation, Sectioning, and Staining / Jingdong Zhang and Huangui Xiong
  • Brain Stereotaxic Injection / Jingdong Zhang and Huangui Xiong
  • Neuronal Tract Tracing with Light and Electron Microscopy / Jingdong Zhang and Huangui Xiong
  • Stereological Analysis / Kristi M. Anderson, Adam M. Szlachetka and R. Lee Mosley
  • Part II. In Vitro Preparations
  • Preparation and Use of Rodent Hippocampal Slices / Huangui Xiong and Jianxun Xia
  • Single-Cell Neuronal Dissociation for Electrophysiological Studies / Yu-Long Li
  • Isolation and Culture of Human Neurons, Microglia, and Astrocytes / Li Wu and Santhi Gorantla
  • Isolation and Culture of Neural Stem/Progenitor Cells / Hui Peng, Qiang Chen and Jialin Zheng
  • Isolation of Mitochondria from Brain Tissue and Cells / Changhai Tian and Jialin Zheng
  • Isolation of Synaptosomes from Archived Brain Tissues / Gurudutt Pendyala, James L. Buescher and Howard S. Fox
  • Xenopus Oocytes Isolation and Microinjection / Huangui Xiong
  • Part III. Leukocyte Isolation and Application in Neuroscience
  • Centrifugal Elutriation for Studies of Neuroimmunity / Santhi Gorantla, Myhanh Che and Howard E. Gendelman
  • Flow Cytometry in Neuroscience Research / Charles Kuszynski
  • Part IV. Standard Laboratory Nucleic Acid and Protein Detections
  • Western Blotting Technique in Biomedical Research / Jianuo Liu, James Haorah and Huangui Xiong
  • Polymerase Chain Reaction (PCR) and Real-Time PCR / Georgette D. Kanmogne
  • Part V. Nanomedicine
  • Nanoformulations / Xin-Ming Liu and Tatiana K. Bronich
  • Neuronanomedicine / JoEllyn M. McMillan, Xin-Ming Liu and Howard E. Gendelman
  • Part VI. Bioimaging
  • Confocal Imaging of Nerve Cells / You Zhou
  • Magnetic Resonance Imaging / Yutong Liu
  • X-Ray, Positron Emission, and Single Photon Emission Tomographic Bioimaging / Katherine A. Estes, Jacob C. Peterson, Adam M. Szlachetka and R. Lee Mosley
  • Noninvasive Neurophysiological Imaging with Magnetoencephalography / Tony W. Wilson
  • Multiphoton Brain Imaging / Anna Dunaevsky
  • Part VII. Neuroelectrophysiology
  • Techniques for Extracellular Recordings / Jingdong Zhang, Jianxun Xia and Huangui Xiong
  • Blind Patch-Clamp Recordings from Rodent Hippocampal Slices / Jianxun Xia and Huangui Xiong
  • Whole-Cell Patch-Clamp Recording / Matthew J. Van Hook and Wallace B. Thoreson
  • Part VIII. Immunohistochemistry and Autoradiography
  • Analysis of Receptor Binding and Quantitative Autoradiography / L. Charles Murrin
  • Techniques in Immunohistochemistry and Immunocytochemistry / Yang Yuan and Jyothi Arikkath
  • Part IX. Analysis of Gene Expression
  • Protein Identification by Mass Spectrometry: Proteomics / Melinda Wojtkiewicz, Kelley Barnett and Pawel Ciborowski
  • DNA Microarrays as a Tool for Neurosciences Research / James D. Eudy, Lynette Smith
  • Metabolomics / Yazen Alnouti
  • Bioinformatic Methods and Resources for Neuroscience Research / Chittibabu Guda
  • Part X. Animal Models: Behavior and Pathology
  • Motor Function in Rodent Models of Neurodegenerative Disorders / Jessica A. Hutter Saunders, Max V. Kuenstling, Robert A. Weir, R. Lee Mosley and Howard E. Gendelman
  • Humanized Mice / Larisa Y. Poluektova and Edward Makarov
  • Animal Models for PD and ALS / Max V. Kuenstling, Adam M. Szlachetka and R. Lee Mosley
  • Animal Models of Alzheimer's Disease / Tomomi Kiyota
  • Animal Models: Behavior and Pathology: Preclinical Assessment of the Putative Cognitive Deficits in HAND / Landhing M. Moran, Rosemarie M. Booze and Charles F. Mactutus.
Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
Book
1 online resource (ix, 170 pages) : illustrations
  • A Short History of Birth Defect Epidemiology.- Genetic and Non-genetic Factors in the Origin of Congenital Malformations.- Ascertainment of Children with Congenital Malformations.- Statistical Considerations.- Epidemiological Methods.- Neural Tube Defects.- Microcephaly.- Hydrocephaly.- Agenesis of Corpus Callosum and Holoprosencephaly.- Severe Eye Malformations.- Severe Ear Malformations.- Cardiovascular Defects.- Orofacial Clefts.- Atresia or Stenosis of the Alimentary Tract.- Pyloric Stenosis.- Malrotation of the Gut.- Megacolon.- Hypospadias.- Epispadias, Cloacal and Bladder Exstrophy.- Severe Renal Malformations.- Posterior Urethral Valve.- Pes Equinovarus.- Other Foot Deformities than Pes Equinovarus.- Polydactyly and Syndactyly.- Limb Reduction Defects.- Craniostenosis.- Diaphragmatic Hernia.- Abdominal Wall Defects.- Children with multiple malformations.- "Syndromes".- Down Syndrome.- Explanation and Prevention of Birth Defects.- Eight Commandments: Rules for the Interpretation of Birth Defect Epidemiological Studies.
  • (source: Nielsen Book Data)
Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden. The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest. The structure of the analysis is such that it excludes studies of, for instance, nutrition, alcohol or street drug use and many other lifestyle factors where prospective information or independent register information is difficult or impossible to obtain. Epidemiology of Human Congenital Malformations culminates with a discussion on how the presence of malformations can be explained and various possibilities for the prevention of birth defects. Moreover, it will include a series of instructions on how to read epidemiological literature in this field making it an essential resource both for those currently working in the field of reproductive epidemiology or those intending to enter it. It will additionally be useful for doctors working with malformations, either as obstetricians, neonatologists or pediatricians.
(source: Nielsen Book Data)
  • A Short History of Birth Defect Epidemiology.- Genetic and Non-genetic Factors in the Origin of Congenital Malformations.- Ascertainment of Children with Congenital Malformations.- Statistical Considerations.- Epidemiological Methods.- Neural Tube Defects.- Microcephaly.- Hydrocephaly.- Agenesis of Corpus Callosum and Holoprosencephaly.- Severe Eye Malformations.- Severe Ear Malformations.- Cardiovascular Defects.- Orofacial Clefts.- Atresia or Stenosis of the Alimentary Tract.- Pyloric Stenosis.- Malrotation of the Gut.- Megacolon.- Hypospadias.- Epispadias, Cloacal and Bladder Exstrophy.- Severe Renal Malformations.- Posterior Urethral Valve.- Pes Equinovarus.- Other Foot Deformities than Pes Equinovarus.- Polydactyly and Syndactyly.- Limb Reduction Defects.- Craniostenosis.- Diaphragmatic Hernia.- Abdominal Wall Defects.- Children with multiple malformations.- "Syndromes".- Down Syndrome.- Explanation and Prevention of Birth Defects.- Eight Commandments: Rules for the Interpretation of Birth Defect Epidemiological Studies.
  • (source: Nielsen Book Data)
Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden. The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest. The structure of the analysis is such that it excludes studies of, for instance, nutrition, alcohol or street drug use and many other lifestyle factors where prospective information or independent register information is difficult or impossible to obtain. Epidemiology of Human Congenital Malformations culminates with a discussion on how the presence of malformations can be explained and various possibilities for the prevention of birth defects. Moreover, it will include a series of instructions on how to read epidemiological literature in this field making it an essential resource both for those currently working in the field of reproductive epidemiology or those intending to enter it. It will additionally be useful for doctors working with malformations, either as obstetricians, neonatologists or pediatricians.
(source: Nielsen Book Data)
Book
1 online resource (xx, 829 p.) : ill.
  • Atlas
  • Basic biology
  • Protocols.
The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. It provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications. It describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes. It educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation. It discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success.
(source: Nielsen Book Data)
  • Atlas
  • Basic biology
  • Protocols.
The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. It provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications. It describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes. It educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation. It discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success.
(source: Nielsen Book Data)
Book
xxii, 384 p. : ill. (some col.).
Book
1 online resource : text file, PDF
  • Human Thermal Environments Introduction Basic Parameters Heat Transfer for a Cylinder Role of Heat Transfer Theory in the Assessment of Human Thermal Environments The Human Heat Balance Equation and the Thermal Audit The Heat Balance Equation for the Human Body The Thermal Audit Expert Estimation of the Thermal Audit Assessment of Environments Using the Thermal Audit Summary Human Thermal Physiology and Thermoregulation Introduction Thermal Properties of the Human Body Human Thermoregulation Physiological Responses Behavioural Thermoregulation Body Temperature Comfort as the Regulated Variable Psychological Responses and Human Behaviour Introduction Psychological Models Thermal Sensation Thermoreception Psychophysics Semantics, Psychological Models and Multidimensional Scaling Mood, Aggression, Depression and Other Psychological Reactions Discussion Measurement Methods and Assessment Techniques Introduction Measuring Kits and Composite Instruments Measurement of Physiological Response Measurement of Psychological Responses Thermal Index: An Assessment Technique Dehydration and Water Requirements Introduction Body Water Dehydration Measures Thirst Bioelectrical Impedance Analysis (BIA) Dehydration Limits Practical Recommendations for Drinking Drinking Too Much Thermal Models Introduction Thermal Models Empirical Models Rational Thermal Models Do Models Work? Hybrid Models Computer-Aided Design Metabolic Heat Production Introduction Where Does the Heat Come from? Estimation of Metabolic Heat Production Collection and Analysis of Expired Air The Doubly Labelled Water (DLW) Method The Use of Tables and Databases Empirical Models Subjective Methods Special Populations: Children, People with Physical Disabilities and People Wearing Protective Clothing and Equipment The Thermal Properties of Clothing Introduction The Two-Parameter Model More Complex Clothing Models and the Three-Parameter Model Testing and Developing Clothing Introduction Determination of the Thermal Properties of Clothing Performance Tests Performance Trials Clothing Specification and the Window of Application Thermal Comfort Introduction Whole-Body Thermal Comfort Thermal Models and Thermal Comfort Thermal Comfort for Special Environments Thermal Comfort in Special Environments Personal Control Environments Displacement Ventilation and Chilled Ceiling Environments Thermal Comfort in Vehicles Outdoor Thermal Comfort Other Special Environments Thermal Comfort for Special Populations Introduction Do Requirements for Comfort Apply Universally? Effects of Acclimatisation State on Thermal Comfort Requirements Other Factors People with Disabilities Babies, Children, the Sick and the Pregnant Heat Stress Introduction Physiological Responses to Heat Heat Stress Indices Direct Heat Stress Indices Acclimatisation Working Practices for Hot Environments Cold Stress Introduction Physiological Responses to Cold Psychological Response to Cold Cold Injury and Illness Cold Stress Indices Working Practices for Cold Environments Case Study of Cold Work in a Hospital 'Plating Area' Thermal Environments and Human Performance Introduction Early Studies: Factory Output and Accidents Performance in Moderate Environments Performance in Cold Performance Models and Indices Summary Models Environmental Design for Productivity Human Skin Contact with Hot, Moderate and Cold Surfaces Introduction Skin Contact with a Hot Surface: Analysis of the Event Mathematical Models of Heat Transfer Surfaces of Moderate Temperature Cold Surfaces International Standards Introduction ISO Standards Standards in the United States Standards in China Standards in the United Kingdom European Standards (CEN) Example of the Application of International ISO Standards to the Assessment of a Hot Environment Example of the Application of International (ISO) Standards for the Assessment of Moderate Environments Example of the Application of International (ISO) Standards for the Assessment of Cold Environments Weather, Climate Change and Energy Use Introduction Meteorological Observations Universal Thermal Climate Index (UTCI) Future Development and Application of the UTCI Climate Change Human Thermal Environments and Energy Use People in Extreme Heat and Cold, Hypobaric and Hyperbaric Environments, Water, Space and Extreme Sport Introduction People in Extreme Heat People in Extreme Cold People Under Pressure People in Hyperbaric Environments People in Water Frozen Terrain, Snow, Rain, Wind and Floods People in Space Extreme Sport Appendix 1 Appendix 2 Appendix 3 References Index.
  • (source: Nielsen Book Data)
In the ten years since the publication of the second edition of Human Thermal Environments: The Effects of Hot, Moderate, and Cold Environments on Human Health, Comfort, and Performance, Third Edition, the world has embraced electronic communications, making international collaboration almost instantaneous and global. However, there is still a need for a compilation of up-to-date information and best practices. Reflecting current changes in theory and applications, this third edition of a bestseller continues to be the standard text for the design of environments for humans to live and work safely, comfortably, and effectively, and for the design of materials that help people cope with their environments. See What's New in the Third Edition: All existing chapters significantly updated Five new chapters Testing and development of clothing Adaptive models Thermal comfort for special populations Thermal comfort for special environments Extreme environments Weather Outdoor environments and climate change Fun runs, cold snaps, and heat waves The book covers hot, moderate, and cold environments, and defines them in terms of six basic parameters: air temperature, radiant temperature, humidity, air velocity, clothing worn, and the person's activity. It focuses on the principles and practice of human response, which incorporates psychology, physiology, and environmental physics with applied ergonomics. The text then discusses water requirements, computer modeling, computer-aided design, and current standards. A systematic treatment of thermal environments and how they affect humans in real-world applications, the book links the health and engineering aspects of the built environment. It provides you with updated tools, techniques, and methods for the design of products and environments that achieve thermal comfort.
(source: Nielsen Book Data)
  • Human Thermal Environments Introduction Basic Parameters Heat Transfer for a Cylinder Role of Heat Transfer Theory in the Assessment of Human Thermal Environments The Human Heat Balance Equation and the Thermal Audit The Heat Balance Equation for the Human Body The Thermal Audit Expert Estimation of the Thermal Audit Assessment of Environments Using the Thermal Audit Summary Human Thermal Physiology and Thermoregulation Introduction Thermal Properties of the Human Body Human Thermoregulation Physiological Responses Behavioural Thermoregulation Body Temperature Comfort as the Regulated Variable Psychological Responses and Human Behaviour Introduction Psychological Models Thermal Sensation Thermoreception Psychophysics Semantics, Psychological Models and Multidimensional Scaling Mood, Aggression, Depression and Other Psychological Reactions Discussion Measurement Methods and Assessment Techniques Introduction Measuring Kits and Composite Instruments Measurement of Physiological Response Measurement of Psychological Responses Thermal Index: An Assessment Technique Dehydration and Water Requirements Introduction Body Water Dehydration Measures Thirst Bioelectrical Impedance Analysis (BIA) Dehydration Limits Practical Recommendations for Drinking Drinking Too Much Thermal Models Introduction Thermal Models Empirical Models Rational Thermal Models Do Models Work? Hybrid Models Computer-Aided Design Metabolic Heat Production Introduction Where Does the Heat Come from? Estimation of Metabolic Heat Production Collection and Analysis of Expired Air The Doubly Labelled Water (DLW) Method The Use of Tables and Databases Empirical Models Subjective Methods Special Populations: Children, People with Physical Disabilities and People Wearing Protective Clothing and Equipment The Thermal Properties of Clothing Introduction The Two-Parameter Model More Complex Clothing Models and the Three-Parameter Model Testing and Developing Clothing Introduction Determination of the Thermal Properties of Clothing Performance Tests Performance Trials Clothing Specification and the Window of Application Thermal Comfort Introduction Whole-Body Thermal Comfort Thermal Models and Thermal Comfort Thermal Comfort for Special Environments Thermal Comfort in Special Environments Personal Control Environments Displacement Ventilation and Chilled Ceiling Environments Thermal Comfort in Vehicles Outdoor Thermal Comfort Other Special Environments Thermal Comfort for Special Populations Introduction Do Requirements for Comfort Apply Universally? Effects of Acclimatisation State on Thermal Comfort Requirements Other Factors People with Disabilities Babies, Children, the Sick and the Pregnant Heat Stress Introduction Physiological Responses to Heat Heat Stress Indices Direct Heat Stress Indices Acclimatisation Working Practices for Hot Environments Cold Stress Introduction Physiological Responses to Cold Psychological Response to Cold Cold Injury and Illness Cold Stress Indices Working Practices for Cold Environments Case Study of Cold Work in a Hospital 'Plating Area' Thermal Environments and Human Performance Introduction Early Studies: Factory Output and Accidents Performance in Moderate Environments Performance in Cold Performance Models and Indices Summary Models Environmental Design for Productivity Human Skin Contact with Hot, Moderate and Cold Surfaces Introduction Skin Contact with a Hot Surface: Analysis of the Event Mathematical Models of Heat Transfer Surfaces of Moderate Temperature Cold Surfaces International Standards Introduction ISO Standards Standards in the United States Standards in China Standards in the United Kingdom European Standards (CEN) Example of the Application of International ISO Standards to the Assessment of a Hot Environment Example of the Application of International (ISO) Standards for the Assessment of Moderate Environments Example of the Application of International (ISO) Standards for the Assessment of Cold Environments Weather, Climate Change and Energy Use Introduction Meteorological Observations Universal Thermal Climate Index (UTCI) Future Development and Application of the UTCI Climate Change Human Thermal Environments and Energy Use People in Extreme Heat and Cold, Hypobaric and Hyperbaric Environments, Water, Space and Extreme Sport Introduction People in Extreme Heat People in Extreme Cold People Under Pressure People in Hyperbaric Environments People in Water Frozen Terrain, Snow, Rain, Wind and Floods People in Space Extreme Sport Appendix 1 Appendix 2 Appendix 3 References Index.
  • (source: Nielsen Book Data)
In the ten years since the publication of the second edition of Human Thermal Environments: The Effects of Hot, Moderate, and Cold Environments on Human Health, Comfort, and Performance, Third Edition, the world has embraced electronic communications, making international collaboration almost instantaneous and global. However, there is still a need for a compilation of up-to-date information and best practices. Reflecting current changes in theory and applications, this third edition of a bestseller continues to be the standard text for the design of environments for humans to live and work safely, comfortably, and effectively, and for the design of materials that help people cope with their environments. See What's New in the Third Edition: All existing chapters significantly updated Five new chapters Testing and development of clothing Adaptive models Thermal comfort for special populations Thermal comfort for special environments Extreme environments Weather Outdoor environments and climate change Fun runs, cold snaps, and heat waves The book covers hot, moderate, and cold environments, and defines them in terms of six basic parameters: air temperature, radiant temperature, humidity, air velocity, clothing worn, and the person's activity. It focuses on the principles and practice of human response, which incorporates psychology, physiology, and environmental physics with applied ergonomics. The text then discusses water requirements, computer modeling, computer-aided design, and current standards. A systematic treatment of thermal environments and how they affect humans in real-world applications, the book links the health and engineering aspects of the built environment. It provides you with updated tools, techniques, and methods for the design of products and environments that achieve thermal comfort.
(source: Nielsen Book Data)
Book
1 online resource.
  • Nanotechnology and Neuroscience: nano-electronic, photonic and mechanical neuronal interfacing
  • Carbon nanotubes for neuron-electrode interface with improved mechanical performance
  • Nanoscale field-effect transistors for minimally invasive, high spatial resolution, and three-dimensional action potential recording
  • In-cell recording and stimulation by engulfment mechanisms.-Micromachining Techniques for Realization of Three-Dimensional Microelectrode Arrays
  • Focused ion beam technology as a fabrication and inspection tool in neuron interfacing
  • Active Pixel Sensor MultiElectrode Array for high spatio-temporal resolution
  • Multi electrode and multi transistor arrays for in vivo recording
  • Optogenetics.
This book provides an overview of the different ways in which the 'nano-world' can be beneficial for neuroscientists. The volume encompasses the latest developments in the field of micro- and nanotechnology applied to neuroscience, discussing technological approaches applied to both in-vitro and in-vivo experiments. A variety of different nanotechnologies are presented that include nanostructured electrodes and their electrical, mechanical and biochemical properties, active and passive 2D and 3D multi-electrode arrays (MEAs), nanoscale transistors for sub-cellular re-cordings and an overview on methods, tools and applications in optoge-netics. The book focuses specifically on fabrication strategies, to offer a compre-hensive guide for developing and applying micro- and nanostructured tools for neuroscientific applications. It is intended as a reference both for neuroscientists and nanotechnologists on the latest developments in neu-rotechnological tools. -Provides readers with state-of-the-art information about developing advanced nanotechnology tools for communicating with the brain; -Includes discussion of the compatibility of fabrication techniques optimized for different target devices, such as electric sensors/transducers based on metallic or semiconductor interfaces and optical probes to guide light into the brain; -Offers a single-source reference to the mechanical, electrical and optical effects of nanostructures on neurons.
  • Nanotechnology and Neuroscience: nano-electronic, photonic and mechanical neuronal interfacing
  • Carbon nanotubes for neuron-electrode interface with improved mechanical performance
  • Nanoscale field-effect transistors for minimally invasive, high spatial resolution, and three-dimensional action potential recording
  • In-cell recording and stimulation by engulfment mechanisms.-Micromachining Techniques for Realization of Three-Dimensional Microelectrode Arrays
  • Focused ion beam technology as a fabrication and inspection tool in neuron interfacing
  • Active Pixel Sensor MultiElectrode Array for high spatio-temporal resolution
  • Multi electrode and multi transistor arrays for in vivo recording
  • Optogenetics.
This book provides an overview of the different ways in which the 'nano-world' can be beneficial for neuroscientists. The volume encompasses the latest developments in the field of micro- and nanotechnology applied to neuroscience, discussing technological approaches applied to both in-vitro and in-vivo experiments. A variety of different nanotechnologies are presented that include nanostructured electrodes and their electrical, mechanical and biochemical properties, active and passive 2D and 3D multi-electrode arrays (MEAs), nanoscale transistors for sub-cellular re-cordings and an overview on methods, tools and applications in optoge-netics. The book focuses specifically on fabrication strategies, to offer a compre-hensive guide for developing and applying micro- and nanostructured tools for neuroscientific applications. It is intended as a reference both for neuroscientists and nanotechnologists on the latest developments in neu-rotechnological tools. -Provides readers with state-of-the-art information about developing advanced nanotechnology tools for communicating with the brain; -Includes discussion of the compatibility of fabrication techniques optimized for different target devices, such as electric sensors/transducers based on metallic or semiconductor interfaces and optical probes to guide light into the brain; -Offers a single-source reference to the mechanical, electrical and optical effects of nanostructures on neurons.
Book
1 online resource (xii, 132 pages) : illustrations (some color) Digital: text file; PDF.
  • Opioid and Non-Opioid Drug Responding Under States of Chronic Pain: A Timeline Spanning 1980 to Present Day
  • Opioid Self-Administration in the Presence of Chronic Pain: Analgesia or Addiction
  • The Influence of Pain on Reward Processing: Current Literature and Prospects
  • Chronic Pain Stimuli Downregulate Mesolimbic Dopaminergic Transmission: Possible Mechanism of the Suppression of Opioid Reward
  • Drug Addiction and Chronic Pain: A Review of Animal Models
  • Biopharmaceutical Considerations of Opioid Analgesics in Models of Self-Administration: Review and Summary
  • Prenatal Exposure to Opioids
  • Opioids in an Evidence-Based World.
Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.
(source: Nielsen Book Data)
  • Opioid and Non-Opioid Drug Responding Under States of Chronic Pain: A Timeline Spanning 1980 to Present Day
  • Opioid Self-Administration in the Presence of Chronic Pain: Analgesia or Addiction
  • The Influence of Pain on Reward Processing: Current Literature and Prospects
  • Chronic Pain Stimuli Downregulate Mesolimbic Dopaminergic Transmission: Possible Mechanism of the Suppression of Opioid Reward
  • Drug Addiction and Chronic Pain: A Review of Animal Models
  • Biopharmaceutical Considerations of Opioid Analgesics in Models of Self-Administration: Review and Summary
  • Prenatal Exposure to Opioids
  • Opioids in an Evidence-Based World.
Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.
(source: Nielsen Book Data)