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Book
1 PDF (xv, 116 pages).
  • 1. Introduction and scope
  • 1.1 Definitions
  • 1.2 User engagement vs. user experience
  • 1.3 Characteristics
  • 1.3.1 Focused attention
  • 1.3.2 Positive affect
  • 1.3.3 Aesthetics appeal
  • 1.3.4 Endurability
  • 1.3.5 Novelty
  • 1.3.6 Richness and control
  • 1.3.7 Reputation, trust, and expectation
  • 1.3.8 User context, motivation, incentives, and benefits
  • 1.4 Measurements
  • 1.5 Scope
  • 1.6 Structure
  • 2. Approaches based on self-report methods
  • 2.1 Self-report approaches
  • 2.2 Advantages and limitations of self-report methods
  • 2.2.1 Communication
  • 2.2.2 Methodology bias
  • 2.2.3 Reliability and validity
  • 2.3 Interviews
  • 2.3.1 Types of interviews
  • 2.3.2 Applying interviews to measure user engagement
  • 2.4 Think aloud and think after protocols
  • 2.4.1 Think aloud
  • 2.4.2 Think after
  • 2.4.3 Relationship to user engagement
  • 2.5 Questionnaires
  • 2.6 Questionnaires for measuring user engagement
  • 2.6.1 Survey to evaluate engagement
  • 2.6.2 Engagement and influences on questionnaire
  • 2.6.3 User engagement scale
  • 2.6.4 eHealth engagement scale
  • 2.7 Constructs related to user engagement
  • 2.7.1 Mental workload
  • 2.7.2 Disorientation
  • 2.7.3 Playfulness
  • 2.7.4 Cognitive absorption
  • 2.8 Summary
  • 3. Approaches based on physiological measurements
  • 3.1 Psychophysiological measurements
  • 3.2 Facial expressions
  • 3.3 Eye tracking
  • 3.3.1 Eye tracking and search
  • 3.3.2 Eye tracking and reading
  • 3.3.3 Eye tracking and selection
  • 3.3.4 Summary and limitations
  • 3.4 Cursor tracking
  • 3.4.1 Aligning eye gaze and mouse movement
  • 3.4.2 Mouse movement in search
  • 3.4.3 Mouse movement elsewhere
  • 3.5 Summary
  • 4. Approaches based on web analytics
  • 4.1 Intra-session vs. inter-session engagement
  • 4.2 Some dimensions of online measurements
  • 4.2.1 Dependence on the type of website
  • 4.2.2 Dependence on the type of user
  • 4.2.3 Dependence on the task
  • 4.3 Large-scale measurements
  • 4.4 Intra-session measurements
  • 4.4.1 Dwell time and similar measures
  • 4.4.2 Revisits to a site
  • 4.4.3 Clickthrough rate
  • 4.4.4 Number of pages viewed
  • 4.4.5 Other measurements
  • 4.5 Inter-session measurements
  • 4.5.1 Direct value measurement
  • 4.5.2 Total use measurement
  • 4.5.3 Return-rate measurement
  • 4.6 Summary
  • 5. Beyond desktop, single site, and single task
  • 5.1 Measuring for online multitasking
  • 5.2 Measuring on a network of sites
  • 5.3 Measuring in mobile information seeking
  • 5.4 Summary
  • 6. Enhancing the rigor of user engagement methods and measures
  • 6.1 Scale
  • 6.2 Setting
  • 6.3 Temporality
  • 6.4 Objectivity and subjectivity
  • 6.5 Process- and product-based
  • 6.6 Summary
  • 7. Conclusions and future research directions
  • 7.1 Summary
  • 7.2 Future research directions
  • 7.3 Take-aways
  • Bibliography
  • Authors' biographies
  • Index.
User engagement refers to the quality of the user experience that emphasizes the positive aspects of interacting with an online application and, in particular, the desire to use that application longer and repeatedly. User engagement is a key concept in the design of online applications (whether for desktop, tablet or mobile), motivated by the observation that successful applications are not just used, but are engaged with. Users invest time, attention, and emotion in their use of technology, and seek to satisfy pragmatic and hedonic needs. Measurement is critical for evaluating whether online applications are able to successfully engage users, and may inform the design of and use of applications. User engagement is a multifaceted, complex phenomenon; this gives rise to a number of potential measurement approaches. Common ways to evaluate user engagement include using self-report measures, e.g., questionnaires; observational methods, e.g. facial expression analysis, speech analysis; neuro-physiological signal processing methods, e.g., respiratory and cardiovascular accelerations and decelerations, muscle spasms; and web analytics, e.g., number of site visits, click depth. These methods represent various trade-offs in terms of the setting (laboratory versus "in the wild"), object of measurement (user behaviour, affect or cognition) and scale of data collected. For instance, small-scale user studies are deep and rich, but limited in terms of generalizability, whereas large-scale web analytic studies are powerful but negate users' motivation and context. The focus of this book is how user engagement is currently being measured and various considerations for its measurement. Our goal is to leave readers with an appreciation of the various ways in which to measure user engagement, and their associated strengths and weaknesses. We emphasize the multifaceted nature of user engagement and the unique contextual constraints that come to bear upon attempts to measure engagement in different settings, and across different user groups and web domains. At the same time, this book advocates for the development of "good" measures and good measurement practices that will advance the study of user engagement and improve our understanding of this construct, which has become so vital in our wired world.
  • 1. Introduction and scope
  • 1.1 Definitions
  • 1.2 User engagement vs. user experience
  • 1.3 Characteristics
  • 1.3.1 Focused attention
  • 1.3.2 Positive affect
  • 1.3.3 Aesthetics appeal
  • 1.3.4 Endurability
  • 1.3.5 Novelty
  • 1.3.6 Richness and control
  • 1.3.7 Reputation, trust, and expectation
  • 1.3.8 User context, motivation, incentives, and benefits
  • 1.4 Measurements
  • 1.5 Scope
  • 1.6 Structure
  • 2. Approaches based on self-report methods
  • 2.1 Self-report approaches
  • 2.2 Advantages and limitations of self-report methods
  • 2.2.1 Communication
  • 2.2.2 Methodology bias
  • 2.2.3 Reliability and validity
  • 2.3 Interviews
  • 2.3.1 Types of interviews
  • 2.3.2 Applying interviews to measure user engagement
  • 2.4 Think aloud and think after protocols
  • 2.4.1 Think aloud
  • 2.4.2 Think after
  • 2.4.3 Relationship to user engagement
  • 2.5 Questionnaires
  • 2.6 Questionnaires for measuring user engagement
  • 2.6.1 Survey to evaluate engagement
  • 2.6.2 Engagement and influences on questionnaire
  • 2.6.3 User engagement scale
  • 2.6.4 eHealth engagement scale
  • 2.7 Constructs related to user engagement
  • 2.7.1 Mental workload
  • 2.7.2 Disorientation
  • 2.7.3 Playfulness
  • 2.7.4 Cognitive absorption
  • 2.8 Summary
  • 3. Approaches based on physiological measurements
  • 3.1 Psychophysiological measurements
  • 3.2 Facial expressions
  • 3.3 Eye tracking
  • 3.3.1 Eye tracking and search
  • 3.3.2 Eye tracking and reading
  • 3.3.3 Eye tracking and selection
  • 3.3.4 Summary and limitations
  • 3.4 Cursor tracking
  • 3.4.1 Aligning eye gaze and mouse movement
  • 3.4.2 Mouse movement in search
  • 3.4.3 Mouse movement elsewhere
  • 3.5 Summary
  • 4. Approaches based on web analytics
  • 4.1 Intra-session vs. inter-session engagement
  • 4.2 Some dimensions of online measurements
  • 4.2.1 Dependence on the type of website
  • 4.2.2 Dependence on the type of user
  • 4.2.3 Dependence on the task
  • 4.3 Large-scale measurements
  • 4.4 Intra-session measurements
  • 4.4.1 Dwell time and similar measures
  • 4.4.2 Revisits to a site
  • 4.4.3 Clickthrough rate
  • 4.4.4 Number of pages viewed
  • 4.4.5 Other measurements
  • 4.5 Inter-session measurements
  • 4.5.1 Direct value measurement
  • 4.5.2 Total use measurement
  • 4.5.3 Return-rate measurement
  • 4.6 Summary
  • 5. Beyond desktop, single site, and single task
  • 5.1 Measuring for online multitasking
  • 5.2 Measuring on a network of sites
  • 5.3 Measuring in mobile information seeking
  • 5.4 Summary
  • 6. Enhancing the rigor of user engagement methods and measures
  • 6.1 Scale
  • 6.2 Setting
  • 6.3 Temporality
  • 6.4 Objectivity and subjectivity
  • 6.5 Process- and product-based
  • 6.6 Summary
  • 7. Conclusions and future research directions
  • 7.1 Summary
  • 7.2 Future research directions
  • 7.3 Take-aways
  • Bibliography
  • Authors' biographies
  • Index.
User engagement refers to the quality of the user experience that emphasizes the positive aspects of interacting with an online application and, in particular, the desire to use that application longer and repeatedly. User engagement is a key concept in the design of online applications (whether for desktop, tablet or mobile), motivated by the observation that successful applications are not just used, but are engaged with. Users invest time, attention, and emotion in their use of technology, and seek to satisfy pragmatic and hedonic needs. Measurement is critical for evaluating whether online applications are able to successfully engage users, and may inform the design of and use of applications. User engagement is a multifaceted, complex phenomenon; this gives rise to a number of potential measurement approaches. Common ways to evaluate user engagement include using self-report measures, e.g., questionnaires; observational methods, e.g. facial expression analysis, speech analysis; neuro-physiological signal processing methods, e.g., respiratory and cardiovascular accelerations and decelerations, muscle spasms; and web analytics, e.g., number of site visits, click depth. These methods represent various trade-offs in terms of the setting (laboratory versus "in the wild"), object of measurement (user behaviour, affect or cognition) and scale of data collected. For instance, small-scale user studies are deep and rich, but limited in terms of generalizability, whereas large-scale web analytic studies are powerful but negate users' motivation and context. The focus of this book is how user engagement is currently being measured and various considerations for its measurement. Our goal is to leave readers with an appreciation of the various ways in which to measure user engagement, and their associated strengths and weaknesses. We emphasize the multifaceted nature of user engagement and the unique contextual constraints that come to bear upon attempts to measure engagement in different settings, and across different user groups and web domains. At the same time, this book advocates for the development of "good" measures and good measurement practices that will advance the study of user engagement and improve our understanding of this construct, which has become so vital in our wired world.
Book
1 online resource.
Book
1 online resource (295 pages)
Calculus of Thought: Neuromorphic Logistic Regression in Cognitive Machines is a must-read for all scientists about a very simple computation method designed to simulate big-data neural processing. This book is inspired by the Calculus Ratiocinator idea of Gottfried Leibniz, which is that machine computation should be developed to simulate human cognitive processes, thus avoiding problematic subjective bias in analytic solutions to practical and scientific problems. The reduced error logistic regression (RELR) method is proposed as such a "Calculus of Thought."
Calculus of Thought: Neuromorphic Logistic Regression in Cognitive Machines is a must-read for all scientists about a very simple computation method designed to simulate big-data neural processing. This book is inspired by the Calculus Ratiocinator idea of Gottfried Leibniz, which is that machine computation should be developed to simulate human cognitive processes, thus avoiding problematic subjective bias in analytic solutions to practical and scientific problems. The reduced error logistic regression (RELR) method is proposed as such a "Calculus of Thought."
Book
1 online resource (408 pages)
  • History of the study and nomenclature of the claustrum
  • The structure and connections of the claustrum
  • The neurochemical organization of the claustrum
  • Development and evolution of the claustrum
  • Physiology of the claustrum
  • Neurocomputation and coding in the claustrum
  • Structural and functional connectivity of the claustrum in the human brain
  • Delayed development of the claustrum in autism
  • The claustrum in schizophrenia
  • Clinical relations: epilepsy
  • The claustrum and Alzheimer's disease
  • Parkinson's disease and the claustrum
  • Hypotheses relating to the function of the claustrum
  • What is it to be conscious?
  • Selected key areas for future research on the claustrum.
Of the Evidence from Expression of Calcium-Binding Proteins.
The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being continually discovered. This process is most developed in the major areas of the brain, such as the cortex, thalamus, and striatum. The Claustrum instead focuses on a small, remote, and, until recently, relatively unknown area of the brain. In recent years, researchers have come to believe that the claustrum is concerned with consciousness, a bold hypothesis supported by the claustrum's two-w.
  • History of the study and nomenclature of the claustrum
  • The structure and connections of the claustrum
  • The neurochemical organization of the claustrum
  • Development and evolution of the claustrum
  • Physiology of the claustrum
  • Neurocomputation and coding in the claustrum
  • Structural and functional connectivity of the claustrum in the human brain
  • Delayed development of the claustrum in autism
  • The claustrum in schizophrenia
  • Clinical relations: epilepsy
  • The claustrum and Alzheimer's disease
  • Parkinson's disease and the claustrum
  • Hypotheses relating to the function of the claustrum
  • What is it to be conscious?
  • Selected key areas for future research on the claustrum.
Of the Evidence from Expression of Calcium-Binding Proteins.
The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being continually discovered. This process is most developed in the major areas of the brain, such as the cortex, thalamus, and striatum. The Claustrum instead focuses on a small, remote, and, until recently, relatively unknown area of the brain. In recent years, researchers have come to believe that the claustrum is concerned with consciousness, a bold hypothesis supported by the claustrum's two-w.
Book
1 online resource (178 p.)
Clinical Anatomy of the Cranial Nerves combines anatomical knowledge, pathology, clinical examination, and explanation of clinical findings, drawing together material typically scattered throughout anatomical textbooks. All of the pertinent anatomical topics are conveniently organized to instruct on anatomy, but also on how to examine the functioning of this anatomy in the patient. Providing a clear and succinct presentation of the underlying anatomy, with directly related applications of the anatomy to clinical examination, the book also provides unique images of anatomical structures.
Clinical Anatomy of the Cranial Nerves combines anatomical knowledge, pathology, clinical examination, and explanation of clinical findings, drawing together material typically scattered throughout anatomical textbooks. All of the pertinent anatomical topics are conveniently organized to instruct on anatomy, but also on how to examine the functioning of this anatomy in the patient. Providing a clear and succinct presentation of the underlying anatomy, with directly related applications of the anatomy to clinical examination, the book also provides unique images of anatomical structures.
Book
1 online resource.
  • 1. Definition of comparative medicine: History and new identity
  • 2. Smallest unit of life: Cell biology
  • 3. Supporting apparatus of vertebrates: Skeleton and bones
  • 4. Locomotor principles: Anatomy and physiology of skeletal muscles
  • 5. Lifeblood flow: The circulatory systems
  • 6. Steering and communication: Nervous system and sensory organs
  • 7. Surface, barrier, and interface zone: Comparative aspects of the skin
  • 8. Body messaging: The endocrine systems
  • 9. Alimentation and elimination: The principles of gastrointestinal digestion
  • 10. Volume and clearance: Kidneys and excretory systems
  • 11. Breathing: Comparative aspects of the respiratory system
  • 12. Propagation: Mammalian reproduction
  • 13. Common concepts of immune defense
  • 14. Laboratory animal law: An introduction to its history and principles
  • 15. Ethics inlaboratory animal science.
  • 1. Definition of comparative medicine: History and new identity
  • 2. Smallest unit of life: Cell biology
  • 3. Supporting apparatus of vertebrates: Skeleton and bones
  • 4. Locomotor principles: Anatomy and physiology of skeletal muscles
  • 5. Lifeblood flow: The circulatory systems
  • 6. Steering and communication: Nervous system and sensory organs
  • 7. Surface, barrier, and interface zone: Comparative aspects of the skin
  • 8. Body messaging: The endocrine systems
  • 9. Alimentation and elimination: The principles of gastrointestinal digestion
  • 10. Volume and clearance: Kidneys and excretory systems
  • 11. Breathing: Comparative aspects of the respiratory system
  • 12. Propagation: Mammalian reproduction
  • 13. Common concepts of immune defense
  • 14. Laboratory animal law: An introduction to its history and principles
  • 15. Ethics inlaboratory animal science.
Book
1 online resource (xiii, 585 pages) : illustrations (some color)
  • Section 1: Neurohistological techniques
  • 1. Brain tissue preparation, sectioning and staining
  • 2. Brain stereotactic injections
  • 3. Tract tracing at light and electron microscopy
  • 4. Stereological analysis of neurological tissues
  • Section 2: In vitro preparations
  • 5. Preparation and use of rodent hippocampal brain slices
  • 6.? Single-Cell Neuronal Dissociation For Electrophysiological Studies
  • 7. Isolation and Culture of Human Neurons, Microglia and Astrocytes
  • 8. Isolation and Culture of Neural Stem/progenitor Cells
  • 9. Isolation of mitochondria from brain tissue and cells
  • 10. Isolation of synaptosomes from archived brain tissues
  • 11. Xenopus oocytes isolation and microinjection
  • Section 3: Leukocyte isolation and application in neuroscience
  • 12. Centrifugal elutriation for studies of neuroimmunity
  • 13. Flow cytometry in neuroscience research
  • Section 4: Standard Laboratory Nucleic Acid and Protein Detections
  • 14. Western Blotting Technique in Biomedical Research
  • 15. Polymerase chain reaction (PCR) and Real-time RT PCR
  • Section 5: Nanomedicine
  • 16. Nanoformulations
  • 17. Neuronanomedicine
  • Section 6: Bioimaging
  • 18. Confocal imaging of nerve cells
  • 19. Magnetic resonance imaging (MRI)
  • 20. X-Ray, Positron Emission, and Single Photon Emission Tomographic Bioimaging
  • 21. Non-Invasive Neurophysiological Imaging with Magnetoencephalography
  • 22. Multiphoton Brain Imaging
  • Section 7: Neuroelectrophysiology
  • 23. Techniques for Extracellular Recordings
  • 24. Blind patch-clamp recordings from rodent hippocampal slices
  • 25. Whole-cell patch clamp recordings
  • Section 8: Immunohistochemistry and autoradiography
  • 26. Analysis of Receptor Binding And Quantitative Autoradiography
  • 27. Techniques in Immunohistochemistry and immunocytochemistry
  • Section 9: Analysis of Gene Expression
  • 28. Protein identification by mass spectrometry: Proteomics
  • 29. DNA Microarrays as a Tool for Neurosciences Research
  • 30. Metabolomics
  • 31. Bioinformatic Methods and Resources for Neuroscience Research
  • Section 10: Animal Models: Behavior and Pathology
  • 32. Motor function in rodent models of neurodegenerative disorders
  • 33. Humanized mice
  • 34. Animal models for PD and ALS
  • 35. Animal models for Alzheimer's Disease
  • 36. Animal Models: Behavior and Pathology.
Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
  • Section 1: Neurohistological techniques
  • 1. Brain tissue preparation, sectioning and staining
  • 2. Brain stereotactic injections
  • 3. Tract tracing at light and electron microscopy
  • 4. Stereological analysis of neurological tissues
  • Section 2: In vitro preparations
  • 5. Preparation and use of rodent hippocampal brain slices
  • 6.? Single-Cell Neuronal Dissociation For Electrophysiological Studies
  • 7. Isolation and Culture of Human Neurons, Microglia and Astrocytes
  • 8. Isolation and Culture of Neural Stem/progenitor Cells
  • 9. Isolation of mitochondria from brain tissue and cells
  • 10. Isolation of synaptosomes from archived brain tissues
  • 11. Xenopus oocytes isolation and microinjection
  • Section 3: Leukocyte isolation and application in neuroscience
  • 12. Centrifugal elutriation for studies of neuroimmunity
  • 13. Flow cytometry in neuroscience research
  • Section 4: Standard Laboratory Nucleic Acid and Protein Detections
  • 14. Western Blotting Technique in Biomedical Research
  • 15. Polymerase chain reaction (PCR) and Real-time RT PCR
  • Section 5: Nanomedicine
  • 16. Nanoformulations
  • 17. Neuronanomedicine
  • Section 6: Bioimaging
  • 18. Confocal imaging of nerve cells
  • 19. Magnetic resonance imaging (MRI)
  • 20. X-Ray, Positron Emission, and Single Photon Emission Tomographic Bioimaging
  • 21. Non-Invasive Neurophysiological Imaging with Magnetoencephalography
  • 22. Multiphoton Brain Imaging
  • Section 7: Neuroelectrophysiology
  • 23. Techniques for Extracellular Recordings
  • 24. Blind patch-clamp recordings from rodent hippocampal slices
  • 25. Whole-cell patch clamp recordings
  • Section 8: Immunohistochemistry and autoradiography
  • 26. Analysis of Receptor Binding And Quantitative Autoradiography
  • 27. Techniques in Immunohistochemistry and immunocytochemistry
  • Section 9: Analysis of Gene Expression
  • 28. Protein identification by mass spectrometry: Proteomics
  • 29. DNA Microarrays as a Tool for Neurosciences Research
  • 30. Metabolomics
  • 31. Bioinformatic Methods and Resources for Neuroscience Research
  • Section 10: Animal Models: Behavior and Pathology
  • 32. Motor function in rodent models of neurodegenerative disorders
  • 33. Humanized mice
  • 34. Animal models for PD and ALS
  • 35. Animal models for Alzheimer's Disease
  • 36. Animal Models: Behavior and Pathology.
Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
Book
1 online resource (ix, 170 pages) : ill.
  • A Short History of Birth Defect Epidemiology
  • Genetic and Non-genetic Factors in the Origin of Congenital Malformations
  • Ascertainment of Children with Congenital Malformations
  • Statistical Considerations
  • Epidemiological Methods
  • Neural Tube Defects
  • Microcephaly
  • Hydrocephaly
  • Agenesis of Corpus Callosum and Holoprosencephaly
  • Severe Eye Malformations
  • Severe Ear Malformations
  • Cardiovascular Defects
  • Orofacial Clefts
  • Atresia or Stenosis of the Alimentary Tract
  • Pyloric Stenosis
  • Malrotation of the Gut
  • Megacolon
  • Hypospadias
  • Epispadias, Cloacal and Bladder Exstrophy
  • Severe Renal Malformations
  • Posterior Urethral Valve
  • Pes Equinovarus
  • Other Foot Deformities than Pes Equinovarus
  • Polydactyly and Syndactyly
  • Limb Reduction Defects
  • Craniostenosis
  • Diaphragmatic Hernia
  • Abdominal Wall Defects
  • Children with multiple malformations
  • Syndromes
  • Down Syndrome
  • Explanation and Prevention of Birth Defects
  • Eight Commandments: Rules for the Interpretation of Birth Defect Epidemiological Studies.
Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden. The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest.
  • A Short History of Birth Defect Epidemiology
  • Genetic and Non-genetic Factors in the Origin of Congenital Malformations
  • Ascertainment of Children with Congenital Malformations
  • Statistical Considerations
  • Epidemiological Methods
  • Neural Tube Defects
  • Microcephaly
  • Hydrocephaly
  • Agenesis of Corpus Callosum and Holoprosencephaly
  • Severe Eye Malformations
  • Severe Ear Malformations
  • Cardiovascular Defects
  • Orofacial Clefts
  • Atresia or Stenosis of the Alimentary Tract
  • Pyloric Stenosis
  • Malrotation of the Gut
  • Megacolon
  • Hypospadias
  • Epispadias, Cloacal and Bladder Exstrophy
  • Severe Renal Malformations
  • Posterior Urethral Valve
  • Pes Equinovarus
  • Other Foot Deformities than Pes Equinovarus
  • Polydactyly and Syndactyly
  • Limb Reduction Defects
  • Craniostenosis
  • Diaphragmatic Hernia
  • Abdominal Wall Defects
  • Children with multiple malformations
  • Syndromes
  • Down Syndrome
  • Explanation and Prevention of Birth Defects
  • Eight Commandments: Rules for the Interpretation of Birth Defect Epidemiological Studies.
Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden. The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest.
Book
1 online resource (xx, 829 p.) : ill.
  • Atlas
  • Basic biology
  • Protocols.
The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy.
  • Atlas
  • Basic biology
  • Protocols.
The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy.
Book
xxii, 384 p. : ill. (some col.).
Book
1 online resource (ix, 414 p.) : ill.
  • Introduction to the human body
  • Cellular chemistry
  • Cell structure and function
  • Tissues
  • Integumentary system
  • Skeletal system
  • Muscle tissue and mode of contraction
  • Muscular system
  • Nervous tissue
  • Central nervous system
  • Peripheral and autonomic nervous systems
  • Sensory organs
  • Endocrine system
  • Cardiovascular system: blood
  • Cardiovascular system: the heart
  • Cardiovascular system: vessels and blood circulation
  • Lymphatic system and body immunity
  • Respiratory system
  • Digestive system
  • Metabolism, nutrition, and temperature regulation
  • Urinary system
  • Water and electrolyte balance
  • Reproductive system.
  • Introduction to the human body
  • Cellular chemistry
  • Cell structure and function
  • Tissues
  • Integumentary system
  • Skeletal system
  • Muscle tissue and mode of contraction
  • Muscular system
  • Nervous tissue
  • Central nervous system
  • Peripheral and autonomic nervous systems
  • Sensory organs
  • Endocrine system
  • Cardiovascular system: blood
  • Cardiovascular system: the heart
  • Cardiovascular system: vessels and blood circulation
  • Lymphatic system and body immunity
  • Respiratory system
  • Digestive system
  • Metabolism, nutrition, and temperature regulation
  • Urinary system
  • Water and electrolyte balance
  • Reproductive system.
Book
1 online resource (x, 174 pages) : illustrations (some color)
  • 1 Introduction (Kazunori Sango and Junji Yamauchi)
  • 2 Recent insights into molecular mechanisms that control growth factor receptor-mediated Schwann cell morphological changes during development (Yuki Miyamoto and Junji Yamauchi)
  • 3 Membrane Skeleton in Schmidt-Lanterman Incisure in Schwann cells of Peripheral Nervous System (Nobuo Terada, Yurika Saitoh, Nobuhiko Ohno, and Shinichi Ohno)
  • 4 Schwann cell-axon interactions: the molecular and metabolic link between Schwann cells and axons (Nobuhiko Ohno, Takashi Sakoh, Yurika Saitoh, Nobuo Terada, and Shinichi Ohno)
  • 5 Schwann cell-dependent regulation of peripheral nerve injury and repair (Keiichiro Susuki )
  • 6 Charcot-Marie-Tooth disease (Toru Ogata)
  • 7 Expression of the transthyretin gene in Schwann cells, and familial amyloidotic polyneuropathy-mediated neurodegeneration (Tatsufumi Murakami and Yoshihide Sunada)
  • 8 Node of Ranvier disruption: a key pathophysiology in immune-mediated neuropathies (Keiichiro Susuki )
  • 9 Pathogenesis of diabetic neuropathy from the viewpoint of Schwann cell abnormalities (Koichi Kato, Eva L. Feldman, and Jiro Nakamura)
  • 10 Spontaneously immortalized adult rodent Schwann cells as valuable tools for the study of peripheral nerve degeneration and regeneration (Kazunori Sango, Masami Tsukamoto, Kazunori Utsunomiya, and Kazuhiko Watabe)
  • BM Index.
This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot?Marie?Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy, and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies, have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop, a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students, and young clinicians.
  • 1 Introduction (Kazunori Sango and Junji Yamauchi)
  • 2 Recent insights into molecular mechanisms that control growth factor receptor-mediated Schwann cell morphological changes during development (Yuki Miyamoto and Junji Yamauchi)
  • 3 Membrane Skeleton in Schmidt-Lanterman Incisure in Schwann cells of Peripheral Nervous System (Nobuo Terada, Yurika Saitoh, Nobuhiko Ohno, and Shinichi Ohno)
  • 4 Schwann cell-axon interactions: the molecular and metabolic link between Schwann cells and axons (Nobuhiko Ohno, Takashi Sakoh, Yurika Saitoh, Nobuo Terada, and Shinichi Ohno)
  • 5 Schwann cell-dependent regulation of peripheral nerve injury and repair (Keiichiro Susuki )
  • 6 Charcot-Marie-Tooth disease (Toru Ogata)
  • 7 Expression of the transthyretin gene in Schwann cells, and familial amyloidotic polyneuropathy-mediated neurodegeneration (Tatsufumi Murakami and Yoshihide Sunada)
  • 8 Node of Ranvier disruption: a key pathophysiology in immune-mediated neuropathies (Keiichiro Susuki )
  • 9 Pathogenesis of diabetic neuropathy from the viewpoint of Schwann cell abnormalities (Koichi Kato, Eva L. Feldman, and Jiro Nakamura)
  • 10 Spontaneously immortalized adult rodent Schwann cells as valuable tools for the study of peripheral nerve degeneration and regeneration (Kazunori Sango, Masami Tsukamoto, Kazunori Utsunomiya, and Kazuhiko Watabe)
  • BM Index.
This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot?Marie?Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy, and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies, have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop, a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students, and young clinicians.
Book
1 online resource (xiii, 908 p.) : ill. (chiefly color).
Yen & Jaffe's Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for fellows preparing for the boards, endocrinologists preparing for recertification, or as a quick reference when making daily diagnostic and therapeutic decisions. It is just the resource you need to offer your patients the best possible reproductive care. Get unmatched guidance you can trust, such as fresh insights into today's field and future advances, through the knowledge gleaned from worldwide fertility experts in reproductive medicine.Further your study of Reproductive Endocrinology with a list of suggested readings at the end of each chapter.Conveniently access the fully searchable text and view all of the images online at Expert Consult.
Yen & Jaffe's Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for fellows preparing for the boards, endocrinologists preparing for recertification, or as a quick reference when making daily diagnostic and therapeutic decisions. It is just the resource you need to offer your patients the best possible reproductive care. Get unmatched guidance you can trust, such as fresh insights into today's field and future advances, through the knowledge gleaned from worldwide fertility experts in reproductive medicine.Further your study of Reproductive Endocrinology with a list of suggested readings at the end of each chapter.Conveniently access the fully searchable text and view all of the images online at Expert Consult.
Book
1 online resource.
dx.doi.org Wiley Online Library
Book
1 online resource (xv, 185 p.) : ill. (some col.)
  • Head and Neck Lymph Node Anatomy
  • Chest Lymph Node Anatomy
  • Abdominal Lymph Node Anatomy
  • Pelvic Lymph Nodes
  • Pitfalls and Mimics of Lymph Nodes on Imaging.
  • Head and Neck Lymph Node Anatomy
  • Chest Lymph Node Anatomy
  • Abdominal Lymph Node Anatomy
  • Pelvic Lymph Nodes
  • Pitfalls and Mimics of Lymph Nodes on Imaging.
dx.doi.org SpringerLink
Book
xi, 182 p. : ill.
  • ch.1 . Automotive ergonomics : 20 years on / Nikolaos Gkikas
  • ch. 2. Digital human modelling (DHM) in the automotive industry / Bryan Beeney and Julie Charland
  • ch. 3. Are you sitting comfortably? : a guide to occupant packaging in automotive design / Paul Herriotts and Paul Johnson
  • ch. 4. IVIS, ADAS, OODA : joining the loops / Nick Reed
  • ch. 5. Ergonomics issues with advanced driver assistance systems (ADAS) / Mark S. Young
  • ch. 6. Human response to vehicle vibration / Neil J. Mansfield
  • ch. 7. Thermal environments and vehicles / Simon Hodder
  • ch. 8. Driving posture and healthy design / Diane Elizabeth Gyi
  • ch. 9. The essential realism of driving simulators for research and training / Andrew Parkes
  • ch. 10. Human-machine interaction (HMI) in the time of electric vehicles / Nikolaos Gkikas.
"The name of Karl Benz, one of the father figures in the automotive industry, is quoted more than once in this book. This is not only because of his undoubted contribution during the initial phase of developments, but also because of the contrast of expectations by key figures such as himself against the established beliefs and practices of today. Common perception of what the automobile is and whom it is addressed to was significantly different back then. From the very few who could afford and the handful of those skilled enough to control such machines, within a few decades we were led to the generalization of the automobile, first in the US, then in Europe and post-WWII Japan"-- Provided by publisher.
  • ch.1 . Automotive ergonomics : 20 years on / Nikolaos Gkikas
  • ch. 2. Digital human modelling (DHM) in the automotive industry / Bryan Beeney and Julie Charland
  • ch. 3. Are you sitting comfortably? : a guide to occupant packaging in automotive design / Paul Herriotts and Paul Johnson
  • ch. 4. IVIS, ADAS, OODA : joining the loops / Nick Reed
  • ch. 5. Ergonomics issues with advanced driver assistance systems (ADAS) / Mark S. Young
  • ch. 6. Human response to vehicle vibration / Neil J. Mansfield
  • ch. 7. Thermal environments and vehicles / Simon Hodder
  • ch. 8. Driving posture and healthy design / Diane Elizabeth Gyi
  • ch. 9. The essential realism of driving simulators for research and training / Andrew Parkes
  • ch. 10. Human-machine interaction (HMI) in the time of electric vehicles / Nikolaos Gkikas.
"The name of Karl Benz, one of the father figures in the automotive industry, is quoted more than once in this book. This is not only because of his undoubted contribution during the initial phase of developments, but also because of the contrast of expectations by key figures such as himself against the established beliefs and practices of today. Common perception of what the automobile is and whom it is addressed to was significantly different back then. From the very few who could afford and the handful of those skilled enough to control such machines, within a few decades we were led to the generalization of the automobile, first in the US, then in Europe and post-WWII Japan"-- Provided by publisher.
Book
1 online resource.
Book
1 online resource.
  • The Bladder as a Dynamic System
  • Investigations into Biomechanics of the Bladder
  • Geometry of Thin Shells
  • Essentials of the Theory of Soft Shells
  • Continual Model of the Detrusor
  • A Model of the Detrusor Fasciculus
  • The Intrinsic Regulatory Pathways
  • The Synaptic Transmission
  • Pharmacology of Detrusor Activity
  • Human Urinary Bladder as a Soft Biological Shell
  • Challenges in Human Urinary Bladder Mechanics.
  • The Bladder as a Dynamic System
  • Investigations into Biomechanics of the Bladder
  • Geometry of Thin Shells
  • Essentials of the Theory of Soft Shells
  • Continual Model of the Detrusor
  • A Model of the Detrusor Fasciculus
  • The Intrinsic Regulatory Pathways
  • The Synaptic Transmission
  • Pharmacology of Detrusor Activity
  • Human Urinary Bladder as a Soft Biological Shell
  • Challenges in Human Urinary Bladder Mechanics.