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Book
1 online resource : text file, PDF
  • 1. Isotope ratio mass spectrometry : devices, methods, applications / V.S. Sevastyanov
  • 2. Universal method for preparation of liquid, solid and gaseous samples for determining the isotopic composition of carbon / T.A. Velivetskaya, A. Ignat'ev, S. Kiyashko
  • 3. Using isotope ratio mass spectrometry for assessing the metabolic potential of soil microbiota / A.M. Zyakun and O. Dilly
  • 4. Study of the isotopic composition of normal alkanes of continental plants / N.A. Pedentchouk
  • 5. Using isotope ratio mass spectroscopy for analysis of tobacco / A.B. Uryupin
  • 6. Using isotope mass ratio spectrometry of carbon in doping control / T. Sobolevski, I.S. Prasolov and G.M. Rodchenkov
  • 7. Isolation methods in isotope geochemistry of noble gases / A.I. Buikin
  • 8. Using laser spectroscopy for measuring the ratios of stable isotopes / V.S. Sevastyanov.
  • 1. Isotope ratio mass spectrometry : devices, methods, applications / V.S. Sevastyanov
  • 2. Universal method for preparation of liquid, solid and gaseous samples for determining the isotopic composition of carbon / T.A. Velivetskaya, A. Ignat'ev, S. Kiyashko
  • 3. Using isotope ratio mass spectrometry for assessing the metabolic potential of soil microbiota / A.M. Zyakun and O. Dilly
  • 4. Study of the isotopic composition of normal alkanes of continental plants / N.A. Pedentchouk
  • 5. Using isotope ratio mass spectroscopy for analysis of tobacco / A.B. Uryupin
  • 6. Using isotope mass ratio spectrometry of carbon in doping control / T. Sobolevski, I.S. Prasolov and G.M. Rodchenkov
  • 7. Isolation methods in isotope geochemistry of noble gases / A.I. Buikin
  • 8. Using laser spectroscopy for measuring the ratios of stable isotopes / V.S. Sevastyanov.
Book
1 online resource (xvi, 600 pages) : illustrations (some color).
Book
xvi, 600 pages : illustrations (some color) ; 24 cm
  • Mass spectrometry for proteomics-based investigation / Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel, and Costel C. Darie
  • MALDI profiling and applications in medicine / Ed Dudley
  • Simplifying the proteome: analytical strategies for improving peak capacity / Lee A. Gethings and Joanne B. Connolly
  • Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences / Lewis M. Brown
  • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics / Esthelle Hoedt, Guoan Zhang, and Thomas A. Neubert
  • Utility of computational structural biology in mass spectrometry / Urmi Roy, Alisa G. Woods, Izabela Sokolowska, and Costel C. Darie
  • Affinity-mass spectrometry approaches for elucidating structures and interactions of protein-ligand complexes / Brînduşa Alina Petre
  • Neurological analyses: focus on gangliosides and mass spectrometry / Alina D. Zamfir
  • Mass spectrometric analysis of post-translational modifications (PTMs) and protein-protein interactions (PPIs) / Armand G. Ngounou Wetie, Alisa G. Woods, and Costel C. Darie
  • Applications for mass spectrometry in the study of ion channel structure and function / Damien S.K. Samways
  • A mass spectrometry view of stable and transient protein interactions / Hanna G. Budayeva and Ileana M. Cristea
  • Mass spectrometry-based tissue imaging of small molecules / Carly N. Ferguson, Joseph W.M. Fowler, Jonathan F. Waxer, Richard A. Gatti, and Joseph A. Loo
  • Redox proteomics: from bench to bedside / Karina Ckless
  • Analysis of fluorinated proteins by mass spectrometry / Linda A. Luck
  • Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system / Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace
  • Mass spectrometry-based biomarkers in drug development / Ronald A. Miller and Daniel S. Spellman
  • Detection of biomedically relevant stilbenes from wines by mass spectrometry / Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, and Alina Vasilescu
  • Mass spectrometric DNA adduct quantification by multiple reaction monitoring and its future use for the molecular epidemiology of cancer / Bernhard H. Monien
  • Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics / Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, and Kathleen F. Arcaro
  • Cancer secretomes and their place in supplementing other hallmarks of cancer / Sapan Patel, Armand G. Ngounou Wetie, Costel C. Darie, and Bayard D. Clarkson
  • Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation / Cristinel Sandu, Armand G. Ngounou Wetie, Costel C. Darie, and Hermann Steller
  • Using proteomics to unravel the mysterious steps of the HBV-life-cycle / Norica Branza-Nichita, Catalina Petrareanu, Catalin Lazar, Izabela Sokolowska, and Costel C. Darie
  • Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends / Mouna Marrakchi, Xiaobo Liu, and Silvana Andreescu
  • Proteomic approaches to dissect neuronal signaling pathways / Heather L. Bowling and Katrin Deinhardt
  • Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF) / Alisa G. Woods, Izabela Sokolowska, Katrin Deinhardt, and Costel C. Darie
  • Mass spectrometry for the study of autism and neurodevelopmental disorders / Armand G. Ngounou Wetie, Robert M. Dekroon, Mihaela Mocanu, Jeanne P. Ryan, Costel C. Darie, and Alisa G. Woods
  • Biomarkers in major depressive disorder: the role of mass spectrometry / Alisa G. Woods, Dan V. Iosifescu, and Costel C. Darie
  • Application of mass spectrometry to characterize localization and efficacy of nanoceria in vivo / Karin L. Heckman, Joseph Erlichman, Ken Reed, and Matthew Skeels
  • Bottlenecks in proteomics / Armand G. Ngounou Wetie, Devon A. Shipp, and Costel C. Darie.
"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.
  • Mass spectrometry for proteomics-based investigation / Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel, and Costel C. Darie
  • MALDI profiling and applications in medicine / Ed Dudley
  • Simplifying the proteome: analytical strategies for improving peak capacity / Lee A. Gethings and Joanne B. Connolly
  • Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences / Lewis M. Brown
  • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics / Esthelle Hoedt, Guoan Zhang, and Thomas A. Neubert
  • Utility of computational structural biology in mass spectrometry / Urmi Roy, Alisa G. Woods, Izabela Sokolowska, and Costel C. Darie
  • Affinity-mass spectrometry approaches for elucidating structures and interactions of protein-ligand complexes / Brînduşa Alina Petre
  • Neurological analyses: focus on gangliosides and mass spectrometry / Alina D. Zamfir
  • Mass spectrometric analysis of post-translational modifications (PTMs) and protein-protein interactions (PPIs) / Armand G. Ngounou Wetie, Alisa G. Woods, and Costel C. Darie
  • Applications for mass spectrometry in the study of ion channel structure and function / Damien S.K. Samways
  • A mass spectrometry view of stable and transient protein interactions / Hanna G. Budayeva and Ileana M. Cristea
  • Mass spectrometry-based tissue imaging of small molecules / Carly N. Ferguson, Joseph W.M. Fowler, Jonathan F. Waxer, Richard A. Gatti, and Joseph A. Loo
  • Redox proteomics: from bench to bedside / Karina Ckless
  • Analysis of fluorinated proteins by mass spectrometry / Linda A. Luck
  • Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system / Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace
  • Mass spectrometry-based biomarkers in drug development / Ronald A. Miller and Daniel S. Spellman
  • Detection of biomedically relevant stilbenes from wines by mass spectrometry / Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, and Alina Vasilescu
  • Mass spectrometric DNA adduct quantification by multiple reaction monitoring and its future use for the molecular epidemiology of cancer / Bernhard H. Monien
  • Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics / Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, and Kathleen F. Arcaro
  • Cancer secretomes and their place in supplementing other hallmarks of cancer / Sapan Patel, Armand G. Ngounou Wetie, Costel C. Darie, and Bayard D. Clarkson
  • Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation / Cristinel Sandu, Armand G. Ngounou Wetie, Costel C. Darie, and Hermann Steller
  • Using proteomics to unravel the mysterious steps of the HBV-life-cycle / Norica Branza-Nichita, Catalina Petrareanu, Catalin Lazar, Izabela Sokolowska, and Costel C. Darie
  • Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends / Mouna Marrakchi, Xiaobo Liu, and Silvana Andreescu
  • Proteomic approaches to dissect neuronal signaling pathways / Heather L. Bowling and Katrin Deinhardt
  • Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF) / Alisa G. Woods, Izabela Sokolowska, Katrin Deinhardt, and Costel C. Darie
  • Mass spectrometry for the study of autism and neurodevelopmental disorders / Armand G. Ngounou Wetie, Robert M. Dekroon, Mihaela Mocanu, Jeanne P. Ryan, Costel C. Darie, and Alisa G. Woods
  • Biomarkers in major depressive disorder: the role of mass spectrometry / Alisa G. Woods, Dan V. Iosifescu, and Costel C. Darie
  • Application of mass spectrometry to characterize localization and efficacy of nanoceria in vivo / Karin L. Heckman, Joseph Erlichman, Ken Reed, and Matthew Skeels
  • Bottlenecks in proteomics / Armand G. Ngounou Wetie, Devon A. Shipp, and Costel C. Darie.
"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER Unknown
Book
xviii, 271 pages : illustrations ; 24 cm
"This book presents an in-depth examination of the process of detecting and identifying microbes using mass spectrometry techniques and the possibility of using this technology in a field application. Through a side-by-side comparative discussion of the different mass spectrometry approaches, it demonstrates the strengths and weaknesses of each approach. The book includes recent findings that show the detection of new viruses, new bacteria, fungi, and other microbes in complex environmental samples. It describes sample preparation methods and discusses the rationale and methods for the detection and identification of unknown, genetically modified, or synthetic microbes"--Provided by publisher.
"This book presents an in-depth examination of the process of detecting and identifying microbes using mass spectrometry techniques and the possibility of using this technology in a field application. Through a side-by-side comparative discussion of the different mass spectrometry approaches, it demonstrates the strengths and weaknesses of each approach. The book includes recent findings that show the detection of new viruses, new bacteria, fungi, and other microbes in complex environmental samples. It describes sample preparation methods and discusses the rationale and methods for the detection and identification of unknown, genetically modified, or synthetic microbes"--Provided by publisher.
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QP519.9 .M3 I346 2014 Unknown
Book
1 online resource : text file, PDF
  • chapter 1. Introduction
  • chapter 2. Electron ionization
  • chapter 3. Accurate mass measurement
  • chapter 4. Modern techniques.
  • chapter 1. Introduction
  • chapter 2. Electron ionization
  • chapter 3. Accurate mass measurement
  • chapter 4. Modern techniques.
Book
1 online resource : text file, PDF
  • chapter 1. An overview
  • chapter 2. Instrumentation
  • chapter 3. Methodologies and strategies
  • chapter 4. Examples from representative publications
  • chapter 5. The absolute essentials
  • chapter 6. Resources.
"Designed specifically for novice users of mass spectronomy, an audience that is not currently well-addressed by existing texts, this book covers the basic concepts, instruments, and techniques with cases illustrating its application in problem solving. Other books in this field focus too narrowly on instrumentation without discussing practical application, or present the information in dense discussions and tables, making the information hard to find. This book does neither, it provides practical advice and key background knowledge in a format that is easy to use"-- Provided by publisher.
"Mass Spectrometry has grown immeasurably over the last twenty years. It may well be the technique to turn to if you want to analyze gases, pharmaceuticals, drugs of abuse, environmental pollutants, search for explosives at airports, to sequence peptides from proteins or understand the role of complex carbohydrates in cancer. There are an ever-increasing number of scientists coming into contact with the technique"-- Provided by publisher.
  • chapter 1. An overview
  • chapter 2. Instrumentation
  • chapter 3. Methodologies and strategies
  • chapter 4. Examples from representative publications
  • chapter 5. The absolute essentials
  • chapter 6. Resources.
"Designed specifically for novice users of mass spectronomy, an audience that is not currently well-addressed by existing texts, this book covers the basic concepts, instruments, and techniques with cases illustrating its application in problem solving. Other books in this field focus too narrowly on instrumentation without discussing practical application, or present the information in dense discussions and tables, making the information hard to find. This book does neither, it provides practical advice and key background knowledge in a format that is easy to use"-- Provided by publisher.
"Mass Spectrometry has grown immeasurably over the last twenty years. It may well be the technique to turn to if you want to analyze gases, pharmaceuticals, drugs of abuse, environmental pollutants, search for explosives at airports, to sequence peptides from proteins or understand the role of complex carbohydrates in cancer. There are an ever-increasing number of scientists coming into contact with the technique"-- Provided by publisher.
Book
1 online resource (xii, 287 pages) : illustrations (some color).
Book
1 online resource (vii, 237 pages) : illustrations (some color)
Book
1 online resource.
Book
1 online resource : text file, PDF
  • chapter 1. History and introduction of UPLC/MS / Mu. Naushad, Mohammad Rizwan Khan, and Zeid Abdullah Alothman
  • chapter 2. UHPLC-MS(/MS) analysis of pesticides in food / Paolo Lucci, Rosa Busquets, and Oscar Nę͠z
  • chapter 3. Ultra-high-performance liquid chromatography in food metabolomics : food quality and authenticity / Cristina C. Jacob and H. Gallart-Ayala
  • chapter 4. UHPLC-MS-based methods for the study of foodborne carcinogens / Lubinda Mbundi and Rosa Busquets
  • chapter 5. Ultra-performance liquid chromatography-mass spectrometry for the determination of capsaicinoids in capsicum species / Saikh Mohammad Wabaidur
  • chapter 6. Applications of UPLC-MS/MS for the quantification of folate vitamers / Maria V. Chandra-Hioe, Jayashree Arcot, and Martin P. Bucknall
  • chapter 7. UPLC-MS/MS analysis of heterocyclic amines in cooked food / Mohammad Rizwan Khan and Mu. Naushad
  • chapter 8. Determination of avocado fruit metabolites by UHPLC-MS : complementarity with other analytical platforms / Elena Hurtado-Fernǹdez, Mara̕ Gm̤ez-Romero, Tiziana Pacchiarotta, Oleg A. Mayboroda, Alegra̕ Carrasco- Pancorbo, and Alberto Fernǹdez-Gutiřrez
  • chapter 9. UHPLC-MS in virgin olive oil analysis : an evolution toward the rationalization and speed of analytical methods / Aadil Bajoub, Alegra̕ Carrasco-Pancorbo, Noureddine Ouazzani, and Alberto Fernǹdez-Gutiřrez
  • chapter 10. Vitamin analysis in food by UPLC-MS / Ahmad Aqel, Kareem Yusuf, Asma'a Al-Rifai, and Zeid Abdullah Alothman
  • chapter 11. UPLC-MS as an analytical tool for the determination of aflatoxins in food / Kareem Yusuf, Ahmad Aqel, Ayman Abdel Ghfar, and Zeid Abdullah Alothman
  • chapter 12. Determination of perfluorochemicals in food and drinking water samples using UHPLC-MS technique / Fabio Gosetti, Eleonora Mazzucco, Maria Carla Gennaro, and Emilio Marengo
  • chapter 13. Determination of acrylamide in foodstuffs using UPLC-MS / Ayman Abdel Ghfar and Ibrahim Hotan Alsohaimi
  • chapter 14. Determination of procyanidins and alkaloids in cocoa and biological samples by ultra-high-performance liquid chromatography coupled to tandem mass spectrometry / Alba Maci, ̉ Maria Jos ̌Motilva, and Nd̉ia Ortega
  • chapter 15. Ultra-performance liquid chromatography-mass spectrometry and its application toward the determination of lactose content in milk / Mahamudur Islam
  • chapter 16. Fast and reliable analysis of phenolic compounds in fruits and vegetables by UHPLC-MS / M.I. Alarcn̤-Flores, R. Romero-Gonzl̀ez, J. L. Martn̕ez Vidal, and A. Garrido Frenich.
"The development of many novel techniques that make our existence so comfortable has been intimately associated with the accessibility of suitable analytical methods. Liquid chromatography-mass spectrometry (LC-MS) is a powerful technique used for various applications based upon its very high sensitivity and selectivity. Generally, its applications are oriented toward the detection and identification of chemicals in a complex mixture. Preparative LC-MS systems can be used for fast and mass-directed purification of natural product extracts and new molecular entities important to food, pharmaceutical, agrochemical, and other industries. This book presents a unique collection of up-to-date UPLC-MS/MS (ultra performance liquid chromatography-tandem mass spectrometric) methods for the separation and quantitative determination of pesticides, capsaicinoids, heterocyclic amines, aflatoxin, perfluorochemicals, acrylamide, procyanidins and alkaloids, lactose content, phenolic compounds, vitamins, and aroma and flavor compounds in a wide variety of foods and food products. This book is the result of the remarkable contributions of 35 experts in interdisciplinary fields of science, with comprehensive, in-depth, and up-to-date research works and reviews. Composed of 16 chapters and compiled using more than 78 figures and 50 tables, this text delivers practical information to all people involved in the research and development, production, or routing analysis of foods and food products. Mu. Naushad and M.R. Khan Editors"-- Provided by publisher.
  • chapter 1. History and introduction of UPLC/MS / Mu. Naushad, Mohammad Rizwan Khan, and Zeid Abdullah Alothman
  • chapter 2. UHPLC-MS(/MS) analysis of pesticides in food / Paolo Lucci, Rosa Busquets, and Oscar Nę͠z
  • chapter 3. Ultra-high-performance liquid chromatography in food metabolomics : food quality and authenticity / Cristina C. Jacob and H. Gallart-Ayala
  • chapter 4. UHPLC-MS-based methods for the study of foodborne carcinogens / Lubinda Mbundi and Rosa Busquets
  • chapter 5. Ultra-performance liquid chromatography-mass spectrometry for the determination of capsaicinoids in capsicum species / Saikh Mohammad Wabaidur
  • chapter 6. Applications of UPLC-MS/MS for the quantification of folate vitamers / Maria V. Chandra-Hioe, Jayashree Arcot, and Martin P. Bucknall
  • chapter 7. UPLC-MS/MS analysis of heterocyclic amines in cooked food / Mohammad Rizwan Khan and Mu. Naushad
  • chapter 8. Determination of avocado fruit metabolites by UHPLC-MS : complementarity with other analytical platforms / Elena Hurtado-Fernǹdez, Mara̕ Gm̤ez-Romero, Tiziana Pacchiarotta, Oleg A. Mayboroda, Alegra̕ Carrasco- Pancorbo, and Alberto Fernǹdez-Gutiřrez
  • chapter 9. UHPLC-MS in virgin olive oil analysis : an evolution toward the rationalization and speed of analytical methods / Aadil Bajoub, Alegra̕ Carrasco-Pancorbo, Noureddine Ouazzani, and Alberto Fernǹdez-Gutiřrez
  • chapter 10. Vitamin analysis in food by UPLC-MS / Ahmad Aqel, Kareem Yusuf, Asma'a Al-Rifai, and Zeid Abdullah Alothman
  • chapter 11. UPLC-MS as an analytical tool for the determination of aflatoxins in food / Kareem Yusuf, Ahmad Aqel, Ayman Abdel Ghfar, and Zeid Abdullah Alothman
  • chapter 12. Determination of perfluorochemicals in food and drinking water samples using UHPLC-MS technique / Fabio Gosetti, Eleonora Mazzucco, Maria Carla Gennaro, and Emilio Marengo
  • chapter 13. Determination of acrylamide in foodstuffs using UPLC-MS / Ayman Abdel Ghfar and Ibrahim Hotan Alsohaimi
  • chapter 14. Determination of procyanidins and alkaloids in cocoa and biological samples by ultra-high-performance liquid chromatography coupled to tandem mass spectrometry / Alba Maci, ̉ Maria Jos ̌Motilva, and Nd̉ia Ortega
  • chapter 15. Ultra-performance liquid chromatography-mass spectrometry and its application toward the determination of lactose content in milk / Mahamudur Islam
  • chapter 16. Fast and reliable analysis of phenolic compounds in fruits and vegetables by UHPLC-MS / M.I. Alarcn̤-Flores, R. Romero-Gonzl̀ez, J. L. Martn̕ez Vidal, and A. Garrido Frenich.
"The development of many novel techniques that make our existence so comfortable has been intimately associated with the accessibility of suitable analytical methods. Liquid chromatography-mass spectrometry (LC-MS) is a powerful technique used for various applications based upon its very high sensitivity and selectivity. Generally, its applications are oriented toward the detection and identification of chemicals in a complex mixture. Preparative LC-MS systems can be used for fast and mass-directed purification of natural product extracts and new molecular entities important to food, pharmaceutical, agrochemical, and other industries. This book presents a unique collection of up-to-date UPLC-MS/MS (ultra performance liquid chromatography-tandem mass spectrometric) methods for the separation and quantitative determination of pesticides, capsaicinoids, heterocyclic amines, aflatoxin, perfluorochemicals, acrylamide, procyanidins and alkaloids, lactose content, phenolic compounds, vitamins, and aroma and flavor compounds in a wide variety of foods and food products. This book is the result of the remarkable contributions of 35 experts in interdisciplinary fields of science, with comprehensive, in-depth, and up-to-date research works and reviews. Composed of 16 chapters and compiled using more than 78 figures and 50 tables, this text delivers practical information to all people involved in the research and development, production, or routing analysis of foods and food products. Mu. Naushad and M.R. Khan Editors"-- Provided by publisher.
Book
1 online resource (xiii, 65 pages) : illustrations (some color).
  • Introduction to quantitative proteomics
  • Specificity of detection is the key attribute of selected reaction monitoring
  • Designing a selected reaction monitoring method
  • Sample processing
  • Sample analysis and data processing
  • Future directions.
A key experiment in biomedical research is monitoring the expression of different proteins in order to detect changes that occur in biological systems under different experimental conditions. The method that is most widely used is the Western blot analysis. While Western blot is a workhorse in laboratories studying protein expression and has several advantages, it also has a number of significant limitations. In particular, the method is semi-quantitative with limited dynamic range. Western blot focuses on a single protein per sample with only a small number of representative samples analyzed in an experiment. New quantitative tools have been needed for some time to at least supplement, & possibly replace, the Western blot. Mass spectrometric methods have begun to compete with Western blot for routine quantitative analyses of proteins. One of these methods is based on the tandem mass spectrometry technique of selected reaction monitoring (SRM), which is also called multiple reaction monitoring (MRM). Selected reaction monitoring is actually an older tandem mass spectrometry technique, first described in the late 70s, that is widely utilized in the quantitative analysis of small molecules like drugs & metabolites. The use of selected reaction monitoring for the quantitative analysis of proteins has a number of advantages. Most importantly, it is fundamentally quantitative with a wide dynamic range. The output of the analysis is a numerical result that can range over several orders of magnitude. Other advantages include sufficient specificity & sensitivity to detect low abundance proteins in complex mixtures. Finally, selected reaction monitoring can be multiplexed to allow the quantitative analysis of relatively large numbers of proteins in a single sample in a single experiment. This Brief will explain both the theoretical & experimental details of the selected reaction monitoring experiment as it is applied to proteins.
  • Introduction to quantitative proteomics
  • Specificity of detection is the key attribute of selected reaction monitoring
  • Designing a selected reaction monitoring method
  • Sample processing
  • Sample analysis and data processing
  • Future directions.
A key experiment in biomedical research is monitoring the expression of different proteins in order to detect changes that occur in biological systems under different experimental conditions. The method that is most widely used is the Western blot analysis. While Western blot is a workhorse in laboratories studying protein expression and has several advantages, it also has a number of significant limitations. In particular, the method is semi-quantitative with limited dynamic range. Western blot focuses on a single protein per sample with only a small number of representative samples analyzed in an experiment. New quantitative tools have been needed for some time to at least supplement, & possibly replace, the Western blot. Mass spectrometric methods have begun to compete with Western blot for routine quantitative analyses of proteins. One of these methods is based on the tandem mass spectrometry technique of selected reaction monitoring (SRM), which is also called multiple reaction monitoring (MRM). Selected reaction monitoring is actually an older tandem mass spectrometry technique, first described in the late 70s, that is widely utilized in the quantitative analysis of small molecules like drugs & metabolites. The use of selected reaction monitoring for the quantitative analysis of proteins has a number of advantages. Most importantly, it is fundamentally quantitative with a wide dynamic range. The output of the analysis is a numerical result that can range over several orders of magnitude. Other advantages include sufficient specificity & sensitivity to detect low abundance proteins in complex mixtures. Finally, selected reaction monitoring can be multiplexed to allow the quantitative analysis of relatively large numbers of proteins in a single sample in a single experiment. This Brief will explain both the theoretical & experimental details of the selected reaction monitoring experiment as it is applied to proteins.
Book
1 online resource (vii, 215 p.) : ill. (some col.)
  • MALDI-ToF Mass Spectrometry for Studying Noncovalent Complexes of Biomolecules / Stefanie Mädler, Elisabetta Boeri Erba
  • Application of MALDI-TOF-Mass Spectrometry to Proteome Analysis Using Stain-Free Gel Electrophoresis / Iuliana Susnea, Bogdan Bernevic, Michael Wicke
  • MALDI Mass Spectrometry for Nucleic Acid Analysis / Xiang Gao, Boon-Huan Tan, Richard J. Sugrue
  • Determination of Peptide and Protein Disulfide Linkages by MALDI Mass Spectrometry / Hongmei Yang, Ning Liu, Shuying Liu
  • MALDI In-Source Decay, from Sequencing to Imaging / Delphine Debois, Nicolas Smargiasso
  • Advances of MALDI-TOF MS in the Analysis of Traditional Chinese Medicines / Minghua Lu, Zongwei Cai
  • Chemical and Biochemical Applications of MALDI TOF-MS Based on Analyzing the Small Organic Compounds / Haoyang Wang, Zhixiong Zhao, Yinlong Guo
  • Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery / Zengyou He, Robert Z. Qi, Weichuan Yu.
  • MALDI-ToF Mass Spectrometry for Studying Noncovalent Complexes of Biomolecules / Stefanie Mädler, Elisabetta Boeri Erba
  • Application of MALDI-TOF-Mass Spectrometry to Proteome Analysis Using Stain-Free Gel Electrophoresis / Iuliana Susnea, Bogdan Bernevic, Michael Wicke
  • MALDI Mass Spectrometry for Nucleic Acid Analysis / Xiang Gao, Boon-Huan Tan, Richard J. Sugrue
  • Determination of Peptide and Protein Disulfide Linkages by MALDI Mass Spectrometry / Hongmei Yang, Ning Liu, Shuying Liu
  • MALDI In-Source Decay, from Sequencing to Imaging / Delphine Debois, Nicolas Smargiasso
  • Advances of MALDI-TOF MS in the Analysis of Traditional Chinese Medicines / Minghua Lu, Zongwei Cai
  • Chemical and Biochemical Applications of MALDI TOF-MS Based on Analyzing the Small Organic Compounds / Haoyang Wang, Zhixiong Zhao, Yinlong Guo
  • Bioinformatic Analysis of Data Generated from MALDI Mass Spectrometry for Biomarker Discovery / Zengyou He, Robert Z. Qi, Weichuan Yu.
Book
1 online resource.
Book
1 online resource (350 p.)
This book describes the importance of the emerging technique Cluster Secondary Ion Mass Spectrometry (SIMS), which is used for the analysis of a range of solid materials, including everything from organic and polymeric materials, to cells and semiconductors. The text covers a wide range of topics, encompassing fundamentals, theory, and applications including cluster sources, organic and polymeric depth profiling, and 3-D imaging in organic and polymeric materials. Written by founders in the field, this guide creates a peerless compendium of knowledge on this cutting edge set of methods.
This book describes the importance of the emerging technique Cluster Secondary Ion Mass Spectrometry (SIMS), which is used for the analysis of a range of solid materials, including everything from organic and polymeric materials, to cells and semiconductors. The text covers a wide range of topics, encompassing fundamentals, theory, and applications including cluster sources, organic and polymeric depth profiling, and 3-D imaging in organic and polymeric materials. Written by founders in the field, this guide creates a peerless compendium of knowledge on this cutting edge set of methods.
dx.doi.org Wiley Online Library
Book
1 online resource.
dx.doi.org Wiley Online Library
Book
1 online resource (1111 p.)
  • Cover; Wiley Series on Mass Spectrometry; Title Page; Copyright; Dedication; Preface; Contributors; Chapter 1: Foodomics: Principles and Applications; 1.1 INTRODUCTION TO FOODOMICS; 1.2 FOODOMICS APPLICATIONS: CHALLENGES, ADVANTAGES, AND DRAWBACKS; 1.3 FOODOMICS, SYSTEMS BIOLOGY, AND FUTURE TRENDS; ACKNOWLEDGMENTS; REFERENCES; Chapter 2: Next Generation Instruments and Methods for Proteomics; 2.1 INTRODUCTION; 2.2 EMERGING METHODS IN PROTEOMICS; 2.3 THE MOVE FROM SHOTGUN TO TARGETED PROTEOMICS APPROACHES; 2.4 NEW INSTRUMENTAL METHODS FOR PROTEOMICS; 2.5 BIOINFORMATICS TOOLS; REFERENCES
  • Chapter 3: Proteomic-based Techniques for the Characterization of Food Allergens3.1 INTRODUCTION: WHAT IS FOOD ALLERGY?; 3.2 FOOD ALLERGY: FEATURES AND BOUNDARIES OF THE DISEASE; 3.3 IMMUNOPATHOLOGY OF FOOD ALLERGY AND ROLE OF PROTEOMICS; 3.4 IDENTIFICATION OF FOOD ALLERGY EPITOPES; 3.5 EXPRESSION PROTEOMICS AND FUNCTIONAL PROTEOMICS IN FOOD ALLERGY; 3.6 IDENTIFICATION OF ALLERGENS IN TRANSFORMED PRODUCTS; 3.7 CONCLUDING REMARKS; REFERENCES; Chapter 4: Examination of the Efficacy of Antioxidant Food Supplements using Advanced Proteomics Methods; 4.1 INTRODUCTION
  • 4.2 METHODS FOR STUDYING THE EFFICACY OF ANTIOXIDANTS4.3 STRATEGIES USED FOR PROTEOMIC ANALYSIS OF CARBONYLATED PROTEINS AND THE IMPACT OF ANTIOXIDANTS; 4.4 STUDYING OXIDATION MECHANISMS; 4.5 QUANTIFICATION OF CARBONYLATION SITES; 4.6 BIOMEDICAL CONSEQUENCE OF PROTEIN OXIDATION AND THE IMPACT OF ANTIOXIDANTS; 4.7 REDOX PROTEOMICS AND TESTING THE EFFICACY OF ANTIOXIDANTS; REFERENCES; Chapter 5: Proteomics in Food Science; 5.1 PROTEOMICS; 5.2 APPLICATIONS IN FOOD SCIENCE; 5.3 SPECIES IDENTIFICATION AND GEOGRAPHIC ORIGIN; 5.4 DETECTION AND IDENTIFICATION OF SPOILAGE AND PATHOGENIC MICROORGANISMS
  • 5.5 CHANGES DURING FOOD STORAGE AND PROCESSING AND THEIR RELATIONSHIP TO QUALITY5.6 PROTEOMICS DATA INTEGRATION TO EXPLORE FOOD METABOLIC PATHWAYS AND PHYSIOLOGICAL ACTIVITY OF FOOD COMPONENTS; 5.7 NUTRIPROTEOMICS; 5.8 FINAL CONSIDERATIONS AND FUTURE TRENDS; REFERENCES; Chapter 6: Proteomics in Nutritional Systems Biology: Defining Health; 6.1 INTRODUCTION; 6.2 FROM FOOD PROTEINS TO NUTRIPROTEOMICS; 6.3 NUTRITIONAL PEPTIDE AND PROTEIN BIOACTIVES; 6.4 NUTRITIONAL PEPTIDE AND PROTEIN BIOMARKERS; 6.5 ECOSYSTEM-LEVEL UNDERSTANDING OF NUTRITIONAL HOST HEALTH; 6.6 CONCLUSIONS AND PERSPECTIVES
This book introduces the principles of foodomics through the review of advanced Mass Spectrometry (MS) technologies applied to this new discipline. The coverage details specific ""omics"" approaches based on MS technologies that have been (or can be) applied in foodomics, providing a picture of the most innovative applications and future trends. It explains the fundamental branches of foodomics such as metabolomics, proteomics, and systems biology. And it provides a global perspective on ""omics"" approaches based on MS techniques combined with systems biology in food science and nutrition, a.
  • Cover; Wiley Series on Mass Spectrometry; Title Page; Copyright; Dedication; Preface; Contributors; Chapter 1: Foodomics: Principles and Applications; 1.1 INTRODUCTION TO FOODOMICS; 1.2 FOODOMICS APPLICATIONS: CHALLENGES, ADVANTAGES, AND DRAWBACKS; 1.3 FOODOMICS, SYSTEMS BIOLOGY, AND FUTURE TRENDS; ACKNOWLEDGMENTS; REFERENCES; Chapter 2: Next Generation Instruments and Methods for Proteomics; 2.1 INTRODUCTION; 2.2 EMERGING METHODS IN PROTEOMICS; 2.3 THE MOVE FROM SHOTGUN TO TARGETED PROTEOMICS APPROACHES; 2.4 NEW INSTRUMENTAL METHODS FOR PROTEOMICS; 2.5 BIOINFORMATICS TOOLS; REFERENCES
  • Chapter 3: Proteomic-based Techniques for the Characterization of Food Allergens3.1 INTRODUCTION: WHAT IS FOOD ALLERGY?; 3.2 FOOD ALLERGY: FEATURES AND BOUNDARIES OF THE DISEASE; 3.3 IMMUNOPATHOLOGY OF FOOD ALLERGY AND ROLE OF PROTEOMICS; 3.4 IDENTIFICATION OF FOOD ALLERGY EPITOPES; 3.5 EXPRESSION PROTEOMICS AND FUNCTIONAL PROTEOMICS IN FOOD ALLERGY; 3.6 IDENTIFICATION OF ALLERGENS IN TRANSFORMED PRODUCTS; 3.7 CONCLUDING REMARKS; REFERENCES; Chapter 4: Examination of the Efficacy of Antioxidant Food Supplements using Advanced Proteomics Methods; 4.1 INTRODUCTION
  • 4.2 METHODS FOR STUDYING THE EFFICACY OF ANTIOXIDANTS4.3 STRATEGIES USED FOR PROTEOMIC ANALYSIS OF CARBONYLATED PROTEINS AND THE IMPACT OF ANTIOXIDANTS; 4.4 STUDYING OXIDATION MECHANISMS; 4.5 QUANTIFICATION OF CARBONYLATION SITES; 4.6 BIOMEDICAL CONSEQUENCE OF PROTEIN OXIDATION AND THE IMPACT OF ANTIOXIDANTS; 4.7 REDOX PROTEOMICS AND TESTING THE EFFICACY OF ANTIOXIDANTS; REFERENCES; Chapter 5: Proteomics in Food Science; 5.1 PROTEOMICS; 5.2 APPLICATIONS IN FOOD SCIENCE; 5.3 SPECIES IDENTIFICATION AND GEOGRAPHIC ORIGIN; 5.4 DETECTION AND IDENTIFICATION OF SPOILAGE AND PATHOGENIC MICROORGANISMS
  • 5.5 CHANGES DURING FOOD STORAGE AND PROCESSING AND THEIR RELATIONSHIP TO QUALITY5.6 PROTEOMICS DATA INTEGRATION TO EXPLORE FOOD METABOLIC PATHWAYS AND PHYSIOLOGICAL ACTIVITY OF FOOD COMPONENTS; 5.7 NUTRIPROTEOMICS; 5.8 FINAL CONSIDERATIONS AND FUTURE TRENDS; REFERENCES; Chapter 6: Proteomics in Nutritional Systems Biology: Defining Health; 6.1 INTRODUCTION; 6.2 FROM FOOD PROTEINS TO NUTRIPROTEOMICS; 6.3 NUTRITIONAL PEPTIDE AND PROTEIN BIOACTIVES; 6.4 NUTRITIONAL PEPTIDE AND PROTEIN BIOMARKERS; 6.5 ECOSYSTEM-LEVEL UNDERSTANDING OF NUTRITIONAL HOST HEALTH; 6.6 CONCLUSIONS AND PERSPECTIVES
This book introduces the principles of foodomics through the review of advanced Mass Spectrometry (MS) technologies applied to this new discipline. The coverage details specific ""omics"" approaches based on MS technologies that have been (or can be) applied in foodomics, providing a picture of the most innovative applications and future trends. It explains the fundamental branches of foodomics such as metabolomics, proteomics, and systems biology. And it provides a global perspective on ""omics"" approaches based on MS techniques combined with systems biology in food science and nutrition, a.
dx.doi.org Wiley Online Library
Book
1 online resource.

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