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Book
1 online resource.
  • An Introduction to Ambient Ionization Mass Spectrometry-- Direct Analysis in real time (DART(R))-- Ionization Mechanisms of Direct Analysis in Real Time (DART)-- Atmospheric Samples Analysis Probe (ASAP) Mass Spectrometry-- Ambient Analysis by Thermal Desorption Atmospheric Pressure Photoionization-- Low Temperature Plasma Probe-- Flowing Atmospheric Pressure Afterglow (FAPA), the Plasma-based Source for your ADI-MS needs-- Spray Desorption Collection and DESI Mechanisms-- Easy Ambient Sonic-Spray Ionization-- Secondary Electrospray Ionization-- Probe Electrospray Ionization-- Desorption Electrospray Mass Spectrometry-- Surface Acoustic Wave Nebulization-- Laser Ablation Electrospray Ionization Mass Spectrometry: Mechanisms, Configurations and Imaging Applications-- Electrospray Laser Desorption Ionization Mass Spectrometry-- Paper Spray-- Inlet and Vacuum Ionization from Ambient Conditions-- Enabling Automated Sample Analysis by Direct Analysis in Real Time (DART) Mass Spectrometry-- Laser Ablation Electrospray Ionization Mass Spectrometry (LAESI(R)-MS): Ambient Ionization Technology for 2D and 3D Molecular Imaging-- Liquid Extraction Surface Analysis Mass Spectrometry (LESA MS): Combining Liquid Extraction, Surface Profiling and Ambient Ionization Mass Spectrometry in One Novel Analysis Technique-- Subject Index.
  • (source: Nielsen Book Data)
Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.
(source: Nielsen Book Data)
  • An Introduction to Ambient Ionization Mass Spectrometry-- Direct Analysis in real time (DART(R))-- Ionization Mechanisms of Direct Analysis in Real Time (DART)-- Atmospheric Samples Analysis Probe (ASAP) Mass Spectrometry-- Ambient Analysis by Thermal Desorption Atmospheric Pressure Photoionization-- Low Temperature Plasma Probe-- Flowing Atmospheric Pressure Afterglow (FAPA), the Plasma-based Source for your ADI-MS needs-- Spray Desorption Collection and DESI Mechanisms-- Easy Ambient Sonic-Spray Ionization-- Secondary Electrospray Ionization-- Probe Electrospray Ionization-- Desorption Electrospray Mass Spectrometry-- Surface Acoustic Wave Nebulization-- Laser Ablation Electrospray Ionization Mass Spectrometry: Mechanisms, Configurations and Imaging Applications-- Electrospray Laser Desorption Ionization Mass Spectrometry-- Paper Spray-- Inlet and Vacuum Ionization from Ambient Conditions-- Enabling Automated Sample Analysis by Direct Analysis in Real Time (DART) Mass Spectrometry-- Laser Ablation Electrospray Ionization Mass Spectrometry (LAESI(R)-MS): Ambient Ionization Technology for 2D and 3D Molecular Imaging-- Liquid Extraction Surface Analysis Mass Spectrometry (LESA MS): Combining Liquid Extraction, Surface Profiling and Ambient Ionization Mass Spectrometry in One Novel Analysis Technique-- Subject Index.
  • (source: Nielsen Book Data)
Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.
(source: Nielsen Book Data)
Book
1 online resource : illustrations (some color)
Book
xviii, 606 p. : ill.
  • Liquid Chromatography-- UHPLC-- Sample Treatment-- Mass Spectrometry-- High Resolution Mass Spectrometry-- Sub-2mum Columns-- Core-Shell Columns-- Monolithic Columns, High-Temperature Liquid Chromatography-- HILIC-- Perfluorinated Stationary Phases-- Sample Treatment-- On-line SPE-- MIPs-- RAM-- Turbulent Flow Chromatography-- Ambient Source Ionization-- DESI-- DART-- DAPPI-- Quantification Aspects in MS-- Confirmation Aspects in MS-- Food Analysis-- Environmental Analysis-- Pesticides-- Polyphenolic Compounds-- Food Packaging Contaminants-- Perfluorinated Compounds-- Mycotoxins--.
  • (source: Nielsen Book Data)
There is a growing need for high-throughput separations in food and environmental research that are able to cope with the analysis of a large number of compounds in very complex matrices. Laboratories worldwide are now demanding fast and efficient analytical procedures with enough sensitivity, robustness, effectiveness and high resolution to be able to perform both qualitative and quantitative analysis while at the same time achieving cost-effective methodologies with reduced analysis times. Whereas the most common approach for solving many analytical problems has often been high-performance liquid chromatography (HPLC), the recent use of fast or ultra-fast chromatographic methods for environmental and food analysis has increased the overall sample throughput and laboratory efficiency without loss (and even with an improvement) in the resolution obtained by conventional HPLC systems.This book brings together researchers at the top of their field from across the world to discuss and analyze recent advances in fast liquid chromatography-mass spectrometry (LC-MS) methods for food and environmental analysis. It focuses on the development of the analytical method: sample preparation, chromatographic separation, mass spectrometry and, finally, confirmation and quantification aspects. These topics are addressed in three main parts. First, the most novel approaches to achieve fast and ultra-fast methods as well as the use of alternative and complementary stationary phases are described. In the second part, advances in fast LC-MS methods are addressed, focusing on novel treatment procedures coupled with LC-MS, new ionization sources, high-resolution mass spectrometry, and the problematic confirmation and quantification aspects in mass spectrometry. Finally, the third part is devoted to relevant LC-MS applications in food and environmental analysis and addresses the analysis of pesticides, mycotoxins, food packaging contaminants, perfluorinated compounds and polyphenolic compounds.This book brings together researchers working at the top of the field at universities and in industry from across the world to present the state-of-the-art in current research on food and environmental analysis. The scope of the book is intentionally broad and is aimed at worldwide analytical laboratories working in food and environmental applications as well as researchers in universities worldwide.
(source: Nielsen Book Data)
  • Liquid Chromatography-- UHPLC-- Sample Treatment-- Mass Spectrometry-- High Resolution Mass Spectrometry-- Sub-2mum Columns-- Core-Shell Columns-- Monolithic Columns, High-Temperature Liquid Chromatography-- HILIC-- Perfluorinated Stationary Phases-- Sample Treatment-- On-line SPE-- MIPs-- RAM-- Turbulent Flow Chromatography-- Ambient Source Ionization-- DESI-- DART-- DAPPI-- Quantification Aspects in MS-- Confirmation Aspects in MS-- Food Analysis-- Environmental Analysis-- Pesticides-- Polyphenolic Compounds-- Food Packaging Contaminants-- Perfluorinated Compounds-- Mycotoxins--.
  • (source: Nielsen Book Data)
There is a growing need for high-throughput separations in food and environmental research that are able to cope with the analysis of a large number of compounds in very complex matrices. Laboratories worldwide are now demanding fast and efficient analytical procedures with enough sensitivity, robustness, effectiveness and high resolution to be able to perform both qualitative and quantitative analysis while at the same time achieving cost-effective methodologies with reduced analysis times. Whereas the most common approach for solving many analytical problems has often been high-performance liquid chromatography (HPLC), the recent use of fast or ultra-fast chromatographic methods for environmental and food analysis has increased the overall sample throughput and laboratory efficiency without loss (and even with an improvement) in the resolution obtained by conventional HPLC systems.This book brings together researchers at the top of their field from across the world to discuss and analyze recent advances in fast liquid chromatography-mass spectrometry (LC-MS) methods for food and environmental analysis. It focuses on the development of the analytical method: sample preparation, chromatographic separation, mass spectrometry and, finally, confirmation and quantification aspects. These topics are addressed in three main parts. First, the most novel approaches to achieve fast and ultra-fast methods as well as the use of alternative and complementary stationary phases are described. In the second part, advances in fast LC-MS methods are addressed, focusing on novel treatment procedures coupled with LC-MS, new ionization sources, high-resolution mass spectrometry, and the problematic confirmation and quantification aspects in mass spectrometry. Finally, the third part is devoted to relevant LC-MS applications in food and environmental analysis and addresses the analysis of pesticides, mycotoxins, food packaging contaminants, perfluorinated compounds and polyphenolic compounds.This book brings together researchers working at the top of the field at universities and in industry from across the world to present the state-of-the-art in current research on food and environmental analysis. The scope of the book is intentionally broad and is aimed at worldwide analytical laboratories working in food and environmental applications as well as researchers in universities worldwide.
(source: Nielsen Book Data)
Book
1 online resource : text file, PDF
  • Preface Isotope Ratio Mass Spectrometry: Devices, Methods, and Applications V.S. Sevastyanov General Characteristics of Mass Spectrometric Methods for the Determination of Isotopic Composition of Light Elements Improvement of Equipment for the Determination Isotope Ratios of Light Elements Mass Spectrometric Methods for Determining the Isotopic Composition of Light Elements Metrological Characteristics of Mass Spectrometry of Isotope Ratios The Effect of the Strength of the Analytical Signal on the Results of Measuring the Isotopic Composition of Light Elements Study of the Completeness of Combustion of Difficult to Oxidise Compounds Developing a New Method of Sample Preparation Based on Solid Electrolytes for Isotope Mass Spectrometric Analysis The Electrochemical Decomposition of Water using a Solid Electrolyte Based on Zirconium Dioxide to Determine the Isotopic Composition of Hydrogen The Distribution of the Isotopes of Light Elements in Various Objects Finding the Source of Drugs and Explosives The Effects of Isotope Fractionation and Accompanying Organic Synthesis Isotope Effects in Carbonaceous Chondrites Determination of the Isotopic Composition of Hydrogen and Oxygen of Water and Isotope Effects during Evaporation The Distribution of Carbon Isotopes in Complex Organic Compounds of Biological Origin (Oil and Hydrocarbon Gases) Determination of the Isotopic Composition of Carbon in the Collagen of Bones of Ancient Tombs Conclusions References Universal Method for Preparation of Liquid, Solid, and Gaseous Samples for Determining the Isotopic Composition of Carbon T.A. Velivetskaya, A. Ignat'ev, and S. Kiyashko Introduction The Experimental Part Equipment and Materials Combustion of Solid and Low-Volatility Liquid Samples to Determine the Isotopic Composition of Carbon Combustion of Volatile Liquids to Determine Carbon Isotopic Composition Combustion of Methane for the Determination of the Isotopic Composition of Carbon Results and Discussion Conclusions Literature Using Isotope Ratio Mass Spectrometry for Assessing the Metabolic Potential of Soil Microbiota A.M. Zyakun and O. Dilly Introduction Methods of Analysis of Microbial Activity in Soil Microbiological Method Isotope Ratio Mass Spectrometry in the Study of Substrate-Induced Respiration (SIR) Kinetics of CO2 Production during Substrate-Induced Respiration Characteristics of Carbon Isotopic Composition of Microbial Products Amount of Metabolic Carbon Dioxide and Characterization of Its Origin in the Soil Using the 13C/12C Ratios to Characterize the Activity of the Microbiota in Arable Soils Analyzed Soil Samples Mineralization of SOM and Exogenous Glucose Priming Effect (PE) of Glucose Estimate of the Duration of the Effect of the Exogenous Substrate on the Microbiota Conclusion References Study of the Isotopic Composition of Normal Alkanes of Continental Plants N.A. Pedentchouk Introduction The Experimental Part General Provisions Methodological Features of Analysis Results and Discussion Conclusion Literature Using Isotope Ratio Mass Spectroscopy for Analysis of Tobacco A.B. Uryupin Literature Using Isotope Mass Ratio Spectrometry of Carbon in Doping Control T. Sobolevski, I.S. Prasolov, and G.M. Rodchenkov Introduction The Metabolism of Steroid Hormones The Experimental Part Equipment Reagents and Materials Sample Preparation Results and Discussion Literature Isolation Methods in Isotope Geochemistry of Noble Gases A.I. Buikin Introduction Stepwise Annealing Release of Gases by Heating with a Laser Beam The Stratified Oxidation Method Stepwise Fragmentation Conclusion Literature Using Laser Spectroscopy for Measuring the Ratios of Stable Isotopes V.S. Sevastyanov Introduction Absorption Spectroscopy Infrared Spectroscopy with Fourier Transform Non-Dispersive Absorption Spectroscopy Laser Cavity Ring-Down Spectroscopy Laser On-Axis Integrated Cavity Output Spectroscopy New Methods and Results Conclusions Literature Index.
  • (source: Nielsen Book Data)
Isotope Ratio Mass Spectrometry of Light Gas-Forming Elements explores different methods of isotope analysis, including spark, secondary ion, laser, glow discharge, and isotope ratio mass spectrometry. It explains how to evaluate the isotopic composition of light elements (H, C, N, O) in solid, liquid, and gaseous samples of organic and inorganic substances, as well as: Presents a universal, economical, simple, and rapid technique for sample preparation of organic substances to measure the isotopic composition of carbon Describes how to determine microbial mineralization of organic matter in soil and the effect of exogenous substrates on environmental sustainability Examines use of the isotopic composition of n-alkanes from continental vegetation to study the paleoclimate and plant physiology Proposes a systematic approach to identifying tobacco areas of origin and tobacco products based on data from the isotopic composition of light elements Discusses ways to detect doping drugs and suggests results assessment criteria based on determining reference intervals for endogenous markers Reviews methods of release of gases from inclusions of rocks and minerals for further implementation of isotope mass spectrometric analysis Considers use of optical isotope analyzers for determining the isotopic composition of carbon in CO2 and of hydrogen and oxygen in water Providing a complete picture of the latest advancements in the field, Isotope Ratio Mass Spectrometry of Light Gas-Forming Elements aids readers from a variety of disciplines in identifying the fundamental processes in biological, ecological, and geological systems and in revealing the subtle features of many physicochemical processes and chemical transformations.
(source: Nielsen Book Data)
  • Preface Isotope Ratio Mass Spectrometry: Devices, Methods, and Applications V.S. Sevastyanov General Characteristics of Mass Spectrometric Methods for the Determination of Isotopic Composition of Light Elements Improvement of Equipment for the Determination Isotope Ratios of Light Elements Mass Spectrometric Methods for Determining the Isotopic Composition of Light Elements Metrological Characteristics of Mass Spectrometry of Isotope Ratios The Effect of the Strength of the Analytical Signal on the Results of Measuring the Isotopic Composition of Light Elements Study of the Completeness of Combustion of Difficult to Oxidise Compounds Developing a New Method of Sample Preparation Based on Solid Electrolytes for Isotope Mass Spectrometric Analysis The Electrochemical Decomposition of Water using a Solid Electrolyte Based on Zirconium Dioxide to Determine the Isotopic Composition of Hydrogen The Distribution of the Isotopes of Light Elements in Various Objects Finding the Source of Drugs and Explosives The Effects of Isotope Fractionation and Accompanying Organic Synthesis Isotope Effects in Carbonaceous Chondrites Determination of the Isotopic Composition of Hydrogen and Oxygen of Water and Isotope Effects during Evaporation The Distribution of Carbon Isotopes in Complex Organic Compounds of Biological Origin (Oil and Hydrocarbon Gases) Determination of the Isotopic Composition of Carbon in the Collagen of Bones of Ancient Tombs Conclusions References Universal Method for Preparation of Liquid, Solid, and Gaseous Samples for Determining the Isotopic Composition of Carbon T.A. Velivetskaya, A. Ignat'ev, and S. Kiyashko Introduction The Experimental Part Equipment and Materials Combustion of Solid and Low-Volatility Liquid Samples to Determine the Isotopic Composition of Carbon Combustion of Volatile Liquids to Determine Carbon Isotopic Composition Combustion of Methane for the Determination of the Isotopic Composition of Carbon Results and Discussion Conclusions Literature Using Isotope Ratio Mass Spectrometry for Assessing the Metabolic Potential of Soil Microbiota A.M. Zyakun and O. Dilly Introduction Methods of Analysis of Microbial Activity in Soil Microbiological Method Isotope Ratio Mass Spectrometry in the Study of Substrate-Induced Respiration (SIR) Kinetics of CO2 Production during Substrate-Induced Respiration Characteristics of Carbon Isotopic Composition of Microbial Products Amount of Metabolic Carbon Dioxide and Characterization of Its Origin in the Soil Using the 13C/12C Ratios to Characterize the Activity of the Microbiota in Arable Soils Analyzed Soil Samples Mineralization of SOM and Exogenous Glucose Priming Effect (PE) of Glucose Estimate of the Duration of the Effect of the Exogenous Substrate on the Microbiota Conclusion References Study of the Isotopic Composition of Normal Alkanes of Continental Plants N.A. Pedentchouk Introduction The Experimental Part General Provisions Methodological Features of Analysis Results and Discussion Conclusion Literature Using Isotope Ratio Mass Spectroscopy for Analysis of Tobacco A.B. Uryupin Literature Using Isotope Mass Ratio Spectrometry of Carbon in Doping Control T. Sobolevski, I.S. Prasolov, and G.M. Rodchenkov Introduction The Metabolism of Steroid Hormones The Experimental Part Equipment Reagents and Materials Sample Preparation Results and Discussion Literature Isolation Methods in Isotope Geochemistry of Noble Gases A.I. Buikin Introduction Stepwise Annealing Release of Gases by Heating with a Laser Beam The Stratified Oxidation Method Stepwise Fragmentation Conclusion Literature Using Laser Spectroscopy for Measuring the Ratios of Stable Isotopes V.S. Sevastyanov Introduction Absorption Spectroscopy Infrared Spectroscopy with Fourier Transform Non-Dispersive Absorption Spectroscopy Laser Cavity Ring-Down Spectroscopy Laser On-Axis Integrated Cavity Output Spectroscopy New Methods and Results Conclusions Literature Index.
  • (source: Nielsen Book Data)
Isotope Ratio Mass Spectrometry of Light Gas-Forming Elements explores different methods of isotope analysis, including spark, secondary ion, laser, glow discharge, and isotope ratio mass spectrometry. It explains how to evaluate the isotopic composition of light elements (H, C, N, O) in solid, liquid, and gaseous samples of organic and inorganic substances, as well as: Presents a universal, economical, simple, and rapid technique for sample preparation of organic substances to measure the isotopic composition of carbon Describes how to determine microbial mineralization of organic matter in soil and the effect of exogenous substrates on environmental sustainability Examines use of the isotopic composition of n-alkanes from continental vegetation to study the paleoclimate and plant physiology Proposes a systematic approach to identifying tobacco areas of origin and tobacco products based on data from the isotopic composition of light elements Discusses ways to detect doping drugs and suggests results assessment criteria based on determining reference intervals for endogenous markers Reviews methods of release of gases from inclusions of rocks and minerals for further implementation of isotope mass spectrometric analysis Considers use of optical isotope analyzers for determining the isotopic composition of carbon in CO2 and of hydrogen and oxygen in water Providing a complete picture of the latest advancements in the field, Isotope Ratio Mass Spectrometry of Light Gas-Forming Elements aids readers from a variety of disciplines in identifying the fundamental processes in biological, ecological, and geological systems and in revealing the subtle features of many physicochemical processes and chemical transformations.
(source: Nielsen Book Data)
Book
1 online resource (viii, 71 pages) : illustrations.
Book
xi, 213 pages : illustrations (some color) ; 27 cm.
  • Current status and future prospects of mass spectrometry imaging of small molecules / Victoria L. Brown and Lin He
  • Sample preparation for 3D SIMS chemical imaging of cells / Nicholas Winograd and Anna Bloom
  • TOF-SIMS imaging of lipids on rat brain sections / David Touboul and Alain Brunelle
  • MALDI-MS-assisted molecular imaging of metabolites in legume plants / Erin Gemperline and Lingjun Li
  • MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections / David Touboul and Alain Brunelle
  • Multiplex MALDI-MS imaging of plant metabolites using a hybrid MS system / Andrew R. Korte [and 3 others]
  • DESI imaging of small molecules in biological tissues / Elaine C. Cabral and Demian R. Ifa
  • Desorption electrospray ionization imaging of small organics on mineral surfaces / Rachel V. Bennett and Facundo M. Fernández-- Imaging of plant materials using indirect desoprtion electrospray ionization mass spectrometry / Christian Janfelt
  • Imaging of lipids and metabolites using nanospray desorption electropray ionization mass spectrometry / Ingela Lanekoff and Julia Laskin
  • Electrospray laser desorption ionization (ELDI) mass spectrometry for molecular imaging of small molecules on tissues / Min-Zong Huang, Siou-Sian Jhang, and Jentaie Shiea
  • Automated cell-by-cell tissue imaging and single-cell analysis for targeted morphologies by laser ablation electrospray ionization mass spectrometry / Hang Li [and 4 others]
  • Laser ablation sample transfer for mass spectrometry imaging / Sung-Gun Park and Kermit K. Murray
  • Nanostructure imaging mass spectrometry : the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity / Michael E. Kurczy [and 3 others]
  • Nanostructure-initiator mass spectrometry (NIMS) for molecular mapping of animal tissues / Tara N. Moening, Victoria L. Brown, and Lin He
  • Nanoparticle-assisted laser desorption/ionization for metabolite imaging / Michihiko Waki [and 4 others]
  • Matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) for mass spectrometry imaging of small molecules / Victoria L. Brown, Qiang Liu, and Lin He
  • Laser desorption postionization mass spectrometry imaging of biological targets / Artem Akhmetov, Chhavi Bhardwaj, and Luke Hanley
  • Data processing and analysis for mass spectrometry imaging / Jiangjiang Liu, Xingchuang Xiong, and Zheng Ouyang.
Mass Spectroscopy Imaging (MSI) has emerged as an enabling technique to provide insight into the molecular entities within cells, tissues and whole-body samples and to understand inherent complexities within biological metabolomes. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, experts in the MSI field present techniques for 2D and 3D visualization and quantification of a wide array of small molecular species present in biologically relevant samples. Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification and from data collection to visualization of small molecule mapping in complex samples. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mass Spectrometry Imaging of Small Molecules: Methods and Protocols aims to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research.
(source: Nielsen Book Data)
  • Current status and future prospects of mass spectrometry imaging of small molecules / Victoria L. Brown and Lin He
  • Sample preparation for 3D SIMS chemical imaging of cells / Nicholas Winograd and Anna Bloom
  • TOF-SIMS imaging of lipids on rat brain sections / David Touboul and Alain Brunelle
  • MALDI-MS-assisted molecular imaging of metabolites in legume plants / Erin Gemperline and Lingjun Li
  • MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections / David Touboul and Alain Brunelle
  • Multiplex MALDI-MS imaging of plant metabolites using a hybrid MS system / Andrew R. Korte [and 3 others]
  • DESI imaging of small molecules in biological tissues / Elaine C. Cabral and Demian R. Ifa
  • Desorption electrospray ionization imaging of small organics on mineral surfaces / Rachel V. Bennett and Facundo M. Fernández-- Imaging of plant materials using indirect desoprtion electrospray ionization mass spectrometry / Christian Janfelt
  • Imaging of lipids and metabolites using nanospray desorption electropray ionization mass spectrometry / Ingela Lanekoff and Julia Laskin
  • Electrospray laser desorption ionization (ELDI) mass spectrometry for molecular imaging of small molecules on tissues / Min-Zong Huang, Siou-Sian Jhang, and Jentaie Shiea
  • Automated cell-by-cell tissue imaging and single-cell analysis for targeted morphologies by laser ablation electrospray ionization mass spectrometry / Hang Li [and 4 others]
  • Laser ablation sample transfer for mass spectrometry imaging / Sung-Gun Park and Kermit K. Murray
  • Nanostructure imaging mass spectrometry : the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity / Michael E. Kurczy [and 3 others]
  • Nanostructure-initiator mass spectrometry (NIMS) for molecular mapping of animal tissues / Tara N. Moening, Victoria L. Brown, and Lin He
  • Nanoparticle-assisted laser desorption/ionization for metabolite imaging / Michihiko Waki [and 4 others]
  • Matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) for mass spectrometry imaging of small molecules / Victoria L. Brown, Qiang Liu, and Lin He
  • Laser desorption postionization mass spectrometry imaging of biological targets / Artem Akhmetov, Chhavi Bhardwaj, and Luke Hanley
  • Data processing and analysis for mass spectrometry imaging / Jiangjiang Liu, Xingchuang Xiong, and Zheng Ouyang.
Mass Spectroscopy Imaging (MSI) has emerged as an enabling technique to provide insight into the molecular entities within cells, tissues and whole-body samples and to understand inherent complexities within biological metabolomes. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, experts in the MSI field present techniques for 2D and 3D visualization and quantification of a wide array of small molecular species present in biologically relevant samples. Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification and from data collection to visualization of small molecule mapping in complex samples. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mass Spectrometry Imaging of Small Molecules: Methods and Protocols aims to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH506 .M45 V.1203 Unknown
Book
xiv, 280 pages : illustrations (some color) ; 24 cm
  • Metabolomics in a Nutshell-- Sastia Prama Putri and Eiichiro Fukusaki Design of Metabolomics Experiment-- Sastia Prama Putri, Fumio Matsuda, and Takeshi Bamba Sample Preparation-- Yoshihiro Izumi, Walter A. Lavina, and Sastia Prama Putri Gas Chromatography/Mass Spectrometry Analysis: Nontargeted Metabolomics Based on Scan Mode Analysis-- Hiroshi Tsugawa and Arjen Lommen LC/QqQ/MS Analysis: Widely Targeted Metabolomics on the Basis of Multiple Reaction Monitoring-- Fumio Matsuda and Hiroshi Tsugawa Statistical Analysis-- Hiroshi Tsugawa and Takeshi Bamba Case Studies-- Walter A. Lavina, Yusuke Fujieda, Udi Jumhawan, Sastia Prama Putri, and Eiichiro Fukusaki.
  • (source: Nielsen Book Data)
Mass Spectrometry-Based Metabolomics: A Practical Guide is a simple, step-by-step reference for profiling metabolites in a target organism. It discusses optimization of sample preparation for urine, serum, blood, tissue, food, and plant and animal cell samples. Encompassing three different technical fields-biology, analytical chemistry, and informatics- mass spectrometry-based metabolomics can be challenging for biologists without special training in quantitative mass spectrometry. This book is designed to overcome this limitation by providing researchers with the knowledge they need to use metabolomics technology in their respective disciplines. The book summarizes all steps in metabolomics research, from experimental design to sample preparation, analytical procedures, and data analysis. Case studies are presented for easy understanding of the metabolomics workflow and its practical applications in different research fields. The book includes an in-house library and built-in software so that those new to the field can begin to analyze real data samples. In addition to being an excellent introductory text, the book also contains the latest advancements in this emerging field and can thus be a useful reference for metabolomics specialists.
(source: Nielsen Book Data)
  • Metabolomics in a Nutshell-- Sastia Prama Putri and Eiichiro Fukusaki Design of Metabolomics Experiment-- Sastia Prama Putri, Fumio Matsuda, and Takeshi Bamba Sample Preparation-- Yoshihiro Izumi, Walter A. Lavina, and Sastia Prama Putri Gas Chromatography/Mass Spectrometry Analysis: Nontargeted Metabolomics Based on Scan Mode Analysis-- Hiroshi Tsugawa and Arjen Lommen LC/QqQ/MS Analysis: Widely Targeted Metabolomics on the Basis of Multiple Reaction Monitoring-- Fumio Matsuda and Hiroshi Tsugawa Statistical Analysis-- Hiroshi Tsugawa and Takeshi Bamba Case Studies-- Walter A. Lavina, Yusuke Fujieda, Udi Jumhawan, Sastia Prama Putri, and Eiichiro Fukusaki.
  • (source: Nielsen Book Data)
Mass Spectrometry-Based Metabolomics: A Practical Guide is a simple, step-by-step reference for profiling metabolites in a target organism. It discusses optimization of sample preparation for urine, serum, blood, tissue, food, and plant and animal cell samples. Encompassing three different technical fields-biology, analytical chemistry, and informatics- mass spectrometry-based metabolomics can be challenging for biologists without special training in quantitative mass spectrometry. This book is designed to overcome this limitation by providing researchers with the knowledge they need to use metabolomics technology in their respective disciplines. The book summarizes all steps in metabolomics research, from experimental design to sample preparation, analytical procedures, and data analysis. Case studies are presented for easy understanding of the metabolomics workflow and its practical applications in different research fields. The book includes an in-house library and built-in software so that those new to the field can begin to analyze real data samples. In addition to being an excellent introductory text, the book also contains the latest advancements in this emerging field and can thus be a useful reference for metabolomics specialists.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QP171 .M37 2015 Unknown
Book
1 online resource.
  • Introduction-- Fatty Acids-- Bioactive Lipid Mediators-- Glycerolipids-- Glycerolphospholipids-- Sphingolipids-- Sterol Lipids-- Index.
  • (source: Nielsen Book Data)
The emerging field of lipidomics has been made possible because of advances in mass spectrometry, and in particular tandem mass spectrometry of lipid ions generated by electrospray ionization. The ability to carry out basic biochemical studies of lipids using electrospray ionization is predicated upon understanding the behaviour of lipid derived ions following collision induced decomposition and mechanisms of product ion formation. During the past 20 years, a wealth of information has been generated about lipid molecules that are now analysed by mass spectrometry, however there is no central source where one can obtain basic information about how these very diverse biomolecules behave following collisional activation. This book brings together, in one volume, this information so that investigators considering using tandem mass spectrometry to structurally characterize lipids or to quantitate their occurrence in a biological matrix, will have a convenient source to review mechanism of decomposition reactions related to the diversity of lipid structures. A separate chapter is devoted to each of seven major lipid classes including fatty acids, eicosanoids and bioactive lipid mediators, fatty acyl esters and amides, glycerol esters, glycerophospholipids, sphingolipids, and steroids. Mechanistic details are provided for understanding the pathways of formation of major product ions and ions used for structural characterization. In most cases specific ancillary information has been critical to understand the pathways, including isotope labeling and high resolution analysis of precursor and product ions. For a few specific examples such data is missing and pathways are proposed as a means to initiate further mass spectral experiments to prove or disprove pathway hypotheses. While this work largely centres on the lipid biochemistry of animal (mammalian) systems, general principles can be taken from the specific examples and applied to lipid biochemistry found in plants, fungi, prokaryotes and archeal organisms.
(source: Nielsen Book Data)
  • Introduction-- Fatty Acids-- Bioactive Lipid Mediators-- Glycerolipids-- Glycerolphospholipids-- Sphingolipids-- Sterol Lipids-- Index.
  • (source: Nielsen Book Data)
The emerging field of lipidomics has been made possible because of advances in mass spectrometry, and in particular tandem mass spectrometry of lipid ions generated by electrospray ionization. The ability to carry out basic biochemical studies of lipids using electrospray ionization is predicated upon understanding the behaviour of lipid derived ions following collision induced decomposition and mechanisms of product ion formation. During the past 20 years, a wealth of information has been generated about lipid molecules that are now analysed by mass spectrometry, however there is no central source where one can obtain basic information about how these very diverse biomolecules behave following collisional activation. This book brings together, in one volume, this information so that investigators considering using tandem mass spectrometry to structurally characterize lipids or to quantitate their occurrence in a biological matrix, will have a convenient source to review mechanism of decomposition reactions related to the diversity of lipid structures. A separate chapter is devoted to each of seven major lipid classes including fatty acids, eicosanoids and bioactive lipid mediators, fatty acyl esters and amides, glycerol esters, glycerophospholipids, sphingolipids, and steroids. Mechanistic details are provided for understanding the pathways of formation of major product ions and ions used for structural characterization. In most cases specific ancillary information has been critical to understand the pathways, including isotope labeling and high resolution analysis of precursor and product ions. For a few specific examples such data is missing and pathways are proposed as a means to initiate further mass spectral experiments to prove or disprove pathway hypotheses. While this work largely centres on the lipid biochemistry of animal (mammalian) systems, general principles can be taken from the specific examples and applied to lipid biochemistry found in plants, fungi, prokaryotes and archeal organisms.
(source: Nielsen Book Data)
Book
xvi, 600 pages : illustrations (some color) ; 24 cm
  • Mass spectrometry for proteomics-based investigation / Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel, and Costel C. Darie
  • MALDI profiling and applications in medicine / Ed Dudley
  • Simplifying the proteome: analytical strategies for improving peak capacity / Lee A. Gethings and Joanne B. Connolly
  • Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences / Lewis M. Brown
  • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics / Esthelle Hoedt, Guoan Zhang, and Thomas A. Neubert
  • Utility of computational structural biology in mass spectrometry / Urmi Roy, Alisa G. Woods, Izabela Sokolowska, and Costel C. Darie
  • Affinity-mass spectrometry approaches for elucidating structures and interactions of protein-ligand complexes / Brînduşa Alina Petre
  • Neurological analyses: focus on gangliosides and mass spectrometry / Alina D. Zamfir
  • Mass spectrometric analysis of post-translational modifications (PTMs) and protein-protein interactions (PPIs) / Armand G. Ngounou Wetie, Alisa G. Woods, and Costel C. Darie
  • Applications for mass spectrometry in the study of ion channel structure and function / Damien S.K. Samways
  • A mass spectrometry view of stable and transient protein interactions / Hanna G. Budayeva and Ileana M. Cristea
  • Mass spectrometry-based tissue imaging of small molecules / Carly N. Ferguson, Joseph W.M. Fowler, Jonathan F. Waxer, Richard A. Gatti, and Joseph A. Loo
  • Redox proteomics: from bench to bedside / Karina Ckless
  • Analysis of fluorinated proteins by mass spectrometry / Linda A. Luck
  • Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system / Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace
  • Mass spectrometry-based biomarkers in drug development / Ronald A. Miller and Daniel S. Spellman
  • Detection of biomedically relevant stilbenes from wines by mass spectrometry / Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, and Alina Vasilescu
  • Mass spectrometric DNA adduct quantification by multiple reaction monitoring and its future use for the molecular epidemiology of cancer / Bernhard H. Monien
  • Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics / Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, and Kathleen F. Arcaro
  • Cancer secretomes and their place in supplementing other hallmarks of cancer / Sapan Patel, Armand G. Ngounou Wetie, Costel C. Darie, and Bayard D. Clarkson
  • Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation / Cristinel Sandu, Armand G. Ngounou Wetie, Costel C. Darie, and Hermann Steller
  • Using proteomics to unravel the mysterious steps of the HBV-life-cycle / Norica Branza-Nichita, Catalina Petrareanu, Catalin Lazar, Izabela Sokolowska, and Costel C. Darie
  • Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends / Mouna Marrakchi, Xiaobo Liu, and Silvana Andreescu
  • Proteomic approaches to dissect neuronal signaling pathways / Heather L. Bowling and Katrin Deinhardt
  • Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF) / Alisa G. Woods, Izabela Sokolowska, Katrin Deinhardt, and Costel C. Darie
  • Mass spectrometry for the study of autism and neurodevelopmental disorders / Armand G. Ngounou Wetie, Robert M. Dekroon, Mihaela Mocanu, Jeanne P. Ryan, Costel C. Darie, and Alisa G. Woods
  • Biomarkers in major depressive disorder: the role of mass spectrometry / Alisa G. Woods, Dan V. Iosifescu, and Costel C. Darie
  • Application of mass spectrometry to characterize localization and efficacy of nanoceria in vivo / Karin L. Heckman, Joseph Erlichman, Ken Reed, and Matthew Skeels
  • Bottlenecks in proteomics / Armand G. Ngounou Wetie, Devon A. Shipp, and Costel C. Darie.
"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.
  • Mass spectrometry for proteomics-based investigation / Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel, and Costel C. Darie
  • MALDI profiling and applications in medicine / Ed Dudley
  • Simplifying the proteome: analytical strategies for improving peak capacity / Lee A. Gethings and Joanne B. Connolly
  • Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences / Lewis M. Brown
  • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics / Esthelle Hoedt, Guoan Zhang, and Thomas A. Neubert
  • Utility of computational structural biology in mass spectrometry / Urmi Roy, Alisa G. Woods, Izabela Sokolowska, and Costel C. Darie
  • Affinity-mass spectrometry approaches for elucidating structures and interactions of protein-ligand complexes / Brînduşa Alina Petre
  • Neurological analyses: focus on gangliosides and mass spectrometry / Alina D. Zamfir
  • Mass spectrometric analysis of post-translational modifications (PTMs) and protein-protein interactions (PPIs) / Armand G. Ngounou Wetie, Alisa G. Woods, and Costel C. Darie
  • Applications for mass spectrometry in the study of ion channel structure and function / Damien S.K. Samways
  • A mass spectrometry view of stable and transient protein interactions / Hanna G. Budayeva and Ileana M. Cristea
  • Mass spectrometry-based tissue imaging of small molecules / Carly N. Ferguson, Joseph W.M. Fowler, Jonathan F. Waxer, Richard A. Gatti, and Joseph A. Loo
  • Redox proteomics: from bench to bedside / Karina Ckless
  • Analysis of fluorinated proteins by mass spectrometry / Linda A. Luck
  • Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system / Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace
  • Mass spectrometry-based biomarkers in drug development / Ronald A. Miller and Daniel S. Spellman
  • Detection of biomedically relevant stilbenes from wines by mass spectrometry / Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, and Alina Vasilescu
  • Mass spectrometric DNA adduct quantification by multiple reaction monitoring and its future use for the molecular epidemiology of cancer / Bernhard H. Monien
  • Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics / Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, and Kathleen F. Arcaro
  • Cancer secretomes and their place in supplementing other hallmarks of cancer / Sapan Patel, Armand G. Ngounou Wetie, Costel C. Darie, and Bayard D. Clarkson
  • Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation / Cristinel Sandu, Armand G. Ngounou Wetie, Costel C. Darie, and Hermann Steller
  • Using proteomics to unravel the mysterious steps of the HBV-life-cycle / Norica Branza-Nichita, Catalina Petrareanu, Catalin Lazar, Izabela Sokolowska, and Costel C. Darie
  • Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends / Mouna Marrakchi, Xiaobo Liu, and Silvana Andreescu
  • Proteomic approaches to dissect neuronal signaling pathways / Heather L. Bowling and Katrin Deinhardt
  • Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF) / Alisa G. Woods, Izabela Sokolowska, Katrin Deinhardt, and Costel C. Darie
  • Mass spectrometry for the study of autism and neurodevelopmental disorders / Armand G. Ngounou Wetie, Robert M. Dekroon, Mihaela Mocanu, Jeanne P. Ryan, Costel C. Darie, and Alisa G. Woods
  • Biomarkers in major depressive disorder: the role of mass spectrometry / Alisa G. Woods, Dan V. Iosifescu, and Costel C. Darie
  • Application of mass spectrometry to characterize localization and efficacy of nanoceria in vivo / Karin L. Heckman, Joseph Erlichman, Ken Reed, and Matthew Skeels
  • Bottlenecks in proteomics / Armand G. Ngounou Wetie, Devon A. Shipp, and Costel C. Darie.
"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER Unknown
Book
1 online resource (xvi, 600 pages) : illustrations (some color).
Book
1 online resource (viii, 291 pages) : illustrations (some color).
  • Preface.- Biological agents and bioterrorism-- M. Bologna.- Immunological Defence Mechanisms against Biological Agents-- M. Bologna.- Mass spectrometry and tandem mass spectrometry: an overview-- G. Giorgi.- Modern Sample Preparation Techniques for Gas Chromatography-Mass Spectrometry. Analysis of Environmental Markers of Chemical Warfare Agents Use-- O. Terzic, P. de Voogt.- An Overview of Matrix-Assisted Laser Desorption/Ionization (MALDI) mass spectrometry and some of its applications-- M.W. Duncan et al.- Field portable mass spectrometry-- S.A. Lammert.- MALDI Imaging Mass Spectrometry-- E.H. Seeley and R.M. Caprioli.- Bacterial Identification by Mass Spectrometry-- C.R. Cox, K.J. Voorhees.- Analysis of bio-nanoparticles by means of nano ES in combination with DMA and PDMA - intact viruses, virus-like-particles and vaccine particles-- G. Allmaier et al.- Mass spectrometric target analysis and proteomics in environmental toxicology-- K. J. Groha, M.J.-F. Suter.- Proteomics for the enhanced discovery of bacterial biomarkers-- E.M. Hartmann, J. Armengaud.- Laser-based detection of explosives and related compounds-- I. Malka et al.-Detection of Metals and Radionuclides using Rapid, On-site, Antibody-based Assays-- D.A. Blake, B.Ban.- Identification of Fraudulently Modified Foods-- G. Sindona.- Tandem mass spectrometric analysis of novel antineoplastic curcumin analogues-- H. Awad et al.- Glycoconjugate vaccines used for prevention from biological agents: Tandem mass spectrometric analysis-- F. Jahouh et al.- Nano-structured solids and heterogeneous catalysts for the selective decontamination of chemical warfare agents-- M. Guidotti and C. Evangelisti.- Strategic Missile Forces in Ukraine: Brief Survey of Past and Present Environmental Problems-- I. Winkler.
  • (source: Nielsen Book Data)
This NATO-ASI installment is designed to provide an advanced overview for doctoral and post-doctoral candidates of the state-of-the-art technologies for bio-detection. The main objective of the work aims at providing readers with the latest developments necessary to successfully understand the CBRN Agents and their associated biotechnologies. The core methods focused on are mass spectrometry (including chromatographic and electrophoretic separation) and comparisons to spectroscopic, immunological and molecular analysis of chemical, biological and nuclear agents.
(source: Nielsen Book Data)
  • Preface.- Biological agents and bioterrorism-- M. Bologna.- Immunological Defence Mechanisms against Biological Agents-- M. Bologna.- Mass spectrometry and tandem mass spectrometry: an overview-- G. Giorgi.- Modern Sample Preparation Techniques for Gas Chromatography-Mass Spectrometry. Analysis of Environmental Markers of Chemical Warfare Agents Use-- O. Terzic, P. de Voogt.- An Overview of Matrix-Assisted Laser Desorption/Ionization (MALDI) mass spectrometry and some of its applications-- M.W. Duncan et al.- Field portable mass spectrometry-- S.A. Lammert.- MALDI Imaging Mass Spectrometry-- E.H. Seeley and R.M. Caprioli.- Bacterial Identification by Mass Spectrometry-- C.R. Cox, K.J. Voorhees.- Analysis of bio-nanoparticles by means of nano ES in combination with DMA and PDMA - intact viruses, virus-like-particles and vaccine particles-- G. Allmaier et al.- Mass spectrometric target analysis and proteomics in environmental toxicology-- K. J. Groha, M.J.-F. Suter.- Proteomics for the enhanced discovery of bacterial biomarkers-- E.M. Hartmann, J. Armengaud.- Laser-based detection of explosives and related compounds-- I. Malka et al.-Detection of Metals and Radionuclides using Rapid, On-site, Antibody-based Assays-- D.A. Blake, B.Ban.- Identification of Fraudulently Modified Foods-- G. Sindona.- Tandem mass spectrometric analysis of novel antineoplastic curcumin analogues-- H. Awad et al.- Glycoconjugate vaccines used for prevention from biological agents: Tandem mass spectrometric analysis-- F. Jahouh et al.- Nano-structured solids and heterogeneous catalysts for the selective decontamination of chemical warfare agents-- M. Guidotti and C. Evangelisti.- Strategic Missile Forces in Ukraine: Brief Survey of Past and Present Environmental Problems-- I. Winkler.
  • (source: Nielsen Book Data)
This NATO-ASI installment is designed to provide an advanced overview for doctoral and post-doctoral candidates of the state-of-the-art technologies for bio-detection. The main objective of the work aims at providing readers with the latest developments necessary to successfully understand the CBRN Agents and their associated biotechnologies. The core methods focused on are mass spectrometry (including chromatographic and electrophoretic separation) and comparisons to spectroscopic, immunological and molecular analysis of chemical, biological and nuclear agents.
(source: Nielsen Book Data)
Book
xviii, 271 pages : illustrations ; 24 cm
  • Detection and Identification of Microbes Using Mass Spectrometry Proteomics Charles H. Wick Mass Analyzers and MS/MS Methods for Microbial Detection and Identification Michael F. Stanford Matching Mass Spectral Profiles of Biomarkers Michael F. Stanford Sequence Information Derived from Proteins or Nucleic Acids Samir V. Deshpande Collection and Processing of Microbial Samples Samir V. Deshpande Computer Software Used for Chemometric and Bioinformatics to Discriminate Microbes Samir V. Deshpande Applications Charles H. Wick Survey of Commercially Available MS-Based Platforms Suitable for Bacterial Detection and Identification Michael F. Stanford Current and Future Trends in Using MS for Microbial Detection and Identification Charles H. Wick References Index.
  • (source: Nielsen Book Data)
All microbes, including bacteria, viruses, and fungi, can be classified and identified by matching a few peptides known to be unique to each organism. Identifying Microbes by Mass Spectrometry Proteomics describes ways to identify microorganisms using powerful new techniques combining hardware and software and yielding highly accurate methods for detection, identification, and classification of microbes. This straightforward technology can be used to detect unknown and unsequenced microorganisms as well as microbes in complex environmental samples. This book reviews various mass analyzers used for detection and describes ionization methods frequently used for analysis of microbial constituents, a necessary step in the preparation of mass spectrometry (MS) samples. The text also discusses diverse processing methods, which are used to analyze MS files for matching mass spectral profiles, and examines protein and nucleic acid sequence-based methods capable of classification and identification of microbial agents. The book also covers sample collection methods and specific sample preparation techniques. The text addresses using computer software and bioinformatics approaches for data mining to discriminate microbes using mass spectrometry proteomics (MSP). It also discusses historical pattern recognition-based methods and other approaches such as analysis of pyrolysis products, chemical ionization (CI) of fatty acid methyl esters, and MALDI-MS. The text contains examples of the application of the MSP technique for microbe detection and includes a survey of suitable and commercially available MS-based platforms. Successful applications include the identification of unknown microbes in honey bees associated with colony collapse disorder and the analysis of virus strains from the 2009 influenza pandemic. The final chapter outlines future trends in these groundbreaking uses of MS techniques, which are fast, not limited by sample type, and show potential in answering complex environmental questions.
(source: Nielsen Book Data)
  • Detection and Identification of Microbes Using Mass Spectrometry Proteomics Charles H. Wick Mass Analyzers and MS/MS Methods for Microbial Detection and Identification Michael F. Stanford Matching Mass Spectral Profiles of Biomarkers Michael F. Stanford Sequence Information Derived from Proteins or Nucleic Acids Samir V. Deshpande Collection and Processing of Microbial Samples Samir V. Deshpande Computer Software Used for Chemometric and Bioinformatics to Discriminate Microbes Samir V. Deshpande Applications Charles H. Wick Survey of Commercially Available MS-Based Platforms Suitable for Bacterial Detection and Identification Michael F. Stanford Current and Future Trends in Using MS for Microbial Detection and Identification Charles H. Wick References Index.
  • (source: Nielsen Book Data)
All microbes, including bacteria, viruses, and fungi, can be classified and identified by matching a few peptides known to be unique to each organism. Identifying Microbes by Mass Spectrometry Proteomics describes ways to identify microorganisms using powerful new techniques combining hardware and software and yielding highly accurate methods for detection, identification, and classification of microbes. This straightforward technology can be used to detect unknown and unsequenced microorganisms as well as microbes in complex environmental samples. This book reviews various mass analyzers used for detection and describes ionization methods frequently used for analysis of microbial constituents, a necessary step in the preparation of mass spectrometry (MS) samples. The text also discusses diverse processing methods, which are used to analyze MS files for matching mass spectral profiles, and examines protein and nucleic acid sequence-based methods capable of classification and identification of microbial agents. The book also covers sample collection methods and specific sample preparation techniques. The text addresses using computer software and bioinformatics approaches for data mining to discriminate microbes using mass spectrometry proteomics (MSP). It also discusses historical pattern recognition-based methods and other approaches such as analysis of pyrolysis products, chemical ionization (CI) of fatty acid methyl esters, and MALDI-MS. The text contains examples of the application of the MSP technique for microbe detection and includes a survey of suitable and commercially available MS-based platforms. Successful applications include the identification of unknown microbes in honey bees associated with colony collapse disorder and the analysis of virus strains from the 2009 influenza pandemic. The final chapter outlines future trends in these groundbreaking uses of MS techniques, which are fast, not limited by sample type, and show potential in answering complex environmental questions.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QP519.9 .M3 I346 2014 Unknown
Book
1 online resource : text file, PDF
  • INTRODUCTION What is Mass? Fragmentation The Mass Spectrometer sample Introduction Ionization Mass Separation Resolution Ion Detection Data Presentation ELECTRON IONIZATION Ion Formation Types of Ions Molecular Ion Fragment Ion Multiply Charged Ion Molecular Ions Isotope Peaks Group 1 Group 2 Group 3 Multiply Charged Ions Neutral Fragments Basic Mass Spectral Reactions Introduction Simple cleavage Multicenter fragmentations Expulsion of Stable Neutral Fragments Interpreting EI Mass Spectra ACCURATE MASS MEASUREMENT Introduction Mass Calibration Elemental Compositions Applications MODERN TECHNIQUES Introduction Gas Chromatography-Mass Spectrometry Introduction Applications Low Energy Ionization Low Electron Energy Field Ionization Fast Atom Bombardment Photoionization Chemical Ionization Electrospray Ionization Atmospheric Pressure Chemical Ionization Matrix-Assisted Laser Desorption Ionization Direct Analysis in Real Time Liquid Chromatography-Mass Spectrometry Introduction Applications Appendix I Answers to Problems Index.
  • (source: Nielsen Book Data)
Mass spectrometry has played an integral part in the study of organic molecular structures for more than 50 years, offering significant information from small amounts of sample. The mass spectrum produced by electron impact ionization presents a pattern of peaks that can often give definitive structural information about an unknown compound. Introductory Mass Spectrometry, Second Edition guides readers in the understanding and recognition of those patterns, discussing mass spectra in terms that are familiar to chemists. It provides a basis for chemists to interpret mass spectra to solve particular structural problems. The Second Edition has been updated with modern techniques and data handling. Beginning with an introduction to the principles and instrumentation, it then sequentially explains the processes that occur in the mass spectrometer following ionization. The book is unique in the large number of mass spectra presented and provides examples of mass spectra from a wide variety of organic chemicals, concentrating on the relationships between fragmentation patterns, common chemical reactions, and chemical structures. The book also discusses mass spectra obtained with softer ionization techniques, which provide definitive information regarding molecular weights. The text describes mass spectra produced by electron ionization, discussing how the spectral peak pattern relates to molecular structure. It details the use of high-resolution and accurate mass measurement to determine elemental composition of ions in order to identify unknown substances. The book also introduces some of the recent techniques that can be employed to extend the usefulness of mass spectrometry to high molecular weight substances and more polar substances. It includes examples and problems representing a cross section of organic chemistry to help readers integrate the principles presented.
(source: Nielsen Book Data)
  • INTRODUCTION What is Mass? Fragmentation The Mass Spectrometer sample Introduction Ionization Mass Separation Resolution Ion Detection Data Presentation ELECTRON IONIZATION Ion Formation Types of Ions Molecular Ion Fragment Ion Multiply Charged Ion Molecular Ions Isotope Peaks Group 1 Group 2 Group 3 Multiply Charged Ions Neutral Fragments Basic Mass Spectral Reactions Introduction Simple cleavage Multicenter fragmentations Expulsion of Stable Neutral Fragments Interpreting EI Mass Spectra ACCURATE MASS MEASUREMENT Introduction Mass Calibration Elemental Compositions Applications MODERN TECHNIQUES Introduction Gas Chromatography-Mass Spectrometry Introduction Applications Low Energy Ionization Low Electron Energy Field Ionization Fast Atom Bombardment Photoionization Chemical Ionization Electrospray Ionization Atmospheric Pressure Chemical Ionization Matrix-Assisted Laser Desorption Ionization Direct Analysis in Real Time Liquid Chromatography-Mass Spectrometry Introduction Applications Appendix I Answers to Problems Index.
  • (source: Nielsen Book Data)
Mass spectrometry has played an integral part in the study of organic molecular structures for more than 50 years, offering significant information from small amounts of sample. The mass spectrum produced by electron impact ionization presents a pattern of peaks that can often give definitive structural information about an unknown compound. Introductory Mass Spectrometry, Second Edition guides readers in the understanding and recognition of those patterns, discussing mass spectra in terms that are familiar to chemists. It provides a basis for chemists to interpret mass spectra to solve particular structural problems. The Second Edition has been updated with modern techniques and data handling. Beginning with an introduction to the principles and instrumentation, it then sequentially explains the processes that occur in the mass spectrometer following ionization. The book is unique in the large number of mass spectra presented and provides examples of mass spectra from a wide variety of organic chemicals, concentrating on the relationships between fragmentation patterns, common chemical reactions, and chemical structures. The book also discusses mass spectra obtained with softer ionization techniques, which provide definitive information regarding molecular weights. The text describes mass spectra produced by electron ionization, discussing how the spectral peak pattern relates to molecular structure. It details the use of high-resolution and accurate mass measurement to determine elemental composition of ions in order to identify unknown substances. The book also introduces some of the recent techniques that can be employed to extend the usefulness of mass spectrometry to high molecular weight substances and more polar substances. It includes examples and problems representing a cross section of organic chemistry to help readers integrate the principles presented.
(source: Nielsen Book Data)
Book
1 online resource : text file, PDF
  • An Overview A Brief History Definitions Concerning Instruments, Mass, m/z, and Ions Components of Instrument and Their Functions Definitions Concerning Instrument Performance Definitions Concerning Applications Information from Mass Spectra Diversity and Scope of Applications Instrumentation Sample Introduction Ion Sources and Methods of Ionization Mass Analyzers Ion Current Detectors Vacuum Systems Data Systems Methodologies and Strategies Measures of Instrument Performance Interpretation of Mass Spectra Analytical Techniques and Strategies Omics Biopolymers Imaging Mass Spectrometry Bioinformatics Buying a Mass Spectrometer Examples from Representative Publications An Open-Access Mass Spectrometry Facility Environmental: Organochlorines in Fish Environmental: Pharmaceuticals in Surface and Wastewaters Pharmacology: Lipitor Metabolism New Techniques: Paper Spray of Pharmaceuticals Petroleomics: Crude Oil Characterization Metabolomics: Disease Markers for a Tropical Disease Metabolomics: Chemical Defense Lipidomics: Coronary Artery Disease Proteomics: Protein Identification in a Painting Proteomics: Protein Identification and Metastasis Proteomics: Noncovalent Interactions Tissue Imaging The Absolute Essentials General Instrument Components Performance Parameters Techniques and Strategies Resources Books, Journals, Review Articles, Classical Publications Major Instrument Manufacturers Mass Spectrometry Societies, Blogs, and Discussion Groups The Mass Spectrometrist and the Internet.
  • (source: Nielsen Book Data)
With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers. The extraordinary versatility can make mass spectrometers daunting to novices. Consequently, new users would benefit greatly from an understanding of the basic concepts as well as the processes that occur in these instruments. Mass Spectrometry for the Novice provides exactly that, with detailed, straightforward descriptions and clear illustrations of principles of operations and techniques. The book begins with an overview that includes essential definitions and then provides information on the components of and the strategies used in the most common instruments. The authors discuss the methodologies available, classes of compounds analyzed, and the types of data that can be generated. A group of representative applications from published articles is summarized, demonstrating the diversity of mass spectrometry. The authors also condense the essentials of the topic into one invaluable chapter that provides a set of concise take-home messages on all aspects of mass spectrometry. The final section provides a collection of resources including books, reviews, and useful websites. Using simple language, new color figures, clever cartoons, and assuming no prior knowledge, this book provides a readily understandable entree to mass spectrometry. A CD-ROM with selected figures and cartoons is included.
(source: Nielsen Book Data)
  • An Overview A Brief History Definitions Concerning Instruments, Mass, m/z, and Ions Components of Instrument and Their Functions Definitions Concerning Instrument Performance Definitions Concerning Applications Information from Mass Spectra Diversity and Scope of Applications Instrumentation Sample Introduction Ion Sources and Methods of Ionization Mass Analyzers Ion Current Detectors Vacuum Systems Data Systems Methodologies and Strategies Measures of Instrument Performance Interpretation of Mass Spectra Analytical Techniques and Strategies Omics Biopolymers Imaging Mass Spectrometry Bioinformatics Buying a Mass Spectrometer Examples from Representative Publications An Open-Access Mass Spectrometry Facility Environmental: Organochlorines in Fish Environmental: Pharmaceuticals in Surface and Wastewaters Pharmacology: Lipitor Metabolism New Techniques: Paper Spray of Pharmaceuticals Petroleomics: Crude Oil Characterization Metabolomics: Disease Markers for a Tropical Disease Metabolomics: Chemical Defense Lipidomics: Coronary Artery Disease Proteomics: Protein Identification in a Painting Proteomics: Protein Identification and Metastasis Proteomics: Noncovalent Interactions Tissue Imaging The Absolute Essentials General Instrument Components Performance Parameters Techniques and Strategies Resources Books, Journals, Review Articles, Classical Publications Major Instrument Manufacturers Mass Spectrometry Societies, Blogs, and Discussion Groups The Mass Spectrometrist and the Internet.
  • (source: Nielsen Book Data)
With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers. The extraordinary versatility can make mass spectrometers daunting to novices. Consequently, new users would benefit greatly from an understanding of the basic concepts as well as the processes that occur in these instruments. Mass Spectrometry for the Novice provides exactly that, with detailed, straightforward descriptions and clear illustrations of principles of operations and techniques. The book begins with an overview that includes essential definitions and then provides information on the components of and the strategies used in the most common instruments. The authors discuss the methodologies available, classes of compounds analyzed, and the types of data that can be generated. A group of representative applications from published articles is summarized, demonstrating the diversity of mass spectrometry. The authors also condense the essentials of the topic into one invaluable chapter that provides a set of concise take-home messages on all aspects of mass spectrometry. The final section provides a collection of resources including books, reviews, and useful websites. Using simple language, new color figures, clever cartoons, and assuming no prior knowledge, this book provides a readily understandable entree to mass spectrometry. A CD-ROM with selected figures and cartoons is included.
(source: Nielsen Book Data)
Book
xvi, 360 pages : illustrations.
  • Overview of mass spectrometry-based metabolomics : opportunities and challenges
  • Global metabolic profiling using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
  • LC-MS profiling to link metabolic and phenotypic diversity in plant mapping populations
  • Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry
  • Sample preparation methods for LC-MS-based global aqueous metabolite profiling
  • Methods of discovery-based and targeted metabolite analysis by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection
  • Analysis of mouse liver metabolites by GC x GC-TOF MS
  • Metabolite fingerprinting by capillary electrophoresis-mass spectrometry
  • Quantitative metabolomic profiling using dansylation isotope labeling and liquid chromatography mass spectrometry
  • Quantitative analysis of amino and organic acids by methyl chloroformate derivatization and GC-MS/MS analysis
  • Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS
  • Multiplexed, quantitative, and targeted metabolite profiling by LC-MS/MRM
  • Multidimensional mass spectrometry-based shotgun lipidomics
  • Comprehensive quantitative determination of PUFA-related bioactive lipids for functional lipidomics using high-resolution mass spectrometry
  • Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids : application to serum, liver tissue, and cultured cells of different species
  • Analysis of volatile organic compounds in exhaled breath by gas chromatography-mass spectrometry combined with chemometric analysis
  • Headspace SPME-GC-MS metabolomics analysis of urinary volatile organic compounds (VOCs)
  • Metabolite profiling by direct analysis in real-time mass spectrometry
  • Analysis of dried blood spots using DESI mass spectrometry
  • DESI-MS imaging of lipids and metabolites from biological samples
  • Metabolic imaging using nanostructure-initiator mass spectrometry (NIMS)
  • Statistical analysis and modeling of mass spectrometry-based metabolomics data.
Metabolomics is a fast growing field in systems biology and offers a powerful and promising approach for a large range of applications. Metabolomics focuses on deriving the concentrations and fluxes of low molecular weight metabolites in bio-fluids, cells or tissue, plants, foods and related samples and this information provides enormous detail on biological systems and their current status. Mass Spectrometry in Metabolomics: Methods and Protocols presents a broad coverage of the major mass spectrometry (MS)-based metabolomics methods and applications. MS is one of most powerful and commonly used analytical methods in metabolomics; because so many different MS systems are used in metabolomics, this volume includes a wide variety such as triple quads, time of flight, Fourier transform ion cyclotron resonance and even simple quadrupole systems. A wide range of studies are described, with samples ranging from blood and urine to tissue and even plants. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mass Spectrometry in Metabolomics: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further the dynamic field of metabolomics.
(source: Nielsen Book Data)
  • Overview of mass spectrometry-based metabolomics : opportunities and challenges
  • Global metabolic profiling using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
  • LC-MS profiling to link metabolic and phenotypic diversity in plant mapping populations
  • Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry
  • Sample preparation methods for LC-MS-based global aqueous metabolite profiling
  • Methods of discovery-based and targeted metabolite analysis by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection
  • Analysis of mouse liver metabolites by GC x GC-TOF MS
  • Metabolite fingerprinting by capillary electrophoresis-mass spectrometry
  • Quantitative metabolomic profiling using dansylation isotope labeling and liquid chromatography mass spectrometry
  • Quantitative analysis of amino and organic acids by methyl chloroformate derivatization and GC-MS/MS analysis
  • Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS
  • Multiplexed, quantitative, and targeted metabolite profiling by LC-MS/MRM
  • Multidimensional mass spectrometry-based shotgun lipidomics
  • Comprehensive quantitative determination of PUFA-related bioactive lipids for functional lipidomics using high-resolution mass spectrometry
  • Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids : application to serum, liver tissue, and cultured cells of different species
  • Analysis of volatile organic compounds in exhaled breath by gas chromatography-mass spectrometry combined with chemometric analysis
  • Headspace SPME-GC-MS metabolomics analysis of urinary volatile organic compounds (VOCs)
  • Metabolite profiling by direct analysis in real-time mass spectrometry
  • Analysis of dried blood spots using DESI mass spectrometry
  • DESI-MS imaging of lipids and metabolites from biological samples
  • Metabolic imaging using nanostructure-initiator mass spectrometry (NIMS)
  • Statistical analysis and modeling of mass spectrometry-based metabolomics data.
Metabolomics is a fast growing field in systems biology and offers a powerful and promising approach for a large range of applications. Metabolomics focuses on deriving the concentrations and fluxes of low molecular weight metabolites in bio-fluids, cells or tissue, plants, foods and related samples and this information provides enormous detail on biological systems and their current status. Mass Spectrometry in Metabolomics: Methods and Protocols presents a broad coverage of the major mass spectrometry (MS)-based metabolomics methods and applications. MS is one of most powerful and commonly used analytical methods in metabolomics; because so many different MS systems are used in metabolomics, this volume includes a wide variety such as triple quads, time of flight, Fourier transform ion cyclotron resonance and even simple quadrupole systems. A wide range of studies are described, with samples ranging from blood and urine to tissue and even plants. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mass Spectrometry in Metabolomics: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies in an effort to further the dynamic field of metabolomics.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
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See circulation desk for access
QH506 .M45 V.1198 Unknown
Book
1 online resource (xii, 287 pages) : illustrations (some color).
Book
1 online resource (vii, 237 pages) : illustrations (some color)
Book
1 online resource (368 pages) : ilustrations
  • Quotation xiii Preface xv SECTION 1 FUNDAMENTALS 1 Background 3 1.1 Volatile Organic Compounds in the Earth s Atmosphere 3 1.2 Volatile Organic Compounds in Other Environments 5 1.3 Techniques for VOC Measurements 6 1.4 Emergence of Proton Transfer Reaction Mass Spectrometry 15 References 23 2 Chemical Ionization: Chemistry, Thermodynamics and Kinetics 25 2.1 Introduction 25 2.2 Proton Transfer 27 2.3 Other Chemical Ionization Processes 44 References 45 3 Experimental: Components and Principles 49 3.1 Introduction 49 3.2 Ion Extraction and Ion Optics 50 3.3 Ion Sources 57 3.4 Drift Tubes 64 3.5 Mass Spectrometry 76 3.6 Ion Detectors 97 3.7 Analogue versus Digital Signal Processing 103 References 106 4 Quantitative Analysis 111 4.1 Introduction 111 4.2 Extracting the Concentration of a Trace Gas from PTR-MS 111 4.3 Normalized Counts per Second 112 4.4 Why Calibrate? 113 4.5 Calibration Techniques 116 4.6 Effect of Humidity 120 4.7 Accuracy, Precision and Limit of Detection 122 4.8 Validation of PTR-MS 125 References 126 SECTION 2 APPLICATIONS 5 PTR-MS in the Environmental Sciences 131 5.1 Background 131 5.2 Use of Reagent Ions Other Than H3O+ 138 5.3 Biogenic VOCs 141 5.4 Anthropogenic VOCs 156 5.5 Biomass Burning 166 5.6 Applications of PTR-MS to Laboratory Studies of Atmospheric Chemistry 169 5.7 Plant Studies 178 5.8 Outlook for Atmospheric and Environmental Applications of PTR-MS 201 References 201 6 PTR-MS in the Food Sciences 219 6.1 Background 219 6.2 Combined GC MS and PTR-MS Studies for Food Analysis 221 6.3 Mass Spectral Fingerprinting 224 6.4 Flavour Release and Perception 225 6.5 Food Classification, Food Quality and Food Control 243 6.6 Outlook for Food Science and Technology Applications 254 References 255 7 PTR-MS in the Medical Sciences 265 7.1 Background 265 7.2 Breath Analysis 266 7.3 Online PTR-MS Measurements of Volatile Emissions from Microbial Cultures 288 7.4 Other Medical Applications 295 References 300 8 Applications of PTR-MS to Homeland Security: The Detection of Threat Agents 309 8.1 Background 309 8.2 Explosives 310 8.3 Chemical Warfare Agents and Toxic Industrial Chemicals 319 8.4 Narcotics 320 8.5 Date Rape Drugs 323 8.6 Ion Mobility Mass Spectrometry and PTR-MS: A Brief Comparison for Homeland Security Applications 324 8.7 Future Directions 325 References 326 9 Liquid Analysis Using PTR-MS 329 9.1 Determination of Henry s Law Constants Using PTR-MS 329 9.2 Analysis of Liquids 331 References 334 Index.
  • (source: Nielsen Book Data)
Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a rapidly growing analytical technique for detecting and identifying very small quantities of chemical compounds in air. It has seen widespread use in atmospheric monitoring and food science and shows increasing promise in applications such as industrial process monitoring, medical science and in crime and security scenarios. Written by leading researchers, this is the first book devoted to PTR-MS and it provides a comprehensive account of the basic principles, the experimental technique and various applications, thus making this book essential reading for researchers, technicians, postgraduate students and professionals in industry. The book contains nine chapters and is divided into two parts. The first part describes the underlying principles of the PTR-MS technique, including the relevant ion-molecule chemistry thermodynamics and reaction kinetics a discussion of ion sources, drift tubes and mass spectrometers practical aspects of PTR-MS, including calibration. The second part of the book turns its attention to some of the many applications of PTR-MS, demonstrating the scope and benefits, as well as the limitations, of the technique. The chapters that make up the second part of the book build upon the material presented in the first part and are essentially self-contained reviews focusing on the following topics: environmental science food science medicine homeland security, and applications of PTR-MS in liquid analysis.
(source: Nielsen Book Data)
  • Quotation xiii Preface xv SECTION 1 FUNDAMENTALS 1 Background 3 1.1 Volatile Organic Compounds in the Earth s Atmosphere 3 1.2 Volatile Organic Compounds in Other Environments 5 1.3 Techniques for VOC Measurements 6 1.4 Emergence of Proton Transfer Reaction Mass Spectrometry 15 References 23 2 Chemical Ionization: Chemistry, Thermodynamics and Kinetics 25 2.1 Introduction 25 2.2 Proton Transfer 27 2.3 Other Chemical Ionization Processes 44 References 45 3 Experimental: Components and Principles 49 3.1 Introduction 49 3.2 Ion Extraction and Ion Optics 50 3.3 Ion Sources 57 3.4 Drift Tubes 64 3.5 Mass Spectrometry 76 3.6 Ion Detectors 97 3.7 Analogue versus Digital Signal Processing 103 References 106 4 Quantitative Analysis 111 4.1 Introduction 111 4.2 Extracting the Concentration of a Trace Gas from PTR-MS 111 4.3 Normalized Counts per Second 112 4.4 Why Calibrate? 113 4.5 Calibration Techniques 116 4.6 Effect of Humidity 120 4.7 Accuracy, Precision and Limit of Detection 122 4.8 Validation of PTR-MS 125 References 126 SECTION 2 APPLICATIONS 5 PTR-MS in the Environmental Sciences 131 5.1 Background 131 5.2 Use of Reagent Ions Other Than H3O+ 138 5.3 Biogenic VOCs 141 5.4 Anthropogenic VOCs 156 5.5 Biomass Burning 166 5.6 Applications of PTR-MS to Laboratory Studies of Atmospheric Chemistry 169 5.7 Plant Studies 178 5.8 Outlook for Atmospheric and Environmental Applications of PTR-MS 201 References 201 6 PTR-MS in the Food Sciences 219 6.1 Background 219 6.2 Combined GC MS and PTR-MS Studies for Food Analysis 221 6.3 Mass Spectral Fingerprinting 224 6.4 Flavour Release and Perception 225 6.5 Food Classification, Food Quality and Food Control 243 6.6 Outlook for Food Science and Technology Applications 254 References 255 7 PTR-MS in the Medical Sciences 265 7.1 Background 265 7.2 Breath Analysis 266 7.3 Online PTR-MS Measurements of Volatile Emissions from Microbial Cultures 288 7.4 Other Medical Applications 295 References 300 8 Applications of PTR-MS to Homeland Security: The Detection of Threat Agents 309 8.1 Background 309 8.2 Explosives 310 8.3 Chemical Warfare Agents and Toxic Industrial Chemicals 319 8.4 Narcotics 320 8.5 Date Rape Drugs 323 8.6 Ion Mobility Mass Spectrometry and PTR-MS: A Brief Comparison for Homeland Security Applications 324 8.7 Future Directions 325 References 326 9 Liquid Analysis Using PTR-MS 329 9.1 Determination of Henry s Law Constants Using PTR-MS 329 9.2 Analysis of Liquids 331 References 334 Index.
  • (source: Nielsen Book Data)
Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a rapidly growing analytical technique for detecting and identifying very small quantities of chemical compounds in air. It has seen widespread use in atmospheric monitoring and food science and shows increasing promise in applications such as industrial process monitoring, medical science and in crime and security scenarios. Written by leading researchers, this is the first book devoted to PTR-MS and it provides a comprehensive account of the basic principles, the experimental technique and various applications, thus making this book essential reading for researchers, technicians, postgraduate students and professionals in industry. The book contains nine chapters and is divided into two parts. The first part describes the underlying principles of the PTR-MS technique, including the relevant ion-molecule chemistry thermodynamics and reaction kinetics a discussion of ion sources, drift tubes and mass spectrometers practical aspects of PTR-MS, including calibration. The second part of the book turns its attention to some of the many applications of PTR-MS, demonstrating the scope and benefits, as well as the limitations, of the technique. The chapters that make up the second part of the book build upon the material presented in the first part and are essentially self-contained reviews focusing on the following topics: environmental science food science medicine homeland security, and applications of PTR-MS in liquid analysis.
(source: Nielsen Book Data)
Book
1 online resource.
  • Quotation xiii Preface xv SECTION 1 FUNDAMENTALS 1 Background 3 1.1 Volatile Organic Compounds in the Earth s Atmosphere 3 1.2 Volatile Organic Compounds in Other Environments 5 1.3 Techniques for VOC Measurements 6 1.4 Emergence of Proton Transfer Reaction Mass Spectrometry 15 References 23 2 Chemical Ionization: Chemistry, Thermodynamics and Kinetics 25 2.1 Introduction 25 2.2 Proton Transfer 27 2.3 Other Chemical Ionization Processes 44 References 45 3 Experimental: Components and Principles 49 3.1 Introduction 49 3.2 Ion Extraction and Ion Optics 50 3.3 Ion Sources 57 3.4 Drift Tubes 64 3.5 Mass Spectrometry 76 3.6 Ion Detectors 97 3.7 Analogue versus Digital Signal Processing 103 References 106 4 Quantitative Analysis 111 4.1 Introduction 111 4.2 Extracting the Concentration of a Trace Gas from PTR-MS 111 4.3 Normalized Counts per Second 112 4.4 Why Calibrate? 113 4.5 Calibration Techniques 116 4.6 Effect of Humidity 120 4.7 Accuracy, Precision and Limit of Detection 122 4.8 Validation of PTR-MS 125 References 126 SECTION 2 APPLICATIONS 5 PTR-MS in the Environmental Sciences 131 5.1 Background 131 5.2 Use of Reagent Ions Other Than H3O+ 138 5.3 Biogenic VOCs 141 5.4 Anthropogenic VOCs 156 5.5 Biomass Burning 166 5.6 Applications of PTR-MS to Laboratory Studies of Atmospheric Chemistry 169 5.7 Plant Studies 178 5.8 Outlook for Atmospheric and Environmental Applications of PTR-MS 201 References 201 6 PTR-MS in the Food Sciences 219 6.1 Background 219 6.2 Combined GC MS and PTR-MS Studies for Food Analysis 221 6.3 Mass Spectral Fingerprinting 224 6.4 Flavour Release and Perception 225 6.5 Food Classification, Food Quality and Food Control 243 6.6 Outlook for Food Science and Technology Applications 254 References 255 7 PTR-MS in the Medical Sciences 265 7.1 Background 265 7.2 Breath Analysis 266 7.3 Online PTR-MS Measurements of Volatile Emissions from Microbial Cultures 288 7.4 Other Medical Applications 295 References 300 8 Applications of PTR-MS to Homeland Security: The Detection of Threat Agents 309 8.1 Background 309 8.2 Explosives 310 8.3 Chemical Warfare Agents and Toxic Industrial Chemicals 319 8.4 Narcotics 320 8.5 Date Rape Drugs 323 8.6 Ion Mobility Mass Spectrometry and PTR-MS: A Brief Comparison for Homeland Security Applications 324 8.7 Future Directions 325 References 326 9 Liquid Analysis Using PTR-MS 329 9.1 Determination of Henry s Law Constants Using PTR-MS 329 9.2 Analysis of Liquids 331 References 334 Index.
  • (source: Nielsen Book Data)
Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a rapidly growing analytical technique for detecting and identifying very small quantities of chemical compounds in air. It has seen widespread use in atmospheric monitoring and food science and shows increasing promise in applications such as industrial process monitoring, medical science and in crime and security scenarios. Written by leading researchers, this is the first book devoted to PTR-MS and it provides a comprehensive account of the basic principles, the experimental technique and various applications, thus making this book essential reading for researchers, technicians, postgraduate students and professionals in industry. The book contains nine chapters and is divided into two parts. The first part describes the underlying principles of the PTR-MS technique, including the relevant ion-molecule chemistry thermodynamics and reaction kinetics a discussion of ion sources, drift tubes and mass spectrometers practical aspects of PTR-MS, including calibration. The second part of the book turns its attention to some of the many applications of PTR-MS, demonstrating the scope and benefits, as well as the limitations, of the technique. The chapters that make up the second part of the book build upon the material presented in the first part and are essentially self-contained reviews focusing on the following topics: environmental science food science medicine homeland security, and applications of PTR-MS in liquid analysis.
(source: Nielsen Book Data)
  • Quotation xiii Preface xv SECTION 1 FUNDAMENTALS 1 Background 3 1.1 Volatile Organic Compounds in the Earth s Atmosphere 3 1.2 Volatile Organic Compounds in Other Environments 5 1.3 Techniques for VOC Measurements 6 1.4 Emergence of Proton Transfer Reaction Mass Spectrometry 15 References 23 2 Chemical Ionization: Chemistry, Thermodynamics and Kinetics 25 2.1 Introduction 25 2.2 Proton Transfer 27 2.3 Other Chemical Ionization Processes 44 References 45 3 Experimental: Components and Principles 49 3.1 Introduction 49 3.2 Ion Extraction and Ion Optics 50 3.3 Ion Sources 57 3.4 Drift Tubes 64 3.5 Mass Spectrometry 76 3.6 Ion Detectors 97 3.7 Analogue versus Digital Signal Processing 103 References 106 4 Quantitative Analysis 111 4.1 Introduction 111 4.2 Extracting the Concentration of a Trace Gas from PTR-MS 111 4.3 Normalized Counts per Second 112 4.4 Why Calibrate? 113 4.5 Calibration Techniques 116 4.6 Effect of Humidity 120 4.7 Accuracy, Precision and Limit of Detection 122 4.8 Validation of PTR-MS 125 References 126 SECTION 2 APPLICATIONS 5 PTR-MS in the Environmental Sciences 131 5.1 Background 131 5.2 Use of Reagent Ions Other Than H3O+ 138 5.3 Biogenic VOCs 141 5.4 Anthropogenic VOCs 156 5.5 Biomass Burning 166 5.6 Applications of PTR-MS to Laboratory Studies of Atmospheric Chemistry 169 5.7 Plant Studies 178 5.8 Outlook for Atmospheric and Environmental Applications of PTR-MS 201 References 201 6 PTR-MS in the Food Sciences 219 6.1 Background 219 6.2 Combined GC MS and PTR-MS Studies for Food Analysis 221 6.3 Mass Spectral Fingerprinting 224 6.4 Flavour Release and Perception 225 6.5 Food Classification, Food Quality and Food Control 243 6.6 Outlook for Food Science and Technology Applications 254 References 255 7 PTR-MS in the Medical Sciences 265 7.1 Background 265 7.2 Breath Analysis 266 7.3 Online PTR-MS Measurements of Volatile Emissions from Microbial Cultures 288 7.4 Other Medical Applications 295 References 300 8 Applications of PTR-MS to Homeland Security: The Detection of Threat Agents 309 8.1 Background 309 8.2 Explosives 310 8.3 Chemical Warfare Agents and Toxic Industrial Chemicals 319 8.4 Narcotics 320 8.5 Date Rape Drugs 323 8.6 Ion Mobility Mass Spectrometry and PTR-MS: A Brief Comparison for Homeland Security Applications 324 8.7 Future Directions 325 References 326 9 Liquid Analysis Using PTR-MS 329 9.1 Determination of Henry s Law Constants Using PTR-MS 329 9.2 Analysis of Liquids 331 References 334 Index.
  • (source: Nielsen Book Data)
Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a rapidly growing analytical technique for detecting and identifying very small quantities of chemical compounds in air. It has seen widespread use in atmospheric monitoring and food science and shows increasing promise in applications such as industrial process monitoring, medical science and in crime and security scenarios. Written by leading researchers, this is the first book devoted to PTR-MS and it provides a comprehensive account of the basic principles, the experimental technique and various applications, thus making this book essential reading for researchers, technicians, postgraduate students and professionals in industry. The book contains nine chapters and is divided into two parts. The first part describes the underlying principles of the PTR-MS technique, including the relevant ion-molecule chemistry thermodynamics and reaction kinetics a discussion of ion sources, drift tubes and mass spectrometers practical aspects of PTR-MS, including calibration. The second part of the book turns its attention to some of the many applications of PTR-MS, demonstrating the scope and benefits, as well as the limitations, of the technique. The chapters that make up the second part of the book build upon the material presented in the first part and are essentially self-contained reviews focusing on the following topics: environmental science food science medicine homeland security, and applications of PTR-MS in liquid analysis.
(source: Nielsen Book Data)

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