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Book
xi, 213 pages : illustrations (some color) ; 27 cm.
  • Current status and future prospects of mass spectrometry imaging of small molecules / Victoria L. Brown and Lin He
  • Sample preparation for 3D SIMS chemical imaging of cells / Nicholas Winograd and Anna Bloom
  • TOF-SIMS imaging of lipids on rat brain sections / David Touboul and Alain Brunelle
  • MALDI-MS-assisted molecular imaging of metabolites in legume plants / Erin Gemperline and Lingjun Li
  • MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections / David Touboul and Alain Brunelle
  • Multiplex MALDI-MS imaging of plant metabolites using a hybrid MS system / Andrew R. Korte [and 3 others]
  • DESI imaging of small molecules in biological tissues / Elaine C. Cabral and Demian R. Ifa
  • Desorption electrospray ionization imaging of small organics on mineral surfaces / Rachel V. Bennett and Facundo M. Fernández-- Imaging of plant materials using indirect desoprtion electrospray ionization mass spectrometry / Christian Janfelt
  • Imaging of lipids and metabolites using nanospray desorption electropray ionization mass spectrometry / Ingela Lanekoff and Julia Laskin
  • Electrospray laser desorption ionization (ELDI) mass spectrometry for molecular imaging of small molecules on tissues / Min-Zong Huang, Siou-Sian Jhang, and Jentaie Shiea
  • Automated cell-by-cell tissue imaging and single-cell analysis for targeted morphologies by laser ablation electrospray ionization mass spectrometry / Hang Li [and 4 others]
  • Laser ablation sample transfer for mass spectrometry imaging / Sung-Gun Park and Kermit K. Murray
  • Nanostructure imaging mass spectrometry : the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity / Michael E. Kurczy [and 3 others]
  • Nanostructure-initiator mass spectrometry (NIMS) for molecular mapping of animal tissues / Tara N. Moening, Victoria L. Brown, and Lin He
  • Nanoparticle-assisted laser desorption/ionization for metabolite imaging / Michihiko Waki [and 4 others]
  • Matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) for mass spectrometry imaging of small molecules / Victoria L. Brown, Qiang Liu, and Lin He
  • Laser desorption postionization mass spectrometry imaging of biological targets / Artem Akhmetov, Chhavi Bhardwaj, and Luke Hanley
  • Data processing and analysis for mass spectrometry imaging / Jiangjiang Liu, Xingchuang Xiong, and Zheng Ouyang.
  • Current status and future prospects of mass spectrometry imaging of small molecules / Victoria L. Brown and Lin He
  • Sample preparation for 3D SIMS chemical imaging of cells / Nicholas Winograd and Anna Bloom
  • TOF-SIMS imaging of lipids on rat brain sections / David Touboul and Alain Brunelle
  • MALDI-MS-assisted molecular imaging of metabolites in legume plants / Erin Gemperline and Lingjun Li
  • MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections / David Touboul and Alain Brunelle
  • Multiplex MALDI-MS imaging of plant metabolites using a hybrid MS system / Andrew R. Korte [and 3 others]
  • DESI imaging of small molecules in biological tissues / Elaine C. Cabral and Demian R. Ifa
  • Desorption electrospray ionization imaging of small organics on mineral surfaces / Rachel V. Bennett and Facundo M. Fernández-- Imaging of plant materials using indirect desoprtion electrospray ionization mass spectrometry / Christian Janfelt
  • Imaging of lipids and metabolites using nanospray desorption electropray ionization mass spectrometry / Ingela Lanekoff and Julia Laskin
  • Electrospray laser desorption ionization (ELDI) mass spectrometry for molecular imaging of small molecules on tissues / Min-Zong Huang, Siou-Sian Jhang, and Jentaie Shiea
  • Automated cell-by-cell tissue imaging and single-cell analysis for targeted morphologies by laser ablation electrospray ionization mass spectrometry / Hang Li [and 4 others]
  • Laser ablation sample transfer for mass spectrometry imaging / Sung-Gun Park and Kermit K. Murray
  • Nanostructure imaging mass spectrometry : the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity / Michael E. Kurczy [and 3 others]
  • Nanostructure-initiator mass spectrometry (NIMS) for molecular mapping of animal tissues / Tara N. Moening, Victoria L. Brown, and Lin He
  • Nanoparticle-assisted laser desorption/ionization for metabolite imaging / Michihiko Waki [and 4 others]
  • Matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) for mass spectrometry imaging of small molecules / Victoria L. Brown, Qiang Liu, and Lin He
  • Laser desorption postionization mass spectrometry imaging of biological targets / Artem Akhmetov, Chhavi Bhardwaj, and Luke Hanley
  • Data processing and analysis for mass spectrometry imaging / Jiangjiang Liu, Xingchuang Xiong, and Zheng Ouyang.
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH506 .M45 V.1203 Unknown
Book
xvi, 600 pages : illustrations (some color) ; 24 cm
  • Mass spectrometry for proteomics-based investigation / Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel, and Costel C. Darie
  • MALDI profiling and applications in medicine / Ed Dudley
  • Simplifying the proteome: analytical strategies for improving peak capacity / Lee A. Gethings and Joanne B. Connolly
  • Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences / Lewis M. Brown
  • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics / Esthelle Hoedt, Guoan Zhang, and Thomas A. Neubert
  • Utility of computational structural biology in mass spectrometry / Urmi Roy, Alisa G. Woods, Izabela Sokolowska, and Costel C. Darie
  • Affinity-mass spectrometry approaches for elucidating structures and interactions of protein-ligand complexes / Brînduşa Alina Petre
  • Neurological analyses: focus on gangliosides and mass spectrometry / Alina D. Zamfir
  • Mass spectrometric analysis of post-translational modifications (PTMs) and protein-protein interactions (PPIs) / Armand G. Ngounou Wetie, Alisa G. Woods, and Costel C. Darie
  • Applications for mass spectrometry in the study of ion channel structure and function / Damien S.K. Samways
  • A mass spectrometry view of stable and transient protein interactions / Hanna G. Budayeva and Ileana M. Cristea
  • Mass spectrometry-based tissue imaging of small molecules / Carly N. Ferguson, Joseph W.M. Fowler, Jonathan F. Waxer, Richard A. Gatti, and Joseph A. Loo
  • Redox proteomics: from bench to bedside / Karina Ckless
  • Analysis of fluorinated proteins by mass spectrometry / Linda A. Luck
  • Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system / Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace
  • Mass spectrometry-based biomarkers in drug development / Ronald A. Miller and Daniel S. Spellman
  • Detection of biomedically relevant stilbenes from wines by mass spectrometry / Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, and Alina Vasilescu
  • Mass spectrometric DNA adduct quantification by multiple reaction monitoring and its future use for the molecular epidemiology of cancer / Bernhard H. Monien
  • Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics / Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, and Kathleen F. Arcaro
  • Cancer secretomes and their place in supplementing other hallmarks of cancer / Sapan Patel, Armand G. Ngounou Wetie, Costel C. Darie, and Bayard D. Clarkson
  • Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation / Cristinel Sandu, Armand G. Ngounou Wetie, Costel C. Darie, and Hermann Steller
  • Using proteomics to unravel the mysterious steps of the HBV-life-cycle / Norica Branza-Nichita, Catalina Petrareanu, Catalin Lazar, Izabela Sokolowska, and Costel C. Darie
  • Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends / Mouna Marrakchi, Xiaobo Liu, and Silvana Andreescu
  • Proteomic approaches to dissect neuronal signaling pathways / Heather L. Bowling and Katrin Deinhardt
  • Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF) / Alisa G. Woods, Izabela Sokolowska, Katrin Deinhardt, and Costel C. Darie
  • Mass spectrometry for the study of autism and neurodevelopmental disorders / Armand G. Ngounou Wetie, Robert M. Dekroon, Mihaela Mocanu, Jeanne P. Ryan, Costel C. Darie, and Alisa G. Woods
  • Biomarkers in major depressive disorder: the role of mass spectrometry / Alisa G. Woods, Dan V. Iosifescu, and Costel C. Darie
  • Application of mass spectrometry to characterize localization and efficacy of nanoceria in vivo / Karin L. Heckman, Joseph Erlichman, Ken Reed, and Matthew Skeels
  • Bottlenecks in proteomics / Armand G. Ngounou Wetie, Devon A. Shipp, and Costel C. Darie.
"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.
  • Mass spectrometry for proteomics-based investigation / Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel, and Costel C. Darie
  • MALDI profiling and applications in medicine / Ed Dudley
  • Simplifying the proteome: analytical strategies for improving peak capacity / Lee A. Gethings and Joanne B. Connolly
  • Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences / Lewis M. Brown
  • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics / Esthelle Hoedt, Guoan Zhang, and Thomas A. Neubert
  • Utility of computational structural biology in mass spectrometry / Urmi Roy, Alisa G. Woods, Izabela Sokolowska, and Costel C. Darie
  • Affinity-mass spectrometry approaches for elucidating structures and interactions of protein-ligand complexes / Brînduşa Alina Petre
  • Neurological analyses: focus on gangliosides and mass spectrometry / Alina D. Zamfir
  • Mass spectrometric analysis of post-translational modifications (PTMs) and protein-protein interactions (PPIs) / Armand G. Ngounou Wetie, Alisa G. Woods, and Costel C. Darie
  • Applications for mass spectrometry in the study of ion channel structure and function / Damien S.K. Samways
  • A mass spectrometry view of stable and transient protein interactions / Hanna G. Budayeva and Ileana M. Cristea
  • Mass spectrometry-based tissue imaging of small molecules / Carly N. Ferguson, Joseph W.M. Fowler, Jonathan F. Waxer, Richard A. Gatti, and Joseph A. Loo
  • Redox proteomics: from bench to bedside / Karina Ckless
  • Analysis of fluorinated proteins by mass spectrometry / Linda A. Luck
  • Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system / Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace
  • Mass spectrometry-based biomarkers in drug development / Ronald A. Miller and Daniel S. Spellman
  • Detection of biomedically relevant stilbenes from wines by mass spectrometry / Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, and Alina Vasilescu
  • Mass spectrometric DNA adduct quantification by multiple reaction monitoring and its future use for the molecular epidemiology of cancer / Bernhard H. Monien
  • Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics / Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, and Kathleen F. Arcaro
  • Cancer secretomes and their place in supplementing other hallmarks of cancer / Sapan Patel, Armand G. Ngounou Wetie, Costel C. Darie, and Bayard D. Clarkson
  • Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation / Cristinel Sandu, Armand G. Ngounou Wetie, Costel C. Darie, and Hermann Steller
  • Using proteomics to unravel the mysterious steps of the HBV-life-cycle / Norica Branza-Nichita, Catalina Petrareanu, Catalin Lazar, Izabela Sokolowska, and Costel C. Darie
  • Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends / Mouna Marrakchi, Xiaobo Liu, and Silvana Andreescu
  • Proteomic approaches to dissect neuronal signaling pathways / Heather L. Bowling and Katrin Deinhardt
  • Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF) / Alisa G. Woods, Izabela Sokolowska, Katrin Deinhardt, and Costel C. Darie
  • Mass spectrometry for the study of autism and neurodevelopmental disorders / Armand G. Ngounou Wetie, Robert M. Dekroon, Mihaela Mocanu, Jeanne P. Ryan, Costel C. Darie, and Alisa G. Woods
  • Biomarkers in major depressive disorder: the role of mass spectrometry / Alisa G. Woods, Dan V. Iosifescu, and Costel C. Darie
  • Application of mass spectrometry to characterize localization and efficacy of nanoceria in vivo / Karin L. Heckman, Joseph Erlichman, Ken Reed, and Matthew Skeels
  • Bottlenecks in proteomics / Armand G. Ngounou Wetie, Devon A. Shipp, and Costel C. Darie.
"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER Unknown
Book
xvi, 360 pages : illustrations.
  • Overview of mass spectrometry-based metabolomics : opportunities and challenges
  • Global metabolic profiling using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
  • LC-MS profiling to link metabolic and phenotypic diversity in plant mapping populations
  • Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry
  • Sample preparation methods for LC-MS-based global aqueous metabolite profiling
  • Methods of discovery-based and targeted metabolite analysis by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection
  • Analysis of mouse liver metabolites by GC x GC-TOF MS
  • Metabolite fingerprinting by capillary electrophoresis-mass spectrometry
  • Quantitative metabolomic profiling using dansylation isotope labeling and liquid chromatography mass spectrometry
  • Quantitative analysis of amino and organic acids by methyl chloroformate derivatization and GC-MS/MS analysis
  • Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS
  • Multiplexed, quantitative, and targeted metabolite profiling by LC-MS/MRM
  • Multidimensional mass spectrometry-based shotgun lipidomics
  • Comprehensive quantitative determination of PUFA-related bioactive lipids for functional lipidomics using high-resolution mass spectrometry
  • Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids : application to serum, liver tissue, and cultured cells of different species
  • Analysis of volatile organic compounds in exhaled breath by gas chromatography-mass spectrometry combined with chemometric analysis
  • Headspace SPME-GC-MS metabolomics analysis of urinary volatile organic compounds (VOCs)
  • Metabolite profiling by direct analysis in real-time mass spectrometry
  • Analysis of dried blood spots using DESI mass spectrometry
  • DESI-MS imaging of lipids and metabolites from biological samples
  • Metabolic imaging using nanostructure-initiator mass spectrometry (NIMS)
  • Statistical analysis and modeling of mass spectrometry-based metabolomics data.
  • Overview of mass spectrometry-based metabolomics : opportunities and challenges
  • Global metabolic profiling using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
  • LC-MS profiling to link metabolic and phenotypic diversity in plant mapping populations
  • Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry
  • Sample preparation methods for LC-MS-based global aqueous metabolite profiling
  • Methods of discovery-based and targeted metabolite analysis by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection
  • Analysis of mouse liver metabolites by GC x GC-TOF MS
  • Metabolite fingerprinting by capillary electrophoresis-mass spectrometry
  • Quantitative metabolomic profiling using dansylation isotope labeling and liquid chromatography mass spectrometry
  • Quantitative analysis of amino and organic acids by methyl chloroformate derivatization and GC-MS/MS analysis
  • Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS
  • Multiplexed, quantitative, and targeted metabolite profiling by LC-MS/MRM
  • Multidimensional mass spectrometry-based shotgun lipidomics
  • Comprehensive quantitative determination of PUFA-related bioactive lipids for functional lipidomics using high-resolution mass spectrometry
  • Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids : application to serum, liver tissue, and cultured cells of different species
  • Analysis of volatile organic compounds in exhaled breath by gas chromatography-mass spectrometry combined with chemometric analysis
  • Headspace SPME-GC-MS metabolomics analysis of urinary volatile organic compounds (VOCs)
  • Metabolite profiling by direct analysis in real-time mass spectrometry
  • Analysis of dried blood spots using DESI mass spectrometry
  • DESI-MS imaging of lipids and metabolites from biological samples
  • Metabolic imaging using nanostructure-initiator mass spectrometry (NIMS)
  • Statistical analysis and modeling of mass spectrometry-based metabolomics data.
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH504 .M45 V.1198 Unavailable In process Request
Book
x, 405 p. : ill. (some col.) ; 26 cm.
  • 1. Introduction to Mass Spectrometry-Based Proteomics Rune Matthiesen and Jakob Bunkenborg 2. LC-MS Spectra Processing Rune Matthiesen 3. Isotopic Distributions Alan L. Rockwood and Magnus Palmblad 4. Retention Time Prediction and Protein Identification Alex A. Henneman and Magnus Palmblad 5. Algorithms for Database Dependent Search of MSMS Data Rune Matthiesen 6. Interpretation of Tandem Mass Spectra of Post-Translationally Modified Peptides Jakob Bunkenborg and Rune Matthiesen 7. Improving Peptide Identification Using Empirical Scoring Systems Robert J. Chalkley 8. Methods and Algorithms for Quantitative Proteomics by Mass Spectrometry Rune Matthiesen and Ana Sofia Carvalho 9. Computational Approaches to Selected Reaction Monitoring (SRM) Assay Design Conrad Bessant and Jun Fan 10. Feature Selection and Machine Learning with Mass Spectrometry Data Susmita Datta 11. Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data Thomas E. Wales, Michael J. Eggertson, and John R. Engen 12. Permethylated N-Glycan Analysis with Mass Spectrometry Zhenxin Lin and David M. Lubman 13. Mass Spectrometry Methods for Studying Glycosylation in Cancer Hugo Osorio and Celso A. Reis 14. Proteomics Data Exchange and Storage: The Need for Common Standards and Public Repositories Rafael C. Jimenez and Juan Antonio Vizcaino 15. Tools for Protein Post Translational Modifications Analysis: FAK, A Case Study Catarina Fonseca, Paula Voabil, Ana Sofia Carvalho, and Rune Matthiesen 16. Proteomic Strategies to Characterize Signaling Pathways H.C. Harsha, Sneha M. Pinto, and Akhilesh Pandey 17. Simple Proteomics Data Analysis in the Object-Oriented PowerShell Yassene Mohammed and Magnus Palmblad.
  • (source: Nielsen Book Data)
Since the publishing of the first edition, the methodologies and instrumentation involved in the field of mass spectrometry-based proteomics has improved considerably. Fully revised and expanded, Mass Spectrometry Data Analysis in Proteomics, Second Edition presents expert chapters on specific MS-based methods or data analysis strategies in proteomics. The volume covers data analysis topics relevant for quantitative proteomics, post translational modification, HX-MS, glycomics, and data exchange standards, among other topics. Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Updated and authoritative, Mass Spectrometry Data Analysis in Proteomics, Second Edition serves as a detailed guide for all researchers seeking to further our knowledge in the field of proteomics.
(source: Nielsen Book Data)
  • 1. Introduction to Mass Spectrometry-Based Proteomics Rune Matthiesen and Jakob Bunkenborg 2. LC-MS Spectra Processing Rune Matthiesen 3. Isotopic Distributions Alan L. Rockwood and Magnus Palmblad 4. Retention Time Prediction and Protein Identification Alex A. Henneman and Magnus Palmblad 5. Algorithms for Database Dependent Search of MSMS Data Rune Matthiesen 6. Interpretation of Tandem Mass Spectra of Post-Translationally Modified Peptides Jakob Bunkenborg and Rune Matthiesen 7. Improving Peptide Identification Using Empirical Scoring Systems Robert J. Chalkley 8. Methods and Algorithms for Quantitative Proteomics by Mass Spectrometry Rune Matthiesen and Ana Sofia Carvalho 9. Computational Approaches to Selected Reaction Monitoring (SRM) Assay Design Conrad Bessant and Jun Fan 10. Feature Selection and Machine Learning with Mass Spectrometry Data Susmita Datta 11. Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data Thomas E. Wales, Michael J. Eggertson, and John R. Engen 12. Permethylated N-Glycan Analysis with Mass Spectrometry Zhenxin Lin and David M. Lubman 13. Mass Spectrometry Methods for Studying Glycosylation in Cancer Hugo Osorio and Celso A. Reis 14. Proteomics Data Exchange and Storage: The Need for Common Standards and Public Repositories Rafael C. Jimenez and Juan Antonio Vizcaino 15. Tools for Protein Post Translational Modifications Analysis: FAK, A Case Study Catarina Fonseca, Paula Voabil, Ana Sofia Carvalho, and Rune Matthiesen 16. Proteomic Strategies to Characterize Signaling Pathways H.C. Harsha, Sneha M. Pinto, and Akhilesh Pandey 17. Simple Proteomics Data Analysis in the Object-Oriented PowerShell Yassene Mohammed and Magnus Palmblad.
  • (source: Nielsen Book Data)
Since the publishing of the first edition, the methodologies and instrumentation involved in the field of mass spectrometry-based proteomics has improved considerably. Fully revised and expanded, Mass Spectrometry Data Analysis in Proteomics, Second Edition presents expert chapters on specific MS-based methods or data analysis strategies in proteomics. The volume covers data analysis topics relevant for quantitative proteomics, post translational modification, HX-MS, glycomics, and data exchange standards, among other topics. Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Updated and authoritative, Mass Spectrometry Data Analysis in Proteomics, Second Edition serves as a detailed guide for all researchers seeking to further our knowledge in the field of proteomics.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH506 .M45 V.1007 Unknown
Book
xi, 339 pages : illustrations ; 26 cm.
  • Introduction to glycosylation and mass spectrometry / Steven M. Patrie, Michael J. Roth, and Jennifer J. Kohler
  • PART I ENRICHMENT AND ISOLATION METHODS
  • Tandem lectin weak affinity chromatography for glycoprotein enrichment / Zhi Yuan Ma, Yuliya Skorobogatko, and Keith Vosseller
  • CSC technology: Selective labeling of glycoproteins by mild oxidation to phenotype cells / Andreas Hofmann, Damaris Bausch-Fluck, and Bernd Wollscheid
  • Use of boronic acid nanoparticles in glycoprotein enrichment / Yawei Xu, Lijuan Zhang, and Haojie Lu
  • Incorporation of unnatural sugars for the identification of glycoproteins / Balyn W. Zaro, Howard C. Hang, and Matthew R. Pratt
  • Characterization of membrane-associated glycoproteins using lectin affinity chromatography and mass spectrometry / Yashu Liu, Jintang He, and David M. Lubman
  • Sialic acid capture-and-release and LC-MS(n) analysis of glycopeptides / Jonas Nilsson and Göran Larson
  • PART II SAMPLE PREPARATION
  • In-solution digestion of glycoproteins for glycopeptide-based mass analysis / Eden P. Go, Kathryn R. Rebecchi, and Heather Desaire
  • Nano-HPLC-MS of glycopeptides obtained after nonspecific proteolysis / Gerhild Zauner, Carolien A.M. Koeleman, André M. Deelder, and Manfred Wuhrer
  • PART III SEPARATION METHODS
  • Glycopeptide enrichment for MALDI-TOF mass spectrometry analysis by hydrophilic interaction liquid chromatography solid phase extraction (HILIC SPE) / Pia Hønnerup Jensen, Simon Mysling, Peter Højrup, and Ole Nørregaard Jensen
  • Separation and identification of glycoforms by capillary electrophoresis with electrospray ionization mass spectrometric detection / Alina D. Zamfir, Corina Flangea, Alina Serb, Ana-Maria Zagrean, Andreas M. Rizzi, and Eugen Sisu
  • Structural separations by ion mobility-MS for glycomics and glycoproteomics / Larissa S. Fenn and John A. McLean
  • PART IV QUANTITATION METHODS
  • Quantitative analysis of glycoprotein glycans / Ron Orlando
  • Stable isotope labeling of N-glycosylated peptides by enzymatic deglycosylation for mass spectrometry-based glycoproteomics / Hiroyuki Kaji and Toshiaki Isobe
  • Approaches for site mapping and quantification of o-linked glycopeptides / Peng Zhao, Stephanie H. Stalnaker, and Lance Wells
  • Glycan profiling: Label-free analysis of glycoproteins / Yoshinao Wada
  • PART V COMPUTATIONAL TOOLS
  • Introduction to informatics in glycoprotein analysis / Kiyoko F. Aoki-Kinoshita
  • Software tools for glycan profiling / Chuan-Yih Yu, Anoop Mayampurath, and Haixu Tang
  • PART VI CASE STUDIES IN MASS SPECTROMETRY OF GLYCOPROTEINS
  • Quantitative characterization of glycoproteins in neurodegenerative disorders using iTRAQ / Min Shi, Hyejin Hwang, and Jing Zhang
  • Quantitative proteomic analysis of N-linked glycoproteins in human tear fluid / Lei Zhou and Roger W. Beuerman
  • Elucidation of N-glycosites within human plasma glycoproteins for cancer biomarker discovery / Penelope Drake, Birgit Schilling, Brad Gibson, and Susan Fisher
  • Characterizing the glycosylation state of therapeutic recombinant glycoproteins. / Nicole Samuels, David Kates, Jun Liu, and Joanne Severs.
Glycosylation is the most abundant post-translational modification of proteins. Estimates vary widely, but a common assessment is that upwards of 50% of eukaryotic proteins are modified by some type of glycan. In Mass Spectrometry of Glycoproteins: Methods and Protocols, expert researchers in the field detail many of the methods that are now commonly used for glycoproteomics. These methods and techniques include robust sample preparation techniques; advanced chromatographic strategies for improving dynamic range; state-of-the-art mass spectrometry instrumentation and associated ionization and fragmentation methods; and informatics tools used for identifying glycoproteins and characterizing the associated glycans. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mass Spectrometry of Glycoproteins: Methods and Protocol is an essential resource for those who work at the interface of glycobiology and mass spectrometry.
(source: Nielsen Book Data)
  • Introduction to glycosylation and mass spectrometry / Steven M. Patrie, Michael J. Roth, and Jennifer J. Kohler
  • PART I ENRICHMENT AND ISOLATION METHODS
  • Tandem lectin weak affinity chromatography for glycoprotein enrichment / Zhi Yuan Ma, Yuliya Skorobogatko, and Keith Vosseller
  • CSC technology: Selective labeling of glycoproteins by mild oxidation to phenotype cells / Andreas Hofmann, Damaris Bausch-Fluck, and Bernd Wollscheid
  • Use of boronic acid nanoparticles in glycoprotein enrichment / Yawei Xu, Lijuan Zhang, and Haojie Lu
  • Incorporation of unnatural sugars for the identification of glycoproteins / Balyn W. Zaro, Howard C. Hang, and Matthew R. Pratt
  • Characterization of membrane-associated glycoproteins using lectin affinity chromatography and mass spectrometry / Yashu Liu, Jintang He, and David M. Lubman
  • Sialic acid capture-and-release and LC-MS(n) analysis of glycopeptides / Jonas Nilsson and Göran Larson
  • PART II SAMPLE PREPARATION
  • In-solution digestion of glycoproteins for glycopeptide-based mass analysis / Eden P. Go, Kathryn R. Rebecchi, and Heather Desaire
  • Nano-HPLC-MS of glycopeptides obtained after nonspecific proteolysis / Gerhild Zauner, Carolien A.M. Koeleman, André M. Deelder, and Manfred Wuhrer
  • PART III SEPARATION METHODS
  • Glycopeptide enrichment for MALDI-TOF mass spectrometry analysis by hydrophilic interaction liquid chromatography solid phase extraction (HILIC SPE) / Pia Hønnerup Jensen, Simon Mysling, Peter Højrup, and Ole Nørregaard Jensen
  • Separation and identification of glycoforms by capillary electrophoresis with electrospray ionization mass spectrometric detection / Alina D. Zamfir, Corina Flangea, Alina Serb, Ana-Maria Zagrean, Andreas M. Rizzi, and Eugen Sisu
  • Structural separations by ion mobility-MS for glycomics and glycoproteomics / Larissa S. Fenn and John A. McLean
  • PART IV QUANTITATION METHODS
  • Quantitative analysis of glycoprotein glycans / Ron Orlando
  • Stable isotope labeling of N-glycosylated peptides by enzymatic deglycosylation for mass spectrometry-based glycoproteomics / Hiroyuki Kaji and Toshiaki Isobe
  • Approaches for site mapping and quantification of o-linked glycopeptides / Peng Zhao, Stephanie H. Stalnaker, and Lance Wells
  • Glycan profiling: Label-free analysis of glycoproteins / Yoshinao Wada
  • PART V COMPUTATIONAL TOOLS
  • Introduction to informatics in glycoprotein analysis / Kiyoko F. Aoki-Kinoshita
  • Software tools for glycan profiling / Chuan-Yih Yu, Anoop Mayampurath, and Haixu Tang
  • PART VI CASE STUDIES IN MASS SPECTROMETRY OF GLYCOPROTEINS
  • Quantitative characterization of glycoproteins in neurodegenerative disorders using iTRAQ / Min Shi, Hyejin Hwang, and Jing Zhang
  • Quantitative proteomic analysis of N-linked glycoproteins in human tear fluid / Lei Zhou and Roger W. Beuerman
  • Elucidation of N-glycosites within human plasma glycoproteins for cancer biomarker discovery / Penelope Drake, Birgit Schilling, Brad Gibson, and Susan Fisher
  • Characterizing the glycosylation state of therapeutic recombinant glycoproteins. / Nicole Samuels, David Kates, Jun Liu, and Joanne Severs.
Glycosylation is the most abundant post-translational modification of proteins. Estimates vary widely, but a common assessment is that upwards of 50% of eukaryotic proteins are modified by some type of glycan. In Mass Spectrometry of Glycoproteins: Methods and Protocols, expert researchers in the field detail many of the methods that are now commonly used for glycoproteomics. These methods and techniques include robust sample preparation techniques; advanced chromatographic strategies for improving dynamic range; state-of-the-art mass spectrometry instrumentation and associated ionization and fragmentation methods; and informatics tools used for identifying glycoproteins and characterizing the associated glycans. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mass Spectrometry of Glycoproteins: Methods and Protocol is an essential resource for those who work at the interface of glycobiology and mass spectrometry.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH506 .M45 V.951 Unknown
Book
xii, 627 p. : ill. (some col.) ; 26 cm.
  • List of contributors-- Part I. Basic Methodological Strategies in Metabolomic Research: 1. Exploring the human metabolome by nuclear magnetic resonance spectroscopy and mass spectroscopy-- 2. Methodological requirements for lipidomics research-- 3. Biological methods for metabolic research-- Part II. Metabolomic Mass Spectrometry: Experimental Techniques and Bioinformatics: 4. Considerations in sample preparation, collection, and extraction approaches applied in microbial, plant, and mammalian metabolic profiling-- 5. Mass spectrometry-based methodologies for single-cell metabolite detection and identification-- 6. Direct metabolomics from tissues and cells: laser ablation electrospray ionization for small molecule and lipid characterization-- 7. Bioinformatic approaches to processing and annotation of high-resolution mass spectrometry data-- 8. Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy-- 9. Metabolomics using ion mobility mass spectrometry-- 10. Metabolomics via biomedical mass spectrometry: from sampling to clinical applications-- Part III. Metabolomics of Biofluids: Nuclear Magnetic Resonance Spectroscopy and Chemometrics: 11. Analytical techniques in metabolomics integrating nuclear magnetic resonance spectroscopy and chromatography with mass spectrometry-- 12. Chemometric methods in nuclear magnetic resonance-based body fluid analysis-- 13. Nuclear magnetic resonance of cerebrospinal fluid: the neurometabolome-- 14. Nuclear magnetic resonance-based saliva metabolomics-- 15. Nuclear magnetic resonance methods for metabolomic investigation of amniotic fluid-- 16. Nuclear magnetic resonance analysis and genetic metabolic disease-- 17. Lipid profiling in health and disease-- Part IV. Metabolomic Nuclear Magnetic Resonance Spectroscopy Techniques for Body Tissue Analysis: 18. Magnetic resonance spectroscopy in investigating the cancer metabolome in preclinical model systems-- 19. Phospholipidomics by phosphorous nuclear magnetic resonance spectroscopy of tissue extracts-- 20. Carbon-13 nuclear magnetic resonance for analysis of metabolic pathways-- 21. Hyperpolarized nuclear magnetic resonance spectroscopy - a new method for metabolomic research-- 22. Metabolomic magnetic resonance spectroscopy of human tissues: comparison of in vivo and high-resolution magic angle spinning ex vivo techniques-- 23. Reproducible sample preparation and spectrum acquisition techniques for metabolic profiling of human tissues by proton high-resolution magic angle spinning nuclear magnetic resonance-- 24. Assignment strategies for nuclear magnetic resonances in metabolomics research-- Index.
  • (source: Nielsen Book Data)
Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
(source: Nielsen Book Data)
  • List of contributors-- Part I. Basic Methodological Strategies in Metabolomic Research: 1. Exploring the human metabolome by nuclear magnetic resonance spectroscopy and mass spectroscopy-- 2. Methodological requirements for lipidomics research-- 3. Biological methods for metabolic research-- Part II. Metabolomic Mass Spectrometry: Experimental Techniques and Bioinformatics: 4. Considerations in sample preparation, collection, and extraction approaches applied in microbial, plant, and mammalian metabolic profiling-- 5. Mass spectrometry-based methodologies for single-cell metabolite detection and identification-- 6. Direct metabolomics from tissues and cells: laser ablation electrospray ionization for small molecule and lipid characterization-- 7. Bioinformatic approaches to processing and annotation of high-resolution mass spectrometry data-- 8. Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy-- 9. Metabolomics using ion mobility mass spectrometry-- 10. Metabolomics via biomedical mass spectrometry: from sampling to clinical applications-- Part III. Metabolomics of Biofluids: Nuclear Magnetic Resonance Spectroscopy and Chemometrics: 11. Analytical techniques in metabolomics integrating nuclear magnetic resonance spectroscopy and chromatography with mass spectrometry-- 12. Chemometric methods in nuclear magnetic resonance-based body fluid analysis-- 13. Nuclear magnetic resonance of cerebrospinal fluid: the neurometabolome-- 14. Nuclear magnetic resonance-based saliva metabolomics-- 15. Nuclear magnetic resonance methods for metabolomic investigation of amniotic fluid-- 16. Nuclear magnetic resonance analysis and genetic metabolic disease-- 17. Lipid profiling in health and disease-- Part IV. Metabolomic Nuclear Magnetic Resonance Spectroscopy Techniques for Body Tissue Analysis: 18. Magnetic resonance spectroscopy in investigating the cancer metabolome in preclinical model systems-- 19. Phospholipidomics by phosphorous nuclear magnetic resonance spectroscopy of tissue extracts-- 20. Carbon-13 nuclear magnetic resonance for analysis of metabolic pathways-- 21. Hyperpolarized nuclear magnetic resonance spectroscopy - a new method for metabolomic research-- 22. Metabolomic magnetic resonance spectroscopy of human tissues: comparison of in vivo and high-resolution magic angle spinning ex vivo techniques-- 23. Reproducible sample preparation and spectrum acquisition techniques for metabolic profiling of human tissues by proton high-resolution magic angle spinning nuclear magnetic resonance-- 24. Assignment strategies for nuclear magnetic resonances in metabolomics research-- Index.
  • (source: Nielsen Book Data)
Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QP171 .M49 2013 Unknown
Book
1 online resource (478 p.)
  • PREFACE Walter A. Korfmacher CONTRIBUTORS 1 Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development 1 Gerard Hopfgartner 2 Utility of High Resolution Mass Spectrometry for New Drug Discovery Applications William Bart Emary and Nanyan Rena Zhang 3 Quantitative Mass Spectrometry Considerations in a Regulated Environment Mohammed Jemal and Yuan-Qing Xia 4 Mass Spectrometry for Quantitative in Vitro ADME Assays Jun Zhang and Wilson Z. Shou 5 Metabolite Identification Using Mass Spectrometry in Drug Development Natalia Penner, Joanna Zgoda-Pols and Chandra Prakash 6 MS Analysis of Biological Drugs, Proteins and Peptides Yi Du, John Mehl and Pavlo Pristatsky 7 Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics Hui Wei, Guodong Chen and Adrienne A. Tymiak 8 Liquid Extraction Surface Analysis (LESA): a New Mass Spectrometry-Based Technique for Ambient Surface Profiling Dan Eikel and Jack Henion 9 MS Applications in Support of Medicinal Chemistry Sciences Maarten Honing, Benno Ingelse and Birendra N. Pramanik 10 Imaging Mass Spectrometry of Proteins and Peptides Michelle L. Reyzer and Richard M. Caprioli 11 Imaging Mass Spectrometry for Drugs and Metabolites Stacey R. Oppenheimer 12 Screening Reactive Metabolites: Role of Liquid Chromatography-High Resolution Mass Spectrometry in Combination with 'Intelligent' Data Mining Tools Shuguang Ma and Swapan K. Chowdhury 13 Mass Spectrometry of siRNA Mark Cancilla and Mike Flanagan 14 Mass Spectrometry for Metabolomics Petia Shipkova and Michael D. Reily 15 Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High Resolution Full Scan? Lieve Dillen and Filip Cuyckens Index.
  • (source: Nielsen Book Data)
Facilitates the discovery and development of new, effective therapeuticsWith coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics."Mass Spectrometry for Drug Discovery and Drug Development" begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC-high-resolution mass spectrometry for quantitative assaysMass spectrometry for siRNAQuantitative analysis of peptidesMass spectrometry analysis of biological drugsApplications that support medicinal chemistry investigationsMass spectrometry imaging and profilingThroughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field."Mass Spectrometry for Drug Discovery and Drug Development" is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.
(source: Nielsen Book Data)
  • PREFACE Walter A. Korfmacher CONTRIBUTORS 1 Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development 1 Gerard Hopfgartner 2 Utility of High Resolution Mass Spectrometry for New Drug Discovery Applications William Bart Emary and Nanyan Rena Zhang 3 Quantitative Mass Spectrometry Considerations in a Regulated Environment Mohammed Jemal and Yuan-Qing Xia 4 Mass Spectrometry for Quantitative in Vitro ADME Assays Jun Zhang and Wilson Z. Shou 5 Metabolite Identification Using Mass Spectrometry in Drug Development Natalia Penner, Joanna Zgoda-Pols and Chandra Prakash 6 MS Analysis of Biological Drugs, Proteins and Peptides Yi Du, John Mehl and Pavlo Pristatsky 7 Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics Hui Wei, Guodong Chen and Adrienne A. Tymiak 8 Liquid Extraction Surface Analysis (LESA): a New Mass Spectrometry-Based Technique for Ambient Surface Profiling Dan Eikel and Jack Henion 9 MS Applications in Support of Medicinal Chemistry Sciences Maarten Honing, Benno Ingelse and Birendra N. Pramanik 10 Imaging Mass Spectrometry of Proteins and Peptides Michelle L. Reyzer and Richard M. Caprioli 11 Imaging Mass Spectrometry for Drugs and Metabolites Stacey R. Oppenheimer 12 Screening Reactive Metabolites: Role of Liquid Chromatography-High Resolution Mass Spectrometry in Combination with 'Intelligent' Data Mining Tools Shuguang Ma and Swapan K. Chowdhury 13 Mass Spectrometry of siRNA Mark Cancilla and Mike Flanagan 14 Mass Spectrometry for Metabolomics Petia Shipkova and Michael D. Reily 15 Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High Resolution Full Scan? Lieve Dillen and Filip Cuyckens Index.
  • (source: Nielsen Book Data)
Facilitates the discovery and development of new, effective therapeuticsWith coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics."Mass Spectrometry for Drug Discovery and Drug Development" begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC-high-resolution mass spectrometry for quantitative assaysMass spectrometry for siRNAQuantitative analysis of peptidesMass spectrometry analysis of biological drugsApplications that support medicinal chemistry investigationsMass spectrometry imaging and profilingThroughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field."Mass Spectrometry for Drug Discovery and Drug Development" is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.
(source: Nielsen Book Data)
dx.doi.org Wiley Online Library
Book
online resource (xx, 589 pages : illustrations ; 24 cm)
  • Aqueous Normal-Phase Chromatography
  • Application of the Calculated Physicochemical Property, Log D, to Hydrophilic Interaction Chromatography in the Bioanalytical Laboratory
  • HILIC Behavior of Reversed-Phase/Ion-Exchange Mixed-Mode Stationary Phases and Their Applications
  • Mechanisms Controlling the Separation and Retention of Proanthocyanidins and Other Plant Polyphenols in Hydrophilic Interaction Chromatography
  • Applications of Hydrophilic Interaction Chromatography to Food Analysis
  • Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry (HILIC-MS) of Paralytic Shellfish Poisoning Toxins, Domoic Acid and Assorted Cyanobacterial Toxins
  • Application of HILIC for Polar Environmental Contaminants (Including Pharmaceuticals) in Aquatic Systems
  • Hydrophilic Interaction Chromatography-Mass Spectrometry
  • Clinical Applications of Hydrophilic Interaction Liquid Chromatography
  • Dimethylarginine Analysis by HILIC-MS/MS and Its Applications in Clinical Chemistry and In Vivo Animal Models
  • Polar Functional Groups for HILIC Method
  • Analysis of Pharmaceutical Impurities Using Hydrophilic Interaction Liquid Chromatography
  • Fast In-Process Method for the Determination of Ioversol and Related Polar Compounds by Hydrophilic Interaction Chromatography (HILIC) and UPLC
  • Retention Behavior of Hydrazine Derivatives in HILIC Mode
  • HILIC Retention Behavior and Method Development for Highly Polar Basic Compounds Used in Pharmaceutical Synthesis
  • Retention of Polar Acidic and Basic Drugs by HILIC
  • Retention and Selectivity of Polar Stationary Phases for Hydrophilic Interaction Chromatography
  • HILIC-MS/MS for the Determination of Polar Bioactive Substances
  • Method Development and Analysis of Mono- and Diphosphorylated Nucleotides by HILIC HPLC-ESI-MS
  • Hydrophilic Interaction Liquid Chromatography-Based Enrichment Protocol Coupled to Mass Spectrometry for Glycoproteome Analysis
  • Development and Application of Methods for Separation of Carbohydrates by Hydrophilic Interaction Liquid Chromatography
  • Hydrophilic Interaction Liquid Chromatography in the Characterization of Glycoproteins
  • Analysis of Protein Glycosylation and Phosphorylation Using HILIC-MS.
  • Aqueous Normal-Phase Chromatography
  • Application of the Calculated Physicochemical Property, Log D, to Hydrophilic Interaction Chromatography in the Bioanalytical Laboratory
  • HILIC Behavior of Reversed-Phase/Ion-Exchange Mixed-Mode Stationary Phases and Their Applications
  • Mechanisms Controlling the Separation and Retention of Proanthocyanidins and Other Plant Polyphenols in Hydrophilic Interaction Chromatography
  • Applications of Hydrophilic Interaction Chromatography to Food Analysis
  • Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry (HILIC-MS) of Paralytic Shellfish Poisoning Toxins, Domoic Acid and Assorted Cyanobacterial Toxins
  • Application of HILIC for Polar Environmental Contaminants (Including Pharmaceuticals) in Aquatic Systems
  • Hydrophilic Interaction Chromatography-Mass Spectrometry
  • Clinical Applications of Hydrophilic Interaction Liquid Chromatography
  • Dimethylarginine Analysis by HILIC-MS/MS and Its Applications in Clinical Chemistry and In Vivo Animal Models
  • Polar Functional Groups for HILIC Method
  • Analysis of Pharmaceutical Impurities Using Hydrophilic Interaction Liquid Chromatography
  • Fast In-Process Method for the Determination of Ioversol and Related Polar Compounds by Hydrophilic Interaction Chromatography (HILIC) and UPLC
  • Retention Behavior of Hydrazine Derivatives in HILIC Mode
  • HILIC Retention Behavior and Method Development for Highly Polar Basic Compounds Used in Pharmaceutical Synthesis
  • Retention of Polar Acidic and Basic Drugs by HILIC
  • Retention and Selectivity of Polar Stationary Phases for Hydrophilic Interaction Chromatography
  • HILIC-MS/MS for the Determination of Polar Bioactive Substances
  • Method Development and Analysis of Mono- and Diphosphorylated Nucleotides by HILIC HPLC-ESI-MS
  • Hydrophilic Interaction Liquid Chromatography-Based Enrichment Protocol Coupled to Mass Spectrometry for Glycoproteome Analysis
  • Development and Application of Methods for Separation of Carbohydrates by Hydrophilic Interaction Liquid Chromatography
  • Hydrophilic Interaction Liquid Chromatography in the Characterization of Glycoproteins
  • Analysis of Protein Glycosylation and Phosphorylation Using HILIC-MS.
Medical Library (Lane)
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Check Medical Library (Lane) catalog for status
CRCNETBASE Unknown
Book
1 online resource.
  • Foreword ( Tom Baillie). Preface (Mike Lee and Mingshe Zhu). Contributors. Part I. Basic Concepts of Drug Metabolism and Disposition. 1. Progression of Drug Metabolism (Ronald E. White). 2. Common Biotransformation Reactions (Bo Wen and Sidney D. Nelson). 3. Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry (Amit S. Kalgutkar). 4. Drug-Metabolizing Enzymes, Transporters, and Drug-Drug Interactions (Steven W. Louie and Magang Shou). 5. Experimental Models of Drug Metabolism and Disposition (Gang Luo, Chuang Lu, Xinxin Ding, and Donglu Zhang). 6. Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery (Takehito Yamamoto, Akihiro Hisaka, and Hiroshi Suzuki). 7. Drug Metabolism Research as Integral Part of Drug Discovery and Development Processes (W. Griffith Humphereys). Part II. Mass Spectrometry in Drug Metabolism: Principles and Common Practice. 8. Theory and Instrumentation of Mass Spectrometry (Gerard Hopfgartner). 9. Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification (Lin Xu, Lewis J. Klunk, and Chandra Prakash). 10. Mass Spectral Interpretation (Li-Kang Zhang and Birendra N. Pramanik). 11. Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography, and Non-Mass-Spectrometric Detection (Mark Hayward, Maria D. Bacolod, Qing Ping Han, Manuel Cajina, and Zack Zou). Part III. Applications of New LC-MS Techniques in Drug Metabolism and Disposition. 12. Quantitative In Vitro ADME Assays Using LC-MS as a Part of Early Drug Metabolism Screening (Walter Korfmacher). 13. High-Resolution Mass Spectrometry and Drug Metabolite Identification (Russell J. Mortishire-Smith, Haiying Zhang, and Kevin P. Bateman). 14. Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging (Richard F. Reich, Daniel P. Magparangalan, Timothy J. Garrett, and Richard A. Yost). 15. Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC-MS Platform in Drug Metabolism and Pharmacokinetics (Wenying Jian, Ming Yao, Bo Wen, Elliott B. Jones, and Mingshe Zhu). 16. Quantitative Drug Metabolism with Accelerator Mass Spectrometry (John S. Vogel, Peter Lohstroh, Brad Keck, and Stephen R. Dueker). 17. Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions (Jing-Tao Wu). 18. Profiling and Characterization of Herbal Medicine and Its Metabolites Using LC-MS (Zeper Abliz, Ruiping Zhang, Ping Geng, Dongmei Dai, Jiuming He, and Jian Liu). 19. Liquid Chromatography Mass Spectrometry Bioanalysis of Protein Therapeutics and Biomarkers in Biological Matrices (Fumin Li and Qin C. Ji). 20. Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress (Stacy L. Gelhaus and Ian A. Blair). 21. LC-MS in Endogenous Metabolite Profiling and Small-Molecule Biomarker Discovery (Michael D. Reily, Petia Shipkova, and Serhiy Hnatyshyn). Appendix. Index.
  • (source: Nielsen Book Data)
This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
(source: Nielsen Book Data)
  • Foreword ( Tom Baillie). Preface (Mike Lee and Mingshe Zhu). Contributors. Part I. Basic Concepts of Drug Metabolism and Disposition. 1. Progression of Drug Metabolism (Ronald E. White). 2. Common Biotransformation Reactions (Bo Wen and Sidney D. Nelson). 3. Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry (Amit S. Kalgutkar). 4. Drug-Metabolizing Enzymes, Transporters, and Drug-Drug Interactions (Steven W. Louie and Magang Shou). 5. Experimental Models of Drug Metabolism and Disposition (Gang Luo, Chuang Lu, Xinxin Ding, and Donglu Zhang). 6. Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery (Takehito Yamamoto, Akihiro Hisaka, and Hiroshi Suzuki). 7. Drug Metabolism Research as Integral Part of Drug Discovery and Development Processes (W. Griffith Humphereys). Part II. Mass Spectrometry in Drug Metabolism: Principles and Common Practice. 8. Theory and Instrumentation of Mass Spectrometry (Gerard Hopfgartner). 9. Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification (Lin Xu, Lewis J. Klunk, and Chandra Prakash). 10. Mass Spectral Interpretation (Li-Kang Zhang and Birendra N. Pramanik). 11. Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography, and Non-Mass-Spectrometric Detection (Mark Hayward, Maria D. Bacolod, Qing Ping Han, Manuel Cajina, and Zack Zou). Part III. Applications of New LC-MS Techniques in Drug Metabolism and Disposition. 12. Quantitative In Vitro ADME Assays Using LC-MS as a Part of Early Drug Metabolism Screening (Walter Korfmacher). 13. High-Resolution Mass Spectrometry and Drug Metabolite Identification (Russell J. Mortishire-Smith, Haiying Zhang, and Kevin P. Bateman). 14. Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging (Richard F. Reich, Daniel P. Magparangalan, Timothy J. Garrett, and Richard A. Yost). 15. Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC-MS Platform in Drug Metabolism and Pharmacokinetics (Wenying Jian, Ming Yao, Bo Wen, Elliott B. Jones, and Mingshe Zhu). 16. Quantitative Drug Metabolism with Accelerator Mass Spectrometry (John S. Vogel, Peter Lohstroh, Brad Keck, and Stephen R. Dueker). 17. Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions (Jing-Tao Wu). 18. Profiling and Characterization of Herbal Medicine and Its Metabolites Using LC-MS (Zeper Abliz, Ruiping Zhang, Ping Geng, Dongmei Dai, Jiuming He, and Jian Liu). 19. Liquid Chromatography Mass Spectrometry Bioanalysis of Protein Therapeutics and Biomarkers in Biological Matrices (Fumin Li and Qin C. Ji). 20. Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress (Stacy L. Gelhaus and Ian A. Blair). 21. LC-MS in Endogenous Metabolite Profiling and Small-Molecule Biomarker Discovery (Michael D. Reily, Petia Shipkova, and Serhiy Hnatyshyn). Appendix. Index.
  • (source: Nielsen Book Data)
This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
(source: Nielsen Book Data)
dx.doi.org Wiley Online Library
Book
online resource (xi, 237 pages : illustrations (some color))
  • Protein Structure Prediction / Patrice Koehl
  • Molecular Modeling of Biomembranes: A How-to Approach / Allison N. Dickey and Roland Faller
  • Introduction to Electron Paramagnetic Resonance Spectroscopy / Marcin Brynda
  • Theory and Applications of Biomolecular NMR Spectroscopy / James B. Ames
  • FRET and Its Biological Application as a Molecular Ruler / Jie Zheng
  • Introduction to Modern Techniques in Mass Spectrometry / Caroline S. Chu and Carlito B. Lebrilla
  • Transmission Electron Microscopy and Computer-Aided Image Processing for 3D Structural Analysis of Macromolecules / Dominik J. Green and R. Holland Cheng
  • Raman Spectroscopy of Living Cells / Tyler Weeks and Thomas Huser.
  • Protein Structure Prediction / Patrice Koehl
  • Molecular Modeling of Biomembranes: A How-to Approach / Allison N. Dickey and Roland Faller
  • Introduction to Electron Paramagnetic Resonance Spectroscopy / Marcin Brynda
  • Theory and Applications of Biomolecular NMR Spectroscopy / James B. Ames
  • FRET and Its Biological Application as a Molecular Ruler / Jie Zheng
  • Introduction to Modern Techniques in Mass Spectrometry / Caroline S. Chu and Carlito B. Lebrilla
  • Transmission Electron Microscopy and Computer-Aided Image Processing for 3D Structural Analysis of Macromolecules / Dominik J. Green and R. Holland Cheng
  • Raman Spectroscopy of Living Cells / Tyler Weeks and Thomas Huser.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER Unknown
Book
xvi, 538 p. : ill. ; 27 cm.
  • 1. The Evolution of Mass Spectrometry in the Clinical Laboratory Catherine A. Hammett-Stabler and Uttam Garg 2. Measurement of Plasma/Serum Acylcarnitines Using Tandem Mass Spectrometry Nathalie Lepage and Susan Aucoin 3. Comprehensive Determination of Amino Acids for Diagnosis of Inborn Errors of Metabolism Dennis J. Dietzen and Annette L. Weindel 4. Identification and Quantitation of Amphetamine, Methamphetamine, MDMA, Pseudoephedrine, and Ephedrine in Blood, Plasma, and Serum Using Gas Chromatography-Mass Spectrometry (GC/MS) Josh Gunn, Scott Kriger, and Andrea R. Terrell 5. Quantification of Antidepressants Using Gas Chromatography-Mass Spectrometry Ruth E. Winecker 6. Quantitation of Argatroban in Plasma using Liquid Chromatography Electrospray Tandem Mass Spectrometry (UPLC-ESI-MS/MS) Ross J. Molinaro 7. Quantitation of Amobarbital, Butalbital, Pentobarbital, Phenobarbital, and Secobarbital in Urine, Serum, and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) Leonard L. Johnson and Uttam Garg 8. Quantitation of Benzodiazepines in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 9. LC-MS/MS Analysis of 13 Benzodiazepines and Metabolites in Urine, Serum, Plasma, and Meconium Stephanie J. Marin and Gwendolyn A. McMillin 10. Simultaneous Determination and Quantification of 12 Benzodiazepines in Serum or Whole Blood Using UPLC/MS/MS Josh Gunn, Scott Kriger, and Andrea R. Terrell 11. Determination of Benzoic Acid in Serum or Plasma by Gas Chromatography-Mass Spectrometry (GC/MS) Jeff M. Knoblauch, David K. Scott, Laurie D. Smith, and Uttam Garg 12. Quantification of Busulfan in Plasma Uing Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Marion L. Snyder and James C. Ritchie 13. Quantitation of Total 11-Nor-9-Carboxy-Delta 9-Tetrahydrocannabinol in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) C. Clinton Frazee III, Michael Kiscoan, and Uttam Garg 14. Quantitation of Cocaine, Benzoylecgonine, Ecgonine Methyl Ester, and Cocaethylene in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Steven W. Fleming, Amitava Dasgupta, and Uttam Garg 15. Identification and Quantitation of Cocaine, Benzoylecgonine, and Cocaethylene in Blood, Serum, and Plasma Using Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry (UPLC-MS/MS) Scott Kriger, Josh Gunn, and Andrea R. Terrell 16. Detection and Quantification of Cocaine and Benzoylecgonine in Meconium Using Solid Phase Extraction and UPLC/MS/MS Josh Gunn, Scott Kriger, and Andrea R. Terrell 17. Diagnosis of Creatine Metabolism Disorders by Determining Creatine and Guanidinoacetate in Plasma and Urine Qin Sun and William E. O'Brien 18. Broad Spectrum Drug Screening Using Electron-Ionization Gas Chromatography-Mass Spectrometry (EI-GCMS) Judy Stone 19. Broad Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry Judy Stone 20. High Sensitivity Measurement of Estrone and Estradiol in Serum and Plasma Using LC-MS/MS Mark M. Kushnir, Alan L. Rockwood, Bingfang Yue, and A. Wayne Meikle 21. 3-Hydroxy-Fatty Acid Analysis by Gas Chromatography-Mass Spectrometry Patricia M. Jones and Michael J. Bennett 22. Quantitation of Fentanyl in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 23. Determination of Total Homocysteine in Plasma Using Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC/MS/MS) Bruno Casetta 24. Quantitation of Homovanillic Acid (HVA) and Vanillylmandelic Acid (VMA) in Urine Using Gas Chromatography-Mass Spectrometry (GC/MS) Ryan Allenbrand and Uttam Garg 25. Quantitation of 17-OH-Progesterone (OHPG) for Diagnosis of Congenital Adrenal Hyperplasia (CAH) Ravinder J. Singh 26. Determination of Hydroxyurea in Serum or Plasma Using Gas Chromatography-Mass Spectrometry (GC/MS) David K. Scott, Kathleen Neville, and Uttam Garg 27. Quantitation of Ibuprofen in Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Gerry Huber and Uttam Garg 28. Quantitation of Indomethacin in Serum and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) Sarah Thomas, Amanda Sutton, and Uttam Garg 29. Quantitation of Iothalamate in Urine and Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Ross J. Molinaro and James C. Ritchie 30. Identification and Quantitation of Ketamine in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Megan Gamble, and Kim Cox 31. Measurement of Filter Paper Bloodspot Lead by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Denise M. Timko and Douglas F. Stickle 32. Multiplex Lysosomal Enzyme Activity Assay on Dried Blood Spots Using Tandem Mass Spectrometry X. Kate Zhang, Carole S. Elbin, Frantisek Turecek, Ronald Scott, Wei-Lien Chuang, Joan M. Keutzer, and Michael Gelb 33. Gas Chromatography-Mass Spectrometry Method for the Determination of Methadone and 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP) Christine L.H. Snozek, Matthew W. Bjergum, and Loralie J. Langman 34. Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) Method for Monitoring Methotrexate in the Setting of Carboxypeptidase-G2 Therapy Vikram S. Kumar, Terence Law, and Mark Kellogg 35. Quantitation of Methylmalonic Acid in Serum or Plasma Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry Jie Chen and Michael J. Bennett 36. Quantitation of Methylmalonic Acid in Plasma Using Liquid Chromatography-Tandem Mass Spectrometry Claudine Fasching and Jasbir Singh 37. Monitoring of Mycophenolate Acid in Serum or Plasma Using LC Tandem Mass Spectrometry Catherine A. Hammett-Stabler, Diane Ciuffetti Geis, James Ritchie, and Christine Papadea 38. Quantitation of Nicotine, Its Metabolites, and Other Related Alkaloids in Urine, Serum, and Plasma Using LC-MS/MS Bingfang Yue, Mark M. Kushnir, Francis M. Urry, and Alan L. Rockwood 39. Quantitation of Opioids in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 40. Quantitation of Morphine, Codeine, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone, and 6-Monoacetylmorphine (6-MAM) in Urine, Blood, Serum, or Plasma Using Liquid Chromatography with Tandem Mass Spectrometry Detection Tim Dahn, Josh Gunn, Scott Kriger, and Andrea R. Terrell 41. Urine Organic Acid Analysis for Inherited Metabolic Disease Using Gas Chromatography-Mass Spectrometry Patricia M. Jones and Michael J. Bennett 42. Identification of Urine Organic Acids for the Detection of Inborn Errors of Metabolism Using Urease and Gas Chromatography-Mass Spectrometry (GC/MS) Stanley F. Lo, Velta Young, and William J. Rhead 43. Quantitation of Orotic Acid in Urine Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry Jie Chen and Michael J. Bennett 44. Quantitation of Oxycodone in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 45. Quantitation of Phencyclidine (PCP) in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Angela M. Ferguson and Uttam Garg 46. Quantitation of Sirolimus Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS) Magdalena Korecka and Leslie M. Shaw 47. Quantitation of Tacrolimus in Whole Blood Using High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC/MS/MS) Keri J. Donaldson and Leslie M. Shaw 48. Analysis of Testosterone in Serum Using Mass Spectrometry Robert L. Fitzgerald, Terrance L. Griffin, and David A. Herold 49. Determination of Tetrahydrozoline in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC/MS) Judy Peat and Uttam Garg 50. Quantitation of 25-OH-Vitamin D (25OHD) Using Liquid Tandem Mass Spectrometry (LC-MS/MS) Ravinder J. Singh 51. Identification and Quantitation of Zolpidem in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Lydia A. Harryman, and Melissa C. Norton 52. Identification and Quantitation of Zopiclone in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Melissa C. Norton, and Lydia A. Harryman.
  • (source: Nielsen Book Data)
As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Protocols, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical protocols, and detailed notes on troubleshooting and avoiding known pitfalls. Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Protocols offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.
(source: Nielsen Book Data)
  • 1. The Evolution of Mass Spectrometry in the Clinical Laboratory Catherine A. Hammett-Stabler and Uttam Garg 2. Measurement of Plasma/Serum Acylcarnitines Using Tandem Mass Spectrometry Nathalie Lepage and Susan Aucoin 3. Comprehensive Determination of Amino Acids for Diagnosis of Inborn Errors of Metabolism Dennis J. Dietzen and Annette L. Weindel 4. Identification and Quantitation of Amphetamine, Methamphetamine, MDMA, Pseudoephedrine, and Ephedrine in Blood, Plasma, and Serum Using Gas Chromatography-Mass Spectrometry (GC/MS) Josh Gunn, Scott Kriger, and Andrea R. Terrell 5. Quantification of Antidepressants Using Gas Chromatography-Mass Spectrometry Ruth E. Winecker 6. Quantitation of Argatroban in Plasma using Liquid Chromatography Electrospray Tandem Mass Spectrometry (UPLC-ESI-MS/MS) Ross J. Molinaro 7. Quantitation of Amobarbital, Butalbital, Pentobarbital, Phenobarbital, and Secobarbital in Urine, Serum, and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) Leonard L. Johnson and Uttam Garg 8. Quantitation of Benzodiazepines in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 9. LC-MS/MS Analysis of 13 Benzodiazepines and Metabolites in Urine, Serum, Plasma, and Meconium Stephanie J. Marin and Gwendolyn A. McMillin 10. Simultaneous Determination and Quantification of 12 Benzodiazepines in Serum or Whole Blood Using UPLC/MS/MS Josh Gunn, Scott Kriger, and Andrea R. Terrell 11. Determination of Benzoic Acid in Serum or Plasma by Gas Chromatography-Mass Spectrometry (GC/MS) Jeff M. Knoblauch, David K. Scott, Laurie D. Smith, and Uttam Garg 12. Quantification of Busulfan in Plasma Uing Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Marion L. Snyder and James C. Ritchie 13. Quantitation of Total 11-Nor-9-Carboxy-Delta 9-Tetrahydrocannabinol in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) C. Clinton Frazee III, Michael Kiscoan, and Uttam Garg 14. Quantitation of Cocaine, Benzoylecgonine, Ecgonine Methyl Ester, and Cocaethylene in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Steven W. Fleming, Amitava Dasgupta, and Uttam Garg 15. Identification and Quantitation of Cocaine, Benzoylecgonine, and Cocaethylene in Blood, Serum, and Plasma Using Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry (UPLC-MS/MS) Scott Kriger, Josh Gunn, and Andrea R. Terrell 16. Detection and Quantification of Cocaine and Benzoylecgonine in Meconium Using Solid Phase Extraction and UPLC/MS/MS Josh Gunn, Scott Kriger, and Andrea R. Terrell 17. Diagnosis of Creatine Metabolism Disorders by Determining Creatine and Guanidinoacetate in Plasma and Urine Qin Sun and William E. O'Brien 18. Broad Spectrum Drug Screening Using Electron-Ionization Gas Chromatography-Mass Spectrometry (EI-GCMS) Judy Stone 19. Broad Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry Judy Stone 20. High Sensitivity Measurement of Estrone and Estradiol in Serum and Plasma Using LC-MS/MS Mark M. Kushnir, Alan L. Rockwood, Bingfang Yue, and A. Wayne Meikle 21. 3-Hydroxy-Fatty Acid Analysis by Gas Chromatography-Mass Spectrometry Patricia M. Jones and Michael J. Bennett 22. Quantitation of Fentanyl in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 23. Determination of Total Homocysteine in Plasma Using Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC/MS/MS) Bruno Casetta 24. Quantitation of Homovanillic Acid (HVA) and Vanillylmandelic Acid (VMA) in Urine Using Gas Chromatography-Mass Spectrometry (GC/MS) Ryan Allenbrand and Uttam Garg 25. Quantitation of 17-OH-Progesterone (OHPG) for Diagnosis of Congenital Adrenal Hyperplasia (CAH) Ravinder J. Singh 26. Determination of Hydroxyurea in Serum or Plasma Using Gas Chromatography-Mass Spectrometry (GC/MS) David K. Scott, Kathleen Neville, and Uttam Garg 27. Quantitation of Ibuprofen in Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Gerry Huber and Uttam Garg 28. Quantitation of Indomethacin in Serum and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) Sarah Thomas, Amanda Sutton, and Uttam Garg 29. Quantitation of Iothalamate in Urine and Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Ross J. Molinaro and James C. Ritchie 30. Identification and Quantitation of Ketamine in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Megan Gamble, and Kim Cox 31. Measurement of Filter Paper Bloodspot Lead by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Denise M. Timko and Douglas F. Stickle 32. Multiplex Lysosomal Enzyme Activity Assay on Dried Blood Spots Using Tandem Mass Spectrometry X. Kate Zhang, Carole S. Elbin, Frantisek Turecek, Ronald Scott, Wei-Lien Chuang, Joan M. Keutzer, and Michael Gelb 33. Gas Chromatography-Mass Spectrometry Method for the Determination of Methadone and 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP) Christine L.H. Snozek, Matthew W. Bjergum, and Loralie J. Langman 34. Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) Method for Monitoring Methotrexate in the Setting of Carboxypeptidase-G2 Therapy Vikram S. Kumar, Terence Law, and Mark Kellogg 35. Quantitation of Methylmalonic Acid in Serum or Plasma Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry Jie Chen and Michael J. Bennett 36. Quantitation of Methylmalonic Acid in Plasma Using Liquid Chromatography-Tandem Mass Spectrometry Claudine Fasching and Jasbir Singh 37. Monitoring of Mycophenolate Acid in Serum or Plasma Using LC Tandem Mass Spectrometry Catherine A. Hammett-Stabler, Diane Ciuffetti Geis, James Ritchie, and Christine Papadea 38. Quantitation of Nicotine, Its Metabolites, and Other Related Alkaloids in Urine, Serum, and Plasma Using LC-MS/MS Bingfang Yue, Mark M. Kushnir, Francis M. Urry, and Alan L. Rockwood 39. Quantitation of Opioids in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 40. Quantitation of Morphine, Codeine, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone, and 6-Monoacetylmorphine (6-MAM) in Urine, Blood, Serum, or Plasma Using Liquid Chromatography with Tandem Mass Spectrometry Detection Tim Dahn, Josh Gunn, Scott Kriger, and Andrea R. Terrell 41. Urine Organic Acid Analysis for Inherited Metabolic Disease Using Gas Chromatography-Mass Spectrometry Patricia M. Jones and Michael J. Bennett 42. Identification of Urine Organic Acids for the Detection of Inborn Errors of Metabolism Using Urease and Gas Chromatography-Mass Spectrometry (GC/MS) Stanley F. Lo, Velta Young, and William J. Rhead 43. Quantitation of Orotic Acid in Urine Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry Jie Chen and Michael J. Bennett 44. Quantitation of Oxycodone in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves 45. Quantitation of Phencyclidine (PCP) in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Angela M. Ferguson and Uttam Garg 46. Quantitation of Sirolimus Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS) Magdalena Korecka and Leslie M. Shaw 47. Quantitation of Tacrolimus in Whole Blood Using High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC/MS/MS) Keri J. Donaldson and Leslie M. Shaw 48. Analysis of Testosterone in Serum Using Mass Spectrometry Robert L. Fitzgerald, Terrance L. Griffin, and David A. Herold 49. Determination of Tetrahydrozoline in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC/MS) Judy Peat and Uttam Garg 50. Quantitation of 25-OH-Vitamin D (25OHD) Using Liquid Tandem Mass Spectrometry (LC-MS/MS) Ravinder J. Singh 51. Identification and Quantitation of Zolpidem in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Lydia A. Harryman, and Melissa C. Norton 52. Identification and Quantitation of Zopiclone in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Melissa C. Norton, and Lydia A. Harryman.
  • (source: Nielsen Book Data)
As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Protocols, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical protocols, and detailed notes on troubleshooting and avoiding known pitfalls. Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Protocols offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH506 .M45 V.603 Unknown
Book
online resource (x, 262 pages : illustrations (some color) ; 24 cm)
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER Unknown
Book
computer files (x, 357 p.) : ill. ; 27 cm
  • Approaches and applications of quantitative LC-MS for proteomics and activitomics / Pedro R. Cutillas and John F. Timms
  • Overview of quantitative LC-MS techniques for proteomics and activitomics / John F. Timms and Pedro R. Cutillas
  • Instrumentation for LC-MS/MS in proteomics / Robert Chalkley
  • Bioinformatics for LC-MS/MS-based proteomics / Richard J. Jacob
  • Analysis of post-translational modifications by LC-MS/MS / Hannah Johnson and Claire E. Eyers
  • In-depth analysis of protein phosphorylation by multidimensional ion exchange chromatography and mass spectrometry / Maria P. Alcolea and Pedro R. Cutillas
  • Mapping of phosphorylation sites by LC-MS/MS / Bertran Gerrits and Bernd Bodenmiller
  • Analysis of carbohydrates on proteins by offline normal-phase liquid chromatography MALDI-TOF-MS/MS / Theodora Tryfona and Elaine Stephens
  • Selected reaction monitoring applied to quantitative proteomics / Reiko Kiyonami and Bruno Domon
  • Basic design of MRM assays for peptide quantification / Andrew James and Claus Jorgensen
  • Proteome-wide quantitation by SILAC / Kristoffer T.G. Rigbolt and Blagoy Blagoev
  • Quantification of proteins by iTRAQ / Richard D. Unwin
  • Quantification of proteins by label-free LC-MS/MS / Yishai Levin and Sabine Bahn
  • Protocol for quantitative proteomics of cellular membranes and membrane rafts / Andrew J. Thompson and Ritchie Williamson
  • Organelle proteomics by label-free and SILAC-based protein correlation profiling / Joern Dengjel, Lis Jakobsen, and Jens S. Andersen
  • Mapping protein-protein interactions by quantitative proteomics / Joern Dengjel, Irina Kratchmarova, and Blagoy Blagoev
  • Analysis of serum proteins by LC-MS/MS / Sarah Tonack, John P. Neoptolemos, and Eithne Costello
  • Urinary proteome profiling using 2D-DIGE and LC-MS/MS / Mark E. Weeks
  • Analysis of peptides in biological fluids by LC-MS/MS / Pedro R. Cutillas
  • Quantification of protein kinase activities by LC-MS / Maria P. Alcolea and Pedro R. Cutillas
  • A protocol for top-down proteomics using HPLC and ETD/PTR-MS / Sarah R. Hart.
  • Approaches and applications of quantitative LC-MS for proteomics and activitomics / Pedro R. Cutillas and John F. Timms
  • Overview of quantitative LC-MS techniques for proteomics and activitomics / John F. Timms and Pedro R. Cutillas
  • Instrumentation for LC-MS/MS in proteomics / Robert Chalkley
  • Bioinformatics for LC-MS/MS-based proteomics / Richard J. Jacob
  • Analysis of post-translational modifications by LC-MS/MS / Hannah Johnson and Claire E. Eyers
  • In-depth analysis of protein phosphorylation by multidimensional ion exchange chromatography and mass spectrometry / Maria P. Alcolea and Pedro R. Cutillas
  • Mapping of phosphorylation sites by LC-MS/MS / Bertran Gerrits and Bernd Bodenmiller
  • Analysis of carbohydrates on proteins by offline normal-phase liquid chromatography MALDI-TOF-MS/MS / Theodora Tryfona and Elaine Stephens
  • Selected reaction monitoring applied to quantitative proteomics / Reiko Kiyonami and Bruno Domon
  • Basic design of MRM assays for peptide quantification / Andrew James and Claus Jorgensen
  • Proteome-wide quantitation by SILAC / Kristoffer T.G. Rigbolt and Blagoy Blagoev
  • Quantification of proteins by iTRAQ / Richard D. Unwin
  • Quantification of proteins by label-free LC-MS/MS / Yishai Levin and Sabine Bahn
  • Protocol for quantitative proteomics of cellular membranes and membrane rafts / Andrew J. Thompson and Ritchie Williamson
  • Organelle proteomics by label-free and SILAC-based protein correlation profiling / Joern Dengjel, Lis Jakobsen, and Jens S. Andersen
  • Mapping protein-protein interactions by quantitative proteomics / Joern Dengjel, Irina Kratchmarova, and Blagoy Blagoev
  • Analysis of serum proteins by LC-MS/MS / Sarah Tonack, John P. Neoptolemos, and Eithne Costello
  • Urinary proteome profiling using 2D-DIGE and LC-MS/MS / Mark E. Weeks
  • Analysis of peptides in biological fluids by LC-MS/MS / Pedro R. Cutillas
  • Quantification of protein kinase activities by LC-MS / Maria P. Alcolea and Pedro R. Cutillas
  • A protocol for top-down proteomics using HPLC and ETD/PTR-MS / Sarah R. Hart.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER PROTOCOLS Unknown
Book
x, 357 p. : ill. ; 27 cm.
  • Part I: Overviews of Techniques and Approaches in LC-MS-Based Proteomics 1. Approaches and Applications of Quantitative LC-MS for Proteomics and Activitomics Pedro R. Cutillas and John F. Timms 2. Overview of Quantitative LC-MS Techniques for Proteomics and Activitomics John F. Timms and Pedro R. Cutillas 3. Instrumentation for LC-MS/MS in Proteomics Robert Chalkley 4. Bioinformatics for LC-MS/MS-Based Proteomics Richard J. Jacob 5. Analysis of Post-Translational Modifications by LC-MS/MS Hannah Johnson and Claire E. Eyers Part II: Structural Analysis of Post-Translational Modifications 6. In-Depth Analysis of Protein Phosphorylation by Multidimensional Ion Exchange Chromatography and Mass Spectrometry Maria P. Alcolea and Pedro R. Cutillas 7. Mapping of Phosphorylation Sites by LC-MS/MS Bertran Gerrits and Bernd Bodenmiller 8. Analysis of Carbohydrates on Proteins by Off-Line Normal Phase Liquid Chromatography MALDI-TOF/TOF-MS/MS Theodora Tryfona and Elaine Stephens Part III: Techniques for Quantitative LC-MS 9. Selected Reaction Monitoring Applied to Quantitative Proteomics Reiko Kiyonami and Bruno Domon 10. Basic Design of MRM Assays for Peptide Quantification Andrew James and Claus Jorgensen 11. Proteome-Wide Quantitation by SILAC Kristoffer T.G. Rigbolt and Blagoy Blagoev 12. Quantification of Proteins by iTRAQ Richard D. Unwin 13. Quantification of Proteins by Label Free LC-MS/MS Yishai Levin and Sabine Bahn Part IV: Analysis of Protein Complexes and Organelles 14. Protocol for Quantitative Proteomics of Cellular Membranes and Membrane Rafts Andrew J. Thompson and Ritchie Williamson 15. Organelle Proteomics by Label-Free and SILAC-Based Protein Correlation Profiling Joern Dengjel, Lis Jakobsen, and Jens S. Andersen 16. Mapping Protein-Protein Interactions by Quantitative Proteomics Joern Dengjel, Irina Kratchmarova, and Blagoy Blagoev Part V: Analysis of Biological Fluids and Clinical Samples 17. Analysis of Serum Proteins by LC-MS/MS Sarah Tonack, John P. Neoptolemos, and Eithne Costello 18. Urinary Proteome Profiling Using 2D-DIGE and LC-MS/MS Mark E. Weeks 19. Analysis of Peptides in Biological Fluids by LC-MS/MS Pedro R. Cutillas Part VI: Novel Applications of LC-MS 20. Quantification of Protein Kinase Activities by LC-MS Maria P. Alcolea and Pedro R. Cutillas 21. A Protocol for Top Down Proteomics Using HPLC and ETD/PTR-MS Sarah R. Hart.
  • (source: Nielsen Book Data)
With the development of new quantitative strategies and powerful bioinformatics tools to cope with the analysis of the large amounts of data generated in proteomics experiments, liquid chromatography with tandem mass spectrometry (LC-MS/MS) is making possible the analysis of proteins on a global scale, meaning that proteomics can now start competing with cDNA microarrays for the analysis of whole genomes. In LC-MS/MS in Proteomics: Methods and Applications, experts in the field provide protocols and up-to-date reviews of the applications of LC-MS/MS, with a particular focus on MS-based methods of protein and peptide quantification and the analysis of post-translational modifications. Beginning with overviews of the use of LC-M/MS in protein analysis, the book continues with topics such as protocols for the analysis of post-translational modifications, with particular focus on phosphorylation and glycosylation, popular techniques for quantitative proteomics, such as multiple reaction monitoring, metabolic labelling, and chemical tagging, biomarker discovery in biological fluids, as well as novel applications of LC-MS/MS. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective subjects, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, LC-MS/MS in Proteomics: Methods and Applications presents the techniques and concepts necessary in order to aid proteomic practitioners in the application of LC-MS/MS to essentially any biological problem.
(source: Nielsen Book Data)
  • Part I: Overviews of Techniques and Approaches in LC-MS-Based Proteomics 1. Approaches and Applications of Quantitative LC-MS for Proteomics and Activitomics Pedro R. Cutillas and John F. Timms 2. Overview of Quantitative LC-MS Techniques for Proteomics and Activitomics John F. Timms and Pedro R. Cutillas 3. Instrumentation for LC-MS/MS in Proteomics Robert Chalkley 4. Bioinformatics for LC-MS/MS-Based Proteomics Richard J. Jacob 5. Analysis of Post-Translational Modifications by LC-MS/MS Hannah Johnson and Claire E. Eyers Part II: Structural Analysis of Post-Translational Modifications 6. In-Depth Analysis of Protein Phosphorylation by Multidimensional Ion Exchange Chromatography and Mass Spectrometry Maria P. Alcolea and Pedro R. Cutillas 7. Mapping of Phosphorylation Sites by LC-MS/MS Bertran Gerrits and Bernd Bodenmiller 8. Analysis of Carbohydrates on Proteins by Off-Line Normal Phase Liquid Chromatography MALDI-TOF/TOF-MS/MS Theodora Tryfona and Elaine Stephens Part III: Techniques for Quantitative LC-MS 9. Selected Reaction Monitoring Applied to Quantitative Proteomics Reiko Kiyonami and Bruno Domon 10. Basic Design of MRM Assays for Peptide Quantification Andrew James and Claus Jorgensen 11. Proteome-Wide Quantitation by SILAC Kristoffer T.G. Rigbolt and Blagoy Blagoev 12. Quantification of Proteins by iTRAQ Richard D. Unwin 13. Quantification of Proteins by Label Free LC-MS/MS Yishai Levin and Sabine Bahn Part IV: Analysis of Protein Complexes and Organelles 14. Protocol for Quantitative Proteomics of Cellular Membranes and Membrane Rafts Andrew J. Thompson and Ritchie Williamson 15. Organelle Proteomics by Label-Free and SILAC-Based Protein Correlation Profiling Joern Dengjel, Lis Jakobsen, and Jens S. Andersen 16. Mapping Protein-Protein Interactions by Quantitative Proteomics Joern Dengjel, Irina Kratchmarova, and Blagoy Blagoev Part V: Analysis of Biological Fluids and Clinical Samples 17. Analysis of Serum Proteins by LC-MS/MS Sarah Tonack, John P. Neoptolemos, and Eithne Costello 18. Urinary Proteome Profiling Using 2D-DIGE and LC-MS/MS Mark E. Weeks 19. Analysis of Peptides in Biological Fluids by LC-MS/MS Pedro R. Cutillas Part VI: Novel Applications of LC-MS 20. Quantification of Protein Kinase Activities by LC-MS Maria P. Alcolea and Pedro R. Cutillas 21. A Protocol for Top Down Proteomics Using HPLC and ETD/PTR-MS Sarah R. Hart.
  • (source: Nielsen Book Data)
With the development of new quantitative strategies and powerful bioinformatics tools to cope with the analysis of the large amounts of data generated in proteomics experiments, liquid chromatography with tandem mass spectrometry (LC-MS/MS) is making possible the analysis of proteins on a global scale, meaning that proteomics can now start competing with cDNA microarrays for the analysis of whole genomes. In LC-MS/MS in Proteomics: Methods and Applications, experts in the field provide protocols and up-to-date reviews of the applications of LC-MS/MS, with a particular focus on MS-based methods of protein and peptide quantification and the analysis of post-translational modifications. Beginning with overviews of the use of LC-M/MS in protein analysis, the book continues with topics such as protocols for the analysis of post-translational modifications, with particular focus on phosphorylation and glycosylation, popular techniques for quantitative proteomics, such as multiple reaction monitoring, metabolic labelling, and chemical tagging, biomarker discovery in biological fluids, as well as novel applications of LC-MS/MS. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective subjects, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, LC-MS/MS in Proteomics: Methods and Applications presents the techniques and concepts necessary in order to aid proteomic practitioners in the application of LC-MS/MS to essentially any biological problem.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH506 .M45 V.658 Unknown
Book
computer files (xiv, 487 p. : ill. (some col.). ; 27 cm.)
  • Imaging mass spectrometry : viewing the future / Sarah A. Schwartz and Richard M. Caprioli
  • A mass spectrometry primer for mass spectrometry imaging / Stanislav S. Rubakhin and Jonathan V. Sweedler
  • Imaging of metals, metalloids, and non-metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in biological tissues / J. Sabine Becker and J. Susanne Becker
  • Lipid detection, identification, and imaging single cells with SIMS / Michael L. Heien ... [et al.]
  • The application and potential of ion mobility mass spectrometry in imaging MS with a focus on lipids / Amina S. Woods and Shelley N. Jackson
  • Quantitative imaging of chemical composition in single cells by secondary ion mass spectrometry : cisplatin affects calcium stores in renal epithelial cells / Subhash Chandra
  • Imaging MALDI mass spectrometry of sphingolipids using an oscillating capillary nebulizer matrix application system / Yanfeng Chen ... [et al.]
  • Mapping pharmaceuticals in rat brain sections using MALDI imaging mass spectrometry / Yunsheng Hsieh, Fangbiao Li, and Walter A. Korfmacher
  • Laser ablation electrospray ionization for atmospheric pressure molecular imaging mass spectrometry / Peter Nemes and Akos Vertes
  • Matrix-assisted laser desorption/ionization and nanoparticle-based imaging mass spectrometry for small metabolites : a practical protocol / Yuki Sugiura and Mitsutoshi Setou
  • Cellular imaging using matrix-enhanced and metal-assisted SIMS / A.F. Maarten Altelaar and Sander R. Piersma
  • Tandem mass spectrometric methods for phospholipid analysis from brain tissue / Timothy J. Garrett and Richard A. Yost
  • Chemical imaging with desorption electrospray ionization mass spectrometry / Vilmos Kertesz and Gary J. Van Berkel
  • Mass spectrometry imaging of small molecules using matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) / Qiang Liu, Yongsheng Xiao, and Lin He
  • Preparation of single cells for imaging mass spectrometry / Elena S.F. Berman, Susan L. Fortson, and Kristen S. Kulp
  • Applying imaging ToF-SIMS and PCA in differentiation of tissue types / Ligang Wu, James S. Felton, and Kuang Jen J. Wu
  • Direct molecular analysis of whole-body animal tissue sections by MALDI imaging mass spectrometry / Michelle L. Reyzer ... [et al.]
  • MALDI direct analysis and imaging of frozen versus FFPE tissues : what strategy for which sample? / Maxence Wisztorski ... [et al.]
  • On tissue protein identification improvement by N-terminal peptide derivatization / Julien Franck ... [et al.]
  • Specific MALDI-MSI : TAG-MASS / Jonathan Stauber ... [et al.]
  • Structurally selective imaging mass spectrometry by imaging ion mobility-mass spectrometry / John A. McLean, Larissa S. Fenn, and Jeffrey R. Enders
  • Tutorial : multivariate statistical treatment of imaging data for clinical biomarker discovery / Sören-Oliver Deininger, Michael Becker, and Detlev Suckau
  • Applications of MALDI-MSI to pharmaceutical research / Brendan Prideaux, Dieter Staab, and Markus Stoeckli
  • Tissue preparation for the in situ MALDI MS imaging of proteins, lipids, and small molecules at cellular resolution / Nathalie Y.R. Agar ... [et al.]
  • Imaging of similar mass neuropeptides in neuronal tissue by enhanced resolution MALDI MS with an ion trap-Orbitrap hybrid instrument / Peter D.E.M. Verhaert ... [et al.]
  • Mass spectrometric imaging of neuropeptides in decapod crustacean neuronal tissues / Ruibing Chen ... [et al.]
  • Mass spectrometry imaging using the stretched sample approach / Tyler A. Zimmerman, Stanislav S. Rubakhin, and Jonathan V. Sweedler.
  • Imaging mass spectrometry : viewing the future / Sarah A. Schwartz and Richard M. Caprioli
  • A mass spectrometry primer for mass spectrometry imaging / Stanislav S. Rubakhin and Jonathan V. Sweedler
  • Imaging of metals, metalloids, and non-metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in biological tissues / J. Sabine Becker and J. Susanne Becker
  • Lipid detection, identification, and imaging single cells with SIMS / Michael L. Heien ... [et al.]
  • The application and potential of ion mobility mass spectrometry in imaging MS with a focus on lipids / Amina S. Woods and Shelley N. Jackson
  • Quantitative imaging of chemical composition in single cells by secondary ion mass spectrometry : cisplatin affects calcium stores in renal epithelial cells / Subhash Chandra
  • Imaging MALDI mass spectrometry of sphingolipids using an oscillating capillary nebulizer matrix application system / Yanfeng Chen ... [et al.]
  • Mapping pharmaceuticals in rat brain sections using MALDI imaging mass spectrometry / Yunsheng Hsieh, Fangbiao Li, and Walter A. Korfmacher
  • Laser ablation electrospray ionization for atmospheric pressure molecular imaging mass spectrometry / Peter Nemes and Akos Vertes
  • Matrix-assisted laser desorption/ionization and nanoparticle-based imaging mass spectrometry for small metabolites : a practical protocol / Yuki Sugiura and Mitsutoshi Setou
  • Cellular imaging using matrix-enhanced and metal-assisted SIMS / A.F. Maarten Altelaar and Sander R. Piersma
  • Tandem mass spectrometric methods for phospholipid analysis from brain tissue / Timothy J. Garrett and Richard A. Yost
  • Chemical imaging with desorption electrospray ionization mass spectrometry / Vilmos Kertesz and Gary J. Van Berkel
  • Mass spectrometry imaging of small molecules using matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) / Qiang Liu, Yongsheng Xiao, and Lin He
  • Preparation of single cells for imaging mass spectrometry / Elena S.F. Berman, Susan L. Fortson, and Kristen S. Kulp
  • Applying imaging ToF-SIMS and PCA in differentiation of tissue types / Ligang Wu, James S. Felton, and Kuang Jen J. Wu
  • Direct molecular analysis of whole-body animal tissue sections by MALDI imaging mass spectrometry / Michelle L. Reyzer ... [et al.]
  • MALDI direct analysis and imaging of frozen versus FFPE tissues : what strategy for which sample? / Maxence Wisztorski ... [et al.]
  • On tissue protein identification improvement by N-terminal peptide derivatization / Julien Franck ... [et al.]
  • Specific MALDI-MSI : TAG-MASS / Jonathan Stauber ... [et al.]
  • Structurally selective imaging mass spectrometry by imaging ion mobility-mass spectrometry / John A. McLean, Larissa S. Fenn, and Jeffrey R. Enders
  • Tutorial : multivariate statistical treatment of imaging data for clinical biomarker discovery / Sören-Oliver Deininger, Michael Becker, and Detlev Suckau
  • Applications of MALDI-MSI to pharmaceutical research / Brendan Prideaux, Dieter Staab, and Markus Stoeckli
  • Tissue preparation for the in situ MALDI MS imaging of proteins, lipids, and small molecules at cellular resolution / Nathalie Y.R. Agar ... [et al.]
  • Imaging of similar mass neuropeptides in neuronal tissue by enhanced resolution MALDI MS with an ion trap-Orbitrap hybrid instrument / Peter D.E.M. Verhaert ... [et al.]
  • Mass spectrometric imaging of neuropeptides in decapod crustacean neuronal tissues / Ruibing Chen ... [et al.]
  • Mass spectrometry imaging using the stretched sample approach / Tyler A. Zimmerman, Stanislav S. Rubakhin, and Jonathan V. Sweedler.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER PROTOCOLS Unknown
Book
xiv, 487 p. : ill. (some col.). ; 27 cm.
  • Introductory Reviews and Tutorials.- Imaging Mass Spectrometry: Viewing the Future.- A Mass Spectrometry Primer for Mass Spectrometry Imaging.- Imaging of Metals, Metalloids, and Non-metals by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) in Biological Tissues.- Protocols for MS Imaging of Distribution of Small Molecules Including Metabolites and Pharmaceuticals.- Lipid Detection, Identification, and Imaging Single Cells with SIMS.- The Application and Potential of Ion Mobility Mass Spectrometry in Imaging MS with a Focus on Lipids.- Quantitative Imaging of Chemical Composition in Single Cells by Secondary Ion Mass Spectrometry: Cisplatin Affects Calcium Stores in Renal Epithelial Cells.- Imaging MALDI Mass Spectrometry of Sphingolipids Using an Oscillating Capillary Nebulizer Matrix Application System.- Mapping Pharmaceuticals in Rat Brain Sections Using MALDI Imaging Mass Spectrometry.- Laser Ablation Electrospray Ionization for Atmospheric Pressure Molecular Imaging Mass Spectrometry.- Matrix-Assisted Laser Desorption/Ionization and Nanoparticle-Based Imaging Mass Spectrometry for Small Metabolites: A Practical Protocol.- Cellular Imaging Using Matrix-Enhanced and Metal-Assisted SIMS.- Tandem Mass Spectrometric Methods for Phospholipid Analysis from Brain Tissue.- Chemical Imaging with Desorption Electrospray Ionization Mass Spectrometry.- Mass Spectrometry Imaging of Small Molecules Using Matrix-Enhanced Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (ME-SALDI-MS).- Preparation of Single Cells for Imaging Mass Spectrometry.- Applying Imaging ToF-SIMS and PCA in Differentiation of Tissue Types.- Protocols for MS Imaging of Distribution of Peptides and Proteins.- Direct Molecular Analysis of Whole-Body Animal Tissue Sections by MALDI Imaging Mass Spectrometry.- MALDI Direct Analysis and Imaging of Frozen Versus FFPE Tissues: What Strategy for Which Sample?.- On Tissue Protein Identification Improvement by N-Terminal Peptide Derivatization.- Specific MALDI-MSI: TAG-MASS.- Structurally Selective Imaging Mass Spectrometry by Imaging Ion Mobility-Mass Spectrometry.- Tutorial: Multivariate Statistical Treatment of Imaging Data for Clinical Biomarker Discovery.- Applications of MALDI-MSI to Pharmaceutical Research.- Tissue Preparation for the In Situ MALDI MS Imaging of Proteins, Lipids, and Small Molecules at Cellular Resolution.- Imaging of Similar Mass Neuropeptides in Neuronal Tissue by Enhanced Resolution MALDI MS with an Ion Trap - OrbitrapTM Hybrid Instrument.- Mass Spectrometric Imaging of Neuropeptides in Decapod Crustacean Neuronal Tissues.- Mass Spectrometry Imaging Using the Stretched Sample Approach.
  • (source: Nielsen Book Data)
Mass spectrometry (MS) offers unmatched capabilities for the detection, characterization, and identification of a broad range of analytes. Mass spectrometry imaging (MSI) integrates MS data with information on the spatial distributions of the analytes, further enhancing the applicability of MS. In Mass Spectrometry Imaging: Principles and Protocols, expert practitioners from academia, industry, and the clinic contribute cutting-edge protocols describing the application of MSI to investigations of analyte localization in a variety of specimens, from microorganisms to plant and animal tissues. Divided into three sections, this volume presents the principles of MS, current and future trends of MSI, and qualitative and quantitative protocols to measure and identify endogenous metabolites and xenobiotics. An array of MSI approaches and technologies for characterizing peptide and protein distributions are described in detail. Written in the highly successful Methods in Molecular Biology(TM) series format, protocol chapters include introductions to their respective topics, lists of the necessary materials and reagents, and step-by-step, readily reproducible laboratory procedures. Also included are notes providing tips to avoid experimental pitfalls and helpful suggestions for method troubleshooting. Comprehensive and up-to-date, Mass Spectrometry Imaging: Principles and Protocols is written for scientists, biological and chemical engineers, and clinicians who are interested in applying MSI in their work and those who would benefit from having detailed experimental guidelines available in a single, convenient source.
(source: Nielsen Book Data)
  • Introductory Reviews and Tutorials.- Imaging Mass Spectrometry: Viewing the Future.- A Mass Spectrometry Primer for Mass Spectrometry Imaging.- Imaging of Metals, Metalloids, and Non-metals by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) in Biological Tissues.- Protocols for MS Imaging of Distribution of Small Molecules Including Metabolites and Pharmaceuticals.- Lipid Detection, Identification, and Imaging Single Cells with SIMS.- The Application and Potential of Ion Mobility Mass Spectrometry in Imaging MS with a Focus on Lipids.- Quantitative Imaging of Chemical Composition in Single Cells by Secondary Ion Mass Spectrometry: Cisplatin Affects Calcium Stores in Renal Epithelial Cells.- Imaging MALDI Mass Spectrometry of Sphingolipids Using an Oscillating Capillary Nebulizer Matrix Application System.- Mapping Pharmaceuticals in Rat Brain Sections Using MALDI Imaging Mass Spectrometry.- Laser Ablation Electrospray Ionization for Atmospheric Pressure Molecular Imaging Mass Spectrometry.- Matrix-Assisted Laser Desorption/Ionization and Nanoparticle-Based Imaging Mass Spectrometry for Small Metabolites: A Practical Protocol.- Cellular Imaging Using Matrix-Enhanced and Metal-Assisted SIMS.- Tandem Mass Spectrometric Methods for Phospholipid Analysis from Brain Tissue.- Chemical Imaging with Desorption Electrospray Ionization Mass Spectrometry.- Mass Spectrometry Imaging of Small Molecules Using Matrix-Enhanced Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (ME-SALDI-MS).- Preparation of Single Cells for Imaging Mass Spectrometry.- Applying Imaging ToF-SIMS and PCA in Differentiation of Tissue Types.- Protocols for MS Imaging of Distribution of Peptides and Proteins.- Direct Molecular Analysis of Whole-Body Animal Tissue Sections by MALDI Imaging Mass Spectrometry.- MALDI Direct Analysis and Imaging of Frozen Versus FFPE Tissues: What Strategy for Which Sample?.- On Tissue Protein Identification Improvement by N-Terminal Peptide Derivatization.- Specific MALDI-MSI: TAG-MASS.- Structurally Selective Imaging Mass Spectrometry by Imaging Ion Mobility-Mass Spectrometry.- Tutorial: Multivariate Statistical Treatment of Imaging Data for Clinical Biomarker Discovery.- Applications of MALDI-MSI to Pharmaceutical Research.- Tissue Preparation for the In Situ MALDI MS Imaging of Proteins, Lipids, and Small Molecules at Cellular Resolution.- Imaging of Similar Mass Neuropeptides in Neuronal Tissue by Enhanced Resolution MALDI MS with an Ion Trap - OrbitrapTM Hybrid Instrument.- Mass Spectrometric Imaging of Neuropeptides in Decapod Crustacean Neuronal Tissues.- Mass Spectrometry Imaging Using the Stretched Sample Approach.
  • (source: Nielsen Book Data)
Mass spectrometry (MS) offers unmatched capabilities for the detection, characterization, and identification of a broad range of analytes. Mass spectrometry imaging (MSI) integrates MS data with information on the spatial distributions of the analytes, further enhancing the applicability of MS. In Mass Spectrometry Imaging: Principles and Protocols, expert practitioners from academia, industry, and the clinic contribute cutting-edge protocols describing the application of MSI to investigations of analyte localization in a variety of specimens, from microorganisms to plant and animal tissues. Divided into three sections, this volume presents the principles of MS, current and future trends of MSI, and qualitative and quantitative protocols to measure and identify endogenous metabolites and xenobiotics. An array of MSI approaches and technologies for characterizing peptide and protein distributions are described in detail. Written in the highly successful Methods in Molecular Biology(TM) series format, protocol chapters include introductions to their respective topics, lists of the necessary materials and reagents, and step-by-step, readily reproducible laboratory procedures. Also included are notes providing tips to avoid experimental pitfalls and helpful suggestions for method troubleshooting. Comprehensive and up-to-date, Mass Spectrometry Imaging: Principles and Protocols is written for scientists, biological and chemical engineers, and clinicians who are interested in applying MSI in their work and those who would benefit from having detailed experimental guidelines available in a single, convenient source.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH506 .M45 V.656 Unknown
Book
xiv, 395 p. : ill. ; 26 cm.
  • Part I: Introduction 1. Peptidomics: Divide et Impera Mikhail Soloviev Part II: From Bacteria to Men 2. Performing Comparative Peptidomics Analyses of Salmonella from Different Growth Conditions Joshua N. Adkins, Heather Mottaz, Thomas O. Metz, Charles Ansong, Nathan P. Manes, Richard D. Smith, and Fred Heffron 3. Approaches to Identify Endogenous Peptides in the Soil Nematode Caenorhabditis elegans Steven J. Husson, Elke Clynen, Kurt Boonen, Tom Janssen, Marleen Lindemans, Geert Baggerman, and Liliane Schoofs 4. Mass Spectrometric Analysis of Molluscan Neuropeptides Ka Wan Li and August B. Smit 5. Monitoring Neuropeptides in vivo via Microdialysis and Mass Spectrometry Heidi L. Behrens and Lingjun Li 6. Protocols for Peptidomic Analysis of Spider Venoms Liang Songping 7. Purification and Characterization of Biologically Active Peptides from Spider Venoms Alexander A. Vassilevski, Sergey A. Kozlov, Tsezi A. Egorov, and Eugene V. Grishin 8. MALDI-TOF Mass Spectrometry Approaches to the Characterization of Insect Neuropeptides Robert J. Weaver and Neil Audsley 9. Direct MALDI-TOF Mass Spectrometric Peptide Profiling of Neuroendocrine Tissue of Drosophila Christian Wegener, Susanne Neupert, and Reinhard Predel 10. Direct Peptide Profiling of Brain Tissue by MALDI-TOF Mass Spectrometry Joachim Schachtner, Christian Wegener, Susanne Neupert, and Reinhard Predel 11. Peptidomic Analysis of Single Identified Neurons Susanne Neupert and Reinhard Predel 12. Identification and Analysis of Bioactive Peptides in Amphibian Skin Secretions J. Michael Conlon and Jerome Leprince 13. An Efficient Protocol for DNA Amplification of Multiple Amphibian Skin Antimicrobial PeptidecDNAs Shawichi Iwamuro and Tetsuya Kobayashi 14. Combined Peptidomics and Genomics Approach to the Isolation of Amphibian Antimicrobial Peptides Ren Lai 15. Identification and Relative Quantification of Neuropeptides from the Endocrine Tissues Kurt Boonen, Steven J. Husson, Bart Landuyt, Geert Baggerman, Eisuke Hayakawa, Walter H.M.L. Luyten, and Liliane Schoofs 16. Peptidome Analysis of Mouse Liver Tissue by Size Exclusion Chromatography Prefractionation Lianghai Hu, Mingliang Ye, and Hanfa Zou 17. Rat Brain Neuropeptidomics: Tissue Collection, Protease Inhibition, Neuropeptide Extraction, and Mass Spectrometric Analysis Robert M. Sturm, James A. Dowell, and Lingjun Li 18. Quantitative Neuroproteomics of the Synapse Dinah Lee Ramos-Ortolaza, Ittai Bushlin, Noura Abul-Husn, Suresh P. Annagudi, Jonathan Sweedler, and Lakshmi A. Devi 19. Peptidomics Analysis of Lymphoblastoid Cell Lines Anne Fogli and Philippe Bulet 20. Peptidomics: Identification of Pathogenic and Marker Peptides Yang Xiang, Manae S. Kurokawa, Mie Kanke, Yukiko Takakuwa, and Tomohiro Kato Part III: Tools and Approaches 21. Peptidomic Approaches to the Identification and Characterization of Functional Peptides in Hydra Toshio Takahashi and Toshitaka Fujisawa 22. Immunochemical Methods for the Peptidomic Analysis of Tachykinin Peptides and their Precursors Nigel M. Page and Nicola J. Weston-Bell 23. Affinity Peptidomics: Peptide Selection and Affinity Capture on Hydrogels and Microarrays Fan Zhang, Anna Dulneva, Julian Bailes, and Mikhail Soloviev 24. In situ Biosynthesis of Peptide Arrays Mingyue He and Oda Stoevesandt 25. Bioinformatic Approaches to the Identification of Novel Neuropeptide Precursors Elke Clynen, Feng.
  • (source: Nielsen Book Data)
Despite being known and studied for years, peptides have never before attracted enough attention to necessitate the invention of the term "peptidomics" in order to specify the study of the complement of peptides from a cell, organelle, tissue or organism. In Peptidomics: Methods and Protocols, expert researchers present a comprehensive range of analytical techniques for the analysis of the peptide contents of complex biological samples with an emphasis often on higher throughput techniques, suitable for the analysis of large numbers of peptides typically present in the peptidomes. Encompassing a number of species ranging from bacteria to man, the methods presented intensively cover topics such as organism handling, tissue and organ dissection, cellular and subcellular fractionation, peptide extraction, fractionation and purification, structural characterization, molecular cloning, and sequence analysis. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Peptidomics: Methods and Protocols brings this ten year old field fully up-to-date in order to inspire novices and experts alike with the easy-to-follow practical advice needed to set up and carry out analysis of the peptide contents of complex biological samples.
(source: Nielsen Book Data)
  • Part I: Introduction 1. Peptidomics: Divide et Impera Mikhail Soloviev Part II: From Bacteria to Men 2. Performing Comparative Peptidomics Analyses of Salmonella from Different Growth Conditions Joshua N. Adkins, Heather Mottaz, Thomas O. Metz, Charles Ansong, Nathan P. Manes, Richard D. Smith, and Fred Heffron 3. Approaches to Identify Endogenous Peptides in the Soil Nematode Caenorhabditis elegans Steven J. Husson, Elke Clynen, Kurt Boonen, Tom Janssen, Marleen Lindemans, Geert Baggerman, and Liliane Schoofs 4. Mass Spectrometric Analysis of Molluscan Neuropeptides Ka Wan Li and August B. Smit 5. Monitoring Neuropeptides in vivo via Microdialysis and Mass Spectrometry Heidi L. Behrens and Lingjun Li 6. Protocols for Peptidomic Analysis of Spider Venoms Liang Songping 7. Purification and Characterization of Biologically Active Peptides from Spider Venoms Alexander A. Vassilevski, Sergey A. Kozlov, Tsezi A. Egorov, and Eugene V. Grishin 8. MALDI-TOF Mass Spectrometry Approaches to the Characterization of Insect Neuropeptides Robert J. Weaver and Neil Audsley 9. Direct MALDI-TOF Mass Spectrometric Peptide Profiling of Neuroendocrine Tissue of Drosophila Christian Wegener, Susanne Neupert, and Reinhard Predel 10. Direct Peptide Profiling of Brain Tissue by MALDI-TOF Mass Spectrometry Joachim Schachtner, Christian Wegener, Susanne Neupert, and Reinhard Predel 11. Peptidomic Analysis of Single Identified Neurons Susanne Neupert and Reinhard Predel 12. Identification and Analysis of Bioactive Peptides in Amphibian Skin Secretions J. Michael Conlon and Jerome Leprince 13. An Efficient Protocol for DNA Amplification of Multiple Amphibian Skin Antimicrobial PeptidecDNAs Shawichi Iwamuro and Tetsuya Kobayashi 14. Combined Peptidomics and Genomics Approach to the Isolation of Amphibian Antimicrobial Peptides Ren Lai 15. Identification and Relative Quantification of Neuropeptides from the Endocrine Tissues Kurt Boonen, Steven J. Husson, Bart Landuyt, Geert Baggerman, Eisuke Hayakawa, Walter H.M.L. Luyten, and Liliane Schoofs 16. Peptidome Analysis of Mouse Liver Tissue by Size Exclusion Chromatography Prefractionation Lianghai Hu, Mingliang Ye, and Hanfa Zou 17. Rat Brain Neuropeptidomics: Tissue Collection, Protease Inhibition, Neuropeptide Extraction, and Mass Spectrometric Analysis Robert M. Sturm, James A. Dowell, and Lingjun Li 18. Quantitative Neuroproteomics of the Synapse Dinah Lee Ramos-Ortolaza, Ittai Bushlin, Noura Abul-Husn, Suresh P. Annagudi, Jonathan Sweedler, and Lakshmi A. Devi 19. Peptidomics Analysis of Lymphoblastoid Cell Lines Anne Fogli and Philippe Bulet 20. Peptidomics: Identification of Pathogenic and Marker Peptides Yang Xiang, Manae S. Kurokawa, Mie Kanke, Yukiko Takakuwa, and Tomohiro Kato Part III: Tools and Approaches 21. Peptidomic Approaches to the Identification and Characterization of Functional Peptides in Hydra Toshio Takahashi and Toshitaka Fujisawa 22. Immunochemical Methods for the Peptidomic Analysis of Tachykinin Peptides and their Precursors Nigel M. Page and Nicola J. Weston-Bell 23. Affinity Peptidomics: Peptide Selection and Affinity Capture on Hydrogels and Microarrays Fan Zhang, Anna Dulneva, Julian Bailes, and Mikhail Soloviev 24. In situ Biosynthesis of Peptide Arrays Mingyue He and Oda Stoevesandt 25. Bioinformatic Approaches to the Identification of Novel Neuropeptide Precursors Elke Clynen, Feng.
  • (source: Nielsen Book Data)
Despite being known and studied for years, peptides have never before attracted enough attention to necessitate the invention of the term "peptidomics" in order to specify the study of the complement of peptides from a cell, organelle, tissue or organism. In Peptidomics: Methods and Protocols, expert researchers present a comprehensive range of analytical techniques for the analysis of the peptide contents of complex biological samples with an emphasis often on higher throughput techniques, suitable for the analysis of large numbers of peptides typically present in the peptidomes. Encompassing a number of species ranging from bacteria to man, the methods presented intensively cover topics such as organism handling, tissue and organ dissection, cellular and subcellular fractionation, peptide extraction, fractionation and purification, structural characterization, molecular cloning, and sequence analysis. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Peptidomics: Methods and Protocols brings this ten year old field fully up-to-date in order to inspire novices and experts alike with the easy-to-follow practical advice needed to set up and carry out analysis of the peptide contents of complex biological samples.
(source: Nielsen Book Data)
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH506 .M45 V.615 Unknown
Book
online resource (xiv, 429 p., [8] p. of plates : ill. (some col.) ; 25 cm)
  • Strategies and techniques for bioanalytical assays as part of new drug discovery / Walter A. Korfmacher
  • The drug discovery process: from molecules to drugs / Mike S. Lee, Steven E. Klohr
  • PK principles and PK/PD applications / Hong Mei, Richard A. Morrison
  • Mass spectrometry for in vitro ADME screening / Inhou Chu
  • Metabolite identification strategies and procedures / Ragu Ramanathan, S. Nilgün Çömezoǧlu, W. Griffith Humphreys
  • Reactive metabolite screening and covalent-binding assays / Gérard Hopfgartner
  • Fast metabolite screening in a discovery setting / Xiaoying Xu
  • Fast chromatography with UPLC and other techniques / Sam Wainhaus
  • Supercritical fluid chromatography-mass spectrometry / Yunsheng Hsieh
  • Biomarkers of efficacy and toxicity: discovery and assay / Joanna R. Pols
  • Imaging mass spectrometry for small molecules / Fangbiao Li
  • MALDI IMS for proteins and biomarkers / Michelle L. Reyzer, Richard M. Caprioli
  • Ambient ionization methods and their early applications in ADME studies / Jing-Tao Wu
  • Pharmaceutical applications of accelerator mass spectrometry / Lan Gao, Swapan Chowdhury.
  • Strategies and techniques for bioanalytical assays as part of new drug discovery / Walter A. Korfmacher
  • The drug discovery process: from molecules to drugs / Mike S. Lee, Steven E. Klohr
  • PK principles and PK/PD applications / Hong Mei, Richard A. Morrison
  • Mass spectrometry for in vitro ADME screening / Inhou Chu
  • Metabolite identification strategies and procedures / Ragu Ramanathan, S. Nilgün Çömezoǧlu, W. Griffith Humphreys
  • Reactive metabolite screening and covalent-binding assays / Gérard Hopfgartner
  • Fast metabolite screening in a discovery setting / Xiaoying Xu
  • Fast chromatography with UPLC and other techniques / Sam Wainhaus
  • Supercritical fluid chromatography-mass spectrometry / Yunsheng Hsieh
  • Biomarkers of efficacy and toxicity: discovery and assay / Joanna R. Pols
  • Imaging mass spectrometry for small molecules / Fangbiao Li
  • MALDI IMS for proteins and biomarkers / Michelle L. Reyzer, Richard M. Caprioli
  • Ambient ionization methods and their early applications in ADME studies / Jing-Tao Wu
  • Pharmaceutical applications of accelerator mass spectrometry / Lan Gao, Swapan Chowdhury.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
CRCNETBASE Unknown
Book
xii, 389 p. : ill. ; 25 cm.
  • Preface vii About the Editor ix Contributors xi 1. Evolving Role of Mass Spectrometry in Drug Discovery and Development 1 Dil M. Ramanathan and Richard M. LeLacheur 2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications 87 Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen 3. Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis 123 Elliott B. Jones 4. Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening 159 Jose M. Castro-Perez 5. Changing Role of FTMS in Drug Metabolism 191 Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders 6. High-Resolution LC-MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection 223 Haiying Zhang, Donglu Zhang, Mingshe Zhu, and Kenneth L. Ray 7. Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies 253 Wing W. Lam, Cho-Ming Loi, Angus Nedderman, and Don Walker 8. Online Electrochemical-LC-MS Techniques for Profiling and Characterizing Metabolites and Degradants 275 Paul H. Gamache, David F. Meyer, Michael C. Granger, and Ian N. Acworth 9. LC-MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine 295 Natalia A. Penner, Joanna Zgoda-Pols, Ragu Ramanathan, Swapan K. Chowdhury, and Kevin B. Alton 10. Turbulent-Flow LC-MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification 311 Joseph L. Herman and Joseph M. Di Bussolo 11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules 341 Jason S. Gobey, John Janiszewski, and Mark J. Cole 12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals 359 Yunsheng Hsieh and Walter A. Korfmacher Index 383.
  • (source: Nielsen Book Data)
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
(source: Nielsen Book Data)
  • Preface vii About the Editor ix Contributors xi 1. Evolving Role of Mass Spectrometry in Drug Discovery and Development 1 Dil M. Ramanathan and Richard M. LeLacheur 2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications 87 Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen 3. Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis 123 Elliott B. Jones 4. Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening 159 Jose M. Castro-Perez 5. Changing Role of FTMS in Drug Metabolism 191 Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders 6. High-Resolution LC-MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection 223 Haiying Zhang, Donglu Zhang, Mingshe Zhu, and Kenneth L. Ray 7. Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies 253 Wing W. Lam, Cho-Ming Loi, Angus Nedderman, and Don Walker 8. Online Electrochemical-LC-MS Techniques for Profiling and Characterizing Metabolites and Degradants 275 Paul H. Gamache, David F. Meyer, Michael C. Granger, and Ian N. Acworth 9. LC-MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine 295 Natalia A. Penner, Joanna Zgoda-Pols, Ragu Ramanathan, Swapan K. Chowdhury, and Kevin B. Alton 10. Turbulent-Flow LC-MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification 311 Joseph L. Herman and Joseph M. Di Bussolo 11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules 341 Jason S. Gobey, John Janiszewski, and Mark J. Cole 12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals 359 Yunsheng Hsieh and Walter A. Korfmacher Index 383.
  • (source: Nielsen Book Data)
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
(source: Nielsen Book Data)
dx.doi.org Wiley Online Library
Book
computer files (xiv, 470 p. : ill.)
  • Generation and analysis of multidimensional protein identification technology datasets / Selene K. Swanson, Laurence Florens, and Michael P. Washburn
  • Quantitative peptide and protein profiling by mass spectrometry / Alexander Schmidt, Birgit Bisle, and Thomas Kislinger
  • Label-free relative quantitation of prokaryotic proteomes using the accurate mass and time tag approach / Kim K. Hixson
  • Classical proteomics: two-dimensional electrophoresis/MALDI mass spectrometry / Ursula Zimny-Arndt ... [et al.]
  • The use of difference in-gel electrophoresis for quantitation of protein expression / Rajat Sapra
  • Liquid-chromatography-mass spectrometry of thylakoid membrane proteins / Christian G. Huber ... [et al.]
  • High accuracy mass spectrometry in large-scale analysis of protein phosphorylation / Jesper V. Olsen and Boris Macek
  • Manual validation of peptide sequence and sites of tyrosine phosphorylation from MS/MS spectra / Amy M. Nichols and Forest M. White
  • Assigning glycosylation sites and microheterogeneities in glycoproteins by liquid chromatography/tandem mass spectrometry / Yehia Mechref, Milan Madera, and Milos V. Novotny
  • Structure analysis of N -glycoproteins / Stefanie Henning, Jasna Peter-Katalinicʹ, and Gottfried Pohlentz
  • Capillary zone electrophoresis-mass spectrometry for the characterization of isoforms of intact glycoproteins / Christian Neusüss, and Matthias Pelzing
  • Top-down proteomics on a high-field fourier transform ion cyclotron resonance mass spectrometer / Séverine A. Ouvry-Patat ... [et al.]
  • Capillary isoelectric focusing/reversed phase liquid chromatography/mass spectrometry / Cheng S. Lee and Brian M. Balgley
  • Integrating accelerated tryptic digestion into proteomics workflows / Gordon W. Slysz and David C. Schriemer
  • Hydrogen/deuterium exchange mass spectrometry / Xuguang Yan and Claudia S. Maier
  • Mass spectrometry detection and characterization of noncovalent protein complexes / Sheng Yin and Joseph A. Loos
  • Chemical cross-linking for protein-protein interaction studies / Xiaoting Tang and James E. Bruce
  • Tissue analysis with high-resolution imaging mass spectrometry / A.F. Maarten Altelaar and Ron M.A. Heeren
  • Proteomic global profiling for cancer biomarker discovery / Vitor Faca, Hong Wang, and Samir Hanash
  • Analysis of protein glycosylation and phosphorylation using liquid phase separation, protein microarray technology, and mass spectrometry / Jia Zhao ... [et al.]
  • Transthyretin mass determination for detection of transthyretin familial amyloid / John F. O'Brien and H. Robert Bergen III
  • Characterization of microorganisms by MALDI mass spectrometry / Catherine E. Petersen, Nancy B. Valentine, and Karen L. Wahl
  • Mass spectrometric characterization of neuropeptides / Stephanie S. DeKeyser, James A. Dowell, and Lingjun Li
  • Peptide and protein ion/ion reactions in electrodynamic ion traps: tools and methods / Scott A. McLuckey
  • Electron capture dissociation LC/MS/MS for bottom-up proteomics / Roman A. Zubarev
  • Two-dimensional ion mobility analyses of proteins and peptides / Alexandre A. Shvartsburg, Keqi Tang, and Richard D. Smith
  • Proteomics for validation of automated gene model predictions / Kemin Zhou ... [et al.]
  • Support vector machines for improved peptide identification from tandem mass spectrometry database search / Bobbie-Jo M. Webb-Robertson.
  • Generation and analysis of multidimensional protein identification technology datasets / Selene K. Swanson, Laurence Florens, and Michael P. Washburn
  • Quantitative peptide and protein profiling by mass spectrometry / Alexander Schmidt, Birgit Bisle, and Thomas Kislinger
  • Label-free relative quantitation of prokaryotic proteomes using the accurate mass and time tag approach / Kim K. Hixson
  • Classical proteomics: two-dimensional electrophoresis/MALDI mass spectrometry / Ursula Zimny-Arndt ... [et al.]
  • The use of difference in-gel electrophoresis for quantitation of protein expression / Rajat Sapra
  • Liquid-chromatography-mass spectrometry of thylakoid membrane proteins / Christian G. Huber ... [et al.]
  • High accuracy mass spectrometry in large-scale analysis of protein phosphorylation / Jesper V. Olsen and Boris Macek
  • Manual validation of peptide sequence and sites of tyrosine phosphorylation from MS/MS spectra / Amy M. Nichols and Forest M. White
  • Assigning glycosylation sites and microheterogeneities in glycoproteins by liquid chromatography/tandem mass spectrometry / Yehia Mechref, Milan Madera, and Milos V. Novotny
  • Structure analysis of N -glycoproteins / Stefanie Henning, Jasna Peter-Katalinicʹ, and Gottfried Pohlentz
  • Capillary zone electrophoresis-mass spectrometry for the characterization of isoforms of intact glycoproteins / Christian Neusüss, and Matthias Pelzing
  • Top-down proteomics on a high-field fourier transform ion cyclotron resonance mass spectrometer / Séverine A. Ouvry-Patat ... [et al.]
  • Capillary isoelectric focusing/reversed phase liquid chromatography/mass spectrometry / Cheng S. Lee and Brian M. Balgley
  • Integrating accelerated tryptic digestion into proteomics workflows / Gordon W. Slysz and David C. Schriemer
  • Hydrogen/deuterium exchange mass spectrometry / Xuguang Yan and Claudia S. Maier
  • Mass spectrometry detection and characterization of noncovalent protein complexes / Sheng Yin and Joseph A. Loos
  • Chemical cross-linking for protein-protein interaction studies / Xiaoting Tang and James E. Bruce
  • Tissue analysis with high-resolution imaging mass spectrometry / A.F. Maarten Altelaar and Ron M.A. Heeren
  • Proteomic global profiling for cancer biomarker discovery / Vitor Faca, Hong Wang, and Samir Hanash
  • Analysis of protein glycosylation and phosphorylation using liquid phase separation, protein microarray technology, and mass spectrometry / Jia Zhao ... [et al.]
  • Transthyretin mass determination for detection of transthyretin familial amyloid / John F. O'Brien and H. Robert Bergen III
  • Characterization of microorganisms by MALDI mass spectrometry / Catherine E. Petersen, Nancy B. Valentine, and Karen L. Wahl
  • Mass spectrometric characterization of neuropeptides / Stephanie S. DeKeyser, James A. Dowell, and Lingjun Li
  • Peptide and protein ion/ion reactions in electrodynamic ion traps: tools and methods / Scott A. McLuckey
  • Electron capture dissociation LC/MS/MS for bottom-up proteomics / Roman A. Zubarev
  • Two-dimensional ion mobility analyses of proteins and peptides / Alexandre A. Shvartsburg, Keqi Tang, and Richard D. Smith
  • Proteomics for validation of automated gene model predictions / Kemin Zhou ... [et al.]
  • Support vector machines for improved peptide identification from tandem mass spectrometry database search / Bobbie-Jo M. Webb-Robertson.
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