Search results
53 results
- Book
- xviii, 538 pages : illustrations ; 26 cm.
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- Enzyme Kinetics in Drug Metabolism : Fundamentals and Applications
- Fundaments of Enzyme Kinetics
- Different Enzyme Kinetic Models
- Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance
- Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions
- Multi-Enzyme Kinetics and Sequential Metabolism
- Consideration of the Unbound Drug Concentration in Enzyme Kinetics
- Enzyme Kinetics of Oxidative Metabolism : Cytochromes P450
- Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase
- Enzyme Kinetics of Conjugative Enzymes : PAPS
- Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)
- Principles and Experimental Considerations for in vitro Transporter Interaction Assays
- Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data : from in vitro Tools to Mechanistic Modeling
- The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
- Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
- Variability in Human in vitro Enzyme Kinetics
- Sources of Interindividual Variability
- Case Study 1. Practical Considerations with Experimental Design and Interpretation
- Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies
- Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies : Real Life Examples
- Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast
- Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development
- Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes
- Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors' Experiences.
(source: Nielsen Book Data)
- Enzyme Kinetics in Drug Metabolism : Fundamentals and Applications
- Fundaments of Enzyme Kinetics
- Different Enzyme Kinetic Models
- Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance
- Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions
- Multi-Enzyme Kinetics and Sequential Metabolism
- Consideration of the Unbound Drug Concentration in Enzyme Kinetics
- Enzyme Kinetics of Oxidative Metabolism : Cytochromes P450
- Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase
- Enzyme Kinetics of Conjugative Enzymes : PAPS
- Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)
- Principles and Experimental Considerations for in vitro Transporter Interaction Assays
- Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data : from in vitro Tools to Mechanistic Modeling
- The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
- Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
- Variability in Human in vitro Enzyme Kinetics
- Sources of Interindividual Variability
- Case Study 1. Practical Considerations with Experimental Design and Interpretation
- Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies
- Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies : Real Life Examples
- Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast
- Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development
- Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes
- Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors' Experiences.
(source: Nielsen Book Data)
At the library
Biology Library (Falconer)
Biology Library (Falconer) | Status |
---|---|
Stacks | |
QH506 .M45 V.1113 | Unknown |
2. Problem solving in enzyme biocatalysis [2014]
- Book
- 1 online resource (xxvi, 318 pages)
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface ix Nomenclature xi Epsilon Software Information xxi 1 Facts and Figures in Enzyme Biocatalysis 1 1.1 Introduction 1 1.2 Enzymes as Process Catalysts 3 1.3 Evolution of Enzyme Biocatalysis: From Hydrolysis toSynthesis 5 1.4 The Enzyme Market: Figures and Outlook 6 References 7 2 Enzyme Kinetics in a Homogeneous System 11 2.1 Introduction 11 2.2 Theory of Enzyme Kinetics 14 2.3 Single-Substrate Reactions 17 2.4 Multiple-Substrate Reactions 19 2.5 Multiple-Enzyme Reactions 21 2.6 Determination of Kinetic Parameters 22 2.7 Effects of Operational Variables on Enzyme Kinetics 24 Solved Problems 29 Supplementary Problems 72 References 84 3 Enzyme Kinetics in a Heterogeneous System 87 3.1 Introduction 87 3.2 Immobilization of Enzymes 87 3.3 Mass-Transfer Limitations in Enzyme Catalysis 92 3.4 Determination of Intrinsic Kinetic and Mass-TransferParameters 102 Solved Problems 105 Supplementary Problems 127 References 138 4 Enzyme Reactor Design and Operation under Ideal Conditions141 4.1 Modes of Operation and Reactor Configurations 141 4.2 Definition of Ideal Conditions 142 4.3 Strategy for Reactor Design and Performance Evaluation143 4.4 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Ideal Conditions 143 Solved Problems 157 Supplementary Problems 174 References 179 5 Enzyme Reactor Design and Operation under Mass-TransferLimitations 181 5.1 Sequential Batch and Continuously Operated Reactors withImmobilized Enzymes 182 5.2 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Mass-Transfer Limitations 183 Solved Problems 185 Supplementary Problems 198 6 Enzyme Reactor Design and Operation under BiocatalystInactivation 203 6.1 Mechanistically Based Mathematical Models of EnzymeInactivation 203 6.2 Effect of Catalytic Modulators on Enzyme Inactivation205 6.3 Mathematical Models for Different Enzyme Kinetics, Modes ofOperation, and Reactor Configurations under BiocatalystInactivation 206 6.4 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Simultaneous Mass-TransferLimitations and Enzyme Inactivation 212 6.5 Strategies for Reactor Operation under BiocatalystInactivation 213 Solved Problems 215 Supplementary Problems 233 References 240 7 Optimization of Enzyme Reactor Operation 243 7.1 Strategy for the Optimization of Enzyme Reactor Performance244 7.2 Mathematical Programming for Static Optimization 247 7.3 Dynamic Programming 248 7.4 Statistical Optimization by Surface Response Methodology249 Solved Problems 254 Supplementary Problems 272 References 275 Appendix A Mathematical Methods 277 A.1. Newton s Method 277 A.2. Curve Fitting by Least Squares 280 A.3. Solving Ordinary Differential Equations 296 A.4. Numerical Methods for Solving Differential Equations302 References 310 Index 311.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface ix Nomenclature xi Epsilon Software Information xxi 1 Facts and Figures in Enzyme Biocatalysis 1 1.1 Introduction 1 1.2 Enzymes as Process Catalysts 3 1.3 Evolution of Enzyme Biocatalysis: From Hydrolysis toSynthesis 5 1.4 The Enzyme Market: Figures and Outlook 6 References 7 2 Enzyme Kinetics in a Homogeneous System 11 2.1 Introduction 11 2.2 Theory of Enzyme Kinetics 14 2.3 Single-Substrate Reactions 17 2.4 Multiple-Substrate Reactions 19 2.5 Multiple-Enzyme Reactions 21 2.6 Determination of Kinetic Parameters 22 2.7 Effects of Operational Variables on Enzyme Kinetics 24 Solved Problems 29 Supplementary Problems 72 References 84 3 Enzyme Kinetics in a Heterogeneous System 87 3.1 Introduction 87 3.2 Immobilization of Enzymes 87 3.3 Mass-Transfer Limitations in Enzyme Catalysis 92 3.4 Determination of Intrinsic Kinetic and Mass-TransferParameters 102 Solved Problems 105 Supplementary Problems 127 References 138 4 Enzyme Reactor Design and Operation under Ideal Conditions141 4.1 Modes of Operation and Reactor Configurations 141 4.2 Definition of Ideal Conditions 142 4.3 Strategy for Reactor Design and Performance Evaluation143 4.4 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Ideal Conditions 143 Solved Problems 157 Supplementary Problems 174 References 179 5 Enzyme Reactor Design and Operation under Mass-TransferLimitations 181 5.1 Sequential Batch and Continuously Operated Reactors withImmobilized Enzymes 182 5.2 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Mass-Transfer Limitations 183 Solved Problems 185 Supplementary Problems 198 6 Enzyme Reactor Design and Operation under BiocatalystInactivation 203 6.1 Mechanistically Based Mathematical Models of EnzymeInactivation 203 6.2 Effect of Catalytic Modulators on Enzyme Inactivation205 6.3 Mathematical Models for Different Enzyme Kinetics, Modes ofOperation, and Reactor Configurations under BiocatalystInactivation 206 6.4 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Simultaneous Mass-TransferLimitations and Enzyme Inactivation 212 6.5 Strategies for Reactor Operation under BiocatalystInactivation 213 Solved Problems 215 Supplementary Problems 233 References 240 7 Optimization of Enzyme Reactor Operation 243 7.1 Strategy for the Optimization of Enzyme Reactor Performance244 7.2 Mathematical Programming for Static Optimization 247 7.3 Dynamic Programming 248 7.4 Statistical Optimization by Surface Response Methodology249 Solved Problems 254 Supplementary Problems 272 References 275 Appendix A Mathematical Methods 277 A.1. Newton s Method 277 A.2. Curve Fitting by Least Squares 280 A.3. Solving Ordinary Differential Equations 296 A.4. Numerical Methods for Solving Differential Equations302 References 310 Index 311.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
3. Problem solving in enzyme biocatalysis [2014]
- Book
- 1 online resource (346 pages) : illustrations
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface ix Nomenclature xi Epsilon Software Information xxi 1 Facts and Figures in Enzyme Biocatalysis 1 1.1 Introduction 1 1.2 Enzymes as Process Catalysts 3 1.3 Evolution of Enzyme Biocatalysis: From Hydrolysis toSynthesis 5 1.4 The Enzyme Market: Figures and Outlook 6 References 7 2 Enzyme Kinetics in a Homogeneous System 11 2.1 Introduction 11 2.2 Theory of Enzyme Kinetics 14 2.3 Single-Substrate Reactions 17 2.4 Multiple-Substrate Reactions 19 2.5 Multiple-Enzyme Reactions 21 2.6 Determination of Kinetic Parameters 22 2.7 Effects of Operational Variables on Enzyme Kinetics 24 Solved Problems 29 Supplementary Problems 72 References 84 3 Enzyme Kinetics in a Heterogeneous System 87 3.1 Introduction 87 3.2 Immobilization of Enzymes 87 3.3 Mass-Transfer Limitations in Enzyme Catalysis 92 3.4 Determination of Intrinsic Kinetic and Mass-TransferParameters 102 Solved Problems 105 Supplementary Problems 127 References 138 4 Enzyme Reactor Design and Operation under Ideal Conditions141 4.1 Modes of Operation and Reactor Configurations 141 4.2 Definition of Ideal Conditions 142 4.3 Strategy for Reactor Design and Performance Evaluation143 4.4 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Ideal Conditions 143 Solved Problems 157 Supplementary Problems 174 References 179 5 Enzyme Reactor Design and Operation under Mass-TransferLimitations 181 5.1 Sequential Batch and Continuously Operated Reactors withImmobilized Enzymes 182 5.2 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Mass-Transfer Limitations 183 Solved Problems 185 Supplementary Problems 198 6 Enzyme Reactor Design and Operation under BiocatalystInactivation 203 6.1 Mechanistically Based Mathematical Models of EnzymeInactivation 203 6.2 Effect of Catalytic Modulators on Enzyme Inactivation205 6.3 Mathematical Models for Different Enzyme Kinetics, Modes ofOperation, and Reactor Configurations under BiocatalystInactivation 206 6.4 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Simultaneous Mass-TransferLimitations and Enzyme Inactivation 212 6.5 Strategies for Reactor Operation under BiocatalystInactivation 213 Solved Problems 215 Supplementary Problems 233 References 240 7 Optimization of Enzyme Reactor Operation 243 7.1 Strategy for the Optimization of Enzyme Reactor Performance244 7.2 Mathematical Programming for Static Optimization 247 7.3 Dynamic Programming 248 7.4 Statistical Optimization by Surface Response Methodology249 Solved Problems 254 Supplementary Problems 272 References 275 Appendix A Mathematical Methods 277 A.1. Newton s Method 277 A.2. Curve Fitting by Least Squares 280 A.3. Solving Ordinary Differential Equations 296 A.4. Numerical Methods for Solving Differential Equations302 References 310 Index 311.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface ix Nomenclature xi Epsilon Software Information xxi 1 Facts and Figures in Enzyme Biocatalysis 1 1.1 Introduction 1 1.2 Enzymes as Process Catalysts 3 1.3 Evolution of Enzyme Biocatalysis: From Hydrolysis toSynthesis 5 1.4 The Enzyme Market: Figures and Outlook 6 References 7 2 Enzyme Kinetics in a Homogeneous System 11 2.1 Introduction 11 2.2 Theory of Enzyme Kinetics 14 2.3 Single-Substrate Reactions 17 2.4 Multiple-Substrate Reactions 19 2.5 Multiple-Enzyme Reactions 21 2.6 Determination of Kinetic Parameters 22 2.7 Effects of Operational Variables on Enzyme Kinetics 24 Solved Problems 29 Supplementary Problems 72 References 84 3 Enzyme Kinetics in a Heterogeneous System 87 3.1 Introduction 87 3.2 Immobilization of Enzymes 87 3.3 Mass-Transfer Limitations in Enzyme Catalysis 92 3.4 Determination of Intrinsic Kinetic and Mass-TransferParameters 102 Solved Problems 105 Supplementary Problems 127 References 138 4 Enzyme Reactor Design and Operation under Ideal Conditions141 4.1 Modes of Operation and Reactor Configurations 141 4.2 Definition of Ideal Conditions 142 4.3 Strategy for Reactor Design and Performance Evaluation143 4.4 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Ideal Conditions 143 Solved Problems 157 Supplementary Problems 174 References 179 5 Enzyme Reactor Design and Operation under Mass-TransferLimitations 181 5.1 Sequential Batch and Continuously Operated Reactors withImmobilized Enzymes 182 5.2 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Mass-Transfer Limitations 183 Solved Problems 185 Supplementary Problems 198 6 Enzyme Reactor Design and Operation under BiocatalystInactivation 203 6.1 Mechanistically Based Mathematical Models of EnzymeInactivation 203 6.2 Effect of Catalytic Modulators on Enzyme Inactivation205 6.3 Mathematical Models for Different Enzyme Kinetics, Modes ofOperation, and Reactor Configurations under BiocatalystInactivation 206 6.4 Mathematical Models for Enzyme Kinetics, Modes of Operation, and Reactor Configurations under Simultaneous Mass-TransferLimitations and Enzyme Inactivation 212 6.5 Strategies for Reactor Operation under BiocatalystInactivation 213 Solved Problems 215 Supplementary Problems 233 References 240 7 Optimization of Enzyme Reactor Operation 243 7.1 Strategy for the Optimization of Enzyme Reactor Performance244 7.2 Mathematical Programming for Static Optimization 247 7.3 Dynamic Programming 248 7.4 Statistical Optimization by Surface Response Methodology249 Solved Problems 254 Supplementary Problems 272 References 275 Appendix A Mathematical Methods 277 A.1. Newton s Method 277 A.2. Curve Fitting by Least Squares 280 A.3. Solving Ordinary Differential Equations 296 A.4. Numerical Methods for Solving Differential Equations302 References 310 Index 311.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
4. Fundamentals of enzyme kinetics [2012]
- Book
- xviii, 498 p. : ill ; 25 cm.
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- Basic Principles of Chemical Kinetics Introduction to Enzyme Kinetics "Alternative" Enzymes Practical Aspects of Kinetics Deriving Steady-state Rate Equations Reversible Inhibition and Activation Tight-binding and Irreversible Inhibitors Reactions of More than One Substrate Use of Isotopes for Studying Enzyme Mechanisms Effect of pH on Enzyme Activity Temperature Effects on Enzyme Activity Regulation of Enzyme Activity Multienzyme Systems Fast Reactions Estimation of Kinetic Constants Standards for Reporting Enzymology Data Solutions and Notes to Problems Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- Basic Principles of Chemical Kinetics Introduction to Enzyme Kinetics "Alternative" Enzymes Practical Aspects of Kinetics Deriving Steady-state Rate Equations Reversible Inhibition and Activation Tight-binding and Irreversible Inhibitors Reactions of More than One Substrate Use of Isotopes for Studying Enzyme Mechanisms Effect of pH on Enzyme Activity Temperature Effects on Enzyme Activity Regulation of Enzyme Activity Multienzyme Systems Fast Reactions Estimation of Kinetic Constants Standards for Reporting Enzymology Data Solutions and Notes to Problems Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
At the library
Biology Library (Falconer)
Biology Library (Falconer) | Status |
---|---|
Stacks | |
QP601 .C756 2012 | Unavailable Assumed lost Request |
- Book
- 1 v. (various pagings) : ill.
- Book
- 1 online resource (1 v. (various pagings)) : ill.
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface. Chapter 1 Biochemical Thermodynamics. Chapter 2 A = P. Chapter 3 Ordered A + B -> Products. Chapter 4 Random A + B -> Products. Chapter 5 A + B = P + Q. Chapter 6 A + B + C -> Products. Chapter 7 Ordered O + mR -> Products. Chapter 8 Random O + mR -> Products. Chapter 9 Inhibition and Activation of A -> Products. Chapter 10 Modification of A -> Products. Chapter 11 Inhibition, Activation, and Modification of A + B -> Products. Chapter 12 Systems of Enzyme-Catalyzed Reactions. References. Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface. Chapter 1 Biochemical Thermodynamics. Chapter 2 A = P. Chapter 3 Ordered A + B -> Products. Chapter 4 Random A + B -> Products. Chapter 5 A + B = P + Q. Chapter 6 A + B + C -> Products. Chapter 7 Ordered O + mR -> Products. Chapter 8 Random O + mR -> Products. Chapter 9 Inhibition and Activation of A -> Products. Chapter 10 Modification of A -> Products. Chapter 11 Inhibition, Activation, and Modification of A + B -> Products. Chapter 12 Systems of Enzyme-Catalyzed Reactions. References. Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- Book
- online resource (ix, 149 pages) : illustrations ; 24 cm
At the library
Medical Library (Lane)
Medical Library (Lane) | Status |
---|---|
Check Medical Library (Lane) catalog for status | |
SPRINGER | Unknown |
- Book
- 1 online resource (ix, 149 p.)
9. Enzyme kinetics [digital] : catalysis & control : a reference of theory and best-practice methods [2010]
- Book
- online resource (xxi, 892 p. : ill. ; 29 cm)
Summary
- Chapter 1. An Introduction to Enzyme Science
- Chapter 2. Active Sites and their Chemical Properties
- Chapter 3. Fundamentals of Chemical Kinetics
- Chapter 4. Practical Aspects of Measuring Initial Rates and Reaction Parameters
- Chapter 5. Initial-Rate Kinetics of One-Substrate Enzyme-Catalyzed Reactions
- Chapter 6. Initial-Rate Kinetics of Multi-Substrate Enzyme-Catalyzed Reactions
- Chapter 7. Factors Influencing Enzyme Activity
- Chapter 8. Kinetic Behavior of Enzyme Inhibitors
- Chapter 9. Isotopic Probes of Biological Catalysis
- Chapter 10. Probing Fast Enzyme Processes
- Chapter 11. Regulatory Behavior of Enzymes
- Chapter 12. Single-Molecule Enzyme Kinetics
- Chapter 13. Mechanoenzymes: Catalysis, Force Generation and Kinetics.
- Chapter 1. An Introduction to Enzyme Science
- Chapter 2. Active Sites and their Chemical Properties
- Chapter 3. Fundamentals of Chemical Kinetics
- Chapter 4. Practical Aspects of Measuring Initial Rates and Reaction Parameters
- Chapter 5. Initial-Rate Kinetics of One-Substrate Enzyme-Catalyzed Reactions
- Chapter 6. Initial-Rate Kinetics of Multi-Substrate Enzyme-Catalyzed Reactions
- Chapter 7. Factors Influencing Enzyme Activity
- Chapter 8. Kinetic Behavior of Enzyme Inhibitors
- Chapter 9. Isotopic Probes of Biological Catalysis
- Chapter 10. Probing Fast Enzyme Processes
- Chapter 11. Regulatory Behavior of Enzymes
- Chapter 12. Single-Molecule Enzyme Kinetics
- Chapter 13. Mechanoenzymes: Catalysis, Force Generation and Kinetics.
At the library
Medical Library (Lane)
Medical Library (Lane) | Status |
---|---|
Check Medical Library (Lane) catalog for status | |
SCIENCEDIRECT | Unknown |
- Book
- p. cm.
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- Introduction to Enzyme Rate Processes
- Active Sites & Their Chemical Properties
- Fundamentals of Chemical Kinetics
- Practical Aspects of Measuring Rates & Kinetic
- Initial-Rate Kinetics of One-Substrate Enzyme-Catalyzed Reactions
- Initial-Rate Kinetics of Multi-Substrate Enzyme-Catalyzed Reactions
- Other Factors Influencing Enzyme Activity
- Kinetic Behavior of Enzyme Inhibitors
- Isotopic Probes of Biological Catalysis
- Probing Fast Enzyme Processes
- Regulatory Behavior of Enzymes
- Single-Molecule Enzyme Kinetics
- Force Generation in Mechanoenzyme Catalysis
- On Keeping a Research Notebook
- Steady-State Rate Equations for Selected One- & Two-Substrate Enzyme-Catalyzed Reactions
- Summary of Enzyme Kinetic Mechanisms Abbreviations & Symbols References.
(source: Nielsen Book Data)
- Introduction to Enzyme Rate Processes
- Active Sites & Their Chemical Properties
- Fundamentals of Chemical Kinetics
- Practical Aspects of Measuring Rates & Kinetic
- Initial-Rate Kinetics of One-Substrate Enzyme-Catalyzed Reactions
- Initial-Rate Kinetics of Multi-Substrate Enzyme-Catalyzed Reactions
- Other Factors Influencing Enzyme Activity
- Kinetic Behavior of Enzyme Inhibitors
- Isotopic Probes of Biological Catalysis
- Probing Fast Enzyme Processes
- Regulatory Behavior of Enzymes
- Single-Molecule Enzyme Kinetics
- Force Generation in Mechanoenzyme Catalysis
- On Keeping a Research Notebook
- Steady-State Rate Equations for Selected One- & Two-Substrate Enzyme-Catalyzed Reactions
- Summary of Enzyme Kinetic Mechanisms Abbreviations & Symbols References.
(source: Nielsen Book Data)
Online
www.sciencedirect.com ScienceDirect
- www.sciencedirect.com ScienceDirect
- Google Books (Full view)
11. Contemporary enzyme kinetics and mechanism [2009]
- Book
- xv, 683 p. : ill. (some col.) ; 24 cm.
Summary
Kinetic studies of enzyme action provide powerful insights into the underlying mechanisms of catalysis and regulation. These approaches are equally useful in examining the action of newly discovered enzymes and therapeutic agents. "Contemporary Enzyme Kinetics and Mechanism, Second Edition" presents key articles from volumes 63, 64, 87, 249, 308 and 354 of "Methods in Enzymology". The chapters describe the most essential and widely applied strategies. A set of exercises and problems is included to facilitate mastery of these topics. The book will aid the reader to design, execute, and analyze kinetic experiments on enzymes. Its emphasis on enzyme inhibition will also make it attractive to pharmacologists and pharmaceutical chemists interested in rational drug design. Of the seventeen chapters presented in this new edition, ten did not previously appear in the first edition. The key features include: transient kinetic approaches to enzyme mechanisms; designing initial rate enzyme assay; deriving initial velocity and isotope exchange rate equations; plotting and statistical methods for analyzing rate data; cooperativity in enzyme function; reversible enzyme inhibitors as mechanistic probes; transition-state and multisubstrate inhibitors; affinity labeling to probe enzyme structure and function; mechanism-based enzyme inactivators; isotope exchange methods for elucidating enzymatic catalysis; kinetic isotope effects in enzyme catalysis; and, site-directed mutagenesis in studies of enzyme catalysis.
(source: Nielsen Book Data)
(source: Nielsen Book Data)
Kinetic studies of enzyme action provide powerful insights into the underlying mechanisms of catalysis and regulation. These approaches are equally useful in examining the action of newly discovered enzymes and therapeutic agents. "Contemporary Enzyme Kinetics and Mechanism, Second Edition" presents key articles from volumes 63, 64, 87, 249, 308 and 354 of "Methods in Enzymology". The chapters describe the most essential and widely applied strategies. A set of exercises and problems is included to facilitate mastery of these topics. The book will aid the reader to design, execute, and analyze kinetic experiments on enzymes. Its emphasis on enzyme inhibition will also make it attractive to pharmacologists and pharmaceutical chemists interested in rational drug design. Of the seventeen chapters presented in this new edition, ten did not previously appear in the first edition. The key features include: transient kinetic approaches to enzyme mechanisms; designing initial rate enzyme assay; deriving initial velocity and isotope exchange rate equations; plotting and statistical methods for analyzing rate data; cooperativity in enzyme function; reversible enzyme inhibitors as mechanistic probes; transition-state and multisubstrate inhibitors; affinity labeling to probe enzyme structure and function; mechanism-based enzyme inactivators; isotope exchange methods for elucidating enzymatic catalysis; kinetic isotope effects in enzyme catalysis; and, site-directed mutagenesis in studies of enzyme catalysis.
(source: Nielsen Book Data)
(source: Nielsen Book Data)
At the library
Biology Library (Falconer)
Biology Library (Falconer) | Status |
---|---|
Stacks | |
QP601.3 .C66 2009 | Unknown |
12. Enzyme kinetics : principles and methods [2008]
- Book
- xviii, 301 p. : ill. ; 25 cm.
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface to the Second English Edition.Preface to the First English Edition.Symbols and Abbreviations.Introduction and Definitions.References.1 Multiple Equilibria.1.1 Diffusion.1.2 Interaction between Macromolecules and Ligands.1.3 Macromolecules with Identical Independent Binding Sites.1.4 Macromolecules with Non-identical, Independent Binding Sites.1.5 Macromolecules with Identical, Interacting Binding Sites, Cooperativity.1.6 Non-identical, Interacting Binding Sites.References.2 Enzyme Kinetics.2.1 Reaction Order.2.2 Steady-State Kinetics and the Michaelis-Menten Equation.2.3 Analysis of Enzyme Kinetic Data.2.4 Reversible Enzyme Reactions.2.5 Enzyme Inhibition.2.6 Multi-substrate Reactions.2.7 Derivation of Rate Equations of Complex Enzyme Mechanisms.2.8 Kinetic Treatment of Allosteric Enzymes.2.9 pH and Temperature Dependence of Enzymes.2.10 Isotope Exchange.2.11 Special Enzyme Mechanisms.2.12 Application of Statistical Methods in Enzyme Kinetics.References.3 Methods.3.1 Methods for Investigation of Multiple Equilibria.3.2 Electrochemical Methods.3.3 Calorimetry.3.4 Spectroscopic Methods.3.5 Measurement of Fast Reactions.References.Subject Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface to the Second English Edition.Preface to the First English Edition.Symbols and Abbreviations.Introduction and Definitions.References.1 Multiple Equilibria.1.1 Diffusion.1.2 Interaction between Macromolecules and Ligands.1.3 Macromolecules with Identical Independent Binding Sites.1.4 Macromolecules with Non-identical, Independent Binding Sites.1.5 Macromolecules with Identical, Interacting Binding Sites, Cooperativity.1.6 Non-identical, Interacting Binding Sites.References.2 Enzyme Kinetics.2.1 Reaction Order.2.2 Steady-State Kinetics and the Michaelis-Menten Equation.2.3 Analysis of Enzyme Kinetic Data.2.4 Reversible Enzyme Reactions.2.5 Enzyme Inhibition.2.6 Multi-substrate Reactions.2.7 Derivation of Rate Equations of Complex Enzyme Mechanisms.2.8 Kinetic Treatment of Allosteric Enzymes.2.9 pH and Temperature Dependence of Enzymes.2.10 Isotope Exchange.2.11 Special Enzyme Mechanisms.2.12 Application of Statistical Methods in Enzyme Kinetics.References.3 Methods.3.1 Methods for Investigation of Multiple Equilibria.3.2 Electrochemical Methods.3.3 Calorimetry.3.4 Spectroscopic Methods.3.5 Measurement of Fast Reactions.References.Subject Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
Online
dx.doi.org Wiley Online Library
- dx.doi.org Wiley Online Library
- www3.interscience.wiley.com Wiley Online Library
- Google Books (Full view)
At the library
Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) | Status |
---|---|
Request at circulation desk | |
QP601.3 .B5713 2008 | Unknown On Reserve 2-hour loan |
Course reserve
CHEMENG-320-01
- Course
- CHEMENG-320-01 -- Chemical Kinetics and Reaction Engineering
- Instructor(s)
- Dunn, Alexander Robert
- Book
- x, 182 p. : ill. ; 24 cm.
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- 1. Performing quantitative experiments with biomolecules 2. Affinity constants 3. Cooperativity in binding 4. Rate constants for binding and dissociation 5. Kinetics of regulation and cooperativity in binding Reactions 6. Constants for a two-step binding reaction 7. Data analysis Appendix 1: Equation derivations Appendix 2: Resources and references Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- 1. Performing quantitative experiments with biomolecules 2. Affinity constants 3. Cooperativity in binding 4. Rate constants for binding and dissociation 5. Kinetics of regulation and cooperativity in binding Reactions 6. Constants for a two-step binding reaction 7. Data analysis Appendix 1: Equation derivations Appendix 2: Resources and references Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
At the library
Biology Library (Falconer)
Biology Library (Falconer) | Status |
---|---|
Stacks | |
QP517 .P76 G66 2007 | Unknown |
14. Enzymatic reaction mechanisms [2007]
- Book
- xviii, 831 p. : ill. (some col.) ; 29 cm.
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- 1. Enzymes and Catalytic Mechanisms-- 2. Kinetics of Enzymatic-- 3. Coenzymes I: Organic Coenzymes-- 4. Coenzymes II: Metallic Coenzymes-- 5. Enzyme Inhibition-- 6. ACYL Group Transfer: Proteases-- 7. Isomerization-- 8. Decarboxylation and Carboxylation-- 9. Addition and Elimination-- 10. Phosphotransfer AND NucleotidylTransfer-- 11. ATP-Dependent Synthetases and Lifases-- 12. Glycosyl Group Transferases-- 13. Nitrogen and Sulfur Transferases-- 14. Carbon-Carbon Condensation and Cleavage-- 15. Alkyltransferases-- 16. Oxidoreductases-- 17. Oxidases and Oxygenases-- 18. Complex Enzymes.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- 1. Enzymes and Catalytic Mechanisms-- 2. Kinetics of Enzymatic-- 3. Coenzymes I: Organic Coenzymes-- 4. Coenzymes II: Metallic Coenzymes-- 5. Enzyme Inhibition-- 6. ACYL Group Transfer: Proteases-- 7. Isomerization-- 8. Decarboxylation and Carboxylation-- 9. Addition and Elimination-- 10. Phosphotransfer AND NucleotidylTransfer-- 11. ATP-Dependent Synthetases and Lifases-- 12. Glycosyl Group Transferases-- 13. Nitrogen and Sulfur Transferases-- 14. Carbon-Carbon Condensation and Cleavage-- 15. Alkyltransferases-- 16. Oxidoreductases-- 17. Oxidases and Oxygenases-- 18. Complex Enzymes.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
At the library
Biology Library (Falconer)
Biology Library (Falconer) | Status |
---|---|
Stacks | |
QP601 .F725 2007 | Unknown |
- Book
- 2 v. (527. 562 p.) : ill.
Summary
- v. 1. Chemical kinetics
- v. 2. Biological kinetics.
- v. 1. Chemical kinetics
- v. 2. Biological kinetics.
- Book
- 1 online resource (xiii, 227 p.) : ill.
Summary
- Dedication
- Preface
- Introduction
- 1. Introduction to Steady-State Kinetics
- 2. The Generation of Experimental Data
- 3. Methods for Model Evaluation
- 4. Derivation of Mathematical Models
- 5. Effects of Substrate Concentration
- 6. Effects of Analog Inhibitors
- 7. Effects of Product Inhibitors
- 8. Effects of Substrate Inhibition
- 9. Slow and Tight Inhibition
- 10. The Thermodynamics of Initial Velocity
- 11. Effects of pH
- 12. Effects of Isotopic Substitution
- 13. Effects of Other Reaction Conditions
- Index.
- Dedication
- Preface
- Introduction
- 1. Introduction to Steady-State Kinetics
- 2. The Generation of Experimental Data
- 3. Methods for Model Evaluation
- 4. Derivation of Mathematical Models
- 5. Effects of Substrate Concentration
- 6. Effects of Analog Inhibitors
- 7. Effects of Product Inhibitors
- 8. Effects of Substrate Inhibition
- 9. Slow and Tight Inhibition
- 10. The Thermodynamics of Initial Velocity
- 11. Effects of pH
- 12. Effects of Isotopic Substitution
- 13. Effects of Other Reaction Conditions
- Index.
17. Fundamentals in enzyme kinetics [2004]
- Book
- xvi, 422 p. : ill. ; 25 cm.
At the library
Biology Library (Falconer)
Biology Library (Falconer) | Status |
---|---|
Stacks | |
QP601 .C756 2004 | Unknown |
18. Comprehensive enzyme kinetics [2003]
- Book
- xi, 438 p. : ill. ; 26 cm.
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- 1. Introduction.- 2. Chemical kinetics.- 3. Kinetics of monosubstrate reactions.- 4. Derivations of rate equations.- 5. Linear inhibition.- 6. Hyperbolic and parabolic inhibition.- 7. Enzyme activation.- 8. Kinetics of rapid equilibrium bisubstrate reactions.- 9. Steady state kinetics of bisubstrate reactions.- 10. Kinetic analysis of bisubstrate mechanisms.- 11. Substrate inhibition and mixed dead-end and product inhibition.- 12. Kinetics of trisubstrate reactions.- 13. Cooperative and allosteric effects.- 14. The pH dependence of enzyme catalysis.- 15. Effects of temperature on enzyme reactions.- 16. Isotope exchange.- 17. Solvent and kinetic isotope effects.- 18. Statistical analysis of initial rate and binding data.- Subject index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- 1. Introduction.- 2. Chemical kinetics.- 3. Kinetics of monosubstrate reactions.- 4. Derivations of rate equations.- 5. Linear inhibition.- 6. Hyperbolic and parabolic inhibition.- 7. Enzyme activation.- 8. Kinetics of rapid equilibrium bisubstrate reactions.- 9. Steady state kinetics of bisubstrate reactions.- 10. Kinetic analysis of bisubstrate mechanisms.- 11. Substrate inhibition and mixed dead-end and product inhibition.- 12. Kinetics of trisubstrate reactions.- 13. Cooperative and allosteric effects.- 14. The pH dependence of enzyme catalysis.- 15. Effects of temperature on enzyme reactions.- 16. Isotope exchange.- 17. Solvent and kinetic isotope effects.- 18. Statistical analysis of initial rate and binding data.- Subject index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
At the library
Biology Library (Falconer)
Biology Library (Falconer) | Status |
---|---|
Stacks | |
QP601.3 .L47 2003 | Unknown |
19. Enzyme kinetics : a modern approach [2003]
- Book
- xiv, 229 p. : ill. ; 25 cm.
Summary
(source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface.Tools and Techniques of Kinetic Analysis.How do Enzymes Work?Characterization of Enzyme Activity.Reversible Enzyme Inhibition.Irreversible Enzyme Inhibition.pH Dependence of Enzyme-Catalyzed Reactions.Two-Substrate Reactions.Multisite and Cooperative Enzymes.Immobilized Enzymes.Interfacial Enzymes.Transient Phases of Enzymatic Reactions.Characterization of Enzyme Stability.Mechanism-Based Inhibition (Leslie J. Copp).Putting Kinetic Principles into Practice (Kirk L. Parkin).Use of Enzyme Kinetic Data in the Study of Structure-Function Relationships of Proteins (Takuji Tanaka and Rickey Y. Yada).Bibliography.Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
- Preface.Tools and Techniques of Kinetic Analysis.How do Enzymes Work?Characterization of Enzyme Activity.Reversible Enzyme Inhibition.Irreversible Enzyme Inhibition.pH Dependence of Enzyme-Catalyzed Reactions.Two-Substrate Reactions.Multisite and Cooperative Enzymes.Immobilized Enzymes.Interfacial Enzymes.Transient Phases of Enzymatic Reactions.Characterization of Enzyme Stability.Mechanism-Based Inhibition (Leslie J. Copp).Putting Kinetic Principles into Practice (Kirk L. Parkin).Use of Enzyme Kinetic Data in the Study of Structure-Function Relationships of Proteins (Takuji Tanaka and Rickey Y. Yada).Bibliography.Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
At the library
Biology Library (Falconer)
Biology Library (Falconer) | Status |
---|---|
Stacks | |
QP601.3 .M37 2003 | Unknown |
- Book
- online resource (xiv, 229 pages) : illustrations ; 25 cm
Summary
- Tools and techniques of kinetic analysis
- How do enzymes work?
- Characterization of enzyme activity
- Reversible enzyme inhibition
- Irreversible enzyme inhibition
- pH dependence of enzyme-catalyzed reactions
- Two-substrate reactions
- Multisite and cooperative enzymes
- Immobilized enzymes
- Interfacial enzymes
- Transient phases of enzymatic reactions
- Characterization of enzyme stability
- Mechanism-based inhibition / Leslie J. Copp
- Putting kinetic principles into practice / Kirk L. Parkin
- Use of enzyme kinetic data in the study of structure-function relationships of proteins / Takuji Tanaka and Ricky Y. Yada.
- Tools and techniques of kinetic analysis
- How do enzymes work?
- Characterization of enzyme activity
- Reversible enzyme inhibition
- Irreversible enzyme inhibition
- pH dependence of enzyme-catalyzed reactions
- Two-substrate reactions
- Multisite and cooperative enzymes
- Immobilized enzymes
- Interfacial enzymes
- Transient phases of enzymatic reactions
- Characterization of enzyme stability
- Mechanism-based inhibition / Leslie J. Copp
- Putting kinetic principles into practice / Kirk L. Parkin
- Use of enzyme kinetic data in the study of structure-function relationships of proteins / Takuji Tanaka and Ricky Y. Yada.
At the library
Medical Library (Lane)
Medical Library (Lane) | Status |
---|---|
Check Medical Library (Lane) catalog for status | |
WILEY | Unknown |
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