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Book
1 online resource : text file, PDF
  • volume 1. Nanoplatforms in drug delivery.
"Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release"--Provided by publisher.
  • volume 1. Nanoplatforms in drug delivery.
"Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release"--Provided by publisher.
Book
1 online resource.
  • Basic ideas in clinical trial design
  • Sampling and inferential statistics
  • Confidence intervals and p-values
  • Tests for simple treatment comparisons
  • Adjusting the analysis
  • Regression and analysis of covariance
  • Intention-to-treat and analysis sets
  • Power and sample size
  • Statistical significance and clinical importance
  • Multiple testing
  • Non-parametric and related methods
  • Equivalence and non-inferiority
  • The analysis of survival data
  • Interim analysis and data monitoring committees
  • Bayesian statistics
  • Adaptive designs
  • Observational studies
  • Meta-analysis
  • Methods for the safety analysis and safety monitoring
  • Diagnosis
  • The role of statistics and statisticians.
  • Basic ideas in clinical trial design
  • Sampling and inferential statistics
  • Confidence intervals and p-values
  • Tests for simple treatment comparisons
  • Adjusting the analysis
  • Regression and analysis of covariance
  • Intention-to-treat and analysis sets
  • Power and sample size
  • Statistical significance and clinical importance
  • Multiple testing
  • Non-parametric and related methods
  • Equivalence and non-inferiority
  • The analysis of survival data
  • Interim analysis and data monitoring committees
  • Bayesian statistics
  • Adaptive designs
  • Observational studies
  • Meta-analysis
  • Methods for the safety analysis and safety monitoring
  • Diagnosis
  • The role of statistics and statisticians.

3. Chemistry of drugs [2014]

Book
x, 260 p. : ill. ; 24 cm.
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
RS403 .B27 2014 Unknown
Book
online resource (xii, 252 pages) : illustrations (some color)
This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead.
This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
CRCNETBASE Unknown
Book
1 online resource (xxiv, 553 pages)
Book
1 online resource (xi, 511 pages) : illustrations (some color).
Book
1 online resource (366 pages) : illustrations.
Book
1 online resource.
Book
1 online resource (viii, 202 pages) : illustrations (some color)
Book
1 online resource.
  • Introduction
  • Lead discovery and lead modification
  • Receptors
  • Enzymes
  • Enzyme inhibition and inactivation
  • Dna-interactive agents
  • Drug resistance and drug synergism
  • Drug metabolism
  • Prodrugs and drug delivery systems.
  • Introduction
  • Lead discovery and lead modification
  • Receptors
  • Enzymes
  • Enzyme inhibition and inactivation
  • Dna-interactive agents
  • Drug resistance and drug synergism
  • Drug metabolism
  • Prodrugs and drug delivery systems.
Book
1 online resource.
"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"-- Provided by publisher.
"Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-- Provided by publisher.
"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"-- Provided by publisher.
"Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-- Provided by publisher.
Book
xiii, 715 pages : ill. (some color, chiefly tables) ; 26 cm.
  • From pharmacogenomics and systems biology to personalized care : a framework of systems and dynamical medicine / Qing Yan
  • Translational bioinformatics approaches for systems and dynamical medicine / Qing Yan
  • Whole blood transcriptomic analysis to identify clinical biomarkers of drug response / Grant P. Parnell and David R. Booth
  • Diagnostic procedures for paraffin-embedded tissues analysis in pharmacogenomic studies / Raffaele Palmirotta [and six others]
  • Approach to clinical and genetic characterization of statin-induced myopathy / QiPing Feng
  • Pharmacogenomics of membrane transporters : a review of current approaches / Tristan M. Sissung [and four others]
  • G protein-coupled receptor accessory proteins and signaling : pharmacogenomic insights / Miles D. Thompson [and three others]
  • G protein-coupled receptor mutations and human genetic disease / Miles D. Thompson [and four others]
  • Pharmacogenetics of the G protein-coupled receptors / Miles D. Thompson [and six others]
  • Pharmacogenomics of heart failure / Anastasios Lymperopoulos and Faren French
  • Pharmacogenomics in the development and characterization of atheroprotective drugs / Efi Valanti, Alexandros Tsompanidis, and Despina Sanoudou
  • Management of side effects in the personalized medicine era : chemotherapy-induced peripheral neuropathy / Paolo Alberti and G. Cavaletti
  • Pharmacogenomics of Alzheimer's disease : novel therapeutic strategies for drug development / Ramón Cacabelos [and four others]
  • Pharmacogenetics of antipsychotic treatment in schizophrenia / Jennie G. Pouget and Daniel J. Müller / Pharmacogenetics of addiction therapy / David A. Nielsen [and three others]
  • Pharmacogenetics in rheumatoid arthritis / Deepali Sen, Jisna R. Paul, and Prabha Ranganathan
  • Pharmacogenetics of osteoporotic fractures / José A. Riancho and Flor M. Pérez-Campo
  • Pharmacogenomics and pharmacoepigenomics in pediatric medicine / Barkur S. Shastry
  • Pharmacogenomics in children / Michael Rieder.
  • From pharmacogenomics and systems biology to personalized care : a framework of systems and dynamical medicine / Qing Yan
  • Translational bioinformatics approaches for systems and dynamical medicine / Qing Yan
  • Whole blood transcriptomic analysis to identify clinical biomarkers of drug response / Grant P. Parnell and David R. Booth
  • Diagnostic procedures for paraffin-embedded tissues analysis in pharmacogenomic studies / Raffaele Palmirotta [and six others]
  • Approach to clinical and genetic characterization of statin-induced myopathy / QiPing Feng
  • Pharmacogenomics of membrane transporters : a review of current approaches / Tristan M. Sissung [and four others]
  • G protein-coupled receptor accessory proteins and signaling : pharmacogenomic insights / Miles D. Thompson [and three others]
  • G protein-coupled receptor mutations and human genetic disease / Miles D. Thompson [and four others]
  • Pharmacogenetics of the G protein-coupled receptors / Miles D. Thompson [and six others]
  • Pharmacogenomics of heart failure / Anastasios Lymperopoulos and Faren French
  • Pharmacogenomics in the development and characterization of atheroprotective drugs / Efi Valanti, Alexandros Tsompanidis, and Despina Sanoudou
  • Management of side effects in the personalized medicine era : chemotherapy-induced peripheral neuropathy / Paolo Alberti and G. Cavaletti
  • Pharmacogenomics of Alzheimer's disease : novel therapeutic strategies for drug development / Ramón Cacabelos [and four others]
  • Pharmacogenetics of antipsychotic treatment in schizophrenia / Jennie G. Pouget and Daniel J. Müller / Pharmacogenetics of addiction therapy / David A. Nielsen [and three others]
  • Pharmacogenetics in rheumatoid arthritis / Deepali Sen, Jisna R. Paul, and Prabha Ranganathan
  • Pharmacogenetics of osteoporotic fractures / José A. Riancho and Flor M. Pérez-Campo
  • Pharmacogenomics and pharmacoepigenomics in pediatric medicine / Barkur S. Shastry
  • Pharmacogenomics in children / Michael Rieder.
Biology Library (Falconer)
Status of items at Biology Library (Falconer)
Biology Library (Falconer) Status
Stacks
QH506 .M45 V.1175 Unavailable In process Request
Book
xii, 176 pages
  • Getting started
  • Discovery and preclinical work
  • Preparing for the clinic
  • Transferring technology
  • Commercialization and entrepreneurship
  • Concluding thoughts.
Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed "too early" to attract industry interest. There are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest.
  • Getting started
  • Discovery and preclinical work
  • Preparing for the clinic
  • Transferring technology
  • Commercialization and entrepreneurship
  • Concluding thoughts.
Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed "too early" to attract industry interest. There are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
RM301.25 .P733 2014 Unknown
Book
xii, 176 pages : illustrations.
Chemistry & ChemEng Library (Swain)
Status of items at Chemistry & ChemEng Library (Swain)
Chemistry & ChemEng Library (Swain) Status
Stacks
RM301.25 .P73 2014 Unknown
Book
1 online resource (xii, 394 pages) : illustrations (some color).
Book
1 online resource : text file, PDF
  • section I. A theory of evaluating drugs
  • section II. A theory of evidence in drug development
  • section III. Additional topics.
  • section I. A theory of evaluating drugs
  • section II. A theory of evidence in drug development
  • section III. Additional topics.
Book
online resource (xvi, 245 pages) : illustrations
  • Section I. A theory of evaluating drugs
  • section II. A theory of evidence in drug development
  • section III. Additional topics.
  • Section I. A theory of evaluating drugs
  • section II. A theory of evidence in drug development
  • section III. Additional topics.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
CRCNETBASE Unknown
Book
online resource (viii, 198 pages) : illustrations (some color)
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER Unknown
Book
online resource (xii, 89 pages) : illustrations
  • Introduction
  • Application of prodrug chemistry to GLP-1
  • Experimental procedures
  • Characterization of prodrugs
  • Conclusion
  • Appendix I. Schematic synthesis of longer acting prodrugs
  • Appendix II: Structure of peptides in Table A.1
  • Appendix III: Structure of peptides in table A.2
  • Appendix IV: Structure of peptides in table A.3
  • Appendix V: Structure of peptides in table A.4 Appendix VI: Structure of peptides in table A.5
  • Appendix VII. Structure of peptides in table A.6
  • Appendix VIII: Acylataion of HO-His7, GLP(8-37)
  • Appendix IX: A note on nomenclature.
  • Introduction
  • Application of prodrug chemistry to GLP-1
  • Experimental procedures
  • Characterization of prodrugs
  • Conclusion
  • Appendix I. Schematic synthesis of longer acting prodrugs
  • Appendix II: Structure of peptides in Table A.1
  • Appendix III: Structure of peptides in table A.2
  • Appendix IV: Structure of peptides in table A.3
  • Appendix V: Structure of peptides in table A.4 Appendix VI: Structure of peptides in table A.5
  • Appendix VII. Structure of peptides in table A.6
  • Appendix VIII: Acylataion of HO-His7, GLP(8-37)
  • Appendix IX: A note on nomenclature.
Medical Library (Lane)
Status of items at Medical Library (Lane)
Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER Unknown
Book
1 online resource.
  • Introduction
  • Application of prodrug chemistry to GLP-1
  • Experimental procedures
  • Characterization of prodrugs
  • Conclusion
  • Appendix I. Schematic synthesis of longer acting prodrugs
  • Appendix II: Structure of peptides in Table A.1
  • Appendix III: Structure of peptides in table A.2
  • Appendix IV: Structure of peptides in table A.3
  • Appendix V: Structure of peptides in table A.4 Appendix VI: Structure of peptides in table A.5
  • Appendix VII. Structure of peptides in table A.6
  • Appendix VIII: Acylataion of HO-His7, GLP(8-37)
  • Appendix IX: A note on nomenclature.
  • Introduction
  • Application of prodrug chemistry to GLP-1
  • Experimental procedures
  • Characterization of prodrugs
  • Conclusion
  • Appendix I. Schematic synthesis of longer acting prodrugs
  • Appendix II: Structure of peptides in Table A.1
  • Appendix III: Structure of peptides in table A.2
  • Appendix IV: Structure of peptides in table A.3
  • Appendix V: Structure of peptides in table A.4 Appendix VI: Structure of peptides in table A.5
  • Appendix VII. Structure of peptides in table A.6
  • Appendix VIII: Acylataion of HO-His7, GLP(8-37)
  • Appendix IX: A note on nomenclature.

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