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Book
xvi, 600 pages : illustrations (some color) ; 24 cm
  • Mass spectrometry for proteomics-based investigation / Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel, and Costel C. Darie
  • MALDI profiling and applications in medicine / Ed Dudley
  • Simplifying the proteome: analytical strategies for improving peak capacity / Lee A. Gethings and Joanne B. Connolly
  • Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences / Lewis M. Brown
  • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics / Esthelle Hoedt, Guoan Zhang, and Thomas A. Neubert
  • Utility of computational structural biology in mass spectrometry / Urmi Roy, Alisa G. Woods, Izabela Sokolowska, and Costel C. Darie
  • Affinity-mass spectrometry approaches for elucidating structures and interactions of protein-ligand complexes / Brînduşa Alina Petre
  • Neurological analyses: focus on gangliosides and mass spectrometry / Alina D. Zamfir
  • Mass spectrometric analysis of post-translational modifications (PTMs) and protein-protein interactions (PPIs) / Armand G. Ngounou Wetie, Alisa G. Woods, and Costel C. Darie
  • Applications for mass spectrometry in the study of ion channel structure and function / Damien S.K. Samways
  • A mass spectrometry view of stable and transient protein interactions / Hanna G. Budayeva and Ileana M. Cristea
  • Mass spectrometry-based tissue imaging of small molecules / Carly N. Ferguson, Joseph W.M. Fowler, Jonathan F. Waxer, Richard A. Gatti, and Joseph A. Loo
  • Redox proteomics: from bench to bedside / Karina Ckless
  • Analysis of fluorinated proteins by mass spectrometry / Linda A. Luck
  • Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system / Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace
  • Mass spectrometry-based biomarkers in drug development / Ronald A. Miller and Daniel S. Spellman
  • Detection of biomedically relevant stilbenes from wines by mass spectrometry / Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, and Alina Vasilescu
  • Mass spectrometric DNA adduct quantification by multiple reaction monitoring and its future use for the molecular epidemiology of cancer / Bernhard H. Monien
  • Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics / Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, and Kathleen F. Arcaro
  • Cancer secretomes and their place in supplementing other hallmarks of cancer / Sapan Patel, Armand G. Ngounou Wetie, Costel C. Darie, and Bayard D. Clarkson
  • Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation / Cristinel Sandu, Armand G. Ngounou Wetie, Costel C. Darie, and Hermann Steller
  • Using proteomics to unravel the mysterious steps of the HBV-life-cycle / Norica Branza-Nichita, Catalina Petrareanu, Catalin Lazar, Izabela Sokolowska, and Costel C. Darie
  • Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends / Mouna Marrakchi, Xiaobo Liu, and Silvana Andreescu
  • Proteomic approaches to dissect neuronal signaling pathways / Heather L. Bowling and Katrin Deinhardt
  • Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF) / Alisa G. Woods, Izabela Sokolowska, Katrin Deinhardt, and Costel C. Darie
  • Mass spectrometry for the study of autism and neurodevelopmental disorders / Armand G. Ngounou Wetie, Robert M. Dekroon, Mihaela Mocanu, Jeanne P. Ryan, Costel C. Darie, and Alisa G. Woods
  • Biomarkers in major depressive disorder: the role of mass spectrometry / Alisa G. Woods, Dan V. Iosifescu, and Costel C. Darie
  • Application of mass spectrometry to characterize localization and efficacy of nanoceria in vivo / Karin L. Heckman, Joseph Erlichman, Ken Reed, and Matthew Skeels
  • Bottlenecks in proteomics / Armand G. Ngounou Wetie, Devon A. Shipp, and Costel C. Darie.
"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.
  • Mass spectrometry for proteomics-based investigation / Alisa G. Woods, Izabela Sokolowska, Armand G. Ngounou Wetie, Kelly Wormwood, Roshanak Aslebagh, Sapan Patel, and Costel C. Darie
  • MALDI profiling and applications in medicine / Ed Dudley
  • Simplifying the proteome: analytical strategies for improving peak capacity / Lee A. Gethings and Joanne B. Connolly
  • Quantitative shotgun proteomics with data-independent acquisition and traveling wave ion mobility spectrometry: a versatile tool in the life sciences / Lewis M. Brown
  • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics / Esthelle Hoedt, Guoan Zhang, and Thomas A. Neubert
  • Utility of computational structural biology in mass spectrometry / Urmi Roy, Alisa G. Woods, Izabela Sokolowska, and Costel C. Darie
  • Affinity-mass spectrometry approaches for elucidating structures and interactions of protein-ligand complexes / Brînduşa Alina Petre
  • Neurological analyses: focus on gangliosides and mass spectrometry / Alina D. Zamfir
  • Mass spectrometric analysis of post-translational modifications (PTMs) and protein-protein interactions (PPIs) / Armand G. Ngounou Wetie, Alisa G. Woods, and Costel C. Darie
  • Applications for mass spectrometry in the study of ion channel structure and function / Damien S.K. Samways
  • A mass spectrometry view of stable and transient protein interactions / Hanna G. Budayeva and Ileana M. Cristea
  • Mass spectrometry-based tissue imaging of small molecules / Carly N. Ferguson, Joseph W.M. Fowler, Jonathan F. Waxer, Richard A. Gatti, and Joseph A. Loo
  • Redox proteomics: from bench to bedside / Karina Ckless
  • Analysis of fluorinated proteins by mass spectrometry / Linda A. Luck
  • Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system / Reshica Baral, Armand G. Ngounou Wetie, Costel C. Darie, and Kenneth N. Wallace
  • Mass spectrometry-based biomarkers in drug development / Ronald A. Miller and Daniel S. Spellman
  • Detection of biomedically relevant stilbenes from wines by mass spectrometry / Veronica Andrei, Armand G. Ngounou Wetie, Iuliana Mihai, Costel C. Darie, and Alina Vasilescu
  • Mass spectrometric DNA adduct quantification by multiple reaction monitoring and its future use for the molecular epidemiology of cancer / Bernhard H. Monien
  • Using breast milk to assess breast cancer risk: the role of mass spectrometry-based proteomics / Sallie S. Schneider, Roshanak Aslebagh, Armand G. Ngounou Wetie, Susan R. Sturgeon, Costel C. Darie, and Kathleen F. Arcaro
  • Cancer secretomes and their place in supplementing other hallmarks of cancer / Sapan Patel, Armand G. Ngounou Wetie, Costel C. Darie, and Bayard D. Clarkson
  • Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation / Cristinel Sandu, Armand G. Ngounou Wetie, Costel C. Darie, and Hermann Steller
  • Using proteomics to unravel the mysterious steps of the HBV-life-cycle / Norica Branza-Nichita, Catalina Petrareanu, Catalin Lazar, Izabela Sokolowska, and Costel C. Darie
  • Oxidative stress and antibiotic resistance in bacterial pathogens: state of the art, methodologies, and future trends / Mouna Marrakchi, Xiaobo Liu, and Silvana Andreescu
  • Proteomic approaches to dissect neuronal signaling pathways / Heather L. Bowling and Katrin Deinhardt
  • Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF) / Alisa G. Woods, Izabela Sokolowska, Katrin Deinhardt, and Costel C. Darie
  • Mass spectrometry for the study of autism and neurodevelopmental disorders / Armand G. Ngounou Wetie, Robert M. Dekroon, Mihaela Mocanu, Jeanne P. Ryan, Costel C. Darie, and Alisa G. Woods
  • Biomarkers in major depressive disorder: the role of mass spectrometry / Alisa G. Woods, Dan V. Iosifescu, and Costel C. Darie
  • Application of mass spectrometry to characterize localization and efficacy of nanoceria in vivo / Karin L. Heckman, Joseph Erlichman, Ken Reed, and Matthew Skeels
  • Bottlenecks in proteomics / Armand G. Ngounou Wetie, Devon A. Shipp, and Costel C. Darie.
"This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease and psychiatry. Additional chapters focus on methodology as well as new technologies and instrumentation. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research but also to initiate and improve their own work. Thus the book acts as a technical guide but also a conceptual guide to the newest information in this exciting field. Mass spectrometry is the central tool used in proteomic research today and is rapidly becoming indispensable to the biomedical scientist. With the completion of the human genome project and the genomic revolution, the proteomic revolution has followed closely behind. Understanding the human proteome has become critical to basic and clinical biomedical research and holds the promise of providing comprehensive understanding of human physiological processes. In addition, proteomics and mass spectrometry are bringing unprecedented biomarker discovery and are helping to personalize medicine"--Publisher's description.
Medical Library (Lane)
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Medical Library (Lane) Status
Check Medical Library (Lane) catalog for status
SPRINGER Unknown
Book
1 online resource (xvi, 600 pages) : illustrations (some color).
Book
1 online resource (vii, 264 pages) : illustrations (some color).
Book
1 online resource : text file, PDF
  • 1. Methodologies on quantum-chemical calculation / V.A. Babkin and G.E. Zaikov
  • 2. Reactivity of tert-butyl ester 3-(3', 5'-di-tert-butyl-4'-hydroxyphenyl)-propionic acid in the reactions of oxidation / A.A. Volodkin, G.E. Zaikov, N.M. Evteeva, S.M. Lomakin, and N.N. Madyuskin
  • 3. Assessment of the potential of enhanced oil recovery from reservoirs with high water content using the heat of nitrate oxidation reactions and in situ hydrocarbon oxidation / E.N. Aleksandrov, P.E. Aleksandrov, N.M. Kuznetsov, A.L. Petrov, and V.Yu. Lidzhi-Goryaev
  • 4. Antioxidative efficiency terpenphenol at thermo-oxidative degradation polyvinyl chloride / R.M. Akhmetkhanov, S.V. Kolesov, I.T. Gabitov, I.Yu. Chukicheva, A.V. Kuchin, and G.E. Zaikov
  • 5. Photoinitiated copolymerization of bifunctional (meth) acrylates : kinetics and mechanism / G.I. Khovanets, Yu.G. Medvedevskikh, I.Yu. Yevchuk, and G.E. Zaikov
  • 6. Nanofibrous on the base of polyhydroxybutyrate / A.A. Olkhov, O.V. Staroverova, Yu.N. Filatov, G.M. Kuzmicheva, A.L. Iordansky, G.E. Zaikov, O.V. Stoyanov, and L.A. Zenitova
  • 7. Degradation of some films under UV-radiation / A.A. Olkhov, A.L. Iordansky, G.E. Zaikov, O.V. Stoyanov, L.A. Zenitova, and S.Yu. Sofina
  • 8. Polyolefin chlorine-containing rubbers : properties and applications / Yu.O. Andriasyan, I.A. Mikhaylov, A.L. Belousova, G.E. Zaikov, A.E. Kornev, and A.A. Popov
  • 9. Adhesion characteristics of ethylene copolymers / N.E. Temnikova, S.N. Rusanova, S.Yu. Sofina, O.V. Stoyanov, R.M. Garipov, A.E. Chalykh, V.K. Gerasimov, and G.E. Zaikov
  • 10. Oxidation of fibrinogen by ozone : effect of dihydroquercetin and cyclodextrin inclusion complex with the new dihydroquercetin derivative / V.S. Rogovsky, T.M. Arzamasova, M.A. Rosenfeld, M.L. Konstantinova, V.B. Leonova, S.D. Razumovsky, G.E. Zaikov, A.I. Matyoushin, N.L. Shimanovsky, A.M. Koroteev, S.E. Mosyurov, M.P. Koroteev, T.S. Kuhareva, and E.E. Nifantiev
  • 11. Industrial drying and evaporation systems / A.K. Haghi, and G.E. Zaikov Petronis
  • 12. Nanopatterned implants loaded with drugs / A.L. Iordanskii, S.Z. Rogovina, I. Afanasov, and A.A. Berlin.
  • 1. Methodologies on quantum-chemical calculation / V.A. Babkin and G.E. Zaikov
  • 2. Reactivity of tert-butyl ester 3-(3', 5'-di-tert-butyl-4'-hydroxyphenyl)-propionic acid in the reactions of oxidation / A.A. Volodkin, G.E. Zaikov, N.M. Evteeva, S.M. Lomakin, and N.N. Madyuskin
  • 3. Assessment of the potential of enhanced oil recovery from reservoirs with high water content using the heat of nitrate oxidation reactions and in situ hydrocarbon oxidation / E.N. Aleksandrov, P.E. Aleksandrov, N.M. Kuznetsov, A.L. Petrov, and V.Yu. Lidzhi-Goryaev
  • 4. Antioxidative efficiency terpenphenol at thermo-oxidative degradation polyvinyl chloride / R.M. Akhmetkhanov, S.V. Kolesov, I.T. Gabitov, I.Yu. Chukicheva, A.V. Kuchin, and G.E. Zaikov
  • 5. Photoinitiated copolymerization of bifunctional (meth) acrylates : kinetics and mechanism / G.I. Khovanets, Yu.G. Medvedevskikh, I.Yu. Yevchuk, and G.E. Zaikov
  • 6. Nanofibrous on the base of polyhydroxybutyrate / A.A. Olkhov, O.V. Staroverova, Yu.N. Filatov, G.M. Kuzmicheva, A.L. Iordansky, G.E. Zaikov, O.V. Stoyanov, and L.A. Zenitova
  • 7. Degradation of some films under UV-radiation / A.A. Olkhov, A.L. Iordansky, G.E. Zaikov, O.V. Stoyanov, L.A. Zenitova, and S.Yu. Sofina
  • 8. Polyolefin chlorine-containing rubbers : properties and applications / Yu.O. Andriasyan, I.A. Mikhaylov, A.L. Belousova, G.E. Zaikov, A.E. Kornev, and A.A. Popov
  • 9. Adhesion characteristics of ethylene copolymers / N.E. Temnikova, S.N. Rusanova, S.Yu. Sofina, O.V. Stoyanov, R.M. Garipov, A.E. Chalykh, V.K. Gerasimov, and G.E. Zaikov
  • 10. Oxidation of fibrinogen by ozone : effect of dihydroquercetin and cyclodextrin inclusion complex with the new dihydroquercetin derivative / V.S. Rogovsky, T.M. Arzamasova, M.A. Rosenfeld, M.L. Konstantinova, V.B. Leonova, S.D. Razumovsky, G.E. Zaikov, A.I. Matyoushin, N.L. Shimanovsky, A.M. Koroteev, S.E. Mosyurov, M.P. Koroteev, T.S. Kuhareva, and E.E. Nifantiev
  • 11. Industrial drying and evaporation systems / A.K. Haghi, and G.E. Zaikov Petronis
  • 12. Nanopatterned implants loaded with drugs / A.L. Iordanskii, S.Z. Rogovina, I. Afanasov, and A.A. Berlin.
Book
1 online resource (xvii, 330 pages) : illustrations (some color).
Book
1 online resource (x, 331 pages) : illustrations (some color).
Book
1 online resource (xviii, 313 pages)
Book
1 online resource (xiii, 354 pages) : illustrations (some color).
Book
1 online resource (ix, 342 pages) : illustrations (some color).
Book
1 online resource (xxi, 161 pages) : illustrations (some color).
Book
1 online resource (xiii, 70 pages) : illustrations.
Book
1 online resource (xii, 210 pages) : illustrations (some color)
  • Saving Solvents in Chromatographic Purifications: The Counter-current Chromatography Technique
  • Ion Size Exclusion Chromatography on Hypercrosslinked Polystyrene Sorbents as a Green Technology of Separating Mineral Electrolytes
  • Supercritical Fluid Chromatography: A Green Approach for Separation and Purification of Organic and Inorganic Analytes
  • High Performance Thin-layer Chromatography
  • Green Techniques in Gas Chromatography
  • Preparation and Purification of Garlic-Derived Organosulfur Compound Allicin by Green Methodologies
  • Green Sample Preparation Focusing on Organic Analytes in Complex Matrices
  • Studies Regarding the Optimization of the Solvent Consumption in the Determination of Organochlorine Pesticides from Complex Fodder
  • Size Exclusion Chromatography: A Useful Technique for Speciation Analysis of Polydimethylsiloxanes.
Green analytical chemistry research calls for the use of green solvents and characterization techniques that can be used for the separation, identification and purification of organic and inorganic analytes. This book presents a unified outlook on counter-current, ion size exclusion, supercritical fluids, high-performance thin layers, and gas and size exclusion chromatographic techniques used for the separation and purification of organic and inorganic analytes. It also describes a number of green techniques, green sample preparation methods and optimization of solvent consumption in the chromatographic analysis of organic and inorganic analytes. This book offers a valuable resource not only for learners, but also for more experienced chromatographers, conveying a deeper understanding of green chromatographic techniques, green solvents and preparation methods.
  • Saving Solvents in Chromatographic Purifications: The Counter-current Chromatography Technique
  • Ion Size Exclusion Chromatography on Hypercrosslinked Polystyrene Sorbents as a Green Technology of Separating Mineral Electrolytes
  • Supercritical Fluid Chromatography: A Green Approach for Separation and Purification of Organic and Inorganic Analytes
  • High Performance Thin-layer Chromatography
  • Green Techniques in Gas Chromatography
  • Preparation and Purification of Garlic-Derived Organosulfur Compound Allicin by Green Methodologies
  • Green Sample Preparation Focusing on Organic Analytes in Complex Matrices
  • Studies Regarding the Optimization of the Solvent Consumption in the Determination of Organochlorine Pesticides from Complex Fodder
  • Size Exclusion Chromatography: A Useful Technique for Speciation Analysis of Polydimethylsiloxanes.
Green analytical chemistry research calls for the use of green solvents and characterization techniques that can be used for the separation, identification and purification of organic and inorganic analytes. This book presents a unified outlook on counter-current, ion size exclusion, supercritical fluids, high-performance thin layers, and gas and size exclusion chromatographic techniques used for the separation and purification of organic and inorganic analytes. It also describes a number of green techniques, green sample preparation methods and optimization of solvent consumption in the chromatographic analysis of organic and inorganic analytes. This book offers a valuable resource not only for learners, but also for more experienced chromatographers, conveying a deeper understanding of green chromatographic techniques, green solvents and preparation methods.
Book
1 online resource (657 p.)
  • Infrared and Raman Spectroscopic Imaging; Contents; Preface; List of Contributors; Part I Basic Methodology; Chapter 1 Infrared and Raman Instrumentation for Mapping and Imaging; 1.1 Introduction to Mapping and Imaging; 1.2 Mid-Infrared Microspectroscopy and Mapping; 1.2.1 Diffraction-Limited Microscopy; 1.2.2 Microscopes and Sampling Techniques; 1.2.3 Detectors for Mid-Infrared Microspectroscopy; 1.2.4 Sources for Mid-Infrared Microspectroscopy; 1.2.5 Spatial Resolution; 1.2.6 Transmission Microspectroscopy; 1.2.7 Attenuated Total Reflection Microspectroscopy
  • 1.3 Raman Microspectroscopy and Mapping1.3.1 Introduction to Raman Microspectroscopy; 1.3.2 CCD Detectors; 1.3.3 Spatial Resolution; 1.3.4 Tip-Enhanced Raman Spectroscopy; 1.4 Near-Infrared Hyperspectral Imaging; 1.5 Raman Hyperspectral Imaging; 1.6 Mid-Infrared Hyperspectral Imaging; 1.6.1 Spectrometers Based on 2D Array Detectors; 1.6.2 Spectrometers Based on Hybrid Linear Array Detectors; 1.6.3 Sampling; 1.7 Mapping with Pulsed Terahertz Radiation; 1.8 Summary; Acknowledgments; References; Chapter 2 Chemometric Tools for Image Analysis; 2.1 Introduction
  • 2.2 Hyperspectral Images: The Measurement2.2.1 The Data Set and the Underlying Model; 2.3 Image Preprocessing; 2.3.1 Signal Preprocessing; 2.3.1.1 De-noising; 2.3.1.2 Baseline Correction; 2.3.1.3 Detection and Suppression of Anomalous Pixels or Anomalous Spectral Readings; 2.3.2 Data Pretreatments; 2.3.3 Image Compression; 2.4 Exploratory Image Analysis; 2.4.1 Classical Image Representations: Limitations; 2.4.2 Multivariate Image Analysis (MIA) and Principal Component Analysis (PCA); 2.5 Quantitative Image Information: Multivariate Image Regression (MIR); 2.6 Image Segmentation
  • 2.6.1 Unsupervised and Supervised Segmentation Methods2.6.2 Hard and Fuzzy Segmentation Approaches; 2.6.3 Including Spatial Information in Image Segmentation; 2.7 Image Resolution; 2.7.1 The Image Resolution Concept; 2.7.2 Spatial and Spectral Exploration; 2.7.3 The Resolution Process: Initial Estimates and Constraints; 2.7.4 Image Multiset Analysis; 2.7.5 Resolution Postprocessing: Compound Identification, Quantitative Analysis, and Superresolution; 2.7.5.1 Compound Identification; 2.7.5.2 Quantitative Analysis; 2.7.5.3 Superresolution; 2.8 Future Trends; References
  • Part II Biomedical ApplicationsChapter 3 Vibrational Spectroscopic Imaging of Soft Tissue; 3.1 Introduction; 3.1.1 Epithelium; 3.1.2 Connective Tissue and Extracellular Matrix; 3.1.3 Muscle Tissue; 3.1.4 Nervous Tissue; 3.2 Preparation of Soft Tissue for Vibrational Spectroscopic Imaging; 3.2.1 General Preparation Strategies; 3.2.2 Vibrational Spectra of Reference Material; 3.2.3 Preparation for FT-IR Imaging; 3.2.4 Preparation for Raman Imaging; 3.3 Applications to Soft Tissue; 3.3.1 Colon Tissue; 3.3.2 Brain Tissue and Brain Tumors; 3.3.2.1 Mouse Brains; 3.3.2.2 Primary Brain Tumors
This second edition of the successful ready reference is updated and revised with approximately 30% new content to reflect the numerous instrumental developments and improvements, as well as the significant expansion of this rapidly developing field. For example, the combination of IR imaging with AFM has enhanced the achievable lateral resolution by an order of magnitude down to a few hundred nanometers, thus launching a multiplicity of new applications in material science. Furthermore, Raman and IR spectroscopic imaging have become key technologies for the life sciences and today contribute.
  • Infrared and Raman Spectroscopic Imaging; Contents; Preface; List of Contributors; Part I Basic Methodology; Chapter 1 Infrared and Raman Instrumentation for Mapping and Imaging; 1.1 Introduction to Mapping and Imaging; 1.2 Mid-Infrared Microspectroscopy and Mapping; 1.2.1 Diffraction-Limited Microscopy; 1.2.2 Microscopes and Sampling Techniques; 1.2.3 Detectors for Mid-Infrared Microspectroscopy; 1.2.4 Sources for Mid-Infrared Microspectroscopy; 1.2.5 Spatial Resolution; 1.2.6 Transmission Microspectroscopy; 1.2.7 Attenuated Total Reflection Microspectroscopy
  • 1.3 Raman Microspectroscopy and Mapping1.3.1 Introduction to Raman Microspectroscopy; 1.3.2 CCD Detectors; 1.3.3 Spatial Resolution; 1.3.4 Tip-Enhanced Raman Spectroscopy; 1.4 Near-Infrared Hyperspectral Imaging; 1.5 Raman Hyperspectral Imaging; 1.6 Mid-Infrared Hyperspectral Imaging; 1.6.1 Spectrometers Based on 2D Array Detectors; 1.6.2 Spectrometers Based on Hybrid Linear Array Detectors; 1.6.3 Sampling; 1.7 Mapping with Pulsed Terahertz Radiation; 1.8 Summary; Acknowledgments; References; Chapter 2 Chemometric Tools for Image Analysis; 2.1 Introduction
  • 2.2 Hyperspectral Images: The Measurement2.2.1 The Data Set and the Underlying Model; 2.3 Image Preprocessing; 2.3.1 Signal Preprocessing; 2.3.1.1 De-noising; 2.3.1.2 Baseline Correction; 2.3.1.3 Detection and Suppression of Anomalous Pixels or Anomalous Spectral Readings; 2.3.2 Data Pretreatments; 2.3.3 Image Compression; 2.4 Exploratory Image Analysis; 2.4.1 Classical Image Representations: Limitations; 2.4.2 Multivariate Image Analysis (MIA) and Principal Component Analysis (PCA); 2.5 Quantitative Image Information: Multivariate Image Regression (MIR); 2.6 Image Segmentation
  • 2.6.1 Unsupervised and Supervised Segmentation Methods2.6.2 Hard and Fuzzy Segmentation Approaches; 2.6.3 Including Spatial Information in Image Segmentation; 2.7 Image Resolution; 2.7.1 The Image Resolution Concept; 2.7.2 Spatial and Spectral Exploration; 2.7.3 The Resolution Process: Initial Estimates and Constraints; 2.7.4 Image Multiset Analysis; 2.7.5 Resolution Postprocessing: Compound Identification, Quantitative Analysis, and Superresolution; 2.7.5.1 Compound Identification; 2.7.5.2 Quantitative Analysis; 2.7.5.3 Superresolution; 2.8 Future Trends; References
  • Part II Biomedical ApplicationsChapter 3 Vibrational Spectroscopic Imaging of Soft Tissue; 3.1 Introduction; 3.1.1 Epithelium; 3.1.2 Connective Tissue and Extracellular Matrix; 3.1.3 Muscle Tissue; 3.1.4 Nervous Tissue; 3.2 Preparation of Soft Tissue for Vibrational Spectroscopic Imaging; 3.2.1 General Preparation Strategies; 3.2.2 Vibrational Spectra of Reference Material; 3.2.3 Preparation for FT-IR Imaging; 3.2.4 Preparation for Raman Imaging; 3.3 Applications to Soft Tissue; 3.3.1 Colon Tissue; 3.3.2 Brain Tissue and Brain Tumors; 3.3.2.1 Mouse Brains; 3.3.2.2 Primary Brain Tumors
This second edition of the successful ready reference is updated and revised with approximately 30% new content to reflect the numerous instrumental developments and improvements, as well as the significant expansion of this rapidly developing field. For example, the combination of IR imaging with AFM has enhanced the achievable lateral resolution by an order of magnitude down to a few hundred nanometers, thus launching a multiplicity of new applications in material science. Furthermore, Raman and IR spectroscopic imaging have become key technologies for the life sciences and today contribute.
Book
1 online resource (x, 274 pages) : illustrations
Mechanochromic fluorescent (or mechanofluorochromic) materials change their emission colours (spectra) when an appropriate external mechanical force stimulus is applied. This is an important group of materials with a huge range of applications, including use in sensors, memory chips, security inks, and light devices.Mechanochromic Fluorescent Materials introduces the reader to the concept of mechanofluorochromism and the variety of applications of this group of materials. Prominent international figures in mechanofluorochromism consider the innovative research in this field over the last ten years. Chapters provide in depth coverage of most reported mechanofluorochromic systems, including organic and organic-inorganic complexes; polymer and polymer composites; and aggregation-induced emission.This book is aimed to inform all students and researchers with an interest in mechanofluorochromism, and to help researchers identify and synthesize more of these materials, and develop the study and application of mechanofluorochromic materials.
Mechanochromic fluorescent (or mechanofluorochromic) materials change their emission colours (spectra) when an appropriate external mechanical force stimulus is applied. This is an important group of materials with a huge range of applications, including use in sensors, memory chips, security inks, and light devices.Mechanochromic Fluorescent Materials introduces the reader to the concept of mechanofluorochromism and the variety of applications of this group of materials. Prominent international figures in mechanofluorochromism consider the innovative research in this field over the last ten years. Chapters provide in depth coverage of most reported mechanofluorochromic systems, including organic and organic-inorganic complexes; polymer and polymer composites; and aggregation-induced emission.This book is aimed to inform all students and researchers with an interest in mechanofluorochromism, and to help researchers identify and synthesize more of these materials, and develop the study and application of mechanofluorochromic materials.
Book
1 online resource (xiii, 174 pages) : illustrations (some color).
  • From the Contents: Introduction
  • Measuring the photoelectron signal
  • The study of ionic dissociations
  • Thermochemistry
  • Experimental
  • The synchrotron radiation source
  • The endstation
  • Capturing the electron signal
  • The experimental results
  • Theory
  • Computational methods
  • Modelling.
Jonelle Harvey's thesis outlines two related experimental techniques which are utilised to investigate small halogenated molecules: threshold photoelectron spectroscopy and threshold photoelectron photoion coincidence techniques. All the experiments were conducted at the vacuum ultraviolet beamline of the Swiss Light Source, which is a synchrotron photon source offering easy tunability. In this thesis, three studies are presented which combine experimental and computational ab initio approaches. The first study involves the fast dissociation of halogenated methanes in order to construct a self-consistent thermochemical network. The second study investigates the fragmentations of fluoroethenes from timebombs, which break apart very slowly but explosively, to fast dissociators. The third study uncovers how vital conical interactions underpin both the results of photoelectron spectra and dissociation patterns.The details included in this work are useful for researchers in the same field as well as those readers wishing to obtain a solid introduction into the types of systems encountered in threshold photoelectron photoion coincidence spectroscopy.
  • From the Contents: Introduction
  • Measuring the photoelectron signal
  • The study of ionic dissociations
  • Thermochemistry
  • Experimental
  • The synchrotron radiation source
  • The endstation
  • Capturing the electron signal
  • The experimental results
  • Theory
  • Computational methods
  • Modelling.
Jonelle Harvey's thesis outlines two related experimental techniques which are utilised to investigate small halogenated molecules: threshold photoelectron spectroscopy and threshold photoelectron photoion coincidence techniques. All the experiments were conducted at the vacuum ultraviolet beamline of the Swiss Light Source, which is a synchrotron photon source offering easy tunability. In this thesis, three studies are presented which combine experimental and computational ab initio approaches. The first study involves the fast dissociation of halogenated methanes in order to construct a self-consistent thermochemical network. The second study investigates the fragmentations of fluoroethenes from timebombs, which break apart very slowly but explosively, to fast dissociators. The third study uncovers how vital conical interactions underpin both the results of photoelectron spectra and dissociation patterns.The details included in this work are useful for researchers in the same field as well as those readers wishing to obtain a solid introduction into the types of systems encountered in threshold photoelectron photoion coincidence spectroscopy.
Book
1 online resource (xiii, 608 pages) : illustrations (some color).
  • Machine generated contents note: 1. Natural Products Analysis: Instrumentation, Methods, and Applications V. Havlíček and J. Spižek 2. The need for new Antifungal and Antimalarial compounds J. Spižek and A. Demain 3. Emerging Instrumental Methods for Antimicrobial Resistance and Virulence Testing P. A. Demirev 4. Plant and Marine Sources: Biological Activity of Natural Products and Therapeutic Use A. Amedei and E. Niccolai 5. Emerging Trends for Stimulating the Discovery of Natural Products N. Adnani, G. A. Ellis, J. C. Kwan, T. P. Wyche, E. W. Schmidt and T.S. Bugni 6. Advances and Challenges in Optical Molecular Spectroscopy Including Surface Plasmon Resonance-based Methods for Bioanalysis P. Matejka, B. Vlckova, L. Bednarova and P. Malon 7. Advanced Techniques for NMR Analysis of Complex Biological Mixtures
  • From Simple NMR to Hyphenated Techniques M. Kuzma, H. Pelantova and S. Bartova 8. Advances in X-ray Diffraction: Implications to Pharmaceutical Industry A. Jegorov and M. Husak 9. Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Tool in Biological Sciences M. Vasinova-Galiova and J. Havlis, V. Kanicky 10. Imaging Mass Spectrometry, metabolism and New Views of the Microbial World B. C. Hoefler and P. D. Straight 11. Structural Separations for Natural Product Characterization by Ion Mobility-Mass Spectrometry: Fundamental Theory to Emerging Applications S. M. Stow, N. M. Lareau, K. M. Hines, C. R. McNees, C. R. Goodwin, B. O. Bachmann and J. A. McLean 12. High-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide Analysis R. H. Wills, M. Tosin and P. B. O'Connor 13. Natural Product Drug Discovery and Analysis Using Mass Spectrometry and Affinity-based Technologies E. H. Wang and K. A. Schug 14. Glycosylated Ribozomally Synthesized Peptide Toxins: Discovery, Characterization and Applications G. E. Norris and M. L. Patchett 15. Using Ultrahigh-Resolution Mass Spectrometry to Unravel the Chemical Space of Complex Natural Product Mixtures C. Muller, M. Harir, N. Hertkorn, B. Kanawati, D. Tziotis and P. Schmitt-Kopplin 16. Functional Amyloid Fibrils: Lessons from Microbes S. L. Gras and D. Claessen Index.
"This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products"-- Provided by publisher.
  • Machine generated contents note: 1. Natural Products Analysis: Instrumentation, Methods, and Applications V. Havlíček and J. Spižek 2. The need for new Antifungal and Antimalarial compounds J. Spižek and A. Demain 3. Emerging Instrumental Methods for Antimicrobial Resistance and Virulence Testing P. A. Demirev 4. Plant and Marine Sources: Biological Activity of Natural Products and Therapeutic Use A. Amedei and E. Niccolai 5. Emerging Trends for Stimulating the Discovery of Natural Products N. Adnani, G. A. Ellis, J. C. Kwan, T. P. Wyche, E. W. Schmidt and T.S. Bugni 6. Advances and Challenges in Optical Molecular Spectroscopy Including Surface Plasmon Resonance-based Methods for Bioanalysis P. Matejka, B. Vlckova, L. Bednarova and P. Malon 7. Advanced Techniques for NMR Analysis of Complex Biological Mixtures
  • From Simple NMR to Hyphenated Techniques M. Kuzma, H. Pelantova and S. Bartova 8. Advances in X-ray Diffraction: Implications to Pharmaceutical Industry A. Jegorov and M. Husak 9. Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Tool in Biological Sciences M. Vasinova-Galiova and J. Havlis, V. Kanicky 10. Imaging Mass Spectrometry, metabolism and New Views of the Microbial World B. C. Hoefler and P. D. Straight 11. Structural Separations for Natural Product Characterization by Ion Mobility-Mass Spectrometry: Fundamental Theory to Emerging Applications S. M. Stow, N. M. Lareau, K. M. Hines, C. R. McNees, C. R. Goodwin, B. O. Bachmann and J. A. McLean 12. High-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide Analysis R. H. Wills, M. Tosin and P. B. O'Connor 13. Natural Product Drug Discovery and Analysis Using Mass Spectrometry and Affinity-based Technologies E. H. Wang and K. A. Schug 14. Glycosylated Ribozomally Synthesized Peptide Toxins: Discovery, Characterization and Applications G. E. Norris and M. L. Patchett 15. Using Ultrahigh-Resolution Mass Spectrometry to Unravel the Chemical Space of Complex Natural Product Mixtures C. Muller, M. Harir, N. Hertkorn, B. Kanawati, D. Tziotis and P. Schmitt-Kopplin 16. Functional Amyloid Fibrils: Lessons from Microbes S. L. Gras and D. Claessen Index.
"This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products"-- Provided by publisher.

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